| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Yu, Mengchen Xu, Yupeng Yan, Shuchen Huang, Mengmeng Yuan, Bing Cui, Cheng Lv, Yu Zhang, Hongrui Wang, Xiaolei Jin, Rutai Hui, Yibo Wan. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37884540. |
zfyve28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. |
2023-10-26 |
2023-11-08 |
mouse |
| Liang Yu, Mengchen Xu, Yupeng Yan, Shuchen Huang, Mengmeng Yuan, Bing Cui, Cheng Lv, Yu Zhang, Hongrui Wang, Xiaolei Jin, Rutai Hui, Yibo Wan. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor degradation via increasing late endosomes production. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37884540. |
overall, in this study, we reveal that zfyve28 is involved in insulin resistance by promoting phosphorylated insulin receptor degradation, and zfyve28 may be a potential therapeutic target to improve insulin sensitivity. |
2023-10-26 |
2023-11-08 |
mouse |
| . Expression of Concern. Marco A. Carvalho-Filho, Mirian Ueno, Sandro M. Hirabara, Amedea B. Seabra, José B.C. Carvalheira, Marcelo G. de Oliveira, Lício A. Velloso, Rui Curi, and Mario J.A. Saad. S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt: A Novel Mechanism of Insulin Resistance. Diabetes 2005;54:959-967. DOI: 10.2337/diabetes.54.4.959. PMID: 15793233. Diabetes. 2023-10-24. PMID:37870461. |
s-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase b/akt: a novel mechanism of insulin resistance. |
2023-10-24 |
2023-11-08 |
Not clear |
| . Expression of Concern. Henrique G. Zecchin, Fernanda B.M. Priviero, Claudio T. Souza, Karina G. Zecchin, Patrícia O. Prada, José B.C. Carvalheira, Licio A. Velloso, Edson Antunes, and Mario J.A. Saad. Defective Insulin and Acetylcholine Induction of Endothelial Cell-Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats. Diabetes 2007;56:1014-1024. DOI: 10.2337/db05-1147. PMID: 17229938. Diabetes. 2023-10-24. PMID:37870456. |
defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/akt signaling pathway in aorta of obese rats. |
2023-10-24 |
2023-11-08 |
rat |
| Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Uek. Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis. Nature communications. vol 14. issue 1. 2023-10-20. PMID:37852976. |
insulin treatment, however, fails to suppress hcc in the male stam mice lacking insulin receptor specifically in intestinal epithelial cells (ieirko), which show dysbiosis and impaired gut barrier function. |
2023-10-20 |
2023-11-08 |
mouse |
| Prasanna K R Allu, Maria Dafne Cardamone, Antonio S Gomes, Alessandra Dall'agnese, Carly Cederquist, Hui Pan, Jonathan M Dreyfuss, Sven Enerbäck, C Ronald Kah. FoxK1 Associated Gene Regulatory Network in Hepatic Insulin Action and It's Relationship to FoxO1 and Insulin Receptor Mediated Transcriptional Regulation. Molecular metabolism. 2023-10-18. PMID:37852413. |
foxk1 associated gene regulatory network in hepatic insulin action and it's relationship to foxo1 and insulin receptor mediated transcriptional regulation. |
2023-10-18 |
2023-11-08 |
Not clear |
| Prasanna K R Allu, Maria Dafne Cardamone, Antonio S Gomes, Alessandra Dall'agnese, Carly Cederquist, Hui Pan, Jonathan M Dreyfuss, Sven Enerbäck, C Ronald Kah. FoxK1 Associated Gene Regulatory Network in Hepatic Insulin Action and It's Relationship to FoxO1 and Insulin Receptor Mediated Transcriptional Regulation. Molecular metabolism. 2023-10-18. PMID:37852413. |
this study aimed to the forkhead box protein k1 (foxk1) associated gene regulatory network as a transcriptional regulator of hepatic insulin action and to determine its role versus foxo1 and possible actions of the insulin receptor at the dna level. |
2023-10-18 |
2023-11-08 |
Not clear |
| Yuncai Zhou, Kerong Liu, Wei Tang, Yan Zhang, Yi Sun, Yangyang Wu, Ying Shi, Zhengjian Yao, Yating Li, Rongjie Bai, Rui Liang, Peng Sun, Xiaoai Chang, Shusen Wang, Yunxia Zhu, Xiao Ha. Beta-cell MiRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation. Diabetes. 2023-10-17. PMID:37847900. |
in addition, β-cell mir-503-5p is packaged in nano-vesicles to dampen insulin signaling transduction in liver and adipose tissues by targeting insulin receptors (insr). |
2023-10-17 |
2023-11-08 |
mouse |
| Stephanie G DiLucia, B Jacob Kendrick, Catrina Sims-Robinso. Hyperinsulinemia Impairs Clathrin-Mediated Endocytosis of the Insulin Receptor and Activation of Endothelial Nitric Oxide Synthase in Brain Endothelial Cells. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834116. |
proper insulin signaling relies on the regulated internalization of insulin bound to the insulin receptor, a process which is disrupted by hyperinsulinemia via an unknown mechanism. |
2023-10-14 |
2023-10-15 |
Not clear |
| Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljad. Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834454. |
insulin receptor isoforms and insulin growth factor-like receptors: implications in cell signaling, carcinogenesis, and chemoresistance. |
2023-10-14 |
2023-10-15 |
Not clear |
| Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljad. Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834454. |
this comprehensive review thoroughly explores the intricate involvement of insulin receptor (ir) isoforms and insulin-like growth factor receptors (igfrs) in the context of the insulin and insulin-like growth factor (igf) signaling (iis) pathway. |
2023-10-14 |
2023-10-15 |
Not clear |
| Chen Lei, Jing Wang, Xin Li, Yuan-Yuan Mao, Jian-Qun Ya. Changes of insulin receptors in high fat and high glucose diet mice with insulin resistance. Adipocyte. vol 12. issue 1. 2023-10-13. PMID:37830511. |
changes of insulin receptors in high fat and high glucose diet mice with insulin resistance. |
2023-10-13 |
2023-10-15 |
mouse |
| Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimiz. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023-10-12. PMID:37822109. |
here we established an ad model with whole-body insulin resistance without persistent hyperglycemia (app/ir-dki mice) by crossbreeding constitutive knock-in mice with p1195l-mutated insulin receptor (ir-ki mice) and those with mutated amyloid precursor protein (app |
2023-10-12 |
2023-10-15 |
mouse |
| Omowumi T Kayode, Jemilat A Bello, Jamiu A Oguntola, Abolanle A A Kayode, Daniel K Olukoy. The interplay between monosodium glutamate (MSG) consumption and metabolic disorders. Heliyon. vol 9. issue 9. 2023-10-09. PMID:37809920. |
similarly for induction of diabetes mellitus, msg consumption resulted in decreased pancreatic beta cell mass, increased oxidative stress and metabolic rates, reduced glucose and insulin transport to adipose tissue and skeletal muscles, insulin insensitivity, reduced insulin receptors and induced severe hyperinsulinemia. |
2023-10-09 |
2023-10-15 |
Not clear |
| Khurshid Ahmad, Sibhghatulla Shaikh, Jeong Ho Lim, Syed Sayeed Ahmad, Hee Jin Chun, Eun Ju Lee, Inho Cho. Therapeutic application of natural compounds for skeletal muscle-associated metabolic disorders: A review on diabetes perspective. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-09. PMID:37812896. |
insulin resistance in sm may result from the impaired activities of insulin receptor tyrosine kinase, insulin receptor substrate 1, phosphoinositide 3-kinase, and akt pathways. |
2023-10-09 |
2023-10-15 |
human |
| Joel Spratt, José M Dias, Christina Kolonelou, Georges Kiriako, Enya Engström, Ekaterina Petrova, Christos Karampelias, Igor Cervenka, Natali Papanicolaou, Antonio Lentini, Björn Reinius, Olov Andersson, Elena Ambrosetti, Jorge L Ruas, Ana I Teixeir. Multivalent insulin receptor activation using insulin-DNA origami nanostructures. Nature nanotechnology. 2023-10-09. PMID:37813939. |
insulin binds the insulin receptor (ir) and regulates anabolic processes in target tissues. |
2023-10-09 |
2023-10-15 |
zebrafish |
| Cristina M Viola, Orsolya Frittmann, Huw T Jenkins, Talha Shafi, Pierre De Meyts, Andrzej M Brzozowsk. Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans. Nature communications. vol 14. issue 1. 2023-10-07. PMID:37805602. |
in humans the iis axis is controlled by insulin, two insulin-like growth factors, two isoforms of the insulin receptor (hir-a and -b), and its homologous igf-1r. |
2023-10-07 |
2023-10-15 |
human |
| Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, Igor F Tsigeln. Targeting of insulin receptor endocytosis as a treatment to insulin resistance. Journal of diabetes and its complications. vol 37. issue 11. 2023-10-03. PMID:37788593. |
targeting of insulin receptor endocytosis as a treatment to insulin resistance. |
2023-10-03 |
2023-10-07 |
Not clear |
| Bryce Tim, Valentina L Kouznetsova, Santosh Kesari, Igor F Tsigeln. Targeting of insulin receptor endocytosis as a treatment to insulin resistance. Journal of diabetes and its complications. vol 37. issue 11. 2023-10-03. PMID:37788593. |
insulin resistance is the decreased effectiveness of insulin receptor function during signaling of glucose uptake. |
2023-10-03 |
2023-10-07 |
Not clear |
| Na-Oh Yunn, Junhong Kim, Sung Ho Ryu, Yunje Ch. A stepwise activation model for the insulin receptor. Experimental & molecular medicine. 2023-10-01. PMID:37779149. |
the binding of insulin to the insulin receptor (ir) triggers a cascade of receptor conformational changes and autophosphorylation, leading to the activation of metabolic and mitogenic pathways. |
2023-10-01 |
2023-10-07 |
Not clear |