| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Praseeda Mol, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Sreeranjini Babu, Pavithra Chandrasekaran, Reshma Raghavan, Sneha Suresh, Namitha Ravishankara, Anu Hemalatha Raju, Bipin Nair, Prashant Kumar Modi, Anita Mahadevan, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raj. A network map of GDNF/RET signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2023-01-30. PMID:36715855. |
glial cell line-derived neurotrophic factor (gdnf) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored gdnf family receptor alpha-1 (gfrα1) and the rearranged during transfection (ret) receptor tyrosine kinase. |
2023-01-30 |
2023-08-14 |
Not clear |
| Ghazaleh Sadeghiani, Maryam Khanehzad, Mohammad Ali Sadighi Gilani, Fardin Amidi, Mehrnoush Malekzadeh, Tayebeh Rastega. Evaluation of Nrf2/ARE Signaling Pathway in the Presence of Pentoxifylline as a Cryoprotectant in Mouse Spermatogonial Stem Cells. Biopreservation and biobanking. 2022-08-25. PMID:36006661. |
sscs extracted from neonatal mice testes were isolated and their purity was measured by flow cytometry with gdnf family receptor alpha-1 (gfrα1) and inhibitor of differentiation 4 (id4). |
2022-08-25 |
2023-08-14 |
mouse |
| Miaomiao Wang, Xiao Han, Wei Zha, Xiaoyu Wang, Liyun Liu, Zimu Li, Yefeng Shi, Xugang Kan, Gui Wang, Dianshuai Gao, Baole Zhan. GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis. Molecular neurobiology. 2022-08-04. PMID:35925441. |
high concentrations of gdnf promote loxl2 expression and secretion in ra cells through gdnf family receptor alpha-1(gfrα1)/rearranged during transfection proto-oncogene (ret)/mitogen-activated protein kinase (mapk)/phosphorylated cyclic amp response element binding protein (pcreb) signaling. |
2022-08-04 |
2023-08-14 |
human |
| Xue-Ming Zhan. GFRα-1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini-review. Anatomia, histologia, embryologia. vol 50. issue 1. 2021-10-19. PMID:32761645. |
the glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfrα-1) is a conserved marker of the gonocytes/sscs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/sscs is debated. |
2021-10-19 |
2023-08-13 |
human |
| Hyun-Jung Park, Won Young Lee, Ran Lee, Jin-Ki Park, Kwon-Ho Hong, Chankyu Park, Hyuk Son. Expression of paired box protein PAX7 in prepubertal boar testicular gonocytes. Acta histochemica. vol 122. issue 6. 2021-06-21. PMID:32778235. |
furthermore, the early-stage spermatogonial markers gdnf family receptor alpha-1 (gfrα1) and sal-like protein 4 (sall4) were coexpressed in pax7 |
2021-06-21 |
2023-08-13 |
Not clear |
| Huiling Chen, Tiyun Han, Liping Gao, Bin Xiong, Xiaoli Li, Guoqing Qi, Pengyun Zeng, Ye Chai, Dekui Zhan. [IL-1β and TNF-α up-regulate the expression of glial cell line-derived neurotrophic factor (GDNF) and down-regulate its receptors in rat intestinal smooth muscle cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696749. |
the relative mrna expression of gdnf, receptor tyrosine kinase (ret) and gdnf family receptor alpha-1 (gfrα1) were measured by real-time quantitative pcr. |
2020-10-30 |
2023-08-13 |
rat |
| Wenxian Li, Di Wei, Jiaxing Lin, Jianye Liang, Xiaomei Xie, Kangping Song, Li'an Huan. Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31456664. |
glial cell line-derived neurotrophic factor (gdnf)/gdnf family receptor alpha-1 (gfrα1)/receptor tyrosine kinase (ret) signaling is altered in the hippocampus of cch rats; however, nbp treatment improved cognitive function, protected against hippocampal neuron apoptosis |
2020-09-29 |
2023-08-13 |
rat |
| Huimin Zhao, Tingting Li, Huan Yang, Muhammad Usman Mehmood, Yangqing Lu, Xingwei Liang, Xiaogan Yang, Huiyan Xu, Kehuan Lu, Shengsheng L. The effects of growth factors on proliferation of spermatogonial stem cells from Guangxi Bama mini-pig. Reproduction in domestic animals = Zuchthygiene. vol 54. issue 12. 2020-05-20. PMID:31544277. |
the growth factors glial cell line-derived neurotrophic factor (gdnf), leukaemia inhibitory factor (lif), gdnf family receptor alpha-1 (gfrα1) and basic fibroblast growth factor (bfgf) were investigated. |
2020-05-20 |
2023-08-13 |
mouse |
| Lihua Dong, Murat Gul, Simone Hildorf, Susanne Elisabeth Pors, Stine Gry Kristensen, Eva R Hoffmann, Dina Cortes, Jorgen Thorup, Claus Yding Anderse. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys. International journal of molecular sciences. vol 20. issue 21. 2020-03-27. PMID:31671863. |
we verified ssc-like cell clusters (ssclcs) by quantitative real-time polymerase chain reaction (pcr) and immune-reaction assay using the ssc markers undifferentiated embryonic cell transcription factor 1 (utf1), ubiquitin carboxyl-terminal hydrolase isozyme l1 (uchl1), gdnf receptor alpha-1 (gfrα-1) fα and promyelocytic leukaemia zinc finger protein (plzf). |
2020-03-27 |
2023-08-13 |
mouse |
| Dong-Hui Wang, Hong-Xia Zhou, Shu-Jun Liu, Cheng-Jie Zhou, Xiang-Wei Kong, Zhe Han, Cheng-Guang Lian. Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development. Theriogenology. vol 113. 2018-09-28. PMID:29477014. |
we show for the first time that gdnf and its receptor, gdnf family receptor alpha-1 (gfra1), are presented in ovarian follicles at different stages as well as during oocyte maturation and early embryo development. |
2018-09-28 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand that activates, through co-receptor gdnf family receptor alpha-1 (gfrα1) and receptor tyrosine kinase "ret", several signaling pathways crucial in the development and sustainment of multiple neuronal populations. |
2017-09-18 |
2023-08-13 |
mouse |
| Ravindran Kumar Pramod, Bo Ram Lee, Young Min Kim, Hong Jo Lee, Young Hyun Park, Tamao Ono, Jeong Mook Lim, Jae Yong Ha. Isolation, Characterization, and In Vitro Culturing of Spermatogonial Stem Cells in Japanese Quail (Coturnix japonica). Stem cells and development. vol 26. issue 1. 2017-09-11. PMID:27702397. |
the percentages of viability of isolated tcs were 91.00% ± 2.12% and 88.00% ± 1.87% in juvenile and adult testes, respectively, and immunohistochemical evaluation indicated the expression of integrin alpha-6 (itga6), gdnf family receptor alpha-1 (gfra1), and deleted in azoospermia-like (dazl) in specific tcs. |
2017-09-11 |
2023-08-13 |
mouse |
| M Curcio, I L Salazar, A R Inácio, E P Duarte, L M T Canzoniero, C B Duart. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell death & disease. vol 6. 2016-01-25. PMID:25675305. |
the glial cell line-derived neurotrophic factor (gdnf) has an important role in neuronal survival through binding to the gfrα1 (gdnf family receptor alpha-1) receptor and activation of the receptor tyrosine kinase ret. |
2016-01-25 |
2023-08-13 |
mouse |
| J Mucksová, J Kalina, M Bakst, H Yan, J P Brillard, B Benešová, B Fafílek, J Hejnar, P Trefi. Expression of the chicken GDNF family receptor α-1 as a marker of spermatogonial stem cells. Animal reproduction science. vol 142. issue 1-2. 2014-05-27. PMID:24060137. |
gdnf family receptor alpha-1 (gfrα1), has been identified as a potential marker for different mouse spermatogonial subtypes. |
2014-05-27 |
2023-08-12 |
mouse |
| Neus Garcia, Manel M Santafé, Marta Tomàs, Maria A Lanuza, Nuria Besalduch, Merche Priego, Josep Tomà. The glial cell line-derived neurotrophic factor (GDNF) does not acutely change acetylcholine release in developing and adult neuromuscular junction. Neuroscience letters. vol 480. issue 2. 2010-10-19. PMID:20542089. |
we use immunocytochemistry to show that the trophic molecule glial cell line-derived neurotrophic factor (gdnf) and its receptor gdnf family receptor alpha-1 (gfralpha-1) are present in both neonatal (p6) and adult (p45) rodent neuromuscular junctions (nmj) colocalized with several synaptic markers. |
2010-10-19 |
2023-08-12 |
Not clear |
| Mamoru Takeda, Junichi Kitagawa, Masanori Nasu, Masayuki Takahashi, Koichi Iwata, Shigeji Matsumot. Glial cell line-derived neurotrophic factor acutely modulates the excitability of rat small-diameter trigeminal ganglion neurons innervating facial skin. Brain, behavior, and immunity. vol 24. issue 1. 2010-02-17. PMID:19679180. |
the fg-labeled small- and medium-diameter gdnf immunoreactive trg neurons, and most of these neurons also expressed the gdnf family receptor alpha-1 (gfralpha-1). |
2010-02-17 |
2023-08-12 |
rat |
| Kathrin Gassei, Jens Ehmcke, Stefan Schlat. Efficient enrichment of undifferentiated GFR alpha 1+ spermatogonia from immature rat testis by magnetic activated cell sorting. Cell and tissue research. vol 337. issue 1. 2009-10-02. PMID:19434428. |
glial-cell-derived neurotrophic factor family receptor alpha-1 (gfralpha1) is expressed on undifferentiated mouse spermatogonia (including sscs) and plays a crucial role, in rodents, for the maintenance of sscs mediated by the sertoli cell product gdnf. |
2009-10-02 |
2023-08-12 |
mouse |
| Vandana Zaman, Heather A Boger, Ann-Charlotte Granholm, Baerbel Rohrer, Alfred Moore, Mona Buhusi, Greg A Gerhardt, Barry J Hoffer, Lawrence D Middaug. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. The European journal of neuroscience. vol 28. issue 8. 2009-01-26. PMID:18973577. |
given the established importance of glial cell line-derived neurotrophic factor (gdnf) in maintaining dopaminergic neurotransmitter systems, the nigrostriatal system and associated behaviors of mice with genetic reduction of its high-affinity receptor, gdnf receptor (gfr)alpha-1 (gfralpha-1(+/-)), were compared with wild-type controls. |
2009-01-26 |
2023-08-12 |
mouse |
| H Qi, D-Q Li, F Bian, E Y Chuang, D B Jones, S C Pflugfelde. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. The British journal of ophthalmology. vol 92. issue 9. 2008-10-01. PMID:18723744. |
to evaluate the expression pattern of glial cell line-derived neurotrophic factor (gdnf) with its receptors gdnf family receptor alpha-1 (gfr alpha-1) and ret in the human corneal and limbal tissues, as well as in the primary human limbal epithelial cultures (phlec). |
2008-10-01 |
2023-08-12 |
human |
| Selma Esseghir, S Katrina Todd, Toby Hunt, Richard Poulsom, Ivan Plaza-Menacho, Jorge S Reis-Filho, Clare M Isack. A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089803. |
by screening a tissue microarray of invasive breast tumors, we have shown that the receptor tyrosine kinase ret (rearranged during transfection) and its coreceptor gfr alpha 1 (gdnf receptor family alpha-1) are overexpressed in a subset of estrogen receptor-positive tumors. |
2008-01-15 |
2023-08-12 |
Not clear |