| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Tong, Genhong Yao, Yueqin Chen, Hairong Xie, Xinyu Zheng, Lingyun Sun, Zhenping Huang, Zhenggao Xi. Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy. Inflammation. 2024-04-16. PMID:38625640. |
overexpression of hmgb1 in microglia reversed the effects of msc treatment, suggesting hmgb1/tlr4 pathway is necessary for mscs' regulatory effects on microglia polarization. |
2024-04-16 |
2024-04-18 |
rat |
| Mark Mizrachi, Betty Diamon. Impact of microglia isolation and culture methodology on transcriptional profile and function. Journal of neuroinflammation. vol 21. issue 1. 2024-04-08. PMID:38589917. |
this study aims to evaluate five different microglia isolation methods-three variants of microglia isolation from neonatal mice and two variants of microglia isolation from adult mice-on transcriptional profile and response to hmgb1. |
2024-04-08 |
2024-04-11 |
mouse |
| Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng, Jiangang She. Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury. Journal of neuroinflammation. vol 21. issue 1. 2024-03-22. PMID:38515139. |
taken together, we conclude that ischemia/hypoxia could activate microglia to release mpo-containing exosomes that transfer mpo to adjacent cells for hocl production; subsequently, the production of hocl could mediate the translocation and secretion of disulfide hmgb1 that aggravates cerebral i/r injury. |
2024-03-22 |
2024-03-24 |
rat |
| Patrick-Brian Bielawski, Issan Zhang, Clara Correa-Paz, Francisco Campos, Martina Migliavacca, Ester Polo, Pablo Del Pino, Beatriz Pelaz, Denis Vivien, Dusica Maysinge. Modulation of Abundance and Location of High-Mobility Group Box 1 in Human Microglia and Macrophages under Oxygen-Glucose Deprivation. ACS pharmacology & translational science. vol 7. issue 3. 2024-03-14. PMID:38481701. |
under ischemic conditions of oxygen-glucose deprivation (ogd), nuclear abundance of hmgb1 and achmgb1 in microglia and macrophages decreased, whereas treatment with csm@rtpa did not alter nuclear or cytosolic abundance. |
2024-03-14 |
2024-03-16 |
human |
| Jian Ye, Shuang-Qi Gao, Zi-Cun Liu, Xi Chen, Jin-Gang He, Zhuang-Li H. The HMGB1-RAGE axis in nucleus accumbens facilitates cocaine-induced conditioned place preference via modulating microglial activation. Brain and behavior. vol 14. issue 3. 2024-03-07. PMID:38450910. |
however, whether the secretion of hmgb1 acts on microglia or contributes to cocaine addiction is largely unknown. |
2024-03-07 |
2024-03-09 |
Not clear |
| Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Le. Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease. Cells. vol 13. issue 2. 2024-01-22. PMID:38247880. |
age-dependent and aβ-induced dynamic changes in the subcellular localization of hmgb1 in neurons and microglia in the brains of an animal model of alzheimer's disease. |
2024-01-22 |
2024-01-24 |
mouse |
| Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Le. Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease. Cells. vol 13. issue 2. 2024-01-22. PMID:38247880. |
triple-fluorescence immunohistochemical analysis indicated that hmgb1 appeared as a ring shape in the cytoplasm of most neurons and microglia in the frontal cortices of 9.5 m tg-app/ps1 mice, indicating that nuclear hmgb1 is reduced by aging and in tg-app/ps1 mice. |
2024-01-22 |
2024-01-24 |
mouse |
| Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Le. Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease. Cells. vol 13. issue 2. 2024-01-22. PMID:38247880. |
our results indicate that nuclear hmgb1 might be translocated from the nucleus to the cytoplasm in both neurons and microglia in the brains of tg-app/ps1 mice, and that it may subsequently be secreted extracellularly. |
2024-01-22 |
2024-01-24 |
mouse |
| Guido S Alvarez Quintero, Analia Lima, Paulina Roig, Maria Meyer, E Ron de Kloet, Alejandro F De Nicola, Laura I Gara. effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis. The Journal of steroid biochemistry and molecular biology. 2024-01-14. PMID:38219844. |
the mr blocker (a) significantly decreased the inflammatory parameters tlr4, myd88, il-1β, and inos mrnas; (b) attenuated hmgb1, nlrp3, tgf-β mrnas, microglia, and aquaporin4 immunoreaction without modifying gfap. |
2024-01-14 |
2024-01-17 |
mouse |
| Zeynep Kaya, Nevin Belder, Melike Sever-Bahcekapili, Buket Donmez-Demir, Şefik Evren Erdener, Naz Bozbeyoglu, Canan Bagci, Emine Eren-Kocak, Muge Yemisci, Hulya Karatas, Esra Erdemli, Ihsan Gursel, Turgay Dalkar. Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes. Journal of neuroinflammation. vol 20. issue 1. 2023-12-12. PMID:38082296. |
ezcolocalization and costes thresholding algorithms were used to assess the colocalization of small extracellular vesicles (sevs) carrying hmgb1 with astrocyte or microglia processes. |
2023-12-12 |
2023-12-17 |
mouse |
| Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Oscar Yip, Antara Rao, Min Joo Kim, Maxine R Nelson, Yung-Hua Wang, Brian Grone, Yanxia Hao, Reuben Thomas, Misha Zilberter, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release. Cell reports. 2023-10-20. PMID:37863057. |
single-nucleus rna sequencing revealed that treatment with hmgb1 inhibitors diminished disease-associated and enriched disease-protective subpopulations of neurons, microglia, and astrocytes in apoe4-tauopathy mice. |
2023-10-20 |
2023-11-08 |
mouse |
| Kaiyi Zhu, Xing Zhu, Jie Yu, Lu Chen, Shiqi Liu, Mingjing Yan, Wei Yang, Yanyan Sun, Zhe Zhang, Jian Li, Tao Shen, Mingyan He. Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage. Journal of neurochemistry. 2023-09-27. PMID:37753942. |
in this study, we aimed to investigate the association between hmgb1 and microglial pyroptosis and elucidate the mechanism involved in rats with hibd (both sexes were included) and in bv2 microglia subjected to oxygen-glucose deprivation. |
2023-09-27 |
2023-10-07 |
rat |
| Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hong-Shiu Chen, Hung-Chuan Pa. Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628850. |
the exact role of inflammasomes in microglia activated by thrombin remains unclear, particularly as it relates to the downstream functions of hmgb1. |
2023-08-26 |
2023-09-07 |
rat |
| Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hong-Shiu Chen, Hung-Chuan Pa. Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells. International journal of molecular sciences. vol 24. issue 16. 2023-08-26. PMID:37628850. |
in conclusion, thrombin induced microglia activation through triggering inflammasomes to release hmgb1, contributing to neuronal death. |
2023-08-26 |
2023-09-07 |
rat |
| Xiaolin Qu, Xiaoxiang Hou, Kaixin Zhu, Wen Chen, Kun Chen, Xianzheng Sang, Chenqing Wang, Yelei Zhang, Haoxiang Xu, Junyu Wang, Qibo Hou, Liquan Lv, Lijun Hou, Danfeng Zhan. Neutrophil extracellular traps facilitate sympathetic hyperactivity by polarizing microglia toward M1 phenotype after traumatic brain injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 9. 2023-08-03. PMID:37534961. |
the findings revealed that sympathetic excitability intensifies and peaks 3 days post-injury, a pattern mirrored by the activation of microglia, and the escalated nets and hmgb1 levels. |
2023-08-03 |
2023-08-14 |
rat |
| Jingjing Mo, Zijing Lu, Jialing Peng, Xiang-Pen Li, Lihuan Lan, Hongxuan Wang, Ying Pen. PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation. Journal of psychiatric research. vol 164. 2023-06-23. PMID:37352811. |
our findings suggested that the secretion of hmgb1 induced by morphine-activated tlr4 in microglia, and the proinflammatory factors released by activated microglia phosphorylated nr1 and nr2b of adjacent neurons, induced increased neuronal excitability. |
2023-06-23 |
2023-08-14 |
mouse |
| Xiao Huang, Bo Wang, Jing Yang, Yong-Jie Lian, Hong-Zhang Yu, Yun-Xia Wan. HMGB1 in depression: An overview of microglial HMBG1 in the pathogenesis of depression. Brain, behavior, & immunity - health. vol 30. 2023-06-08. PMID:37288063. |
microglia, as the immune cell of the brain, interacts with hmgb1 and induces neuroinflammation and neurodegeneration in the cns. |
2023-06-08 |
2023-08-14 |
Not clear |
| Si-Jie Dai, Yu-Ying Shao, Yang Zheng, Jin-Yi Sun, Zhi-Sheng Li, Jia-Ying Shi, Meng-Qi Yan, Xiao-Yun Qiu, Ceng-Lin Xu, Wan-Sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Che. Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation. Acta pharmacologica Sinica. 2023-04-19. PMID:37076634. |
notably, in ca1 region, the seizure focus, icm pretreatment mainly inhibited hmgb1 translocation in microglia. |
2023-04-19 |
2023-08-14 |
mouse |
| Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pa. Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway. Neural regeneration research. vol 18. issue 9. 2023-03-17. PMID:36926733. |
hmgb1 regulated nuclear factor κb p65 phosphorylation and interleukin-1β production by increasing toll-like receptor 4 receptor expression in microglia, thereby inducing morphine tolerance. |
2023-03-17 |
2023-08-14 |
mouse |
| Chengbin Wang, Pingfeng Zhang, Yanni Li, Xiong Wang, Lingzhi Guo, Jingluan Li, Huihui Jia. Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis. Journal of chemical neuroanatomy. 2023-02-16. PMID:36796734. |
in addition, overexpression of hmgb1 impaired the effects of trim27 downregulation on improving ogd-induced cell viability, inhibiting inflammatory reactions and microglia activation. |
2023-02-16 |
2023-08-14 |
rat |