| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. |
this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. |
2023-12-21 |
2023-12-23 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Conceição Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
however, a central feature consists of regional aggregation of proteins in the brain, such as the accumulation of β-amyloid plaques in alzheimer's disease (ad), inclusions of hyperphosphorylated microtubule-binding tau in ad and other tauopathies, or inclusions containing α-synuclein in parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2023-06-29 |
2023-08-14 |
Not clear |
| Hao Chen, Yajie Li, Jingwen Gao, Qi Cheng, Lei Liu, Rong Ca. Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions. Molecular neurobiology. 2023-05-30. PMID:37249790. |
through in vivo studies, we examined neuron-specific overexpression of tau in drosophila, mouse models of app/ps1 alzheimer's disease (ad), and a rat model of multiple system atrophy (msa) via the viral expression of α-synuclein in the striatum. |
2023-05-30 |
2023-08-14 |
mouse |
| Makoto T Tanaka, Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Fumiaki Mori, Hideki Hayashi, Akiyoshi Kakita, Koichi Wakabayash. Phosphorylation of Tau at Threonine 231 in Patients With Multiple System Atrophy and in a Mouse Model. Journal of neuropathology and experimental neurology. 2022-09-09. PMID:36083205. |
phosphorylation of tau at threonine 231 in patients with multiple system atrophy and in a mouse model. |
2022-09-09 |
2023-08-14 |
mouse |
| Feng-Tao Liu, Xin-Yi Li, Jia-Ying Lu, Ping Wu, Ling Li, Xiao-Niu Liang, Zi-Zhao Ju, Fang-Yang Jiao, Ming-Jia Chen, Jing-Jie Ge, Yi-Min Sun, Jian-Jun Wu, Tzu-Chen Yen, Jian-Feng Luo, Chuantao Zuo, Jian Wan. Movement disorders : official journal of the Movement Disorder Society. 2022-07-21. PMID:35861378. |
anecdotal evidence suggests that patients diagnosed with the parkinsonian subtype of multiple system atrophy (msa-p) may show uptake of the second-generation tau positron emission tomography (pet) tracer |
2022-07-21 |
2023-08-14 |
Not clear |
| Alessandra Fanciulli, Fabian Leys, Fabienne Lehner, Victoria Sidoroff, Viktoria C Ruf, Cecilia Raccagni, Philipp Mahlknecht, Demy J S Kuipers, Wilfred F J van IJcken, Heike Stockner, Thomas Musacchio, Jens Volkmann, Camelia Maria Monoranu, Iva Stankovic, Guido Breedveld, Federico Ferraro, Christina Fevga, Otto Windl, Jochen Herms, Stefan Kiechl, Werner Poewe, Klaus Seppi, Nadia Stefanova, Sonja W Scholz, Vincenzo Bonifati, Gregor K Wennin. A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson's disease with dementia. Brain communications. vol 4. issue 4. 2022-07-20. PMID:35855480. |
neuropathological examination confirmed multiple system atrophy in the index case and advanced lewy body disease, as well as tau pathology in her cousin. |
2022-07-20 |
2023-08-14 |
Not clear |
| Sushma, Amal Chandra Monda. Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes. CNS & neurological disorders drug targets. 2021-12-29. PMID:34963438. |
these proteins are amyloid-β peptide, tau, α-synuclein, and mhtt, which cause alzheimer's disease, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, parkinson's disease, multiple system atrophy, dementia with lewy-body and huntington's disease. |
2021-12-29 |
2023-08-13 |
Not clear |
| Christos Proukaki. Somatic mutations in neurodegeneration: An update. Neurobiology of disease. vol 144. 2021-09-24. PMID:32712267. |
in common sporadic neurodegenerative disorders, relevant mutations have been reported in synucleinopathies, comprising somatic gains of snca in parkinson's disease and multiple system atrophy, and in alzheimer's disease, where a novel recombination mechanism leading to somatic variants of app, as well as an excess of somatic snvs affecting tau phosphorylation, have been reported. |
2021-09-24 |
2023-08-13 |
human |
| David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology. vol 80. issue 8. 2021-09-13. PMID:34388235. |
others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and creutzfeldt-jakob disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Matteo Manca, Allison Krau. Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32854212. |
to date, rt-quic assays have been developed for the detection of protein seeds related to known prion diseases of mammals, the αsyn aggregates of parkinson's disease, dementia with lewy bodies, and multiple system atrophy, and the tau aggregates of alzheimer's disease, chronic traumatic encephalopathy, and other tauopathies including progressive supranuclear palsy. |
2021-09-07 |
2023-08-13 |
human |
| Junghwan Shin, Han-Joon Kim, Beomseok Jeo. Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies. Journal of movement disorders. vol 13. issue 1. 2020-10-01. PMID:31847513. |
α-synuclein and tau deposition in the central nervous system is responsible for various parkinsonian syndromes, including parkinson's disease, multiple system atrophy, dementia with lewy bodies, progressive supranuclear palsy and corticobasal degeneration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yusuke Seino, Takumi Nakamura, Takeshi Kawarabayashi, Mie Hirohata, Sakiko Narita, Yasuhito Wakasaya, Kozue Kaito, Tetsuya Ueda, Yasuo Harigaya, Mikio Shoj. Cerebrospinal Fluid and Plasma Biomarkers in Neurodegenerative Diseases. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-18. PMID:30814356. |
increased total tau levels in add/mci, encephalopathy, and multiple system atrophy, and increased p181tau in add/mci indicated that these biomarkers corresponded to neurodegeneration and tauopathy, respectively. |
2020-06-18 |
2023-08-13 |
human |
| Chiara Maria Giulia De Luca, Antonio Emanuele Elia, Sara Maria Portaleone, Federico Angelo Cazzaniga, Martina Rossi, Edoardo Bistaffa, Elena De Cecco, Joanna Narkiewicz, Giulia Salzano, Olga Carletta, Luigi Romito, Grazia Devigili, Paola Soliveri, Pietro Tiraboschi, Giuseppe Legname, Fabrizio Tagliavini, Roberto Eleopra, Giorgio Giaccone, Fabio Mod. Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy. Translational neurodegeneration. vol 8. 2020-02-25. PMID:31406572. |
pd is characterized by intraneuronal accumulation of abnormal α-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of either α-synuclein, as in the case of multiple system atrophy (msa) or tau, as in the case of corticobasal degeneration (cbd) and progressive supranuclear palsy (psp), in other disease-specific brain regions. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yuta Takaichi, Yasuhisa Ano, James K Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy. Journal of neuropathology and experimental neurology. vol 77. issue 10. 2019-10-03. PMID:30107539. |
specifically, hyperphosphorylated tau (hp-tau) accumulates in alzheimer disease, frontotemporal dementia with parkinsonism linked to chromosome 17, and progressive supranuclear palsy; furthermore, phosphorylated α-synuclein (p-αsyn) accumulates in parkinson disease, dementia with lewy bodies, and multiple system atrophy. |
2019-10-03 |
2023-08-13 |
mouse |
| Kerstin Schweyer, Johannes Levin, Günter U Höglinge. [Current therapy studies in atypical Parkinson syndromes]. Fortschritte der Neurologie-Psychiatrie. vol 86. issue S 01. 2019-05-10. PMID:29996158. |
on the basis of the underlying pathology, namely the abnormal aggregation of the proteins alpha-synuclein or tau, atypical parkinson syndromes can be divided into synucleinopathies (multiple system atrophy, lewy body dementia) and tauopathies (progressive supranuclear palsy, corticobasal degeneration). |
2019-05-10 |
2023-08-13 |
Not clear |
| Kurt Giles, Amanda L Woerman, David B Berry, Stanley B Prusine. Bioassays and Inactivation of Prions. Cold Spring Harbor perspectives in biology. vol 9. issue 8. 2018-04-23. PMID:28246183. |
a wealth of recent data argues that both β-amyloid (aβ) and tau proteins form prions that cause alzheimer's disease, and α-synuclein forms prions that cause multiple system atrophy and parkinson's disease. |
2018-04-23 |
2023-08-13 |
Not clear |
| Sarah Coakeley, Sang Soo Cho, Yuko Koshimori, Pablo Rusjan, Madeleine Harris, Christine Ghadery, Jinhee Kim, Anthony E Lang, Alan Wilson, Sylvain Houle, Antonio P Strafell. Positron emission tomography imaging of tau pathology in progressive supranuclear palsy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 37. issue 9. 2017-09-19. PMID:28155586. |
while many parkinsonian disorders such as parkinson's disease, lewy body dementia, and multiple system atrophy are classified as synucleinopathies, progressive supranuclear palsy is coined a tauopathy due to the aggregation of pathological tau in the brain. |
2017-09-19 |
2023-08-13 |
Not clear |
| Ashley M Brouillette, Gülin Öz, Christopher M Gome. Cerebrospinal Fluid Biomarkers in Spinocerebellar Ataxia: A Pilot Study. Disease markers. vol 2015. 2016-04-26. PMID:26265793. |
we analyzed the cerebrospinal fluid (csf) level of tau, α-synuclein, dj-1, and glial fibrillary acidic protein (gfap), proteins previously associated with neurodegenerative processes, in patients with the autosomal dominant sca1, sca2, and sca6, and the sporadic disease multiple system atrophy, cerebellar type (msa-c), compared with age-matched controls. |
2016-04-26 |
2023-08-13 |
Not clear |
| Steven E Arnold, Jon B Toledo, Dina H Appleby, Sharon X Xie, Li-San Wang, Young Baek, David A Wolk, Edward B Lee, Bruce L Miller, Virginia M-Y Lee, John Q Trojanowsk. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of comparative neurology. vol 521. issue 18. 2014-06-11. PMID:23881776. |
these include: 1) amyloid-β and tau lesions in alzheimer's disease; 2) tau lesions in three other tauopathies including pick's disease, progressive supranuclear palsy and corticobasal degeneration; 3) α-synuclein inclusion ratings in four synucleinopathies including parkinson's disease, parkinson's disease with dementia, dementia with lewy bodies, and multiple system atrophy; and 4) tdp-43 lesions in two tdp-43 proteinopathies, including frontotemporal lobar degeneration associated with tdp-43 and amyotrophic lateral sclerosis. |
2014-06-11 |
2023-08-12 |
Not clear |
| Takashi Kurashige, Tetsuya Takahashi, Yuu Yamazaki, Masanori Hiji, Yuishin Izumi, Takemori Yamawaki, Masayasu Matsumot. Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 33. issue 3. 2014-01-10. PMID:22989140. |
we examined the brainstems of 17 patients with parkinson's disease (pd), incidental lewy body disease (ilbd), multiple system atrophy (msa), and alzheimer's disease (ad) immunohistochemically using antibodies against phosphorylated αs (pαs), phosphorylated tau and chmp2b. |
2014-01-10 |
2023-08-12 |
Not clear |