All Relations between con and apoptosis

Publication Sentence Publish Date Extraction Date Species
Zhichao Li, Hui He, Mengjuan Chen, Mengke Ni, Chaohui Guo, Zhiyi Wan, Jianshe Zhou, Zhitong Wang, Yaling Wang, Hanfang Cai, Ming Li, HuiZeng Sun, Huifen X. Novel mechanism of Clostridium butyricum alleviated coprophagy prevention-induced intestinal inflammation in rabbit. International immunopharmacology. vol 130. 2024-03-02. PMID:38430808. compared to con and scp, cp augmented cecum inflammation and apoptosis, as well as bacterial adhesion to the cecal epithelial mucosa, while decreasing the expression of tight junction proteins (zo-1, occluding, and claudin-1). 2024-03-02 2024-03-06 rabbit
Cong Meng, Yu Liu, Yuping Ming, Cao Lu, Yanggege Li, Yulu Zhang, Dongdong Su, Xueyun Gao, Qing Yua. Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258120. in vivo and in vitro mechanism studies indicated that auncs could suppress the secretion of ifn-γ by con a-stimulated t cells and subsequently inhibit the activation of the jak2/stat1 pathway and eventual hepatocyte apoptosis induced by ifn-γ. 2024-01-23 2024-01-25 mouse
Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhan. Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250898. functional annotation analysis revealed that de-mirnas in the low vs. con group may be involved in cell development, proliferation, and apoptosis. 2023-05-30 2023-08-14 Not clear
Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhan. Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250898. in the high vs. con group, rsv functions were associated with metabolic processes and responses to stimuli, while the pathways were related to pi3k24, akt, wnt, and apoptosis. 2023-05-30 2023-08-14 Not clear
Hasan Alkan, Fatma Satilmis, Mehmet Akif Demirel, Mustafa Bodu, Omer Faruk Yesilkaya, Muhammed Furkan Ciftci, Huseyin Erdem, Mustafa Agah Tekindal, Kubra Karakas Alka. Does Using Microfluidic Sperm Sorting Chips in Bovine IVEP Affect Blastocyst Development? Reproduction in domestic animals = Zuchthygiene. 2023-05-29. PMID:37246427. a statistically significant difference was found in the number of cells with apoptosis per embryo (5.14±0.77 vs 11.91±0.79) and apoptotic index rates (3.06±0.47 vs 7.72±0.55%) of the mfsc and con groups. 2023-05-29 2023-08-14 cattle
Fen Zhang, Lanlan Xiao, Ya Yang, Menghao Zhou, Yalei Zhao, Zhongyang Xie, Xiaoxi Ouyang, Feiyang Ji, Shima Tang, Lanjuan L. Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro. Frontiers of medicine. 2023-04-03. PMID:37010727. apoptosis analysis demonstrated that the protein expression of cleaved caspase 3 was increased by con a injection and reduced by menscs transplantation, consistent with the tunel staining results. 2023-04-03 2023-08-14 mouse
Xiangli Zhao, Cheng Fu, Lingjuan Sun, Hao Feng, Peiling Xie, Meng Wu, Xiaosheng Tan, Gang Che. New Insight into the Concanavalin A-Induced Apoptosis in Hepatocyte of an Animal Model: Possible Involvement of Caspase-Independent Pathway. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770978. we further observed in vitro that hepatocytes underwent a dose-dependent but caspase-independent apoptosis in response to con a stimulation in vitro. 2023-02-11 2023-08-14 mouse
Xiangli Zhao, Cheng Fu, Lingjuan Sun, Hao Feng, Peiling Xie, Meng Wu, Xiaosheng Tan, Gang Che. New Insight into the Concanavalin A-Induced Apoptosis in Hepatocyte of an Animal Model: Possible Involvement of Caspase-Independent Pathway. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770978. we conclude that con a can directly induce rapid but non-classical apoptosis in hepatocytes without the participation of immunocytes. 2023-02-11 2023-08-14 mouse
Haoran Jiang, Xianxin Wen, Xue Zhang, Bingyu Zhan. Concanavalin A inhibits human liver cancer cell migration by regulating F-actin redistribution and assembly via MAPK signaling pathway. Oncology letters. vol 24. issue 5. 2022-10-24. PMID:36276493. concanavalin a (con a), the first and most typical representative of the legume lectin family, has a potent anti-liver cancer effect by inducing cell apoptosis and autophagy. 2022-10-24 2023-08-14 human
Huatao Li, Xia Cong, Wenhui Yu, Zhongling Jiang, Kaiqiang Fu, Rongfeng Cao, Wenru Tian, Yanni Fen. Baicalin inhibits oxidative injures of mouse uterine tissue induced by acute heat stress through activating the Keap1/Nrf2 signaling pathway. Research in veterinary science. vol 152. 2022-10-21. PMID:36270181. compared with con group, heat stress up-regulated caspase-3 and caspase-9, enhanced the apoptosis of endometrial epithelial and glandular epithelial cells, improved the ho-1 mrna/protein and nqo1 protein expressions, while down-regulated the mrna/protein of keap1. 2022-10-21 2023-08-14 mouse
Mahmoud Elshal, Sara H Haze. Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice. Inflammopharmacology. 2022-09-05. PMID:36063304. our results showed that escin inhibited con a-induced elevation in liver enzymes (alt, ast, and ldh) and curbed the con a-induced hepatocyte necrosis and apoptosis together with abrogating the death pathway, jnk. 2022-09-05 2023-08-14 mouse
Ge Yu, Shuli Ji, Yang Yun, Kang Cheng, Hao Zhang, Peilu Jia, Tian Wang, Lili Zhan. Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets. Journal of animal science. 2022-05-31. PMID:35641131. the hepatic apoptosis rate was lower (p >0.05) in ble treatment than in the con group. 2022-05-31 2023-08-13 Not clear
Caiyun Yu, Dong Wang, Qiming Li, Yichun Tong, Zaibin Yang, Tian Wan. Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells. International immunopharmacology. vol 108. 2022-05-26. PMID:35617845. compared with the control group (con), lps stimulus resulted in decreased cell viability, intestinal barrier injury, increased cell apoptosis and cell cycle arrest at the g2/m phase. 2022-05-26 2023-08-13 rat
Mohamed E Shaker, Omnia M Hendawy, Mohamed El-Mesery, Sara H Haze. The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice. International immunopharmacology. vol 103. 2021-12-24. PMID:34952468. the results showed that rxb pretreatments were efficient in abrogating con a-instigated hepatocellular injury (alt, ast, ldh), necrosis (histopathology), apoptosis (cleaved caspase-3) and nuclear proliferation due to damage (pcna). 2021-12-24 2023-08-13 mouse
Lulu Deng, Shasha Cheng, Jiang Li, Xinglian Xu, Xiaojiang Hao, Yanhua Fan, Shuzhen M. Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents. European journal of medicinal chemistry. vol 227. 2021-12-03. PMID:34688010. mechanistic studies in vitro revealed that 1b inhibited cell apoptosis and inflammatory responses caused by con a treatment via il-6/jak2/stat3 signaling pathway. 2021-12-03 2023-08-13 mouse
Wenjie Wang, Yiwei Zhang, Jiamin Cao, Jiahui Xu, Linguo Zhao, Xianying Fan. Extracts of Waste from Poplar Wood Processing Alleviate Experimental Dextran Sulfate-Induced Colitis by Ameliorating Oxidative Stress, Inhibiting the Th1/Th17 Response and Inducing Apoptosis in Inflammatory Lymphocytes. Antioxidants (Basel, Switzerland). vol 10. issue 11. 2021-11-30. PMID:34829556. furthermore, pse and ple could induce apoptosis in con a-activated lymphocytes, which may be associated with the increase in p-tbk1, as the molecular docking results also indicated that salireposide in pse and ple could interact with the tbk1 protein. 2021-11-30 2023-08-13 mouse
Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahintur. Concanavalin A induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells. Journal of biochemical and molecular toxicology. vol 35. issue 5. 2021-07-28. PMID:33604990. in the present study, it was aimed to decide the impacts of various doses of con a on c6 glioblastoma cells regarding cytotoxicity, thiol/disulfide homeostasis, apoptosis, and inflammation. 2021-07-28 2023-08-13 rat
Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahintur. Concanavalin A induces apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in C6 glioblastoma cells. Journal of biochemical and molecular toxicology. vol 35. issue 5. 2021-07-28. PMID:33604990. this study revealed that con a, known as carbohydrate-binding protein, generated oxidative damage, inflammation, and apoptosis in a dose-dependent manner by modulating thiol/disulfide homeostasis in c6 glioblastoma cells. 2021-07-28 2023-08-13 rat
Wencong Tian, Lei Yang, Yuansheng Liu, Jianxiang He, Liang Yang, Qiong Zhang, Fei Liu, Jing Li, Jie Liu, Shoichiro Sumi, Yanna Shen, Zhi Q. Resveratrol attenuates doxorubicin-induced cardiotoxicity in rats by up-regulation of vascular endothelial growth factor B. The Journal of nutritional biochemistry. vol 79. 2021-04-05. PMID:30857673. increased cell death and apoptosis of cardiomyocytes were also observed in dox group in comparison with con group. 2021-04-05 2023-08-13 rat
Salma Y AboElnazar, Hossam E Ghoneim, Amany A Ghazy, Mohamed I El-Shamandy, Amani H Kazem, Eman K Rashwa. Concanavalin-A as a Model for Induction of Murine Autoimmune Hepatitis: Role of TNF-α and NF-κβ During The Acute Phase. The Egyptian journal of immunology. vol 27. issue 2. 2021-02-17. PMID:33548974. administration of another dose of con a resulted in sharp significant elevation of liver enzymes, inflammatory infiltrate and hepatocyte apoptosis after 24 hours and sustained till the end of the study. 2021-02-17 2023-08-13 mouse