| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vijay Lyall, Tam-Hao T Phan, Shobha Mummalaneni, Pamela Melone, Sunila Mahavadi, Karnam S Murthy, John A DeSimon. Regulation of the benzamil-insensitive salt taste receptor by intracellular Ca2+, protein kinase C, and calcineurin. Journal of neurophysiology. vol 102. issue 3. 2009-10-23. PMID:19553475. |
the regulation of the benzamil (bz)-insensitive salt taste receptor was investigated by intracellular ca2+ ([ca2+]i), protein kinase c (pkc), and the ca2+-dependent serine-threonine phosphatase, calcineurin (pp2b), by monitoring chorda tympani taste nerve responses to 0.1 m nacl solutions containing bz (5x10(-6) m) and resiniferatoxin (rtx; 0-10x10(-6) m) in sprague-dawley rats and in wild-type (wt) and transient receptor potential vanilloid-1 knockout (trpv1 ko) mice. |
2009-10-23 |
2023-08-12 |
mouse |
| Anna Vardanyan, Ruizhong Wang, Todd W Vanderah, Michael H Ossipov, Josephine Lai, Frank Porreca, Tamara Kin. TRPV1 receptor in expression of opioid-induced hyperalgesia. The journal of pain. vol 10. issue 3. 2009-05-13. PMID:18774343. |
because animals treated with opiates show thermal hyperalgesia, we examined the possible role of trpv1 receptors in the development of morphine-induced hyperalgesia using trpv1 wild-type (wt) and knock-out (ko) mice and with administration of a trpv1 antagonist in mice and rats. |
2009-05-13 |
2023-08-12 |
mouse |
| Ratan K Banik, Timothy J Brenna. Trpv1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision. Pain. vol 141. issue 1-2. 2009-04-08. PMID:19010598. |
the current study examined the relationship between the marked reduction in heat hyperalgesia after incision in trpv1 knockout (ko) mice and the activity of the nociceptors in these same mice. |
2009-04-08 |
2023-08-12 |
mouse |
| Vijay Lyall, Tam-Hao T Phan, Shobha Mummalaneni, Mahdis Mansouri, Gerard L Heck, Gerd Kobal, John A DeSimon. Effect of nicotine on chorda tympani responses to salty and sour stimuli. Journal of neurophysiology. vol 98. issue 3. 2008-01-07. PMID:17615133. |
trpv1 ko mice demonstrated no bz-insensitive ct response to nacl and no sensitivity to nicotine, rtx, and elevated temperature. |
2008-01-07 |
2023-08-12 |
mouse |
| Natalie Clark, Julie Keeble, Elizabeth S Fernandes, Anna Starr, Lihuan Liang, David Sugden, Patricia de Winter, Susan D Brai. The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 13. 2007-12-03. PMID:17601984. |
findings correlated with liver edema and raised plasma levels of aspartate aminotransferase in trpv1 ko mice. |
2007-12-03 |
2023-08-12 |
mouse |
| Kata Bölcskei, Zsuzsanna Helyes, Árpád Szabó, Katalin Sándor, Krisztián Elekes, József Németh, Róbert Almási, Erika Pintér, Gábor Pethő, János Szolcsány. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain. vol 117. issue 3. 2006-01-25. PMID:16150543. |
thermal hyperalgesia (drop of noxious heat threshold) and mechanical hyperalgesia induced by a mild heat injury (51 degrees c, 15s) was smaller in ko mice suggesting a pronociceptive role for trpv1 receptor in burn injury. |
2006-01-25 |
2023-08-12 |
mouse |
| Kata Bölcskei, Zsuzsanna Helyes, Árpád Szabó, Katalin Sándor, Krisztián Elekes, József Németh, Róbert Almási, Erika Pintér, Gábor Pethő, János Szolcsány. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain. vol 117. issue 3. 2006-01-25. PMID:16150543. |
chronic mechanical hyperalgesia evoked by streptozotocin-induced diabetic and cisplatin-evoked toxic polyneuropathy occurred earlier and were greater in the trpv1 ko group. |
2006-01-25 |
2023-08-12 |
mouse |
| Kata Bölcskei, Zsuzsanna Helyes, Árpád Szabó, Katalin Sándor, Krisztián Elekes, József Németh, Róbert Almási, Erika Pintér, Gábor Pethő, János Szolcsány. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain. vol 117. issue 3. 2006-01-25. PMID:16150543. |
in both polyneuropathy models, at time points when maximal difference in mechanical hyperalgesia between the two groups was measured, plasma somatostatin concentrations determined by radioimmunoassay significantly increased in wt but not in trpv1 ko mice. |
2006-01-25 |
2023-08-12 |
mouse |
| Esther M Pogatzki-Zahn, Isao Shimizu, Michael Caterina, Srinivasa N Raj. Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. Pain. vol 115. issue 3. 2005-07-28. PMID:15911156. |
behavioral experiments involving trpv1 ko mice demonstrate that, as previously observed in inflammatory models, trpv1 is necessary for heat (but not mechanical) hyperalgesia after incision. |
2005-07-28 |
2023-08-12 |
mouse |
| Esther M Pogatzki-Zahn, Isao Shimizu, Michael Caterina, Srinivasa N Raj. Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain. Pain. vol 115. issue 3. 2005-07-28. PMID:15911156. |
however, differences in c-fos staining between heat exposed trpv1 ko and wt mice after incision suggest that the incision-mediated enhancement of heat-evoked signaling to the spinal cord involves a trpv1-dependent mechanism. |
2005-07-28 |
2023-08-12 |
mouse |