| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yujie Zhao, Yao Liu, Jianjun Deng, Chenhui Zhu, Xiaoxuan Ma, Min Jiang, Daidi Fa. Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus. Journal of agricultural and food chemistry. 2023-09-19. PMID:37726223. |
on the one hand, the inhibition of ptp1b activity by f4 resulted in increased insulin receptor (insr) and insulin receptor substrate 1 tyrosine phosphorylation and enhanced insulin sensitivity. |
2023-09-19 |
2023-10-07 |
mouse |
| Valeria Calcaterra, Gianvincenzo Zuccotti, Alessandra Mari, Fernanda Iafusco, Giovanna Maione, Dario Iafusco, Nadia Tint. Can obesity exacerbate hyperinsulinaemia in the presence of the mutation of an insulin receptor gene? Clinical obesity. 2023-09-17. PMID:37717597. |
insulin receptor gene (insr) mutations are a relatively rare and diverse cause of insulin resistance (ir), typically associated with a lean phenotype. |
2023-09-17 |
2023-10-07 |
Not clear |
| Briony E Forbe. The three-dimensional structure of insulin and its receptor. Vitamins and hormones. vol 123. 2023-09-17. PMID:37717984. |
there are now >40 structures of the insulin:insulin receptor complex deposited in the protein data bank. |
2023-09-17 |
2023-10-07 |
Not clear |
| Briony E Forbe. The three-dimensional structure of insulin and its receptor. Vitamins and hormones. vol 123. 2023-09-17. PMID:37717984. |
in this review, the focus will be on the most recent structural studies of insulin:insulin receptor complexes and how they have contributed to the current understanding of insulin receptor activation and signaling outcome. |
2023-09-17 |
2023-10-07 |
Not clear |
| Bamaprasad Dutta, Shining Loo, Antony Kam, James P Ta. Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-09-16. PMID:37715850. |
here we show that am1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the pi3k/akt signaling pathway independent of the insulin receptor leading to translocation of glucose transporter glut4 to the cell surface to promote glucose uptake. |
2023-09-16 |
2023-10-07 |
Not clear |
| Melek Tunc-Ata, Zeynep Mine Altunay, Aysel Alphan, Vural Kucukata. Effect of insulin on IR and GLP1-R expressions in HT22 cells. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-15. PMID:37712993. |
insulin is a significant growth factor that specifically binds to the insulin receptor (ir) in the brain and then activates the pi3k-akt pathway. |
2023-09-15 |
2023-10-07 |
mouse |
| Melek Tunc-Ata, Zeynep Mine Altunay, Aysel Alphan, Vural Kucukata. Effect of insulin on IR and GLP1-R expressions in HT22 cells. Medical oncology (Northwood, London, England). vol 40. issue 10. 2023-09-15. PMID:37712993. |
this study aims to investigate the effect of insulin administered to immortalized clonal mouse hippocampal cell line (ht22) at different doses and intervals on ir, insulin receptor a (ira), insulin receptor b (irb), and glucagon-like peptide 1 receptor (glp1-r) mrna expression and protein levels. |
2023-09-15 |
2023-10-07 |
mouse |
| Liwei Wang, Catherine E Hall, Emiko Uchikawa, Dailu Chen, Eunhee Choi, Xuewu Zhang, Xiao-Chen Ba. Structural basis of insulin fibrillation. Science advances. vol 9. issue 37. 2023-09-15. PMID:37713485. |
insulin is a hormone responsible for maintaining normal glucose levels by activating insulin receptor (ir) and is the primary treatment for diabetes. |
2023-09-15 |
2023-10-07 |
Not clear |
| Thomas Ebert, Gerhard Behre, Lorenz Weidhase, Vladan Vucinic, Cornelia Gewert, Robert K Semple, Michael Stumvoll, Anke Tönje. Case report: Allogeneic stem cell transplantation for type B insulin resistance. Frontiers in medicine. vol 10. 2023-09-14. PMID:37706022. |
type b insulin resistance (tbir) is a rare, often fulminant form of insulin resistance caused by autoantibodies against the insulin receptor. |
2023-09-14 |
2023-10-07 |
Not clear |
| Mathis Neuhaus, Claes Fryklund, Holly Taylor, Andrea Borreguero-Muñoz, Franziska Kopietz, Hamidreza Ardalani, Oksana Rogova, Laura Stirrat, Shaun K Bremner, Peter Spégel, Nia J Bryant, Gwyn W Gould, Karin G Stenkul. EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events. Molecular biology of the cell. 2023-09-13. PMID:37703099. |
in conclusion, these data highlight the importance of ehd2 for the integrity of the plasma membrane milieu, insulin receptor stability, and downstream insulin receptor signalling events, involved in glucose uptake and ultimately underscore its role in insulin resistance and obesity. |
2023-09-13 |
2023-10-07 |
mouse |
| Andreas Thomas, Sophia Krombholz, Johanna Breuer, Katja Walpurgis, Mario Thevi. Insulin-mimetic peptides in sports drug testing. Drug testing and analysis. 2023-09-11. PMID:37691519. |
the biological effects of insulin and its analogs are mediated through binding to the insulin receptor, which was also found to be activated by different peptides structurally largely unrelated to insulin. |
2023-09-11 |
2023-10-07 |
Not clear |
| Gayathri Sekar, Merlin G, Madhan Krishnan, Shyamaladevi Babu, Padmini K, Pushpa Konduru, Mangai . Effect of β-sitosterol on insulin resistance & protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats. Bioinformation. vol 18. issue 11. 2023-09-11. PMID:37693081. |
at the end of the experimental period, fasting blood sugar (fbg), oral glucose (ogtt) and insulin tolerances (it), tissue glycogen, serum insulin, homeostasis model assessment for insulin resistance (homa-ir) and quantitative insulin sensitivity check index (quicki), as well as the levels of insulin signalling molecules like insulin receptor (ir), glucose transporter subtype 4 (glut4) proteins and glycogen concentration within the quadriceps muscle were assessed. |
2023-09-11 |
2023-10-07 |
rat |
| Rodrigo Daza-Arnedo, Jorge Rico-Fontalvo, Gustavo Aroca-Martínez, Tomás Rodríguez-Yanez, María Cristina Martínez-Ávila, Amilkar Almanza-Hurtado, María Cardona-Blanco, Carlos Henao-Velásquez, Jorge Fernández-Franco, Mario Unigarro-Palacios, Carolina Osorio-Restrepo, Isabella Uparella-Gulf. Insulin and the kidneys: a contemporary view on the molecular basis. Frontiers in nephrology. vol 3. 2023-09-07. PMID:37675359. |
on the other hand, there is sufficient evidence showing the insulin receptor's involvement in renal functions and its responsibility for the regulation of glucose homeostasis, which enables us to understand its contribution to the insulin resistance phenomenon and its association with the progression of diabetic kidney disease. |
2023-09-07 |
2023-10-07 |
Not clear |
| Ha J Lim, Jae E Park, Ji S Ha. HM-chromanone alleviates hyperglycemia and inflammation in mice with endotoxin-induced insulin resistance. Toxicology research. vol 12. issue 4. 2023-09-04. PMID:37663814. |
suppression of mammalian target of rapamycin, s6 kinase 1, protein kinase c θ, c-jun-nh2-terminal kinase, and ikb kinase β also ameliorated insulin resistance by reducing the phosphorylation of insulin receptor substrate-1 serine 307, thereby decreasing hyperglycemia. |
2023-09-04 |
2023-09-07 |
mouse |
| Asma K Omar, Lance C Li Puma, Luke A Whitcomb, Briana D Risk, Aria C Witt, Jason E Bruemmer, Quinton A Winger, Gerrit J Bouma, Adam J Chicc. High-fat diet during pregnancy promotes fetal skeletal muscle fatty acid oxidation and insulin resistance in an ovine model. American journal of physiology. Regulatory, integrative and comparative physiology. 2023-08-29. PMID:37642284. |
however, serine-308 phosphorylation of insulin receptor substrate-1 was greater in fetal muscle from hfd pregnancies along with c-jun-n terminal kinase activation, consistent with prenatal inhibition of skeletal muscle insulin signaling. |
2023-08-29 |
2023-09-07 |
Not clear |
| S El-Amouri, A Karakashian, E Bieberich, M Nikolova-Karakashia. Regulated translocation of Neutral Sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes. Journal of lipid research. 2023-08-28. PMID:37640282. |
it is unknown however whether the excess ceramide is generated proximal to the insulin receptor, i.e., at the plasma membrane (pm), where it could affect the insulin signaling pathway directly, or the onset of insulin resistance is due to ceramide-induced mitochondrial dysfunction and/or lipotoxicity. |
2023-08-28 |
2023-09-07 |
Not clear |
| Tetsuhiro Watanabe, Saori Okabe, Shohei Sakamot. Polycystic ovary syndrome in a patient with type B insulin resistance syndrome can improve with glucocorticoid treatment: a case report and literature review. Endocrine journal. 2023-08-27. PMID:37635072. |
it is possible that elimination of insulin receptor antibodies by glucocorticoid treatment attenuated insulin resistance and subsequently improved pcos in tbirs. |
2023-08-27 |
2023-09-07 |
Not clear |
| Mulin He, Zhiqiang Li, Victoria Sook Keng Tung, Meixia Pan, Xianlin Han, Oleg Evgrafov, Xian-Cheng Jian. Inhibiting phosphatidylcholine remodeling in adipose tissue increases insulin sensitivity. Diabetes. 2023-08-25. PMID:37625119. |
lpcat3 deficiency influenced membrane lipid rafts, which activated insulin receptors and akt in adipose tissue, and attenuated diet-induced insulin resistance. |
2023-08-25 |
2023-09-07 |
mouse |
| Marinna C Okawa, Rebecca M Tuska, Marissa Lightbourne, Brent S Abel, Mary Walter, Yuhai Dai, Elaine Cochran, Rebecca J Brow. Insulin signaling through the insulin receptor increases linear growth through effects on bone and the GH-IGF-1 axis. The Journal of clinical endocrinology and metabolism. 2023-08-18. PMID:37595266. |
insulin signaling through the insulin receptor increases linear growth through effects on bone and the gh-igf-1 axis. |
2023-08-18 |
2023-10-07 |
Not clear |
| Yoo Kim, Junsik M Lee, Youngah Han, Rongya Tao, Morris F White, Renyan Liu, Sang Won Par. BRD7 improves glucose homeostasis independent of IRS proteins. The Journal of endocrinology. vol 258. issue 3. 2023-08-14. PMID:37578842. |
of note, the upregulation of hepatic brd7 levels activates the akt cascade in response to insulin without enhancing the sensitivity of the insulin receptor (insr)-insulin receptor substrate (irs) axis. |
2023-08-14 |
2023-09-07 |
mouse |