| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
overexpression of tau decreased arc stability in an activity-dependent manner, exclusively in neuronal dendrites, which was coupled to an increase in the expression of dendritic and somatic surface glua1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors. |
2024-03-29 |
2024-04-01 |
mouse |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
our findings confirm that arc is misregulated in ad, and further show a physiological role for tau in regulating arc stability and ampa receptor targeting. |
2024-03-29 |
2024-04-01 |
mouse |
| Daniel P Chapman, Sarah D Power, Stefano Vicini, Tomás J Ryan, Mark P Burn. Amnesia after repeated head impact is caused by impaired synaptic plasticity in the memory engram. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-01-16. PMID:38228367. |
in sham mice the hippocampal engram neurons exhibited synaptic plasticity, evident in amplified ampa:nmda ratio, enhanced ampa-weighted tau, and increased dendritic spine volume compared to non-engram neurons. |
2024-01-16 |
2024-01-19 |
mouse |
| Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. |
recent evidence indicates that aβ drives mis-localisation of tau from axons to synapses, resulting in ampa receptor (ampar) internalisation and impaired excitatory synaptic function. |
2023-10-12 |
2023-10-15 |
Not clear |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
alteration in the synaptic and extrasynaptic organization of ampa receptors in the hippocampus of p301s tau transgenic mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Steffen Pockes, Michael A Walters, Karen H Ash. Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias. Translational research : the journal of laboratory and clinical medicine. 2022-11-07. PMID:36343883. |
through a not yet fully delineated mechanism, Δtau314 catalyzes the mislocalization and accumulation of tau to dendritic spines leading to the internalization of ampa receptors and the concomitant weakening of synaptic transmission. |
2022-11-07 |
2023-08-14 |
Not clear |
| Emmanuel Prikas, Esmeralda Paric, Prita R Asih, Kristie Stefanoska, Holly Stefen, Thomas Fath, Anne Poljak, Arne Ittne. Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation. The EMBO journal. 2022-08-22. PMID:35993331. |
tau target identification reveals nsf-dependent effects on ampa receptor trafficking and memory formation. |
2022-08-22 |
2023-08-14 |
mouse |
| Maria Italia, Elena Ferrari, Monica Diluca, Fabrizio Gardon. NMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies. Biomedicines. vol 10. issue 7. 2022-07-27. PMID:35884851. |
nmda and ampa receptors at synapses: novel targets for tau and α-synuclein proteinopathies. |
2022-07-27 |
2023-08-14 |
Not clear |
| Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying M. A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. Molecules (Basel, Switzerland). vol 27. issue 13. 2022-07-09. PMID:35807406. |
we detected the levels of synapse-related proteins, hdacs, tau phosphorylation, and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors using western blotting and immunohistochemistry. |
2022-07-09 |
2023-08-14 |
mouse |
| Naveen Kumar, Vijay Kumar, Piyush Anand, Vinay Kumar, Ashish Ranjan Dwivedi, Vinod Kuma. Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. vol 61. 2022-04-10. PMID:35398739. |
a multipotent drug for ad has the potential to bind or inhibit multiple targets responsible for the progression of the disease like aggregated aβ, hyperphosphorylated tau proteins, cholinergic and adrenergic receptors, mao enzymes, overactivated n-methyl-d-aspartate (nmda), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor etc. |
2022-04-10 |
2023-08-13 |
Not clear |
| Philip Regan, Scott J Mitchell, Seung-Chan Kim, Younbok Lee, Jee Hyun Yi, Saviana A Barbati, Christopher Shaw, Kwangwook Ch. Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 34. 2021-11-09. PMID:34290082. |
knock-down of tau or pacsin1 increases ampa receptor (ampar)-mediated current at extrasynaptic regions, supporting a role for these proteins in affecting ampar trafficking. |
2021-11-09 |
2023-08-13 |
human |
| Benjamin R Smith, Kathryn M Nelson, Lisa J Kemper, Kailee Leinonen-Wright, Ashley Petersen, C Dirk Keene, Karen H Ash. A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta neuropathologica communications. vol 7. issue 1. 2020-06-23. PMID:31362787. |
cleavage of tau by casp2 promotes the mislocalization of tau to dendritic spines leading to a reduction in postsynaptic ampa receptors and excitatory neurotransmission, which suggests a mechanism of the synaptic dysfunction underlying cognitive impairment in lbd. |
2020-06-23 |
2023-08-13 |
mouse |
| Peter J Teravskis, Ana Covelo, Eric C Miller, Balvindar Singh, Héctor A Martell-Martínez, Michael A Benneyworth, Christopher Gallardo, Breeta R Oxnard, Alfonso Araque, Michael K Lee, Dezhi Lia. A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 45. 2019-10-10. PMID:30249789. |
mechanistically, postsynaptic dysfunction requires glycogen synthase kinase 3β-mediated tau phosphorylation, tau mislocalization to dendritic spines, and calcineurin-dependent ampa receptor internalization. |
2019-10-10 |
2023-08-13 |
mouse |
| David Baglietto-Vargas, Gilberto Aleph Prieto, Agenor Limon, Stefania Forner, Carlos J Rodriguez-Ortiz, Kenji Ikemura, Rahasson R Ager, Rodrigo Medeiros, Laura Trujillo-Estrada, Alessandra C Martini, Masashi Kitazawa, Jose C Davila, Carl W Cotman, Antonia Gutierrez, Frank M LaFerl. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging cell. vol 17. issue 4. 2019-10-07. PMID:29877034. |
ampa dysfunction and spine alteration correlate with the presence of soluble but not insoluble aβ and tau species. |
2019-10-07 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
we also investigated changes in ampa receptor expression in the synaptic membrane of wild-type and tau knockout mice. |
2019-09-23 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
our results reveal the role of tau protein phosphorylation in the mechanism of ketamine neurotoxicity, suggesting that the changes of membrane ampa receptor and synaptic function induced by ketamine are mediated by abnormal phosphorylation of tau protein at specific sites. |
2019-09-23 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
long-term ketamine administration causes tau protein phosphorylation and tau protein-dependent ampa receptor reduction in the hippocampus of mice. |
2019-09-23 |
2023-08-13 |
mouse |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
most importantly, long-term ketamine administration decreased ampa receptor levels in the hippocampal cell membrane in a tau protein-dependent manner. |
2019-09-23 |
2023-08-13 |
mouse |
| Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. |
because the phosphorylation process of tau is involved in the trafficking of ampa receptors, which accompanies the long-term depression (ltd) of synapses, we examined the effect of ltd-inducing low-frequency stimulation (lfs) on the formation of pathological tau aggregates in adult and aged wild-type mice. |
2018-05-07 |
2023-08-13 |
mouse |
| Mamiko Suzuki, Tetsuya Kimur. Microtubule-associated tau contributes to intra-dendritic trafficking of AMPA receptors in multiple ways. Neuroscience letters. vol 653. 2018-04-27. PMID:28554859. |
microtubule-associated tau contributes to intra-dendritic trafficking of ampa receptors in multiple ways. |
2018-04-27 |
2023-08-13 |
Not clear |