All Relations between gli1 and smo

Publication Sentence Publish Date Extraction Date Species
Jessica E Pritchard, Juliette E Pearce, Inge A M Snoeren, Stijn N R Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S Nagai, Monica T Hannani, Anna K Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L Levine, Ivan G Costa, Hélène F E Gleitz, Rafael Kramann, Rebekka K Schneide. Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms. Cell reports. vol 43. issue 1. 2023-12-20. PMID:38117649. we show that gli1 protein levels in patient peripheral blood mononuclear cells (pbmcs) mark fibrotic progression and that, in murine mpn models, absence of hematopoietic gli1, but not gli2 or smo, significantly reduces mpn phenotype and fibrosis, indicating that gli1 in the mpn clone can be activated in a non-canonical fashion. 2023-12-20 2023-12-23 Not clear
Changle Zhao, Xiang Liu, Lei Liu, Jianeng Li, Xingyong Liu, Wenjing Tao, Deshou Wang, Jing We. Smoothened mediates medaka spermatogonia proliferation via Gli1-Rgcc-Cdk1 axis. Biology of reproduction. 2023-08-08. PMID:37552059. furthermore, gli1 transcriptionally upregulated the expression of rgcc, and rgcc overexpression rescued cell apoptosis caused by smo or gli1 inhibition. 2023-08-08 2023-08-14 Not clear
Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. 2023-01-30 2023-08-14 human
Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. 2021-12-02 2023-08-13 Not clear
Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. 2021-12-02 2023-08-13 Not clear
Tarapati Rana, Tapan Behl, Aayush Sehgal, Monika Sachdeva, Vineet Mehta, Neelam Sharma, Sukhbir Singh, Simona Bunga. Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33786718. furthermore, there is decreased expression of a glioma-associated oncogene (gli1) and smoothened (smo) in depression. 2021-10-18 2023-08-13 Not clear
Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zo. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:33993101. here, we found that the immunosuppressant cyclosporin a (csa) decreased the number of brdu+, brdu+/dcx+, brdu+/neun + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including shh, smo and gli1. 2021-06-22 2023-08-13 Not clear
Beng Zhang, Xiao-Hong Dai, Xue-Ping Yu, Wei Zou, Wei Teng, Xiao-Wei Sun, Wei-Wei Yu, Hao Liu, Hui Wang, Meng-Juan Sun, Meng L. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127121. our results showed that baihui-penetrating-qubin acupuncture promoted recovery of motor and sensory function, reduced the apoptotic cell percentage in the perihemorrhagic penumbra, and up-regulated smo and gli1 expression. 2020-09-30 2023-08-13 rat
Jingjie Luan, Haitao Tao, Yue S. Taladegib controls early chondrocyte hypertrophy via inhibiting smoothened/Gli1 pathway. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509193. abs treatment accelerated the process of chondrocyte hypertrophy and upregulated the expression of type x collagen, matrix metalloproteinase-13 (mmp-13), runx-2 but decreased type ii collagen, sox-9, and aggrecan both in protein and mrna levels, which abolished by the present of taladegib with the activation of smo and gli1. 2020-09-28 2023-08-13 human
Jingjie Luan, Haitao Tao, Yue S. Taladegib controls early chondrocyte hypertrophy via inhibiting smoothened/Gli1 pathway. American journal of translational research. vol 12. issue 5. 2020-09-28. PMID:32509193. smoothened (smo) is a connecting protein among the ihh signaling pathway that triggers glioma-associated oncogene homologue 1 (gli1) to active the hypertrophic process. 2020-09-28 2023-08-13 human
Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena P M Mariyath, Nabeela Khanam, Javier S Castresana, M Mobarak Hossai. Sonic hedgehog, Wnt, and brain-derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression. Journal of neuroscience research. vol 96. issue 1. 2018-06-22. PMID:28631844. moreover, the expression of gli1 and smo is downregulated in depression. 2018-06-22 2023-08-13 Not clear
Pei Yu, Jinqing Yang, Yan Zhan. Identification and characterization of two novel PTCH1 splice variants. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28390897. finally, all these isoforms have been revealed to inhibit gli1 activation by either the classical hh signaling pathway or a new pathway not reliant on both smo and apoptosis. 2017-06-12 2023-08-13 mouse
Sita Sharan Patel, Neeraj Mahindroo, Malairaman Udayaban. Urtica dioica leaves modulates hippocampal smoothened-glioma associated oncogene-1 pathway and cognitive dysfunction in chronically stressed mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27470568. cus significantly downregulated smo (p<0.05), gli1 (p<0.01), cyclin d1 (p<0.05), bdnf (p<0.01), trkb (p<0.01) and mapk1 (p<0.01) mrna expression in hippocampus as compared to control mice. 2017-02-07 2023-08-13 mouse
Sita Sharan Patel, Neeraj Mahindroo, Malairaman Udayaban. Urtica dioica leaves modulates hippocampal smoothened-glioma associated oncogene-1 pathway and cognitive dysfunction in chronically stressed mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27470568. chronic ud administration significantly upregulated hippocampal smo (p<0.05), gli1 (p<0.001), cyclin d1 (p<0.05), bdnf (p<0.05), trkb (p<0.05) and mapk1 (p<0.05) in stressed mice. 2017-02-07 2023-08-13 mouse
Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. utilizing smosirna transfected esophageal squamous carcinoma ec9706 cells, adopting rt-pcr and western blot technology to detect smo, gli1 mrna and protein expression in each group of cells, employing mtt and fcm to detect the influence of smosirna on cell proliferation and apoptosis. 2015-01-22 2023-08-13 human
Malay Chaklader, Prosun Das, Jacintha Archana Pereira, Samaresh Chaudhuri, Sujata La. Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model. Arhiv za higijenu rada i toksikologiju. vol 63. issue 3. 2014-07-17. PMID:23152377. the results depicted pancytopenic feature of peripheral blood, developmental anomaly of neutrophils, depression of primitive stem and progenitor population along with shh, ptch1, smo and gli1 expression in aplasia group. 2014-07-17 2023-08-12 mouse
Joon Won Yoon, Marisa Gallant, Marilyn L G Lamm, Stephen Iannaccone, Karl-Frederic Vieux, Maria Proytcheva, Elizabeth Hyjek, Philip Iannaccone, David Walterhous. Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23525267. exposure to sonic or indian hedgehog or cyclopamine (smo inhibitor) does not modulate gli1 expression, cell proliferation, or apoptosis in most burkitt lymphoma cell lines. 2014-04-17 2023-08-12 human
Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. interestingly, stimulation of cultured adrenal cells with forskolin led to a decrease in expression of gli1 and smo mrnas. 2014-02-03 2023-08-12 mouse
Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. the hh-pathway components shh, gli1, ptch1 and smo were detectable in all adrenal glands. 2014-02-03 2023-08-12 mouse
Pascal Werminghaus, Matthias Haase, Peter J Hornsby, Sven Schinner, Matthias Schott, Ludwik K Malendowicz, Bernhard J Lammers, Peter E Goretzki, Volker Müller-Mattheis, Markus Giessing, Holger S Willenber. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. The Journal of steroid biochemistry and molecular biology. vol 139. 2014-02-03. PMID:24063979. we studied the expression of sonic hedgehog (shh), smoothened (smo), patched1 (ptch1) and gli family zinc finger 1 (gli1) in human adrenal and in adrenocortical tumors using immunohistochemistry and semi-quantitative reverse transcriptase-polymerase chain reaction. 2014-02-03 2023-08-12 mouse