| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotom. The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration. Laboratory investigation; a journal of technical methods and pathology vol 103 issue 4 2023 36870285 |
postinjury oe thickness improved faster in trpv4 ko mice than wt mice but without acceleration of orn maturation. |
2023-03-04 |
2023-03-06 |
mouse |
| Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotom. The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration. Laboratory investigation; a journal of technical methods and pathology vol 103 issue 4 2023 36870285 |
trpv1 knockout (ko), trpv4 ko, and wild-type (wt) mice were used to model methimazole-induced olfactory dysfunction. |
2023-03-04 |
2023-03-06 |
mouse |
| Jolien Beeken, Melanie Mertens, Nathan Stas, Sofie Kessels, Liese Aerts, Bieke Janssen, Femke Mussen, Silvia Pinto, Rudi Vennekens, Jean-Michel Rigo, Laurent Nguyen, Bert Br\\xc3\\xb4ne, Yeranddy A Alpiza. Acute inhibition of transient receptor potential vanilloid-type 4 cation channel halts cytoskeletal dynamism in microglia. Glia vol issue 2022 35809029 |
here we show that acute inhibition of trpv4, but not its constitutive absence in the trpv4 ko cells, affects the morphology and motility of microglia in vitro. |
2022-07-09 |
2023-01-27 |
Not clear |
| Nosayba Al-Azzam, Lakshminarayan Reddy Teegala, Sabita Pokhrel, Samrawit Ghebreigziabher, Tatiana Chachkovskyy, Sathwika Thodeti, Ignacio Gavilanes, Kayla Covington, Charles K Thodeti, Sailaja Paruchur. Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4. Scientific reports vol 10 issue 1 2020 32555397 |
further, nox4 expression is up-regulated in the lungs of d.farinae-treated wild type mice (wt) relative to saline-treated wt, which was attenuated in trpv4 knockout (ko) mice. |
2020-12-10 |
2023-01-26 |
mouse |
| Marwan Mannaa, Lajos Mark\\xc3\\xb3, Andr\\xc3\\xa1s Balogh, Emilia Vigolo, Gabriele N'diaye, Mario Ka\\xc3\\x9fmann, Laura Michalick, Ulrike Weichelt, Kai M Schmidt-Ott, Wolfgang B Liedtke, Yu Huang, Dominik N M\\xc3\\xbcller, Wolfgang M Kuebler, Maik Gollasc. Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion. Scientific reports vol 8 issue 1 2019 29559678 |
detailed histological analysis revealed that iri caused aggravated renal tubular damage in trpv4 ko mice, especially in the renal cortex. |
2019-11-04 |
2023-01-26 |
mouse |
| Anantha K Kanugula, Ravi K Adapala, Priya Midha, Holly C Cappelli, J Gary Meszaros, Sailaja Paruchuri, William M Chilian, Charles K Thodet. Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 33 issue 1 2019 29957061 |
furthermore, trpv4 deletion/knockdown enhanced vegf-mediated migration in vitro and increased expression of vegfr2 in vivo in the vasculature of trpv4 ko tumors compared with wild-type tumors. |
2019-07-08 |
2023-01-26 |
human |
| Shailesh Bihari, Dani-Louise Dixon, Mark D Lawrence, Dylan De Bellis, Claudine S Bonder, David P Dimasi, Andrew D Berste. Fluid-induced lung injury-role of TRPV4 channels. Pflugers Archiv : European journal of physiology vol 469 issue 9 2018 28456852 |
the role of trpv4 channels in fluid-induced lung injury was subsequently examined by the administration of ruthenium red (rr) in this established rat model and again in trpv4 ko mice. |
2018-12-11 |
2023-01-26 |
rat |
| Yuka Okada, Kumi Shirai, Masayasu Miyajima, Peter S Reinach, Osamu Yamanaka, Takayoshi Sumioka, Masahide Kokado, Katsuo Tomoyose, Shizuya Saik. Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas. PloS one vol 11 issue 12 2017 28030558 |
tail vein reciprocal bone marrow transplantation between wt and ko chimera mouse models mice showed that reduced scarring and inflammation in ko mice are due to loss of trpv4 expression on both corneal resident immune cells, fibroblasts and infiltrating polymorphonuclear leukocytes and macrophages. |
2017-07-05 |
2023-01-26 |
mouse |
| Yuka Okada, Kumi Shirai, Masayasu Miyajima, Peter S Reinach, Osamu Yamanaka, Takayoshi Sumioka, Masahide Kokado, Katsuo Tomoyose, Shizuya Saik. Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas. PloS one vol 11 issue 12 2017 28030558 |
taken together, alkali-induced trpv4 activation contributes to inducing fibrosis and inflammation since corneal transparency recovery was markedly improved in ko mice. |
2017-07-05 |
2023-01-26 |
mouse |
| Mitsuharu Yoshiyama, Tsutomu Mochizuki, Hiroshi Nakagomi, Tatsuya Miyamoto, Satoru Kira, Ryoji Mizumachi, Takaaki Sokabe, Yasunori Takayama, Makoto Tominaga, Masayuki Taked. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle. American journal of physiology. Renal physiology vol 308 issue 10 2015 25761879 |
in metabolic cage experiments conducted under conscious conditions (i.e., voluntary voiding behavior), trpv4 ko mice showed a markedly higher voiding frequency (vf; 19.3 \xc2\xb1 1.2 times/day) and a smaller urine volume/voiding (uvv; 114 \xc2\xb1 9 \xce\xbcl) compared with wild-type (wt) littermates (vf: 5.2 \xc2\xb1 0.5 times/day and uvv: 380 \xc2\xb1 34 \xce\xbcl). |
2015-08-04 |
2023-01-25 |
mouse |
| Mitsuharu Yoshiyama, Tsutomu Mochizuki, Hiroshi Nakagomi, Tatsuya Miyamoto, Satoru Kira, Ryoji Mizumachi, Takaaki Sokabe, Yasunori Takayama, Makoto Tominaga, Masayuki Taked. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle. American journal of physiology. Renal physiology vol 308 issue 10 2015 25761879 |
the present study used a dual analysis of voiding behavior and reflex micturition to examine lower urinary tract function in transient receptor potential vanilloid (trpv)1 knockout (ko) mice and trpv4 ko mice. |
2015-08-04 |
2023-01-25 |
mouse |
| Claire A Sand, Anna Starr, Manasi Nandi, Andrew D Gran. Blockade or deletion of transient receptor potential vanilloid 4 (TRPV4) is not protective in a murine model of sepsis. F1000Research vol 4 issue 2015 26064477 |
multi-parameter monitoring of conscious systemic haemodynamics (by radiotelemetry probe), mesenteric microvascular blood flow (laser speckle contrast imaging) and blood biochemistry (istat blood gas analysis) was carried out in wild type (wt) and trpv4 knockout (ko) mice. |
2015-06-11 |
2023-01-25 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus vol 23 issue 8 2014 23536486 |
ltd at excitatory synapses on s. radiatum hippocampal interneurons was attenuated in slices from trpv3 ko mice (as well as in trpv1 ko mice as previously reported), but not in slices from trpv4 ko mice. |
2014-03-05 |
2023-01-25 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus vol 23 issue 8 2014 23536486 |
here we tested the role of other trpv channels in hippocampal synaptic plasticity, using hippocampal slices from trpv1, trpv3 and trpv4 knockout (ko) mice. |
2014-03-05 |
2023-01-25 |
mouse |
| Hiroshi Mihara, Ammar Boudaka, Toshiro Sugiyama, Yoshinori Moriyama, Makoto Tominag. Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. The Journal of physiology vol 589 issue Pt 14 2012 21540339 |
several known trpv4 activators (chemicals, heat and stretch stimulus) increased cytosolic ca2+ concentrations in cultured wt keratinocytes but not in trpv4 knockout (ko) cells. |
2012-04-16 |
2023-01-25 |
mouse |
| Fabien Vincent, Alejandra Acevedo, Margaret T Nguyen, Michelle Dourado, Jeff DeFalco, Amy Gustafson, Peter Spiro, Daniel E Emerling, Michael G Kelly, Matthew A J Duncto. Identification and characterization of novel TRPV4 modulators. Biochemical and biophysical research communications vol 389 issue 3 2009 19737537 |
while its multiple roles in vivo are being explored with ko mice and selective agonists, there is a dearth of selective antagonists available to examine trpv4 function. |
2009-11-13 |
2023-01-25 |
rat |
| Scott Earley, Thierry Pauyo, Rebecca Drapp, Matthew J Tavares, Wolfgang Liedtke, Joseph E Brayde. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. American journal of physiology. Heart and circulatory physiology vol 297 issue 3 2009 19617407 |
in the present study, we examined arterial vasomotor activity in vitro and recorded blood pressure dynamics in vivo using trpv4 knockout (ko) mice. |
2009-09-21 |
2023-01-25 |
mouse |
| Scott Earley, Thierry Pauyo, Rebecca Drapp, Matthew J Tavares, Wolfgang Liedtke, Joseph E Brayde. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. American journal of physiology. Heart and circulatory physiology vol 297 issue 3 2009 19617407 |
in contrast, 11,12-eet had no effect on membrane potential, diameter, or ionic currents in the mesenteric arteries from trpv4 ko mice. |
2009-09-21 |
2023-01-25 |
mouse |