| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Y Lin, B T Wu, C C Lee, J J Sheu, S H Liu, W F Wang, C H Tsai, H P Liu, F J Tsa. Association analysis of dopaminergic gene variants (Comt, Drd4 And Dat1) with Alzheimer s disease. Journal of biological regulators and homeostatic agents. vol 26. issue 3. 2012-11-30. PMID:23034259. |
association analysis of dopaminergic gene variants (comt, drd4 and dat1) with alzheimer s disease. |
2012-11-30 |
2023-08-12 |
human |
| W Y Lin, B T Wu, C C Lee, J J Sheu, S H Liu, W F Wang, C H Tsai, H P Liu, F J Tsa. Association analysis of dopaminergic gene variants (Comt, Drd4 And Dat1) with Alzheimer s disease. Journal of biological regulators and homeostatic agents. vol 26. issue 3. 2012-11-30. PMID:23034259. |
two catechol-o-methyltransferase (comt) single-nucleotide polymorphisms (snps) (rs2020917 and rs4646312), two dopamine d4 receptor (drd4) snps (rs3758653 and rs916455), and four dopamine transporter (dat1) snps (rs2937639, rs6347, rs12516948 and rs11133762) were investigated. |
2012-11-30 |
2023-08-12 |
human |
| Eric Stice, Sonja Yokum, Kyle Burger, Leonard Epstein, Andy Smole. Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 29. 2012-10-24. PMID:22815523. |
the objective of the study was to test the hypotheses that humans with genotypes putatively associated with low dopamine (da) signaling capacity, including the taqia a1 allele, drd2-141c ins/ins genotype, drd4 7-repeat or longer allele, dat1 10-repeat allele, and the met/met comt genotype, and with a greater number of these genotypes per a multilocus composite, show less responsivity of reward regions that primarily rely on da signaling. |
2012-10-24 |
2023-08-12 |
human |
| Gabor Varga, Anna Szekely, Peter Antal, Peter Sarkozy, Zsofia Nemoda, Zsolt Demetrovics, Maria Sasvari-Szekel. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 3. 2012-10-05. PMID:22259185. |
here we report an association study of both dopaminergic (comt rs4680, drd4 48 bp vntr, drd2/ankk1 rs1800497) and serotonergic (htr1a rs6925, htr1b rs13212041, slc6a4 5-httlpr) gene polymorphisms and trait impulsivity assessed with the barratt impulsiveness scale (bis-11) in a sample of 687 caucasian young adults. |
2012-10-05 |
2023-08-12 |
Not clear |
| Marta Ribasés, Josep Antoni Ramos-Quiroga, Amaia Hervás, Cristina Sánchez-Mora, Rosa Bosch, Anna Bielsa, Xavier Gastaminza, Klaus-Peter Lesch, Andreas Reif, Tobias J Renner, Marcel Romanos, Andreas Warnke, Susanne Walitza, Christine Freitag, Jobst Meyer, Haukur Palmason, Miquel Casas, Mònica Bayés, Bru Corman. Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 4. 2012-09-17. PMID:22404661. |
based on this information we evaluated the contribution to adhd of nine genes involved in dopaminergic neurotransmission (drd1, drd2, drd3, drd4, drd5, dat1, th, dbh and comt). |
2012-09-17 |
2023-08-12 |
Not clear |
| Janusz K Rybakowski, Piotr Czerski, Monika Dmitrzak-Weglarz, Sebastian Kliwicki, Anna Leszczynska-Rodziewicz, Agnieszka Permoda-Osip, Maria Skibinska, Aleksandra Suwalska, Aleksandra Szczepankiewicz, Joanna Hause. Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy. Journal of psychopharmacology (Oxford, England). vol 26. issue 3. 2012-08-03. PMID:21890592. |
some association with lithium prophylactic efficacy was found for the polymorphisms of 5htt, drd1, comt, bdnf and fyn genes, but not for 5ht2a, 5ht2c, drd2, drd3, drd4, gsk-3, ntrk2, grin2b and mmp-9. |
2012-08-03 |
2023-08-12 |
Not clear |
| Melinda Bence, Julia Koller, Maria Sasvari-Szekely, Gergely Keszle. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 1. 2012-05-07. PMID:21785940. |
to this end, short-term parallel cultures of sk-nf-i neuroblastoma cells were treated with tsa either alone or in combination with hypoxia, and mrna levels of dopamine receptor d3 (drd3) and d4 (drd4), dopamine transporter (dat), dopamine hydroxylase (dbh), dopamine receptor regulating factor (drrf), catechol-o-methyltransferase (comt), serotonin receptor 1a (htr1a), monoamino oxidase a (mao-a), serotonin transporter (slc6a4) and tryptophan hydroxylase 2 (tph2) were determined by quantitative pcr. |
2012-05-07 |
2023-08-12 |
human |
| Maartje P C M Luijk, Glenn I Roisman, John D Haltigan, Henning Tiemeier, Cathryn Booth-Laforce, Marinus H van Ijzendoorn, Jay Belsky, Andre G Uitterlinden, Vincent W V Jaddoe, Albert Hofman, Frank C Verhulst, Anne Tharner, Marian J Bakermans-Kranenbur. Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 12. 2012-02-23. PMID:21749372. |
in two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (drd4, drd2, comt, 5-htt, oxtr) on attachment security and disorganization. |
2012-02-23 |
2023-08-12 |
Not clear |
| Aneek Das Bhowmik, Subhramay Chaudhury, Samikshan Dutta, Jyoti Shaw, Arpita Chatterjee, Arnab Choudhury, Amrita Saha, Dipanjana Sadhukhan, Turban Kar, Swagata Sinha, Kanchan Mukhopadhya. Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 7. 2012-02-08. PMID:21609749. |
in the present study the role of functional polymorphisms in three dopaminergic genes, dopamine receptor d4 (drd4: exon3 vntr and rs1800955), dopamine transporter (dat1: 3'utr vntr and intron8 vntr) and catechol-o-methyl transferase (comt: rs4680 and rs165599), was explored in iid. |
2012-02-08 |
2023-08-12 |
human |
| Manali Das, Aneek Das Bhowmik, Nipa Bhaduri, Kanyakumarika Sarkar, Paramita Ghosh, Swagata Sinha, Anirban Ray, Anindita Chatterjee, Kanchan Mukhopadhya. Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 2. 2011-11-22. PMID:21216270. |
gene-gene interaction analysis revealed significant additive effect of dbh rs1108580 and drd4 rs1800955 with significant main effects of drd4 exon3 vntr, dat1 3'utr and intron 8 vntr, maoa u-vntr, rs6323, comt rs4680, rs362204, dbh rs1611115 and rs1108580 thereby pointing towards a strong association of these markers with adhd. |
2011-11-22 |
2023-08-12 |
Not clear |
| Michael J Frank, John A Fossell. Neurogenetics and pharmacology of learning, motivation, and cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 1. 2011-11-10. PMID:20631684. |
we provide an integrative synthesis across human and animal studies, focusing on a recent spate of evidence implicating a role for genes controlling dopaminergic function in frontostriatal circuitry, including comt, darpp-32, dat1, drd2, and drd4. |
2011-11-10 |
2023-08-12 |
human |
| Estela Camara, Ulrike M Krämer, Toni Cunillera, Josep Marco-Pallarés, David Cucurell, Wido Nager, Anna Mestres-Missé, Peter Bauer, Rebecca Schüle, Ludger Schöls, Claus Tempelmann, Antoni Rodriguez-Fornells, Thomas F Münt. The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 8. 2011-02-18. PMID:20038544. |
the effects of comt (val108/158met) and drd4 (snp -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. |
2011-02-18 |
2023-08-12 |
human |
| Yannis Paloyelis, Philip Asherson, Mitul A Mehta, Stephen V Faraone, Jonna Kunts. DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 12. 2011-02-16. PMID:20736997. |
participants, who were also genotyped for the comt(val158met) and drd4(48bp-vntr) polymorphisms, performed a hypothetical and a real-time discounting task and provided self-ratings of trait impulsivity. |
2011-02-16 |
2023-08-12 |
human |
| David K Miller, Abdalla Bowirrat, Matthew Manka, Merlene Miller, Stanley Stokes, Debra Manka, Cameron Allen, Charles Gant, B William Downs, Andrew Smolen, Emily Stevens, Swetha Yeldandi, Kenneth Blu. Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports. Postgraduate medicine. vol 122. issue 6. 2011-02-14. PMID:21084795. |
the genes tested included the dopamine transporter (dat1, locus symbol slc6a3), dopamine d4 receptor exon 3 vntr (drd4), drd2 taqia (rs1800497), comt val158 met snp (rs4680), monoamine oxidase a upstream vntr (maoa-uvntr), and serotonin transporter-linked polymorphic region (5httlpr, locus symbol slc6a4). |
2011-02-14 |
2023-08-12 |
Not clear |
| L S Colzato, W P M van den Wildenberg, A J W Van der Does, B Homme. Genetic markers of striatal dopamine predict individual differences in dysfunctional, but not functional impulsivity. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20678555. |
in a sample of 130 healthy adults, we studied the relation between dat1, drd4, and c957t polymorphism at the drd2 gene (polymorphisms related to striatal da) and catechol-omethyltransferase (comt) val158met (a polymorphism related to frontal da) on self-reported dysfunctional and functional impulsivity, assessed by the dickman impulsivity inventory (dii), and the efficiency of inhibitory control, assessed by the stop-signal paradigm. |
2011-01-11 |
2023-08-12 |
human |
| Josep Marco-Pallarés, Wido Nager, Ulrike M Krämer, Toni Cunillera, Estela Càmara, David Cucurell, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Thomas F Münt. Neurophysiological markers of novelty processing are modulated by COMT and DRD4 genotypes. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:20156565. |
here we studied the impact of two polymorphisms affecting dopaminergic functioning (comt val108/158met and drd4 snp -521) on neurophysiological correlates of novelty processing. |
2011-01-03 |
2023-08-12 |
human |
| Kapelski Paweł, Joanna Hauser, Maria Skibińska, Aleksandra Szczepankiewicz, Monika Dmitrzak-Weglarz, Karolina Gorzkowska, Joanna Pawlak, Piotr M Czersk. [Family based association study of DRD1, DRD2, DRD3, DRD4, DAT, COMT gene polymorphism in schizophrenia]. Psychiatria polska. vol 44. issue 3. 2010-09-21. PMID:20672519. |
[family based association study of drd1, drd2, drd3, drd4, dat, comt gene polymorphism in schizophrenia]. |
2010-09-21 |
2023-08-12 |
Not clear |
| Monika Wiłkość, Joanna Hauser, Marta Tomaszewska, Monika Dmitrzak-Weglarz, Maria Skibińska, Aleksandra Szczepankiewicz, Alina Borkowsk. Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects. Acta neurobiologiae experimentalis. vol 70. issue 1. 2010-07-28. PMID:20407490. |
the purpose of this study was to assess the association between the polymorphisms of dopaminergic (drd1, drd3, drd4, comt) and serotoninergic (sert--serotonin transporter, 5ht2a, 5ht2c) genes' polymorphisms and performance on wcst in 200 volunteers from the polish population. |
2010-07-28 |
2023-08-12 |
human |
| Jonathan Savitz, Lize van der Merwe, Timothy K Newman, Dan J Stein, Raj Ramesa. Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits. Behavior genetics. vol 40. issue 3. 2010-07-20. PMID:20033274. |
variants of catechol-o-methyltransferase (comt) and four other dopamine pathway-related genes: drd4, drd2,maoa, and slc6a3, were typed. |
2010-07-20 |
2023-08-12 |
human |
| Karla Holmboe, Zsofia Nemoda, R M Pasco Fearon, Gergely Csibra, Maria Sasvari-Szekely, Mark H Johnso. Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Developmental psychology. vol 46. issue 2. 2010-06-04. PMID:20210499. |
polymorphisms in the catechol-o-methyltransferase (comt) and the dopamine d4 receptor (drd4) genes are likely to impact directly on the functioning of the frontal cortex, whereas polymorphisms in the dopamine d2 receptor (drd2) and dopamine transporter (dat1) genes might influence frontal cortex functioning indirectly via strong frontostriatal connections. |
2010-06-04 |
2023-08-12 |
Not clear |