| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. |
the present study demonstrated for the first time that acute as well as subchronic (4 days) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3 mg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the β-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). |
2023-03-04 |
2023-08-14 |
rat |
| Jinxiang Jiang, Ying Zheng, Yunan Chen, Aqeela Zahra, Cheng Long, Li Yan. Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice. Brain research. vol 1717. 2020-09-24. PMID:30986408. |
the dendritic length and number of dendritic branches in prefrontal neurons of these ctm-exposed mice are significantly reduced, consistent with decreased levels of n-methyl-d-aspartate receptors (nmdars) and calcium/calmodulin-dependent protein kinase ii (camkii) in the medial prefrontal cortex (mpfc). |
2020-09-24 |
2023-08-13 |
mouse |
| Yasushi Yabuki, Lei Wu, Kohji Fukunag. Cognitive enhancer ST101 improves schizophrenia-like behaviors in neonatal ventral hippocampus-lesioned rats in association with improved CaMKII/PKC pathway. Journal of pharmacological sciences. vol 140. issue 3. 2020-02-13. PMID:31474557. |
the cognitive enhancer st101 (spiro[imi-dazo[1,2-a]pyridine-3,2-indan]-2(3h)-one) stimulates camkii activity in the hippocampus and medial prefrontal cortex (mpfc). |
2020-02-13 |
2023-08-13 |
rat |
| Yasushi Yabuki, Norifumi Shioda, Tomomi Maeda, Sachiko Hiraide, Hiroko Togashi, Kohji Fukunag. Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats. Brain research. vol 1557. 2014-12-03. PMID:24561222. |
interestingly, ca(2+)/calmodulin-dependent protein kinase ii (camkii) activity, which is essential for memory and learning acquisition, was excessively elevated in the medial prefrontal cortex (mpfc) but not in the hippocampal ca1 region of shrsp compared with wistar-kyoto (wky) rats. |
2014-12-03 |
2023-08-12 |
rat |
| Yasushi Yabuki, Norifumi Shioda, Tomomi Maeda, Sachiko Hiraide, Hiroko Togashi, Kohji Fukunag. Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats. Brain research. vol 1557. 2014-12-03. PMID:24561222. |
aberrant camkii activity in the medial prefrontal cortex is associated with cognitive dysfunction in adhd model rats. |
2014-12-03 |
2023-08-12 |
rat |
| Yasushi Yabuki, Osamu Nakagawasai, Takeshi Tadano, Kohji Fukunag. [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 133. issue 5. 2014-04-09. PMID:23649390. |
immunohistochemical analyses using anti-autophosphorylated camkii antibody revealed that camkii autophosphorylation was significantly reduced in the medial prefrontal cortex (mpfc) of nvh-lesioned rats compared with control animals. |
2014-04-09 |
2023-08-12 |
rat |
| Y Yabuki, O Nakagawasai, S Moriguchi, N Shioda, H Onogi, K Tan-No, T Tadano, K Fukunag. Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats. Neuroscience. vol 234. 2013-10-25. PMID:23313709. |
immunohistochemical analyses using anti-autophosphorylated ca(2+)/calmodulin-dependent protein kinase ii (camkii) antibody indicated significantly reduced camkii autophosphorylation, especially in the medial prefrontal cortex (mpfc), striatum and hippocampal ca1 region, of nvh-lesioned rats relative to control animals. |
2013-10-25 |
2023-08-12 |
rat |
| Phillip R Zoladz, Collin R Park, Joshua D Halonen, Samina Salim, Karem H Alzoubi, Marisa Srivareerat, Monika Fleshner, Karim A Alkadhi, David M Diamon. Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia. Hippocampus. vol 22. issue 3. 2012-07-23. PMID:21538655. |
we have studied the effects of spatial learning and predator stress-induced amnesia on the expression of calcium/calmodulin-dependent protein kinase ii (camkii), brain-derived neurotrophic factor (bdnf) and calcineurin in the hippocampus, basolateral amygdala (bla), and medial prefrontal cortex (mpfc). |
2012-07-23 |
2023-08-12 |
rat |
| Ipe Ninan, Kent E Jardemark, Xiaofu Liang, Rex Y Wan. Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells. Synapse (New York, N.Y.). vol 47. issue 4. 2003-04-08. PMID:12539202. |
using the method of intracellular recording in in vitro brain slices, we investigated whether calcium/calmodulin-dependent kinase ii (camkii) is involved in the facilitating action produced by the atypical antipsychotic drug (apd) clozapine on n-methyl-d-aspartate (nmda)-induced inward currents and electrically evoked excitatory postsynaptic currents (epscs) in pyramidal cells of the medial prefrontal cortex (mpfc). |
2003-04-08 |
2023-08-12 |
mouse |