| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shotaro Masuoka, Takashi Tanaka, Miwa Kanaji, Karin Furukawa, Keiko Koshiba, Zento Yamada, Eri Watanabe, Mai Kawazoe, Shun Ito, Ayako Fuchigami, Toshihiro Nank. A case of systemic lupus erythematosus in a patient with Noonan syndrome with recurrent severe hypoglycemia. Modern rheumatology case reports. 2024-01-22. PMID:38252597. |
since insulin receptor antibody levels were higher to the upper normal range and decreased after treatment, hypoglycemia probably appeared to be attributed to type b insulin resistance syndrome (tbirs). |
2024-01-22 |
2024-01-25 |
Not clear |
| Yang Hai, Ke Ren, Yarong Zhang, Lili Yang, Haoshi Cao, Xianxia Yuan, Linling Su, Hailong Li, Xiaoli Feng, Dongling Li. HIF-1α serves as a co-linker between AD and T2DM. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-19. PMID:38242039. |
tissue oxygen consumption disrupts hif-1α homeostasis, leading to increased reactive oxygen species levels and the inhibition of insulin receptor pathway activity, causing neuroinflammation, insulin resistance, abnormal aβ deposition, and tau hyperphosphorylation. |
2024-01-19 |
2024-01-22 |
Not clear |
| Yuxing Tai, Xiaoqian Yang, Xiaochao Gang, Zhengri Cong, Sixian Wang, Peizhe Li, Mingjun Li. Metabolomic signature between diabetic and non-diabetic obese patients: A protocol for systematic review. PloS one. vol 19. issue 1. 2024-01-17. PMID:38232103. |
type 2 diabetes mellitus (t2dm) is a chronic and progressive condition defined by hyperglycemia caused by abnormalities in insulin production, insulin receptor sensitivity, or both. |
2024-01-17 |
2024-01-20 |
human |
| Syed Sayeed Ahmad, Hee Jin Chun, Khurshid Ahmad, Inho Cho. Therapeutic applications of ginseng for skeletal muscle-related disorder management. Journal of ginseng research. vol 48. issue 1. 2024-01-15. PMID:38223826. |
ginsenoside compounds are also used for obesity management, and their anti-obesity effects are attributed to peroxisome proliferator activated receptor gamma (pparγ) inhibition, ampk activation, glucose transporter type 4 (glut4) translocation, and increased phosphorylations of insulin resistance (ir), insulin receptor substrate-1 (irs-1), and akt. |
2024-01-15 |
2024-01-17 |
Not clear |
| Wenmin Tian, Dongxue Shi, Yinmei Zhang, Hongli Wang, Haohao Tang, Zhongyu Han, Catherine C L Wong, Liyan Cui, Jiajia Zheng, Yang Che. Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. Communications biology. vol 7. issue 1. 2024-01-15. PMID:38225453. |
increased levels of von willebrand factor (vwf) and insulin receptor (insr) were identified as candidate biomarkers, which shed light on hypercoagulability and abnormal insulin signaling in disease progression. |
2024-01-15 |
2024-01-18 |
Not clear |
| Wen-Xing Sun, Kai-Hui Zhang, Qian Zhou, Song-Hua Hu, Yan Lin, Wei Xu, Shi-Min Zhao, Yi-Yuan Yua. Tryptophanylation of insulin receptor by WARS attenuates insulin signaling. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-11. PMID:38212570. |
tryptophanylation of insulin receptor by wars attenuates insulin signaling. |
2024-01-11 |
2024-01-14 |
mouse |
| Wen-Xing Sun, Kai-Hui Zhang, Qian Zhou, Song-Hua Hu, Yan Lin, Wei Xu, Shi-Min Zhao, Yi-Yuan Yua. Tryptophanylation of insulin receptor by WARS attenuates insulin signaling. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-11. PMID:38212570. |
herein, we show that tryptophan modifies insulin receptor (ir) to attenuate insulin signaling and impair glucose uptake. |
2024-01-11 |
2024-01-14 |
mouse |
| Chisato Kubota, Ryoko Torii, Masahiro Hosaka, Toshiyuki Takeuchi, Hiroshi Gomi, Seiji Tori. Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201998. |
concurrent with glucose-stimulated insulin secretion, phogrin translocates to pancreatic β-cell plasma membranes, where it interacts with insulin receptors (irs) to stabilize insulin receptor substrate 2 (irs2) that, in turn, contributes to glucose-responsive β-cell growth. |
2024-01-11 |
2024-01-13 |
mouse |
| Jiayu Jin, Yunquan He, Jieyu Guo, Qi Pan, Xiangxiang Wei, Chen Xu, Zhiyuan Qi, Qinhan Li, Siyu Ma, Jiayi Lin, Nan Jiang, Jinghua Ma, Xinhong Wang, Lindi Jiang, Qiurong Ding, Elena Osto, Xiuling Zhi, Dan Men. BACH1 controls hepatic insulin signaling and glucose homeostasis in mice. Nature communications. vol 14. issue 1. 2023-12-21. PMID:38129407. |
bach1 directly interacts with the protein-tyrosine phosphatase 1b (ptp1b) and the insulin receptor β (ir-β), and loss of bach1 reduces the interaction between ptp1b and ir-β upon insulin stimulation and enhances insulin signaling in hepatocytes. |
2023-12-21 |
2023-12-24 |
mouse |
| Hui-Yan Zhang, Guo Shen, Chen Yang, Jian Tan, Jian-Cang Cao, Jing Tian, Zhou-Le Li, Gang Huang, Lian-Ping Zha. The reduced gray matter volume and functional connectivity of the cerebellum in T2DM with high insulin resistance. Neuroendocrinology. 2023-12-19. PMID:38113872. |
insulin resistance is widely thought to be a critical feature in type 2 diabetes mellitus (t2dm), and there is significant evidence indicating a higher abundance of insulin receptors in the human cerebellum than cerebrum. |
2023-12-19 |
2023-12-23 |
human |
| Wei Jiang, Jin Tan, Jiacheng Zhang, Xin Deng, Xinyue He, Jin Zhang, Tong Liu, Rong Sun, Mengxun Sun, Kuo Chen, Tingjia Xu, Yuling Yan, Ali Moazzami, E-Jiao Wu, Jiasui Zhan, Binhong H. Polysaccharides from Dendrobium officinale improve obesity-induced insulin resistance through the gut microbiota and the SOCS3-mediated insulin receptor substrate-1 signaling pathway. Journal of the science of food and agriculture. 2023-12-19. PMID:38111200. |
polysaccharides from dendrobium officinale improve obesity-induced insulin resistance through the gut microbiota and the socs3-mediated insulin receptor substrate-1 signaling pathway. |
2023-12-19 |
2023-12-21 |
human |
| Md Nur Kabidul Azam, Partha Biswas, Md Mohaimenul Islam Tareq, Md Ridoy Hossain, Shabana Bibi, Md Anisul Hoque, Amia Khandker, Md Ashraful Alam, Md Nazmul Hasan Zilani, Mohammad Shahedur Rahman, Norah A Albekairi, Abdulrahman Alshammari, Md Nazmul Hasa. Identification of antidiabetic inhibitors from Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 32. issue 1. 2023-12-13. PMID:38090733. |
identification of antidiabetic inhibitors from diabetes mellitus (dm) is a metabolic disorder arising from insulin deficiency and defectiveness of the insulin receptor functioning on transcription factor where the body loses control to regulate glucose metabolism in β-cells, pancreatic and liver tissues to homeostat glucose level. |
2023-12-13 |
2023-12-17 |
mouse |
| Patricia O Benedet, Nooshin S Safikhan, Maria J Pereira, Bryan M Lum, José Diego Botezelli, Cheng-Hsiang Kuo, Hua-Lin Wu, Barbara P Craddock, W Todd Miller, Jan W Eriksson, Jessica T Y Yue, Edward M Conwa. CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine. vol 99. 2023-12-07. PMID:38061240. |
cd248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. |
2023-12-07 |
2023-12-17 |
mouse |
| Marvis Monteiro, Xihong Zhang, Douglas Ye. Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells. Experimental cell research. 2023-11-30. PMID:38036052. |
insulin promotes growth in breast cancer cells through the type i igf receptor in insulin receptor deficient cells. |
2023-11-30 |
2023-12-10 |
Not clear |
| Chunnan Li, Jiaming Shen, Xiaolong Jing, Kaiyue Zhang, Lu Liu, Yuelong Wang, Hui Zhang, Jiaming Su. Mechanism of action of Huangbaichen Sanwei formulation in treating T2DM based on network pharmacology and molecular docking. Medicine. vol 102. issue 46. 2023-11-21. PMID:37986298. |
enrichment analyses showed that hbcs was involved mainly including insulin receptor signaling pathway, extracellular region, and insulin-like growth factor receptor binding and other biological processes; common targets had roles in treating t2dm by regulating diabetic cardiomyopathy and insulin resistance. |
2023-11-21 |
2023-11-29 |
Not clear |
| Patrick Vincent N Lubenia, Eduardo R Mendoza, Angelyn R La. Comparative analysis of kinetic realizations of insulin signaling. Journal of theoretical biology. 2023-11-20. PMID:37984585. |
the analysis uses network decomposition to identify the different subsystems involved in insulin signaling (e.g., insulin receptor binding and recycling, glut4 translocation, and erk signaling pathway, among others). |
2023-11-20 |
2023-11-29 |
human |
| Xingpei Fan, Xiaoyan Li, Jiaxin Li, Yuxia Zhang, Xiangjuan Wei, Hailong Hu, Boya Zhang, Haining Du, Meimei Zhao, Ruijiao Zhu, Daqian Yang, Yuri Oh, Ning G. Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice. Journal of environmental sciences (China). vol 137. 2023-11-18. PMID:37980039. |
constitutive activation of the mapk signaling proteins induced high continued phosphorylation of insulin receptor substrate-1, in turn, leading to decreased protein kinase b (akt) activity, which weakened the sensitivity of liver cells to insulin signals and induced insulin resistance. |
2023-11-18 |
2023-11-20 |
mouse |
| Corina Ramona Nicolescu, Clara Cremillieux, Jean-Louis Stepha. Duodenogastric Intussusception in a 14-Week-Old Infant with Donohue Syndrome: Case Study. Case reports in pediatrics. vol 2023. 2023-10-27. PMID:37885901. |
donohue syndrome (ds) is a rare recessively inherited disorder characterized by severe insulin resistance caused by genetic defects affecting the insulin receptor. |
2023-10-27 |
2023-11-08 |
Not clear |
| Liang Yu, Mengchen Xu, Yupeng Yan, Shuchen Huang, Mengmeng Yuan, Bing Cui, Cheng Lv, Yu Zhang, Hongrui Wang, Xiaolei Jin, Rutai Hui, Yibo Wan. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37884540. |
zfyve28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. |
2023-10-26 |
2023-11-08 |
mouse |
| Liang Yu, Mengchen Xu, Yupeng Yan, Shuchen Huang, Mengmeng Yuan, Bing Cui, Cheng Lv, Yu Zhang, Hongrui Wang, Xiaolei Jin, Rutai Hui, Yibo Wan. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37884540. |
overall, in this study, we reveal that zfyve28 is involved in insulin resistance by promoting phosphorylated insulin receptor degradation, and zfyve28 may be a potential therapeutic target to improve insulin sensitivity. |
2023-10-26 |
2023-11-08 |
mouse |