| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinnan Zhao, Gang Liu, Xin Yu, Xiaohan Yang, Wenting Gao, Zinan Zhao, Jianmei Ma, Tonghui M. Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman's gland. Chemical senses. 2023-08-16. PMID:37586060. |
based on the study of the expression characteristics of aqp5 protein in nasal mucosa, the olfaction dysfunction in aqp5 knockout (ko) mice was found by olfactory behavior analysis which accompanied by reduced secretion volume of bowman's gland by using in vitro secretion measure system, and the change of acid mucin in nasal mucus layer were identified. |
2023-08-16 |
2023-09-07 |
mouse |
| Xinnan Zhao, Gang Liu, Xin Yu, Xiaohan Yang, Wenting Gao, Zinan Zhao, Jianmei Ma, Tonghui M. Ablation of AQP5 gene in mice leads to olfactory dysfunction caused by hyposecretion of Bowman's gland. Chemical senses. 2023-08-16. PMID:37586060. |
our results indicate that aqp5 can affect the olfactory functions by regulating the water supply of bgs and the mucus layer upper the oe which can explain the olfactory loss in the patients of ss, and aqp5 ko mice might be used as an ideal model to study the olfactory dysfunction. |
2023-08-16 |
2023-09-07 |
mouse |
| Sarang Mahajan, Deepshikha Sen, Anantu Sunil, Priyadharshini Srikanth, Shruti D Marathe, Karishma Shaw, Mahesh Sahare, Sanjeev Galande, Nixon M Abraha. Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell. Frontiers in neuroscience. vol 17. 2023-07-05. PMID:37404465. |
as ace2 receptors are expressed in different olfactory centers and higher brain areas, we studied the morphological changes in the olfactory epithelium (oe) and olfactory bulb (ob) of ace2 ko mice in comparison with wild type animals. |
2023-07-05 |
2023-08-14 |
mouse |
| Sarang Mahajan, Deepshikha Sen, Anantu Sunil, Priyadharshini Srikanth, Shruti D Marathe, Karishma Shaw, Mahesh Sahare, Sanjeev Galande, Nixon M Abraha. Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell. Frontiers in neuroscience. vol 17. 2023-07-05. PMID:37404465. |
aberrations in the olfactory circuits were revealed by lowered immunoreactivity toward microtubule associated protein 2 (map2) in the glomerular layer of ace2 ko mice. |
2023-07-05 |
2023-08-14 |
mouse |
| Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotom. The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 4. 2023-03-04. PMID:36870285. |
trpv1 knockout (ko), trpv4 ko, and wild-type (wt) mice were used to model methimazole-induced olfactory dysfunction. |
2023-03-04 |
2023-08-14 |
mouse |
| Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotom. The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 4. 2023-03-04. PMID:36870285. |
the proliferation of orn progenitor cells was reduced in trpv1 ko mice, which delayed orn regeneration and the improvement of olfactory behavior. |
2023-03-04 |
2023-08-14 |
mouse |
| Andrea Maset, Marco Albanesi, Antonio di Soccio, Martina Canova, Marco Dal Maschio, Claudia Lodovich. Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice. Cells. vol 10. issue 11. 2021-12-07. PMID:34831434. |
we found that lrrk2 ko mice exhibit olfactory behavioral deficits. |
2021-12-07 |
2023-08-13 |
mouse |
| Roberto Rodríguez-Morales, Viveca Vélez-Negrón, Aranza Torrado-Tapias, Gaurav Varshney, Martine Behr. Expression patterns of activating transcription factor 5 (atf5a and atf5b) in zebrafish. Gene expression patterns : GEP. vol 37. 2021-07-19. PMID:32663618. |
atf5 is strongly expressed in the rodent nose and mice knockout (ko) pups have defective olfactory sensory neurons (osns), smaller olfactory bulbs (ob), while adults are smell deficient. |
2021-07-19 |
2023-08-13 |
mouse |
| Ching-San Tseng, Shen-Ju Chou, Yi-Shuian Huan. CPEB4-Dependent Neonate-Born Granule Cells Are Required for Olfactory Discrimination. Frontiers in behavioral neuroscience. vol 13. 2020-09-30. PMID:30728769. |
our previous study demonstrated that the translational regulator, cytoplasmic polyadenylation element-binding protein 4 (cpeb4), is a survival factor exclusively for neonate-born but not svz/adult-derived gcs, so cpeb4-knockout (ko) mice provide unique leverage to study early postnatal-born gc-regulated olfactory functions. |
2020-09-30 |
2023-08-13 |
mouse |
| Lamees Alhassen, Alvin Phan, Wedad Alhassen, Paul Nguyen, Alice Lo, Hanan Shaharuddin, Nayna Sanathara, Olivier Civelli, Amal Alachka. The role of Olfaction in MCH-regulated spontaneous maternal responses. Brain research. vol 1719. 2020-09-25. PMID:31121161. |
strikingly, however, we found that while mchr1 ko mice were unable to detect pups' chemosensory signals and displayed impairment in general olfactory discrimination, mch cko mice exhibited normal olfactory function. |
2020-09-25 |
2023-08-13 |
mouse |
| Liangcai Gao, Zejie Lin, Wenhao Hu, Chi Liu, Tian Zhou, Guixiang Xie, Min Qian, Bing N. Age-specific effects of P2X7 receptors on olfactory function in mice. Neuroreport. vol 30. issue 16. 2020-07-14. PMID:31425346. |
in this study, we analyzed olfactory functions of 2-month-old, 10-month-old and 18-month-old female p2x7r ko mice and age-matched female c57bl/6 wildtype mice (wt mice) by buried food seeking test and olfactory avoidance test. |
2020-07-14 |
2023-08-13 |
mouse |
| Liangcai Gao, Zejie Lin, Wenhao Hu, Chi Liu, Tian Zhou, Guixiang Xie, Min Qian, Bing N. Age-specific effects of P2X7 receptors on olfactory function in mice. Neuroreport. vol 30. issue 16. 2020-07-14. PMID:31425346. |
the results indicated that middle and old-aged p2x7r ko mice showed better olfactory function than middle and old-aged wt mice. |
2020-07-14 |
2023-08-13 |
mouse |
| Liangcai Gao, Zejie Lin, Wenhao Hu, Chi Liu, Tian Zhou, Guixiang Xie, Min Qian, Bing N. Age-specific effects of P2X7 receptors on olfactory function in mice. Neuroreport. vol 30. issue 16. 2020-07-14. PMID:31425346. |
however, worse olfactory function was observed in young-aged p2x7r ko mice compared with young-aged wt mice. |
2020-07-14 |
2023-08-13 |
mouse |
| Heidi Hsieh, Michael C Horwath, Mary Beth Gente. Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice. Neurotoxicology. vol 58. 2017-11-24. PMID:27979773. |
in vivo studies using wild-type, mt1/2 knockout mice (mt ko), and heterozygotes administered zg by in instillation showed profound loss of the olfactory mucosa in the nasal cavity. |
2017-11-24 |
2023-08-13 |
mouse |
| Gianluca Pietra, Michele Dibattista, Anna Menini, Johannes Reisert, Anna Boccacci. The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. The Journal of general physiology. vol 148. issue 4. 2017-11-22. PMID:27619419. |
suction electrode recordings from isolated olfactory neurons and on-cell loose-patch recordings from dendritic knobs of neurons in the olfactory epithelium show that randomly selected neurons from tmem16b ko mice respond to stimulation with increased firing activity than those from wild-type (wt) mice. |
2017-11-22 |
2023-08-13 |
mouse |
| Jin Hwan Lee, Ling Wei, Todd C Deveau, Xiaohuan Gu, Shan Ping Y. Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse. Brain structure & function. vol 221. issue 6. 2017-09-28. PMID:26334321. |
in littermate glun3a knockout (glun3a(-/-); ko) mice, the expression of olfactory marker protein normally found in mature olfactory sensory neurons was significantly reduced in the olfactory bulb and epithelium. |
2017-09-28 |
2023-08-13 |
mouse |
| Jin Hwan Lee, Ling Wei, Todd C Deveau, Xiaohuan Gu, Shan Ping Y. Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse. Brain structure & function. vol 221. issue 6. 2017-09-28. PMID:26334321. |
a butyl alcohol stimulus increased immediate-early gene c-fos expression in the olfactory system of wt mice, while this response was absent in glun3a ko mice. |
2017-09-28 |
2023-08-13 |
mouse |
| Nelly Redolfi, Luisa Galla, Andrea Maset, Luca Murru, Eleonora Savoia, Ilaria Zamparo, Angela Gritti, Pierre Billuart, Maria Passafaro, Claudia Lodovich. Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb. Human molecular genetics. vol 25. issue 23. 2017-07-24. PMID:27742778. |
furthermore, we found that olfactory behaviour was perturbed in ophn1 ko mice. |
2017-07-24 |
2023-08-13 |
mouse |
| Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Yukio Takamatsu, Wakako Sawada, Maaya Matsuzawa, Soichiro Ide, Toshifumi Yamamoto, Masayoshi Mishina, Kazutaka Iked. Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:27480795. |
despite apparently normal olfactory function and social interaction, glun2d ko mice exhibited a decrease in preference for social novelty, suggesting a deficit in social recognition or memory. |
2017-07-11 |
2023-08-13 |
mouse |
| Hiroo Takahashi, Yoichi Ogawa, Sei-Ichi Yoshihara, Ryo Asahina, Masahito Kinoshita, Tatsuro Kitano, Michiko Kitsuki, Kana Tatsumi, Mamiko Okuda, Kouko Tatsumi, Akio Wanaka, Hirokazu Hirai, Peter L Stern, Akio Tsubo. A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 31. 2017-07-10. PMID:27488640. |
remarkably, in olfactory behavior tests, 5t4 ko mice had higher odor detection thresholds than the wt, as well as defects in odor discrimination learning. |
2017-07-10 |
2023-08-13 |
mouse |