| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana G Fronza, Diego Alves, Domenico Praticò, Lucielli Savegnag. The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease. Ageing research reviews. vol 90. 2023-08-24. PMID:37595640. |
bace1 is the rate-limiting step in the aβ production, gsk-3β is considered the main kinase responsible for tau hyperphosphorylation, and ache play an important role in modulating memory formation and learning. |
2023-08-24 |
2023-09-07 |
Not clear |
| Jaime Fernández Arias, Joseph Therriault, Emilie Thomas, Firoza Z Lussier, Gleb Bezgin, Cécile Tissot, Stijn Servaes, Sulantha S Mathotaarachchi, Dorothée Schoemaker, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita Poltronetti, Yi-Ting Wang, Peter Kunach, Mira Chamoun, Kely M Quispialaya S, Paolo Vitali, Gassan Massarweh, Serge Gauthier, Maria N Rajah, Tharick Pascoal, Pedro Rosa-Net. Verbal memory formation across PET-based Braak stages of tau accumulation in Alzheimer's disease. Brain communications. vol 5. issue 3. 2023-05-30. PMID:37252014. |
verbal memory formation across pet-based braak stages of tau accumulation in alzheimer's disease. |
2023-05-30 |
2023-08-14 |
Not clear |
| Joseph Nowell, Eleanor Blunt, Paul Ediso. Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease. Molecular psychiatry. 2022-10-18. PMID:36258018. |
preclinical studies have demonstrated that glp-1 receptor agonists reduce neuroinflammation, reduce tau phosphorylation, reduce amyloid deposition, increase synaptic function, and improve memory formation. |
2022-10-18 |
2023-08-14 |
Not clear |
| Emmanuel Prikas, Esmeralda Paric, Prita R Asih, Kristie Stefanoska, Holly Stefen, Thomas Fath, Anne Poljak, Arne Ittne. Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation. The EMBO journal. 2022-08-22. PMID:35993331. |
tau target identification reveals nsf-dependent effects on ampa receptor trafficking and memory formation. |
2022-08-22 |
2023-08-14 |
mouse |
| Hongchun Li, Xinglong Zhou, Rong Chen, Yuzhou Xiao, Tao Zho. The Src-Kinase Fyn is Required for Cocaine-Associated Memory Through Regulation of Tau. Frontiers in pharmacology. vol 13. 2022-02-21. PMID:35185557. |
in addition, the regulation of cocaine-associated memory formation by fyn depends on tau expression, as restoring tau to normal levels disrupted cocaine memory formation. |
2022-02-21 |
2023-08-13 |
Not clear |
| Hannah Walgrave, Evgenia Salta, Sarah Snoeck, Renzo Mancuso, Sriram Balusu, Kristofer Davie, Francis Impens, Bart de Stroope. Systematic evaluation of the therapeutic potential of microRNA-132 in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108990. |
of particular interest is microrna-132 (mir-132), which is consistently and robustly downregulated in ad patient brain and has been shown to be involved in pivotal processes in the central nervous system that are also affected in ad, such as amyloid plaque deposition, tau phosphorylation, inflammation, synaptic plasticity and memory formation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
male mice hippocampal expression of tau was significantly decreased during the cocaine-associated memory formation. |
2021-11-22 |
2023-08-13 |
mouse |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
collectively, 4r tau modulates cocaine memory formation by disrupting ahn, suggesting a novel mechanism underlying cocaine memory formation and provide a new strategy for the treatment of cocaine addiction. |
2021-11-22 |
2023-08-13 |
mouse |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32546772. |
modelling this cyfip2 reduction in mice, we find age-dependent aβ accumulation in the thalamus, development of tau pathology in entorhinal cortex and hippocampus, as well as gliosis and synapse loss in the hippocampus, together with deficits in memory formation. |
2021-06-18 |
2023-08-13 |
mouse |
| A Ahnaou, D Moechars, L Raeymaekers, R Biermans, N V Manyakov, A Bottelbergs, C Wintmolders, K Van Kolen, T Van De Casteele, J A Kemp, W H Drinkenbur. Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer's disease pathology. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29079799. |
moreover, the tau pathology disrupted the mmn complex amplitude and evoked gamma oscillations to standard and deviant stimuli suggesting altered memory formation and recall. |
2019-07-05 |
2023-08-13 |
mouse |
| Ekram N Abd Al Haleem, Wesam M El-Bakl. The role of MAPK signaling pathway in selenium amelioration of high fat/high cholesterol diet-induced tauopathy in rats. Chemico-biological interactions. vol 302. 2019-03-29. PMID:30695686. |
map kinases, creb, and tau are signaling molecules among downstream synaptic targets involved in synaptic function, memory formation and cognition. |
2019-03-29 |
2023-08-13 |
rat |
| Shawn M Marks, Samuel N Lockhart, Suzanne L Baker, William J Jagus. Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 12. 2017-08-18. PMID:28213439. |
normal aging is associated with a decline in episodic memory and also with aggregation of the β-amyloid (aβ) and tau proteins and atrophy of medial temporal lobe (mtl) structures crucial to memory formation. |
2017-08-18 |
2023-08-13 |
Not clear |
| Komal Arora, Justin Cheng, Robert A Nichol. Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid. The Journal of biological chemistry. vol 290. issue 35. 2015-12-08. PMID:26139609. |
among putative downstream synaptic targets of β-amyloid (aβ) are signaling molecules involved in synaptic function, memory formation and cognition, such as the map kinases, mkps, camkii, creb, fyn, and tau. |
2015-12-08 |
2023-08-13 |
mouse |
| Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Karunya Ramani, Rashmi K Ambast. Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 43. issue 2. 2015-07-06. PMID:25096626. |
several kinases, e.g., mark, mapk, and protein kinase c, are known to hyperphosphorylate tau, leading to disruption of the microtubular network and formation of neurofibrillary tangles (nfts), which are further glycosylated, glycated, and have lipid peroxide adducts that impair the neuronal transport system and affect memory formation and retention. |
2015-07-06 |
2023-08-13 |
Not clear |
| Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierk. Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations. International journal of cell biology. vol 2013. 2013-10-25. PMID:24159335. |
recent studies show that extracellular oligomeric tau can inhibit memory formation and synaptic function and also transmit pathology to neighboring neurons. |
2013-10-25 |
2023-08-12 |
human |
| Lindsay C Reese, Giulio Taglialatel. A role for calcineurin in Alzheimer's disease. Current neuropharmacology. vol 9. issue 4. 2012-08-23. PMID:22654726. |
this bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (aβ). |
2012-08-23 |
2023-08-12 |
Not clear |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
the results shown that streptozotocin induced a series of alzheimer disease -like changes in behaviour, a significant decline in learning and memory formation, an increased expression of total tau and an increased ratio of phosphorylated tau, and damage to nucleus and nucleolus as seen in electron micrographs. |
2012-05-03 |
2023-08-12 |
rat |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
in the present study, (val(8))glp-1 was used to prevent impairments in memory formation, tau hyperphosphorylation and ultra-structural changes induced by streptozotocin intracerebroventricular (i.c.v.) |
2012-05-03 |
2023-08-12 |
rat |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
our results indicated that (val(8))glp-1 might prevent age-related neurodegenerative changes by preventing decline of learning and memory formation, reduction of phosphorylated tau levels and protection of subcellular structures and morphology of neurons. |
2012-05-03 |
2023-08-12 |
rat |
| Lin Li, Zhi-Feng Zhang, Christian Holscher, Chong Gao, Yuan-Hong Jiang, Yue-Ze Li. (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22115895. |
a spatial water maze task was used to test the rats' learning and memory formation, western blot was used to measure tau hyperphosphorylation/total tau, and transmission electron microscope was used to find ultra-structural changes. |
2012-05-03 |
2023-08-12 |
rat |