All Relations between cd86 and hippocampus

Publication Sentence Publish Date Extraction Date Species
Bao-Wen Zhang, Ying Li, Xian-Juan Ko. [Resistance exercise regulates hippocampal microglia polarization through TREM2/NF-κB/STAT3 signal pathway to improve cognitive dysfunction in T2DM mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468808. the mrna expression levels of inflammatory factors and trem2 in hippocampus were evaluated by qrt-pcr, and the expression and localization of iba-1, cd206, cd86, and trem2 were determined by immunofluorescence staining. 2024-10-29 2024-10-31 mouse
Xiaopeng Sun, Shugang Xu, Jingjing Wang, Xiaohong Li, Hongtao Sun, Wanyong Zha. Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats. Neuroreport. 2024-10-18. PMID:39423323. the motor function of the rats in each group was evaluated by beam walking test and inclined-grid climbing test, brain water content was calculated by the wet-dry weight method, evan's blue staining was used to measure the blood-brain barrier (bbb) permeability, the change of hippocampal neurons was observed by nissl staining, the expressions of brdu, neun, and cd86 positive cells were detected by immunofluorescence staining, and the expressions of bcl-2, bax, inos, il-10, and arg-1 were detected by western blot. 2024-10-18 2024-10-21 rat
Marilou Poitras, Alexandra Doiron, Hélène Plamondo. Selective Estrogen Receptor Activation Prior to Global Cerebral Ischemia in Female Rats Impacts Microglial Activation and Anxiety-Like Behaviors Without Effects on CA1 Neuronal Injury. Behavioural brain research. 2024-06-06. PMID:38844057. microglial activation (iba1, cd68, cd86) in the basolateral amygdala (bla), ca1 of the hippocampus, and paraventricular nucleus of the hypothalamus (pvn) was determined 8 days post-ischemia. 2024-06-06 2024-06-10 rat
Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. we demonstrated that 500 ng of ifn-γ injection results in significant decrease in social index and social novelty recognition index, and induces microglial priming in hippocampus, characterized by enlarged cell bodies, shortened branches, increased expression of cd68, cd86, cd74, cd11b, cd11c, cd47, il-33, il-1β, il-6 and inos, and decreased expression of mcr1, arg-1, igf-1 and bdnf. 2024-05-17 2024-05-27 mouse
Miguel Farinha-Ferreira, Daniela M Magalhães, Mariana Neuparth-Sottomayor, Hugo Rafael, Catarina Miranda-Lourenço, Ana M Sebastiã. Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression. Journal of neurochemistry. 2024-03-02. PMID:38430009. in a separate cohort, we assessed prefrontal cortex (pfc), hippocampus and amygdala levels of markers of astrocytic (gfap, s100a10) and microglial (iba1, cd86, ym1) activation status, as well as of three key proinflammatory cytokines (il-1β, il-6, tnf-α). 2024-03-02 2024-03-04 rat
Lorena Morton, Philipp Arndt, Alejandra P Garza, Solveig Henneicke, Hendrik Mattern, Marilyn Gonzalez, Alexander Dityatev, Deniz Yilmazer-Hanke, Stefanie Schreiber, Ildiko R Duna. Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states. Acta neuropathologica communications. vol 11. issue 1. 2023-12-20. PMID:38115109. at early-stage hypertension, hippocampal microglia exhibited upregulated cd11b/c, p2y12r, cd200r, and cd86 surface expression. 2023-12-20 2023-12-23 human
Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha. International review of neurobiology. vol 172. 2023-10-13. PMID:37833015. after 48 h of spinal cord injury elevation of amyloid beta peptide, phosphorylated tau (p-tau) and tumor necrosis factor-alpha (tnf-α) was seen in t9 and t12 segments of spinal cord in cerebral cortex, hippocampus and brain stem regions associated with microglial activation as seen by upregulation of iba1 and cd86. 2023-10-13 2023-10-15 Not clear
Jie Wu, Ziwen Hao, Ying Wang, Dongying Yan, Jia Meng, Honglin M. Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-25. PMID:36566971. besides obvious hippocampal neuron damage, increased microglial activation and pro-inflammatory markers (cd86, tnfα, and il-1β), meanwhile, decreased anti-inflammatory molecules (cd206, il-10, and arg1) were induced by bde-209. 2022-12-25 2023-08-14 rat
Michael J Butler, Nicholas P Deems, Stephanie Muscat, Christopher M Butt, Martha A Belury, Ruth M Barriento. Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34425209. these memory deficits were accompanied by increased expression of inflammatory genes, such as il-1β, cd11b, mhc class ii, cd86, nlrp3, and complement component 3, in the hippocampus and amygdala of aged rats. 2021-12-09 2023-08-13 rat
Yan-Ling Liao, Xiao-Yan Zhou, Mu-Huo Ji, Liang-Cheng Qiu, Xiao-Hui Chen, Can-Sheng Gong, Ying Lin, Yan-Hua Guo, Jian-Jun Yan. S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice. Inflammation. vol 44. issue 1. 2021-10-07. PMID:32918665. our results showed that clp-induced and lps-induced memory impairments were accompanied with increased expressions of hippocampal microglia iba1 and cd86 (m1 markers), but reduced expression of arg1 (m2 marker). 2021-10-07 2023-08-13 mouse
Kinga Gawlińska, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Fili. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. International journal of molecular sciences. vol 21. issue 21. 2021-03-08. PMID:33120991. cocaine self-administration significantly decreased myelin regulatory factor (myrf) and cyclic nucleotide phosphodiesterase (cnp) expression in the hippocampus as well as pleckstrin (plek) and t-lymphocyte activation antigen (cd86) in the rat striatum. 2021-03-08 2023-08-13 rat
Yasuhisa Ano, Rena Ohya, Keiji Kondo, Hiroyuki Nakayam. Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:30778295. when compared with young mice, aged mice showed impairment in spatial working memory during the y-maze spontaneous alternation test, impairment in object recognition memory during the novel object recognition test (nort), a pro-inflammatory hippocampal microglial phenotype with increased cd86 expression and inflammatory cytokine production, increased levels of glutamate and amyloid β 2020-09-29 2023-08-13 mouse
Anna A Tyrtyshnaia, Igor V Manzhulo, Ruslan M Sultanov, Ekaterina V Ermolenk. Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment. Acta histochemica. vol 119. issue 8. 2018-10-25. PMID:29107326. in addition, we observed a decrease in hippocampal pro-inflammatory microglia marker cd86 immunostaining on day 28 after surgery in alkyl glycerol ethers-treated mice with sciatic nerve ligation. 2018-10-25 2023-08-13 mouse
Marcus Boehme, Madlen Guenther, Anna Stahr, Marie Liebmann, Nadine Jaenisch, Otto W Witte, Christiane Frah. Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24796813. during hippocampal aging, the transcript expression of pro-inflammatory cytokines (tnfα, il-1α, il-1β), the chemokine mip-1α, and markers for activated astrocytes (gfap, lcn2, but not vim and serpina3n) and microglia (iba1, f4/80, cd68, cd86) significantly increased. 2014-12-23 2023-08-13 mouse
Shai Abutbul, Jenny Shapiro, Irit Szaingurten-Solodkin, Nitzan Levy, Yaron Carmy, Rona Baron, Steffen Jung, Alon Monsoneg. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia. vol 60. issue 7. 2012-09-20. PMID:22511296. here, we show that upon co-culturing of either cd117(+) /lin(-) hematopoietic progenitors or cd11c(+) bone marrow derived cells with organotypic hippocampal slices or primary glia, the cells acquire a ramified morphology concomitant with reduced levels of cd86, mhcii, and cd11c and up-regulation of the microglial cell-surface proteins cx(3) cr1 and iba-1. 2012-09-20 2023-08-12 Not clear
Xing-Mei Zhang, Xi-Jing Mao, Hong-Liang Zhang, Xiang-Yu Zheng, Therese Pham, Abdu Adem, Bengt Winblad, Eilhard Mix, Jie Zh. Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22079154. (1) they had more severe ka-induced seizures than apoe2 and 3 mice, (2) they exhibited neuron loss in hippocampus that was higher than in apoe2, 3 and wt mice, (3) ka administration resulted in higher counts of their head drops in the cross-area of elevated plus-maze, (4) they showed lower ka-induced rearing activity than apoe2 mice in the open-field test, (5) their ka-induced microglial expression of mhc-ii and cd86 was elevated compared to apoe3 mice, (6) the ka-induced increase of microglial inos was higher than that in the other groups of mice, and (7) the tnf-α and il-6 expression was decreased 7 days after ka application compared to untreated mice and mice treated 1 day with ka. 2012-03-25 2023-08-12 mouse
Rui-Sheng Duan, Zhiguo Chen, Ying-Chun Dou, Hernan Concha Quezada, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16919271. mice lacking apoe demonstrated more hunching and less rearing, more damage to neurons in the ca3 region (mean histopathologic score: 3.7 vs. 1.6, p < 0.05), greater microglial activation confirmed by high levels of cd11b and cd86 expression in hippocampus (cd11b p < 0.01, cd86 p < 0.05), and a greater percentage of activated microglia expressing cc chemokine receptors 3 (ccr3) (p < 0.05). 2007-01-03 2023-08-12 mouse