| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veera M Rajagopal, Anto P Rajkumar, Kuruthukulangara S Jacob, Molly Jaco. Gene-gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia. Pharmacogenetics and genomics. vol 28. issue 1. 2018-07-13. PMID:29087970. |
here, we studied independent and epistatic genetic associations of polymorphisms in drd4 (120-bp duplication) and comt (val158met) with clinical response to clozapine in people with treatment-resistant schizophrenia. |
2018-07-13 |
2023-08-13 |
human |
| Veera M Rajagopal, Anto P Rajkumar, Kuruthukulangara S Jacob, Molly Jaco. Gene-gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia. Pharmacogenetics and genomics. vol 28. issue 1. 2018-07-13. PMID:29087970. |
participants with the comt val/met or met/met genotype, who also had one or two drd4 120-bp alleles (120/240 and 120/120), showed significantly better clinical response to clozapine. |
2018-07-13 |
2023-08-13 |
human |
| Djûke M Brinksma, Pieter J Hoekstra, Barbara van den Hoofdakker, Annelies de Bildt, Jan K Buitelaar, Catharina A Hartman, Andrea Dietric. Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. Journal of psychiatric research. vol 90. 2018-03-19. PMID:28259004. |
linear mixed models were used to examine the association of candidate genes (i.e., drd4, drd2, 5-httlpr, comt, and maoa), pre- and perinatal factors (i.e., index measure of various pregnancy and delivery complications, maternal smoking, maternal drinking, and low birth weight), and their interactions with adhd symptoms across adolescence. |
2018-03-19 |
2023-08-13 |
human |
| Rabia R Chhangur, Joyce Weeland, Geertjan Overbeek, Walter Matthys, Bram Orobio de Castro, Danielle van der Giessen, Jay Belsk. Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children. Child development. vol 88. issue 3. 2018-03-13. PMID:27629597. |
this study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (drd4, drd2, dat1, maoa, and comt) benefited the most from the incredible years (iy) parent program. |
2018-03-13 |
2023-08-13 |
Not clear |
| Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt, J Hain, P Riederer, E Koutsilier. The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 4. 2018-02-21. PMID:27909828. |
the dopamine-related polymorphisms bdnf, comt, drd2, drd3, and drd4 are not linked with changes in csf dopamine levels and frequency of hiv infection. |
2018-02-21 |
2023-08-13 |
human |
| Philippe Jawinski, Sophie Tegelkamp, Christian Sander, Madlen Häntzsch, Jue Huang, Nicole Mauche, Markus Scholz, Janek Spada, Christine Ulke, Ralph Burkhardt, Andreas Reif, Ulrich Hegerl, Tilman Hensc. Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep. Chronobiology international. vol 33. issue 7. 2018-01-31. PMID:27148829. |
however, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-o-methyltransferase val158met (comt val158met; rs4680) and the dopamine d4 receptor exon iii variable-number-of-tandem-repeat polymorphism (drd4 vntr). |
2018-01-31 |
2023-08-13 |
human |
| Rebecca A Lundwall, James L Dannemiller, H Hill Goldsmit. Genetic associations with reflexive visual attention in infancy and childhood. Developmental science. vol 20. issue 3. 2018-01-03. PMID:26613685. |
the genetic markers (single nucleotide polymorphisms and variable number tandem repeats on the genes apoe, bdnf, chrna4, comt, drd4, htr4, igf2, maoa, slc5a7, slc6a3, and snap25) are related to brain development and/or to the availability of neurotransmitters such as acetylcholine, dopamine, or serotonin. |
2018-01-03 |
2023-08-13 |
Not clear |
| Subin Park, Bung-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Hee Jeong Yoo, Soo-Churl Ch. Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD. Journal of attention disorders. vol 21. issue 3. 2017-12-04. PMID:25063767. |
to investigate the interaction between childhood trauma exposure with the catechol-o-methyltransferase (comt) and dopamine receptor d4 (drd4) polymorphisms in relation to neuropsychological measures in children with adhd. |
2017-12-04 |
2023-08-13 |
Not clear |
| Sarah A Eisenstein, Ryan Bogdan, Ling Chen, Stephen M Moerlein, Kevin J Black, Joel S Perlmutter, Tamara Hershey, Deanna M Barc. Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27886638. |
a subset of participants (n = 124) were genotyped for da-related polymorphisms in genes for drd4, drd2/ankk1, dat1, and comt, which were used to construct biologically-informed multi-locus genetic profile (mgp) scores reflective of subcortical dopaminergic signaling. |
2017-09-12 |
2023-08-13 |
human |
| Anna Junkiert-Czarnecka, Olga Hau. Genetical background of intelligence. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27333929. |
studies on genetic background of intelligence focus on dopaminergic (drd2, drd4, comt, slc6a3, dat1, cckar) and adrenergic system (adrb2, chrm2) genes as well as, neutrofins (bdnf) and oxidative stress genes (ltf, prnp). |
2017-07-10 |
2023-08-13 |
human |
| Lindsay N Douglas, Austen B McGuire, Ann M Manzardo, Merlin G Butle. High-resolution chromosome ideogram representation of recognized genes for bipolar disorder. Gene. vol 586. issue 1. 2017-01-03. PMID:27063557. |
the identified genes impacted a broad range of biological pathways and processes including cellular signaling pathways particularly camp and calcium (e.g., cacna1c, camk2a, camk2d, adcy1, adcy2); glutamatergic (e.g., grik1, grm3, grm7), dopaminergic (e.g., drd2, drd4, comt, maoa) and serotonergic (e.g., htr1a, htr2a, htr3b) neurotransmission; molecular transporters (e.g., slc39a3, slc6a3, slc8a1); and neuronal growth (e.g., bdnf, igfbp1, nrg1, nrg3). |
2017-01-03 |
2023-08-13 |
human |
| Howard Steiger, Lea Thaler, Lise Gauvin, Ridha Joober, Aurelie Labbe, Mimi Israel, Audrey Kuce. Epistatic interactions involving DRD2, DRD4, and COMT polymorphisms and risk of substance abuse in women with binge-purge eating disturbances. Journal of psychiatric research. vol 77. 2016-12-27. PMID:26950642. |
tests for main and interaction effects of various allele combinations revealed that individuals who carried high function comt and low-function drd4 7r alleles (a combination expected to be associated with higher risk) did indeed show more lifetime substance abuse and, specifically, more cannabis abuse. |
2016-12-27 |
2023-08-13 |
Not clear |
| Joyce Weeland, Geertjan Overbeek, Bram Orobio de Castro, Walter Matthy. Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms. Clinical child and family psychology review. vol 18. issue 4. 2016-12-14. PMID:26537239. |
over the last decade, several candidate genes (i.e., maoa, drd4, drd2, dat1, 5-httlpr, and comt) have been extensively studied as potential moderators of the detrimental effects of postnatal family adversity on child externalizing behaviors, such as aggression and conduct disorder. |
2016-12-14 |
2023-08-13 |
Not clear |
| Milky Kohno, Erika L Nurmi, Christopher P Laughlin, Angelica M Morales, Emma H Gail, Gerhard S Hellemann, Edythe D Londo. Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 3. 2016-10-06. PMID:26119471. |
for each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: drd2, drd3, drd4, dat1, and comt. |
2016-10-06 |
2023-08-13 |
human |
| Arielle Y Zahavi, Mark A Sabbagh, Dustin Washburn, Raegan Mazurka, R Michael Bagby, John Strauss, James L Kennedy, Arun Ravindran, Kate L Harknes. Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation. PloS one. vol 11. issue 3. 2016-08-01. PMID:26974654. |
the current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (slc6a4), dopamine transporter (dat1), dopamine receptor d4 (drd4), and catechol-o-methyl transferase (comt) genes with theory of mind decoding in a sample of adults with major depression. |
2016-08-01 |
2023-08-13 |
human |
| Z Naumovska, A K Nestorovska, A Filipce, Z Sterjev, K Brezovska, A Dimovski, L J Suturkov. Pharmacogenetics and antipsychotic treatment response. Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki). vol 36. issue 1. 2016-07-15. PMID:26076775. |
it highlights the most important findings about the impact of functional polymorphisms in genes coding the cyp450 metabolizing enzymes, abcb1 transporter gene, dopaminergic and serotonergic drug targets (drd2, drd3, drd4, 5-ht1, 5ht-2a, 5ht-2c, 5ht6) as well as genes responsible for metabolism of neurotransmitters and g signalling pathways (5-httlpr, bdnf, comt, rgs4) and points their role as potential biomarkers in everyday clinical practice. |
2016-07-15 |
2023-08-13 |
Not clear |
| Eric L Thibodeau, Dante Cicchetti, Fred A Rogosc. Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Development and psychopathology. vol 27. issue 4 Pt 2. 2016-06-17. PMID:26535948. |
five genotypes in four dopaminergic genes (dopamine receptors d4, d2, known as drd4, drd2; dopamine active transporter 1, known as dat1; and catechol-o-methyltransferase, known as comt) conferring heightened environmental sensitivity were combined into one polygenic index. |
2016-06-17 |
2023-08-13 |
Not clear |
| Harleen Hehar, Keith Yeates, Bryan Kolb, Michael J Esser, Richelle Mychasiu. Impulsivity and Concussion in Juvenile Rats: Examining Molecular and Structural Aspects of the Frontostriatal Pathway. PloS one. vol 10. issue 10. 2016-06-10. PMID:26448536. |
as these behaviours are believed to be associated with the frontostriatal circuit involving the nucleus accumbens (nac) and the prefrontal cortex (pfc), the expression patterns of 8 genes (comt, drd2, drd3, drd4, maoa, sert, tph1, and tph2) from these two regions were examined. |
2016-06-10 |
2023-08-13 |
rat |
| Ansley Stanfill, Donna Hathaway, Ann Cashion, Ramin Homayouni, Patricia Cowan, Carol Thompson, Behrouz Madahian, Yvette Conle. A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients. PloS one. vol 10. issue 9. 2016-05-27. PMID:26406335. |
the purpose of this pilot study is to first examine the feasibility and methodology, and then to examine the associations of age, race, sex, and genotype for 13 snps and 3 vntrs in 9 dopaminergic pathway genes (ankk1, drd2, drd3, drd4, slc6a3/dat1, maoa, maob, comt, cpe) for associations with percent weight change at 12 months post-transplantation. |
2016-05-27 |
2023-08-13 |
Not clear |
| April S Masarik, Rand D Conger, M Brent Donnellan, Michael C Stallings, Monica J Martin, Thomas J Schofield, Tricia K Neppl, Laura V Scaramella, Andrew Smolen, Keith F Widama. For better and for worse: genes and parenting interact to predict future behavior in romantic relationships. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43). vol 28. issue 3. 2016-04-04. PMID:24821524. |
we created an index for hypothesized genetic plasticity by summing g2's allelic variation for polymorphisms in 5 genes (serotonin transporter gene [linked polymorphism], 5-htt; ankyrin repeat and kinase domain containing 1 gene/dopamine receptor d2 gene, ankk1/drd2; dopamine receptor d4 gene, drd4; dopamine active transporter gene, dat; and catechol-o-methyltransferase gene, comt). |
2016-04-04 |
2023-08-13 |
human |