Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Shu-Ling Chiu, Chih-Ming Chen, Richard L Hugani. ICA69 regulates activity-dependent synaptic strengthening and learning and memory. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251649. |
here, we showed that ica69 regulates pick1's distribution in neurons and stability in the mouse hippocampus, which in turn can impact ampar function in the brain. |
2023-05-30 |
2023-08-14 |
mouse |
Kunyuan Han, Anqi Zhang, Yunchang Mo, Tingting Mao, Binbin Ji, Dan Li, Xiuxiu Zhuang, Meizi Qian, Shuangdong Chen, Zhen Wang, Junlu Wan. Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain. vol 160. issue 3. 2019-06-26. PMID:30699097. |
in this study, we evaluated the role of ica69 in the antihyperalgesic effects of ea and the underlying mechanism through regulation of glur2 and pick1 in spinal dorsal horn. |
2019-06-26 |
2023-08-13 |
mouse |
Kunyuan Han, Anqi Zhang, Yunchang Mo, Tingting Mao, Binbin Ji, Dan Li, Xiuxiu Zhuang, Meizi Qian, Shuangdong Chen, Zhen Wang, Junlu Wan. Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain. vol 160. issue 3. 2019-06-26. PMID:30699097. |
ica69 knockout led to reduced protein interacting with c-kinase 1 (pick1) expression and increased glutamate receptor subunit 2 (glur2) phosphorylation at ser880 in spinal dorsal horn. |
2019-06-26 |
2023-08-13 |
mouse |
Qian-Jun Li, Zhen Wang, Yong-Xing Yao, Shen-Hui Jin, Mei-Zi Qian, Na-Na Li, Ya-Nan Wang, Ya-Wen Zhang, Bin-Yu Chen, Dan-Yun Jia, Ying Shen, Jun-Lu Wan. Loss of ICA69 potentiates long-lasting hyperalgesia after subcutaneous formalin injection into the mouse hindpaw. Neurochemical research. vol 40. issue 3. 2015-12-04. PMID:25547463. |
here we reported that expression of pick1 in spinal cord was reduced largely in ica69 knockout mice. |
2015-12-04 |
2023-08-13 |
mouse |
Zhen Wang, Ya-Nan Wang, Cheng-Long Sun, Dong Yang, Li-Da Su, Ya-Jun Xie, Lin Zhou, Yin Wang, Ying She. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity. PloS one. vol 8. issue 12. 2014-09-16. PMID:24358315. |
c-terminal domain of ica69 interacts with pick1 and acts on trafficking of pick1-pkcα complex and cerebellar plasticity. |
2014-09-16 |
2023-08-12 |
Not clear |
Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K Y Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xi. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS biology. vol 11. issue 4. 2013-10-17. PMID:23630453. |
together, our results indicate that pick1 and ica69 are key regulators of the formation and maturation of insulin granules. |
2013-10-17 |
2023-08-12 |
mouse |
Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K Y Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xi. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS biology. vol 11. issue 4. 2013-10-17. PMID:23630453. |
pick1 and ica69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. |
2013-10-17 |
2023-08-12 |
mouse |
Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K Y Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xi. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS biology. vol 11. issue 4. 2013-10-17. PMID:23630453. |
here we report that pick1 and ica69, two cytosolic lipid-binding proteins, formed heteromeric bar-domain complexes that associated with insulin granules at different stages of their maturation. |
2013-10-17 |
2023-08-12 |
mouse |
Mian Cao, Junyu Xu, Chong Shen, Chuen Kam, Richard L Huganir, Jun Xi. PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032668. |
ica69 regulates ampa receptor trafficking by forming heteromeric bar domain complexes with pick1 and preventing formation of pick1 homomeric complexes. |
2007-12-18 |
2023-08-12 |
Not clear |