| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Abdul Hakim, Wenbin Jiang, Lei Luo, Bowen Li, Shilong Yang, Yuzhu Song, Ren La. Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel. Toxins. vol 7. issue 9. 2016-06-10. PMID:26389953. |
bmp01 evoked currents in wt dorsal root ganglion (drg) neurons but had no effect on drg neurons of trpv1 ko mice. |
2016-06-10 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
in this study, trpv1 knockout (ko) and wild-type (wt) mice (as controls) were fed a high-fat diet (hfd), and metabolic studies were performed to measure insulin and leptin action. |
2015-10-19 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
the hyperinsulinemic-euglycemic clamp experiment showed that the trpv1 ko mice were more insulin resistant after hfd because of the ∼40% reduction in glucose metabolism in the white and brown adipose tissue, compared with that in the wt mice. |
2015-10-19 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
leptin treatment failed to suppress food intake, and leptin-mediated hypothalamic signal transducer and activator of transcription (stat)-3 activity was blunted in the trpv1 ko mice. |
2015-10-19 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
we also found that the trpv1 ko mice were more obese and insulin resistant than the wt mice at 9 mo of age. |
2015-10-19 |
2023-08-13 |
mouse |
| Masaya Watanabe, Takashi Ueda, Yasuhiro Shibata, Natsuko Kumamoto, Shinya Ugaw. The role of TRPV1 channels in carrageenan-induced mechanical hyperalgesia in mice. Neuroreport. vol 26. issue 3. 2015-10-16. PMID:25590988. |
here, we examined the role of trpv1 channels in carrageenan-induced mechanical hyperalgesia using wild-type and trpv1-knockout (ko) mice and compared the results with those obtained in mice peripherally administered capsazepine, a trpv1 antagonist, or capsaicin, a trpv1 agonist. |
2015-10-16 |
2023-08-13 |
mouse |
| Zhijuan Cao, Adithya Balasubramanian, Sean P Marrell. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. American journal of physiology. Regulatory, integrative and comparative physiology. vol 306. issue 2. 2014-03-13. PMID:24305062. |
core temperature (t(core)) was measured after subcutaneous infusion of trpv1 agonist dihydrocapsaicin (dhc) in conscious c57bl/6 wt and trpv1 knockout (ko) mice. |
2014-03-13 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
loss of interneuron ltd and attenuated pyramidal cell ltp in trpv1 and trpv3 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
here we tested the role of other trpv channels in hippocampal synaptic plasticity, using hippocampal slices from trpv1, trpv3 and trpv4 knockout (ko) mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
ltd at excitatory synapses on s. radiatum hippocampal interneurons was attenuated in slices from trpv3 ko mice (as well as in trpv1 ko mice as previously reported), but not in slices from trpv4 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
a previous study found that in hippocampal area ca1, slices from trpv1 ko mice have reduced tetanus-induced long-term potentiation (ltp) following high-frequency stimulation; here we confirmed this and found a similar reduction in trpv3 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
consistent with this idea, blocking gabaergic inhibition rescued ltp in slices from trpv1 ko and trpv3 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Axel J Fenwick, Shaw-Wen Wu, James H Peter. Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses. Frontiers in neuroscience. vol 8. 2014-02-19. PMID:24550768. |
we found st afferent innervation at nts neurons and synchronous vesicle release from trpv1 ko mice was not different to control animals; however, only half of trpv1 ko st afferents completely lacked asynchronous glutamate release. |
2014-02-19 |
2023-08-12 |
mouse |
| ZuoJun Ren, Mee-Ra Rhyu, Tam-Hao T Phan, Shobha Mummalaneni, Karnam S Murthy, John R Grider, John A DeSimone, Vijay Lyal. TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. American journal of physiology. Gastrointestinal and liver physiology. vol 305. issue 1. 2013-09-09. PMID:23639808. |
to investigate if the amiloride- and benzamil (bz)-insensitive nacl chorda tympani (ct) taste nerve response is also regulated in part by trpm5, ct responses to 100 mm nacl + 5 μm bz (nacl + bz) were monitored in sprague-dawley rats, wild-type (wt) mice, and trp vanilloid subfamily member 1 (trpv1) and trpm5 knockout (ko) mice in the presence of resiniferatoxin (rtx), a trpv1 agonist. |
2013-09-09 |
2023-08-12 |
mouse |
| Mark L Dewis, Tam-Hao T Phan, ZuoJun Ren, Xuanyu Meng, Meng Cui, Shobha Mummalaneni, Mee-Ra Rhyu, John A DeSimone, Vijay Lyal. N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models. Journal of neurophysiology. vol 109. issue 4. 2013-08-09. PMID:23221408. |
effects of n-geranyl cyclopropyl-carboxamide (ngcc) and four structurally related compounds (n-cyclopropyl e2,z6-nonadienamide, n-geranyl isobutanamide, n-geranyl 2-methylbutanamide, and allyl n-geranyl carbamate) were evaluated on the chorda tympani (ct) nerve response to nacl and monosodium glutamate (msg) in rats and wild-type (wt) and trpv1 knockout (ko) mice and on human salty and umami taste intensity. |
2013-08-09 |
2023-08-12 |
mouse |
| Kimberly R Smith, Yada Treesukosol, A Brennan Paedae, Robert J Contreras, Alan C Specto. Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 11. 2013-02-07. PMID:23054171. |
using a brief-access taste test, we examined generalization profiles of water-deprived c57bl/6j (wt) and trpv1 knockout (ko) mice conditioned (via licl injection) to avoid 100 μm amiloride-prepared 0.25 m nacl and tested with 0.25 m nacl, sodium gluconate, kcl, nh(4)cl, 6.625 mm citric acid, 0.15 mm quinine, and 0.5 m sucrose. |
2013-02-07 |
2023-08-12 |
mouse |
| Kimberly R Smith, Yada Treesukosol, A Brennan Paedae, Robert J Contreras, Alan C Specto. Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 11. 2013-02-07. PMID:23054171. |
both licl-injected wt and trpv1 ko groups learned to avoid nacl+amiloride relative to controls, but their generalization profiles did not differ; licl-injected mice avoided the nonsodium salts and quinine suggesting that a trpv1-independent pathway contributes to the taste quality of the amiloride-insensitive portion of the nacl signal. |
2013-02-07 |
2023-08-12 |
mouse |
| Andras Garami, Eszter Pakai, Daniela L Oliveira, Alexandre A Steiner, Samuel P Wanner, M Camila Almeida, Vladimir A Lesnikov, Narender R Gavva, Andrej A Romanovsk. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 5. 2011-04-01. PMID:21289181. |
with age (observed for up to 14 months), the body mass of trpv1 ko mice exceeded that of controls, sometimes approaching 60 g. in summary, trpv1 ko mice possess a distinct thermoregulatory phenotype, which is coupled with a predisposition to age-associated overweight and includes hypometabolism, enhanced skin vasoconstriction, decreased thermopreferendum, and hyperkinesis. |
2011-04-01 |
2023-08-12 |
mouse |
| Vijay Lyall, Tam-Hao T Phan, ZuoJun Ren, Shobha Mummalaneni, Pamela Melone, Sunila Mahavadi, Karnam S Murthy, John A DeSimon. Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate. Journal of neurophysiology. vol 103. issue 3. 2010-06-11. PMID:20032236. |
regulation of the putative amiloride and benzamil (bz)-insensitive trpv1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate (pip(2)) was studied by monitoring chorda tympani (ct) taste nerve responses to 0.1 m nacl solutions containing bz (5 x 10(-6) m; a specific enac blocker) and resiniferatoxin (rtx; 0-10 x 10(-6) m; a specific trpv1 agonist) in sprague-dawley rats and in wildtype (wt) and trpv1 knockout (ko) mice. |
2010-06-11 |
2023-08-12 |
mouse |
| Yong Chen, Helen H Willcockson, Juli G Valtschanof. Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Experimental neurology. vol 220. issue 2. 2009-12-07. PMID:19815011. |
to test the hypothesis that activation of spinal glia is mediated, at least in part, by trpv1, we studied the expression of markers for microglia (ionized calcium-binding adapter molecule 1, iba1) and astrocytes (glial fibrillary acidic protein, gfap) in the spinal cord of trpv1 knockout mice (ko) vs. wild-type mice (wt) in models of acute (intraplantar capsaicin), inflammatory (adjuvant-induced arthritis, aia), and neuropathic pain (partial sciatic nerve ligation, psnl). |
2009-12-07 |
2023-08-12 |
mouse |