| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Chung, Jia-Ling Wu, Wen-Ching Huan. Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation. Food research international (Ottawa, Ont.) vol 165 issue 2023 36869551 |
results showed that sleep deprivation caused intestinal inflammation (increased tnfa and il1b) and decreased intestinal permeability with a significant decrease in the tight junction genes (ocln, cldn1, tjp1, and tjp2) of intestine and brain. |
2023-03-04 |
2023-03-06 |
mouse |
| Maika S Deffieu, Camille M H Cl\\xc3\\xa9ment, Cristina M Dorobantu, Emma Partiot, Yonis Bare, Orestis Faklaris, Benjamin Rivi\\xc3\\xa8re, Nilda Vanesa Ayala-Nunez, Thomas F Baumert, Philippe Rond\\xc3\\xa9, Yves M\\xc3\\xa9ly, Vincent Lucansky, Raphael Gaudi. Occludin stalls HCV particle dynamics apart from hepatocyte tight junctions, promoting virion internalization. Hepatology (Baltimore, Md.) vol issue 2022 35388524 |
to decipher the mechanism underlying virus slow-down upon ocln recruitment, we performed crispr knock out of claudin1 (cldn1), a hcv entry factor proposed to act upstream of ocln. |
2022-04-07 |
2023-01-27 |
human |
| Marco Tretola, Giuseppe Bee, Paolo Silacc. Gallic acid affects intestinal-epithelial-cell integrity and selected amino-acid uptake in porcine The British journal of nutrition vol 126 issue 4 2021 33143768 |
both intestinal porcine enterocyte cell line-j2 cells and porcine middle-jejunum segments were treated with 5 (t5), 25 (t25) and 50 (t50) \xc2\xb5m ga and mounted in ussing chambers to determine transepithelial resistance (teer), claudin-1 (cldn1), occludin (ocln), zonula occludens-1 (zo-1) protein (in tissues and cells) and mrna (in cells) expression. |
2021-12-07 |
2023-01-26 |
Not clear |
| Marco Tretola, Giuseppe Bee, Paolo Silacc. Gallic acid affects intestinal-epithelial-cell integrity and selected amino-acid uptake in porcine The British journal of nutrition vol 126 issue 4 2021 33143768 |
ex vivo, t50 decreased the teer values and the protein levels of cldn1, ocln and zo-1, whereas t5 and t25 only decreased cldn1 protein expression compared with untreated tissues. |
2021-12-07 |
2023-01-26 |
Not clear |
| Chen Yang, Pei Luo, Shi-Jian Chen, Zhi-Chao Deng, Xin-Liang Fu, Dan-Ning Xu, Yun-Bo Tian, Yun-Mao Huang, Wen-Jun Li. Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress. Poultry science vol 100 issue 11 2021 34614430 |
furthermore, the gene expression of heat shock proteins (hsp60, hsp70, and hsp90) and tight junction proteins (cldn1 and ocln) was significantly increased in the resveratrol group compared to that in the control groups. |
2021-11-12 |
2023-01-26 |
cat |
| Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Ji. Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway. Acta biochimica et biophysica Sinica vol 53 issue 11 2021 34549778 |
results showed that ctl exposure increased the paracellular permeability of the monolayers and downregulated mrna levels of the tj genes (zo-1, ocln, and cldn1), polarity marker gene (si), and anti-apoptosis gene (bcl-2) but upregulated the mrna levels of apoptosis-related genes, including bad, bax, casp3, and casp8. |
2021-11-11 |
2023-01-26 |
human |
| Rashed A Alhotan, Ali R Al Sulaiman, Abdulrahman S Alharthi, Alaeldein M Abudabo. Protective influence of betaine on intestinal health by regulating inflammation and improving barrier function in broilers under heat stress. Poultry science vol 100 issue 9 2021 34329984 |
the hs group showed an elevation (p < 0.05) in serum corticosterone (cort) concentration, d-lactate acid (d-la) content, and diamine oxidase (dao) activity, mucosal interleukin-1\xce\xb2 (il-1\xce\xb2) level, and expression of heat shock protein 70 (hsp70) gene, and a reduction (p < 0.05) in mucosal interleukin-10 (il-10) level and secretory immunoglobulin a (siga) content and relative abundance of mrna for occludin (ocln), zonula occludens-1 (zo-1), claudin-1 (cldn1), and claudin-4 (cldn4). |
2021-08-31 |
2023-01-26 |
Not clear |
| Morteza H Ghaffari, Hassan Sadri, Julia Steinhoff-Wagner, Harald M Hammon, Helga Sauerwei. Effects of colostrum feeding on the mRNA abundance of genes related to toll-like receptors, key antimicrobial defense molecules, and tight junctions in the small intestine of neonatal dairy calves. Journal of dairy science vol 104 issue 9 2021 34218909 |
the objective of the present study was to elucidate the effect of feeding either colostrum or milk-based formula on the mrna abundance of genes related to pathogen recognition [toll-like receptors (tlr1-10)], antimicrobial defense [\xce\xb2-defensin 1 (defb1) and peptidoglycan recognition protein 1 (pglyrp1)], and tight junctions (claudin 1 = cldn1, claudin 4 = cldn4, and occludin = ocln) in different sections of the small intestine of neonatal calves at d 4 of life. |
2021-08-24 |
2023-01-26 |
Not clear |
| M Y Wang, Y Li, M Gao, L W Song, M Xu, X L Zhao, Y Jia, M Zhao, Y Y Sun, H L H. Effects of subacute ruminal acidosis on colon epithelial morphological structure, permeability, and expression of key tight junction proteins in dairy goats. Journal of dairy science vol 104 issue 4 2021 33485680 |
subacute ruminal acidosis increased mrna and protein expression levels of cldn1 and ocln in the colonic epithelium. |
2021-04-14 |
2023-01-26 |
Not clear |
| Jianghong Gao, Xinmei Li, Liping Gao, Haiyan Chen, Bashayer H Baras, Xiaojing Liu, Hao Liu, Ayesha Rana, Meili Gao, Jianping Rua. Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of\\xc2\\xa0kallikrein\\xe2\\x80\\x91related peptidase\\xc2\\xa04 and tight junction proteins in ameloblasts. International journal of molecular medicine vol 46 issue 1 2021 32626909 |
the aim of the present study was to assess the effects of amoxicillin on enamel mineralization, the morphology of ameloblasts, as well as the expression of kallikrein\xe2\x80\x91related peptidase\xc2\xa04 (klk4), and the tight junction proteins, claudin\xc2\xa01 (cldn1), claudin\xc2\xa04 (cldn4) and occludin (ocln), in ameloblasts of juvenile mice. |
2021-03-15 |
2023-01-26 |
mouse |
| Jianghong Gao, Xinmei Li, Liping Gao, Haiyan Chen, Bashayer H Baras, Xiaojing Liu, Hao Liu, Ayesha Rana, Meili Gao, Jianping Rua. Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of\\xc2\\xa0kallikrein\\xe2\\x80\\x91related peptidase\\xc2\\xa04 and tight junction proteins in ameloblasts. International journal of molecular medicine vol 46 issue 1 2021 32626909 |
amoxicillin decreased klk4 and cldn1, cldn4 and ocln expression in mature ameloblasts. |
2021-03-15 |
2023-01-26 |
mouse |
| Jianghong Gao, Xinmei Li, Liping Gao, Haiyan Chen, Bashayer H Baras, Xiaojing Liu, Hao Liu, Ayesha Rana, Meili Gao, Jianping Rua. Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of\\xc2\\xa0kallikrein\\xe2\\x80\\x91related peptidase\\xc2\\xa04 and tight junction proteins in ameloblasts. International journal of molecular medicine vol 46 issue 1 2021 32626909 |
the klk4, cldn1, cldn4 and ocln expression levels of ameloblasts were observed by immunohistochemical staining. |
2021-03-15 |
2023-01-26 |
mouse |
| Yan-Fang Cui, Lei Yu, Feng-Jie Wang, Xiu-Li Shen, Gui-Bo Yan. Molecular cloning, expression and biological activity of rhesus macaque interleukin-17A and interleukin-17F. Molecular immunology vol 114 issue 2020 31377676 |
moreover, the antibacterial proteins (such as \xce\xb2-defensin 2, s100a8, s100a9, regiii\xce\xb1 and muc1) and the tight junction associated genes (including cldn1, cldn4, ocln, and zo1) expressed by caco-2 cells were largely enhanced after treatment with rhil-17a and rhil-17f. |
2020-01-21 |
2023-01-26 |
human |
| Yasmine Baktash, Anisha Madhav, Kelly E Coller, Glenn Randal. Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process. Cell host & microbe vol 23 issue 3 2018 29544098 |
hepatitis c virus (hcv) enters hepatocytes via various entry factors, including scavenger receptor bi (sr-b1), cluster of differentiation 81 (cd81), epidermal growth factor receptor (egfr), claudin-1 (cldn1), and occludin (ocln). |
2018-09-24 |
2023-01-26 |
Not clear |
| Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U Emerson, Patrizia Farc. Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma. PLoS pathogens vol 14 issue 3 2018 29538454 |
entry of hepatitis c virus (hcv) into hepatocytes is a complex process that involves numerous cellular factors, including the scavenger receptor class b type 1 (sr-b1), the tetraspanin cd81, and the tight junction (tj) proteins claudin-1 (cldn1) and occludin (ocln). |
2018-07-24 |
2023-01-26 |
human |
| Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U Emerson, Patrizia Farc. Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma. PLoS pathogens vol 14 issue 3 2018 29538454 |
tacstd2 gene silencing disrupts the typical linear distribution of cldn1 and ocln along the cellular membrane in both hepatoma cells and primary human hepatocytes, recapitulating the pattern observed in vivo in primary hcc tissue. |
2018-07-24 |
2023-01-26 |
human |
| Marek Svoboda, Marta Hlobilov\\xc3\\xa1, Mark\\xc3\\xa9ta Mare\\xc5\\xa1ov\\xc3\\xa1, Michaela Sochorov\\xc3\\xa1, Andrej Kov\\xc3\\xa1\\xc4\\x8dik, Kate\\xc5\\x99ina V\\xc3\\xa1vrov\\xc3\\xa1, Iva Dole\\xc4\\x8dkov\\xc3\\xa. Comparison of suction blistering and tape stripping for analysis of epidermal genes, proteins and lipids. Archives of dermatological research vol 309 issue 9 2018 28905096 |
in the sb samples, wb and qrt-pcr could easily detect all the selected proteins (claudin-1, occludin, filaggrin, laminin and gapdh) and genes (cldn1, ocln, flg, lama3 and rpl13a), respectively. |
2018-07-23 |
2023-01-26 |
human |
| Mitsutoki Hatta, Yuki Miyake, Kunitoshi Uchida, Jun Yamazak. Keratin 13 gene is epigenetically suppressed during transforming growth factor-\\xce\\xb21-induced epithelial-mesenchymal transition in a human keratinocyte cell line. Biochemical and biophysical research communications vol 496 issue 2 2018 29326042 |
quantitative rt-pcr analysis revealed that tgf-\xce\xb21 increased the mrna levels of emt transcription factors (snai2, twist1, and zeb1) and mesenchymal markers (cdh2, vim, and fn1), while it decreased the transcripts of epithelial phenotypic genes (cldn1, ocln, krt5, krt15, krt13, and tgm1). |
2018-02-13 |
2023-01-26 |
human |
| Zhijiang Miao, Zhenrong Xie, Jing Miao, Jieyu Ran, Yue Feng, Xueshan Xi. Regulated Entry of Hepatitis C Virus into Hepatocytes. Viruses vol 9 issue 5 2018 28486435 |
the scavenger receptor class b type i (sr-bi) and claudin-1 (cldn1), together with human cluster of differentiation (cd) 81 and occludin (ocln), constitute the minimal set of hcv entry receptors. |
2018-02-05 |
2023-01-26 |
human |
| M P Walker, C M Evock-Clover, T H Elsasser, E E Conno. Short communication: Glucagon-like peptide-2 and coccidiosis alter tight junction gene expression in the gastrointestinal tract of dairy calves. Journal of dairy science vol 98 issue 5 2016 25726101 |
the mrna expression of coxsackie and adenovirus receptor (cxadr), claudins 1, 2, and 4 (cldn1, cldn2, and cldn4), f11 receptor (f11r), junction adhesion molecule 2 (jam2), occludin (ocln), and tight junction protein zo-1 (tjp1) was determined by real-time quantitative pcr. |
2016-03-28 |
2023-01-25 |
Not clear |