All Relations between microtubule-associated protein tau and microglial cell

Reference Sentence Publish Date Extraction Date Species
Mengmeng Jin, Ziyuan Ma, Peng Jian. Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia. STAR protocols vol 3 issue 4 2023 36595906 in addition, we detail steps for intracerebral injection of pathological tau and magnetic cell isolation of human microglia from chimeric mouse brains for single-cell rna sequencing. 2023-01-03 2023-01-05 Not clear
Teresa H Evering, Jez L Marston, Li Gan, Douglas F Nixo. Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences vol issue 2023 36588011 microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (te) transcription. 2023-01-01 2023-01-05 Not clear
Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating \"Alzheimer's Disease\": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology vol 44 issue 12 2022 36547082 interestingly, recent studies revealed that in ad brains the microglia transformed into a disease-associated microglia (dam) status in a trem2-dependent manner to restrain the toxicity of a\xce\xb2 and propagation of tau. 2022-12-22 2022-12-28 Not clear
Guanying You, Jinyi Yao, Qiong Liu, Nan L. The Strategies for Treating \"Alzheimer's Disease\": Insulin Signaling May Be a Feasible Target. Current issues in molecular biology vol 44 issue 12 2022 36547082 in this review, we summarize the main strategies for curing ad, including lowering the level of a\xce\xb2, suppressing the phosphorylation of tau, the ablation and/or repopulation of microglia, and especially the supply of insulin. 2022-12-22 2022-12-28 Not clear
Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M Zolezzi, Nibaldo C Inestros. Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological research vol 55 issue 1 2022 36550479 importantly, a\xce\xb2 and tau species are able to activate astrocytes and microglia, which release several proinflammatory cytokines, such as tumor necrosis factor \xce\xb1 (tnf-\xce\xb1) and interleukin 1\xce\xb2 (il-1\xce\xb2), together with reactive oxygen (ros) and nitrogen species (rns), triggering neuroinflammation. 2022-12-22 2022-12-28 Not clear
Dong Won Kim, Kevin J Tu, Alice Wei, Ashley J Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P Ling, Juan C Troncoso, Philip C Wong, Seth Blackshaw, Ronald L Schnaar, Tong L. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular neurodegeneration vol 17 issue 1 2022 36536457 amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. 2022-12-19 2022-12-28 Not clear
Dong Won Kim, Kevin J Tu, Alice Wei, Ashley J Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P Ling, Juan C Troncoso, Philip C Wong, Seth Blackshaw, Ronald L Schnaar, Tong L. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular neurodegeneration vol 17 issue 1 2022 36536457 yet, how canonical amyloid-\xce\xb2 (a\xce\xb2) and tau pathologies regulate microglia subtypes during the progression of ad remains poorly understood. 2022-12-19 2022-12-28 Not clear
Kseniya B Varshavskaya, Vladimir A Mitkevich, Alexander A Makarov, Evgeny P Baryki. Synthetic, Cell-Derived, Brain-Derived, and Recombinant \\xce\\xb2-Amyloid: Modelling Alzheimer's Disease for Research and Drug Development. International journal of molecular sciences vol 23 issue 23 2022 36499362 the development of ad is a pathological cascade starting according to the amyloid hypothesis with the accumulation and aggregation of the \xce\xb2-amyloid peptide (a\xce\xb2), which induces hyperphosphorylation of tau and promotes the pro-inflammatory activation of microglia leading to synaptic loss and, ultimately, neuronal death. 2022-12-11 2022-12-15 Not clear
Ruxin Zhang, Yanrong Song, Xuefeng S. Necroptosis and Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Opportunities. Journal of Alzheimer's disease : JAD vol issue 2022 36463451 the keywords in the search included: "necroptosis", "alzheimer's disease", "signaling pathways", "a\xce\xb2", a\xce\xb2o", "tau", "p-tau", "neuronal death", "bbb damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "nec-1", "nec-1s", "gsk872", "nsa", "oga", "ripk1", "ripk3", and "mlkl". 2022-12-04 2022-12-08 Not clear
Na Li, Mingru Deng, Gonghui Hu, Nan Li, Haicheng Yuan, Yu Zho. New Insights into Microglial Mechanisms of Memory Impairment in Alzheimer's Disease. Biomolecules vol 12 issue 11 2022 36421736 activated microglia not only directly mediate the central immune response, but also participate in the pathological changes of ad, including amyloid-beta (a\xce\xb2) aggregation, tau protein phosphorylation, synaptic dissection, neuron loss, memory function decline, etc. 2022-11-24 2022-11-28 Not clear
Nimansha Jain, Jason D Ulric. TREM2 and microglia exosomes: a potential highway for pathological tau. Molecular neurodegeneration vol 17 issue 1 2022 36397070 trem2 and microglia exosomes: a potential highway for pathological tau. 2022-11-18 2022-11-21 Not clear
Nimansha Jain, Jason D Ulric. TREM2 and microglia exosomes: a potential highway for pathological tau. Molecular neurodegeneration vol 17 issue 1 2022 36397070 the mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for microglia in the spread of tau pathology. 2022-11-18 2022-11-21 Not clear
Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gess. Microglia and Alzheimer's Disease. International journal of molecular sciences vol 23 issue 21 2022 36361780 extracellular amyloid and/or intraneuronal phosphorylated tau in ad can both activate microglia. 2022-11-11 2022-11-15 Not clear
Maud Gratuze, Johannes C M Schlachetzki, Ricardo D'Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O'Brien, Martina P Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K Glass, Jason D Ulrich, David M Holtzma. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron vol issue 2022 36368315 apoe4 exacerbates tau-linked neurodegeneration and inflammation in p301s tau mice and removal of microglia blocks tau-dependent neurodegeneration. 2022-11-11 2022-11-21 Not clear
Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences vol issue 2022 36302379 dysfunctional microglia and tau pathology in alzheimer's disease. 2022-10-27 2022-11-01 Not clear
Gunel Ayyubov. Dysfunctional microglia and tau pathology in Alzheimer's disease. Reviews in the neurosciences vol issue 2022 36302379 loss of microglial neuroprotective and phagocytic functions, as indicated by the faulty clearance of amyloid plaques, as well as correlations between microglial activation and tau tangle spread, all demonstrate the critical involvement of malfunctioning microglia in driving tau propagation. 2022-10-27 2022-11-01 Not clear
Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M Reima. AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy. Aging vol 14 issue undefined 2022 36227739 we defined the mechanisms by which the chaperone atpase inhibitor ar12 and the multi-kinase inhibitor neratinib interacted to reduce expression of tau and amyloid-precursor protein (app) in microglia and neuronal cells. 2022-10-13 2022-10-25 Not clear
Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M Reima. AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy. Aging vol 14 issue undefined 2022 36227739 we conclude that ar12 has the potential to reduce tau and app levels in neurons and microglia via the actions of lap, endoplasmic reticulum stress signaling and macroautophagy. 2022-10-13 2022-10-25 Not clear
Nimansha Jain, Caroline A Lewis, Jason D Ulrich, David M Holtzma. Chronic TREM2 activation exacerbates A\\xce\\xb2-associated tau seeding and spreading. The Journal of experimental medicine vol 220 issue 1 2022 36219197 thus, microglia and trem2 are at a critical intersection of a\xce\xb2 and tau pathologies in ad. 2022-10-11 2022-10-25 Not clear
Lin Lin, Ronald S Petralia, Lynne Holtzclaw, Ya-Xian Wang, Daniel Abebe, Dax A Hoffma. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice. Neurobiology of disease vol issue 2022 36209950 the amyloid \xce\xb2 and phosphorylated tau pathologies were associated with neuroinflammation characterized by increases in microglia and astrocytes. 2022-10-09 2022-10-25 Not clear
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