All Relations between microtubule-associated protein tau and microglial cell

Reference Sentence Publish Date Extraction Date Species
Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine vol 14 issue 661 2022 36070367 weekly treatment of 5xfad mice (a model of ad) with ab18 tvd-ig/\xce\xb1tfr showed a considerable reduction of amyloid burden with increased microglia migration to and phagocytosis of amyloid plaques, improved synaptic and neuronal marker intensity, improved cognitive functions, reduced endogenous tau hyperphosphorylation, and decreased phosphorylated neurofilament h immunostaining. 2022-09-07 2022-09-14 Not clear
Boris-Stephan Rauchmann, Matthias Brendel, Nicolai Franzmeier, Lena Trappmann, Mirlind Zaganjori, Ersin Ersoezlue, Estrella Morenas-Rodriguez, Selim Guersel, Lena Burow, Carolin Kurz, Jan Haeckert, Maia Tat\\xc3\\xb2, Julia Utecht, Boris Papazov, Oliver Pogarell, Daniel Janowitz, Katharina Buerger, Michael Ewers, Carla Palleis, Endy Weidinger, Gloria Biechele, Sebastian Schuster, Anika Finze, Florian Eckenweber, Rainer Rupprecht, Axel Rominger, Oliver Goldhardt, Timo Grimmer, Daniel Keeser, Sophia Stoecklein, Olaf Dietrich, Peter Bartenstein, Johannes Levin, G\\xc3\\xbcnter H\\xc3\\xb6glinger, Robert Perneczk. Microglial Activation and Connectivity in Alzheimer Disease and Aging. Annals of neurology vol issue 2022 36053756 alzheimer disease (ad) is characterized by amyloid \xce\xb2 (a\xce\xb2) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven by the activation of microglia. 2022-09-02 2022-09-06 Not clear
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland) vol issue 2022 36054524 pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in alzheimer's disease, progressive supranuclear palsy, and dementia with lewy bodies. 2022-09-02 2022-09-06 Not clear
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland) vol issue 2022 36054524 microglia and astrocytes have been described as playing important roles in synaptic spreading of toxic tau in several neurodegenerative diseases (nds). 2022-09-02 2022-09-06 Not clear
Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland) vol issue 2022 36054524 by immunohistochemistry and co-immunofluorescence assays using toma/ttc-ms and cell-type specific markers for neurons, astrocytes, and microglia, we observed that toma/ttc-ms were immunoreactive to diverse tau species in different cell types. 2022-09-02 2022-09-06 Not clear
Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Pi\\xc3\\xb1a-Crespo, Huaxi Xu, Timothy Y Huan. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular neurodegeneration vol 17 issue 1 2022 36056435 trem2 deletion enhances tau dispersion and pathology through microglia exosomes. 2022-09-02 2022-09-06 Not clear
Qing Wang, Chunming Xi. Microglia activation linking amyloid-\\xce\\xb2 drive tau spatial propagation in Alzheimer's disease. Frontiers in neuroscience vol 16 issue 2022 36033617 microglia activation linking amyloid-\xce\xb2 drive tau spatial propagation in alzheimer's disease. 2022-08-29 2022-08-31 Not clear
Emily Sun, Aishat Motolani, Leonardo Campos, Tao L. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease. International journal of molecular sciences vol 23 issue 16 2022 36012242 some of these cell types and molecules include reactive microglia and astrocytes, \xce\xb2-secretase, apoe, glutamate, mirna, and tau protein, among others. 2022-08-26 2022-08-29 Not clear
Erin John Rieger de Almeida, H\\xc3\\xa9lio Jungkenn Ibrahim, Maria Rosa Chitolina Schetinger, Cinthia Melazzo de Andrade, Andr\\xc3\\xa9ia Machado Cardos. Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases. Neurochemical research vol issue 2022 35962936 in this context, ad is a neurodegenerative and neuroinflammatory disease characterized by the deposition of beta-amyloid plaques, formation of fibrillar tangles of tau protein, and loss of neurons due to neurotoxic activation of microglia. 2022-08-13 2022-08-15 Not clear
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. A\\xce\\xb2 and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines vol 10 issue 8 2022 35892700 a\xce\xb2 and tau regulate microglia metabolism via exosomes in alzheimer's disease. 2022-07-27 2022-08-08 Not clear
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. A\\xce\\xb2 and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines vol 10 issue 8 2022 35892700 the main targets are a\xce\xb2 and tau, but whether there is a causal relationship between neurodegenerative proteins, including a\xce\xb2 oligomer and tau oligomer, and regulation of microglia metabolism in neuroinflammation is still controversial. 2022-07-27 2022-08-08 Not clear
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. A\\xce\\xb2 and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines vol 10 issue 8 2022 35892700 currently, the accumulation of a\xce\xb2 and tau by exosomes or other means of propagation is proposed as a regulator in neurological disorders, leading to metabolic disorders of microglia that can play a key role in the regulation of immune cells. 2022-07-27 2022-08-08 Not clear
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing S. A\\xce\\xb2 and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer's Disease. Biomedicines vol 10 issue 8 2022 35892700 in this review, we propose that the accumulation of a\xce\xb2 oligomer and tau oligomer can propagate to adjacent microglia through exosomes and change the neuroinflammatory microenvironment by microglia metabolic reprogramming. 2022-07-27 2022-08-08 Not clear
Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud LaJoie, Adam M Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy P. Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults. Brain : a journal of neurology vol issue 2022 35869598 alternative models tested the role of microglia activation as the precipitating event (microglial activation\xe2\x86\x92 amyloid-\xce\xb2 \xe2\x86\x92 tau). 2022-07-23 2022-07-25 Not clear
Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud LaJoie, Adam M Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy P. Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults. Brain : a journal of neurology vol issue 2022 35869598 alternative models suggested that in women, microglial activation was a significant exposure both preceding the amyloid-\xce\xb2 to tau relationship (mediational effect: 50%, 95%ci 23-90) and directly related to tau burden (microglia direct effect: 50%, 95%ci 10-77). 2022-07-23 2022-07-25 Not clear
Torben Johann Hausrat, Philipp C Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneusse. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nature communications vol 13 issue 1 2022 35858909 disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. 2022-07-20 2022-07-25 Not clear
Torben Johann Hausrat, Philipp C Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneusse. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nature communications vol 13 issue 1 2022 35858909 notably, crossbreeding of the tuba4a knock-in mouse with the htau tauopathy model, expressing a human tau transgene, reversed hyper-phosphorylation and oligomerization of tau and normalized microglia activation in brain. 2022-07-20 2022-07-25 Not clear
Michael J Paidas, Daniela S Cosio, Saad Ali, Norma Sue Kenyon, Arumugam R Jayakuma. Long-Term Sequelae of COVID-19 in Experimental Mice. Molecular neurobiology vol issue 2022 35831558 these changes were associated with increased reactive astrocytes and microglia, hyperphosphorylated tdp-43 and tau, and a decrease in synaptic protein synaptophysin-1, suggesting the possible long-term impact of sars-cov-2 infection on defective neuronal integrity. 2022-07-13 2022-07-19 Not clear
Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell vol 29 issue 7 2022 35803230 in response to human brain tissue-derived pathological tau, ds microglia undergo cellular senescence and exhibit elevated type-i-interferon signaling. 2022-07-08 2022-07-11 Not clear
Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell vol 29 issue 7 2022 35803230 our findings provide in\xc2\xa0vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes. 2022-07-08 2022-07-11 Not clear
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