| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
notably, examination of ftl-positive microglia in cbd astrocytic plaques indicate a potential role for microglial involvement in the pathogenesis of these tau lesions. |
2024-04-08 |
2024-04-10 |
human |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
while the majority of microglia are similar across brain regions, we identified a specific subset unique to ec which may contribute to the early tau pathology present in this region. |
2024-04-01 |
2024-04-04 |
human |
| Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-Aad, Huan Li, Matthew P Frosch, Markus P Kummer, Sudeshna Das, Tammy Dellovade, Eric H Karran, Xavier Langlois, Janina S Ried, Alberto Serrano-Pozo, Robert V Talanian, Knut Biber, Bradley T Hyma. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta neuropathologica. vol 147. issue 1. 2024-04-01. PMID:38557897. |
we used expression patterns of early tau progression to identify genes whose expression is reversed along spreading of spatial tau pathology (ec > itg > pfc > v2 > v1) and identified their potential involvement in microglia subtype conversion to a diseased state. |
2024-04-01 |
2024-04-04 |
human |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
over-activated microglia is related to amyloid-beta (aβ) and phosphorylated tau (phospho-tau) accumulation in the ad brain. |
2024-03-29 |
2024-03-31 |
mouse |
| Tal Ganz, Tamir Ben-Hu. The "Hit and Run" Hypothesis for Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542219. |
this model, highlighting microglia as a pivotal player in risk factor-mediated neurodegeneration, offers a new point of view on the complex associations of modifiable risk factors and proteinopathy in ad pathogenesis, which may act in parallel to the thoroughly studied amyloid-driven tau pathology, and strengthens the therapeutic rationale of combining immune modulation with tight control of risk factor-driven insults. |
2024-03-28 |
2024-03-30 |
Not clear |
| Yeong Jin Kim, Bo-Ram Mun, Kyu Yeong Choi, Won-Seok Cho. Oral Administration of Probiotic Bacteria Alleviates Tau Phosphorylation, Aβ Accumulation, Microglia Activation, and Memory Loss in 5xFAD Mice. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539597. |
oral administration of probiotic bacteria alleviates tau phosphorylation, aβ accumulation, microglia activation, and memory loss in 5xfad mice. |
2024-03-28 |
2024-03-30 |
mouse |
| Jingji Wang, Yilan Zhen, Jun Yang, Shaojie Yang, Guoqi Zh. Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis? CNS neuroscience & therapeutics. vol 30. issue 3. 2024-03-22. PMID:38516808. |
accumulation of amyloid beta, tau hyperphosphorylation, and microglia activation are the three highly acknowledged pathological factors of alzheimer's disease (ad). |
2024-03-22 |
2024-03-24 |
Not clear |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
measuring antibody-mediated tau fibril uptake in microglia by flow cytometry. |
2024-03-21 |
2024-03-24 |
Not clear |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
data suggest that tau-specific antibodies act on extracellular tau aggregates by promoting uptake into microglia cells and thus preventing its prion-like spread to unaffected neurons. |
2024-03-21 |
2024-03-24 |
Not clear |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
here we describe a protocol to test the effect of tau-specific antibodies on tau uptake into microglia by flow cytometry. |
2024-03-21 |
2024-03-24 |
Not clear |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
uptake of tau into microglia is then assessed by measuring fluorescence intensity by flow cytometry. |
2024-03-21 |
2024-03-24 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512683. |
neuroinflammation is the brain condition that occurs due to the hyper-activation of brain's immune cells and microglia, over the stimulation of extracellular aggregated proteins such as amyloid plaques and by extracellular tau as well. |
2024-03-21 |
2024-03-24 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512683. |
the enhanced phagocytic ability of microglia might induce the clearance of extracellular aggregated proteins, such as amyloid beta and tau. |
2024-03-21 |
2024-03-24 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512683. |
in this study, we emphasized on the effect of α-linolenic acid (ala) on the activation of microglia and internalization of the extracellular tau seed in microglia. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
purinergic receptor p2y12-mediated tau internalization in microglia. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
in alzheimer's disease, microglia get over activated upon the accumulation of tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
microglia phagocytose the extracellular tau species by several mechanisms among which p2y12 receptor-mediated internalization of extracellular tau is recently studied. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
extracellular tau activates microglia and directly interacts with the p2y12 receptor. |
2024-03-21 |
2024-03-24 |
Not clear |
| Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Ba. Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model. Molecular nutrition & food research. 2024-03-16. PMID:38491393. |
in summary, this study demonstrates that prolonged hfd consumption exacerbates amyloid deposition, tau pathology, and cognitive deficits, which is associated with the accumulation of lipid droplets within microglia. |
2024-03-16 |
2024-03-19 |
mouse |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |