| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julien Bensalem, Leanne K Hein, Sofia Hassiotis, Paul J Trim, Christopher G Proud, Leonie K Heilbronn, Timothy J Sargean. Modifying dietary protein impacts mTOR signaling and brain deposition of amyloid beta in a knock-in mouse model of Alzheimer's disease. The Journal of nutrition vol issue 2023 36870538 |
alzheimer's disease (ad) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. |
2023-03-04 |
2023-03-06 |
mouse |
| John P Seibyl, Jonathan M DuBois, Annie Racine, Jessica Collins, Qi Guo, Dustin Wooten, Eddie Stage, David Cheng, Roger N Gunn, Lilly Porat, Alex Whittington, Phillip H Kuo, Masanori Ichise, Robert Comley, Laurent Martarello, Cristian Salina. A Visual Interpretation Algorithm for Assessing Brain Tauopathy with Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol 64 issue 3 2023 36175137 |
a visual interpretation algorithm for assessing brain tauopathy with in vivo characterization of pathologic deposition of tau protein in the human brain by pet imaging is a promising tool in drug development trials of alzheimer disease (ad). |
2023-03-03 |
2023-03-06 |
human |
| Cailin Wang, Yanmin Chang, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Siyi Zheng, Gang Li, Rong M. AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease. Experimental neurology vol issue 2023 36868546 |
adiporon mitigates tau pathology and restores mitochondrial dynamics via ampk-related pathway in a mouse model of alzheimer's disease. |
2023-03-03 |
2023-03-06 |
mouse |
| Ergina Vourkou, Eva D Rouiz Ortega, Sumeet Mahajan, Amrit Mudher, Efthimios Mc Skoulaki. Human Tau aggregates are permissive to Protein Synthesis Dependent Memory in Drosophila Tauopathy models. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2023 36868851 |
tauopathies including alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration and intraneuronal aggregates comprised largely of the axonal protein tau. |
2023-03-03 |
2023-03-06 |
human |
| Kimberly L Fiock, Ryan K Betters, Marco M Heft. Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol issue 2023 36861683 |
tau phosphorylation, aggregation, and toxicity are the main drivers of neurodegeneration in multiple tauopathies, including alzheimer's disease (ad) and frontotemporal lobar degeneration with tau. |
2023-03-02 |
2023-03-06 |
Not clear |
| Vikas Kotari, Sudeepti Southekal, Michael Navitsky, Ian A Kennedy, Ming Lu, Amanda Morris, Jennifer Ann Zimmer, Adam S Fleisher, Mark A Mintun, Michael D Devous, Michael J Pontecorv. Early tau detection in flortaucipir images: validation in autopsy-confirmed data and implications for disease progression. Alzheimer's research & therapy vol 15 issue 1 2023 36855201 |
there is an increasing interest in utilizing tau pet to identify patients early in alzheimer's disease (ad). |
2023-03-01 |
2023-03-06 |
Not clear |
| Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaa. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology vol issue 2023 36859689 |
our understanding of the biological functions of the tau protein now includes its role as a scaffolding protein involved in signaling regulation, which also has implications for tau-mediated dysfunction and degeneration in alzheimer's disease and other tauopathies. |
2023-03-01 |
2023-03-06 |
rat |
| Rahul Sharma, Prema Mondal, Srinivasa M Srinivasul. CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono-ubiquitination. The FEBS journal vol issue 2023 36853170 |
the development of neurological pathologies is linked to the accumulation of protein aggregates like alpha-synuclein in parkinson's disease and tau protein in alzheimer's disease. |
2023-02-28 |
2023-03-06 |
Not clear |
| Kanta Horie, Yan Li, Nicolas R Barth\\xc3\\xa9lemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology vol issue 2023 36843330 |
change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in dominantly inherited alzheimer's disease. |
2023-02-27 |
2023-03-06 |
Not clear |
| Kanta Horie, Yan Li, Nicolas R Barth\\xc3\\xa9lemy, Brian A Gordon, Jason Hassenstab, Tammie L S Benzinger, Anne M Fagan, John C Morris, Celeste M Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory S Day, Peter R Schofield, Colin L Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa Reyderman, Randall J Bateman, Eric McDad. Change in cerebrospinal fluid tau microtubule binding region detects symptom onset, cognitive decline, tangles, and atrophy in Dominantly Inherited Alzheimer's Disease. Annals of neurology vol issue 2023 36843330 |
identifying cerebrospinal fluid measures of the microtubule binding region of tau (mtbr-tau) species that reflect tau aggregation could provide fluid biomarkers that track alzheimer disease related neurofibrillary tau pathological changes. |
2023-02-27 |
2023-03-06 |
Not clear |
| Qi Qiu, Xia Lei, Yueying Wang, Hui Xiong, Yanming Xu, Huifeng Sun, Hongdan Xu, Ning Zhan. Naringin Protects against Tau Hyperphosphorylation in A Behavioural neurology vol 2023 issue 2023 36844418 |
naringin protects against tau hyperphosphorylation in a alzheimer's disease (ad) is the most common form of dementia and a significant social and economic burden. |
2023-02-27 |
2023-03-06 |
Not clear |
| Christian F Pantoja, Alain Ib\\xc3\\xa1\\xc3\\xb1ez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstette. Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie (International ed. in English) vol issue 2023 36847235 |
application of spatially-resolved nmr to condensates formed by the alzheimer's disease-associated protein tau demonstrates decreased water content, exclusion of the molecular crowding agent dextran, presence of a specific chemical environment of the small molecule dss, and ~150-fold increased concentration of tau inside the condensate. |
2023-02-27 |
2023-03-06 |
Not clear |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology vol 12 issue 2 2023 36829593 |
therefore, research into the regulation of tau protein phosphorylation is important for understanding alzheimer's disease. |
2023-02-25 |
2023-03-06 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology vol 12 issue 2 2023 36829593 |
to examine whether haspin is involved in the onset of alzheimer's disease through tau protein phosphorylation, we investigated the effects of a diet including soybean sprouts rich in the haspin inhibitor coumestrol in a mouse model of alzheimer's disease (5xfad). |
2023-02-25 |
2023-03-06 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology vol 12 issue 2 2023 36829593 |
these results indicate that haspin may be one of the target molecules for the repression of tau phosphorylation in the treatment of alzheimer's disease. |
2023-02-25 |
2023-03-06 |
mouse |
| Eisuke Muto, Toshio Okada, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inaz. Licochalcone E, a \\xce\\xb2-Amyloid Aggregation Inhibitor, Regulates Microglial M1/M2 Polarization via Inhibition of CTL1-Mediated Choline Uptake. Biomolecules vol 13 issue 2 2023 36830561 |
alzheimer's disease (ad) is thought to be a series of neuroinflammatory diseases caused by abnormal deposits of amyloid-\xce\xb2 (a\xce\xb2) and tau protein in the brain as part of its etiology. |
2023-02-25 |
2023-03-06 |
mouse |
| Zheng-Kui Weng, Te-Hsien Lin, Kuo-Hsuan Chang, Ya-Jen Chiu, Chih-Hsin Lin, Pei-Hsuan Tseng, Ying-Chieh Sun, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Che. Using \\xce\\x94K280 Tau Biomolecules vol 13 issue 2 2023 36830589 |
using \xce\x94k280 tau misfolded aggregation of the hyperphosphorylated microtubule binding protein tau in the brain is a pathological hallmark of alzheimer's disease (ad). |
2023-02-25 |
2023-03-06 |
human |
| Zohreh Mohammadi, Hadi Alizadeh, J\\xc3\\xa1nos Marton, Paul Cummin. The Sensitivity of Tau Tracers for the Discrimination of Alzheimer's Disease Patients and Healthy Controls by PET. Biomolecules vol 13 issue 2 2023 36830659 |
the sensitivity of tau tracers for the discrimination of alzheimer's disease patients and healthy controls by pet. |
2023-02-25 |
2023-03-06 |
Not clear |
| Zohreh Mohammadi, Hadi Alizadeh, J\\xc3\\xa1nos Marton, Paul Cummin. The Sensitivity of Tau Tracers for the Discrimination of Alzheimer's Disease Patients and Healthy Controls by PET. Biomolecules vol 13 issue 2 2023 36830659 |
hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark neuropathological feature of alzheimer's disease (ad). |
2023-02-25 |
2023-03-06 |
Not clear |
| Fangyang Jiao, Min Wang, Xiaoming Sun, Zizhao Ju, Jiaying Lu, Luyao Wang, Jiehui Jiang, Chuantao Zu. Based on Tau PET Radiomics Analysis for the Classification of Alzheimer's Disease and Mild Cognitive Impairment. Brain sciences vol 13 issue 2 2023 36831910 |
based on tau pet radiomics analysis for the classification of alzheimer's disease and mild cognitive impairment. |
2023-02-25 |
2023-03-06 |
human |