| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
we previously demonstrated that extracellular soluble tau triggers p38 mapk activation in microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
given the activation of this signaling pathway in ad and its involvement in neuroinflammation processes, here we evaluated the effect of p38 inhibition on primary microglia cultures subjected to tau treatment. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
our data showed that the toxic effect driven by tau in microglia was diminished through p38 inhibition. |
2022-01-10 |
2023-08-13 |
Not clear |
| Whitaker Cohn, Mikhail Melnik, Calvin Huang, Bruce Teter, Sujyoti Chandra, Chunni Zhu, Laura Beth McIntire, Varghese John, Karen H Gylys, Tina Bilousov. Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures. Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925024. |
our data suggest that loss of the homeostatic microglia signature in late ad stages may be accompanied by endolysosomal impairment and the release of undigested neuronal and myelin debris, including tau, through extracellular vesicles. |
2021-12-20 |
2023-08-13 |
human |
| Denisa Palova, Natalia Turic Csokova, Karina Markova, Eva Kontsekova, Branislav Kovacech, Monika Zilkov. The engagement of microglia in tau-targeted immunotherapy in Alzheimer's disease. General physiology and biophysics. vol 40. issue 6. 2021-12-13. PMID:34897021. |
in this review, we summarize activities of microglia in healthy and ad brains and their possible role during immunotherapy targeted against pathological tau proteins. |
2021-12-13 |
2023-08-13 |
Not clear |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged tupaia belangeri. |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
adult (mean age 3.8 years), old (mean age 6 years), and aged (mean age 7.5 years) tree shrews were used for histochemical and immunostaining techniques to determine ferritin and iba1 positive microglia, iron tissue content, tau hyperphosphorylation and oxidized-rna in dentate gyrus, subiculum, and ca1-ca3 hippocampal regions. |
2021-11-30 |
2023-08-13 |
Not clear |
| Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazaw. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34782623. |
tau activates microglia via the pqbp1-cgas-sting pathway to promote brain inflammation. |
2021-11-30 |
2023-08-13 |
mouse |
| Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. |
our study showed that pd mice with tau intervention recovered motor and non-motor functions to some extent, and the number of dopaminergic (dac) neurons in the substantia nigra and the level of dopamine (da) secretion in the striatum were also significantly increased compared with the pq-dyed group, and the protein content of pi3k and pdk-1 and the phosphorylation level of akt were reduced in parallel with the reduction in the expression of microglia and related inflammatory factors. |
2021-11-27 |
2023-08-13 |
mouse |
| Samantha M Rossano, William Charles Kreis. Untangling the relationship between microglia and tau in Alzheimer's disease. Trends in neurosciences. vol 44. issue 12. 2021-11-25. PMID:34674877. |
untangling the relationship between microglia and tau in alzheimer's disease. |
2021-11-25 |
2023-08-13 |
Not clear |
| Liang Chen, Yi-Ping Zhou, Hua-Yi Liu, Juan-Hua Gu, Xin-Fu Zhou, Zeng Yue-Qi. Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice. Neurochemistry international. vol 151. 2021-11-18. PMID:34601013. |
after 9 months of treatment, we found that hyperoside can improve spatial learning and memory in app/ps1 transgenic mice, reduce amyloid plaque deposition and tau phosphorylation, decrease the number of activated microglia and astrocytes, and attenuate neuroinflammation and oxidative stress in the brain of app/ps1 mice. |
2021-11-18 |
2023-08-13 |
mouse |
| Emma Gerrits, Nieske Brouwer, Susanne M Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, Jan Mulder, Markus Kummer, Thomas Möller, Knut Biber, Wilfred F A den Dunnen, Peter P De Deyn, Bart J L Eggen, Erik W G M Boddek. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33609158. |
how increasing levels of amyloid-β and tau pathology affect human microglia transcriptional profiles is unknown. |
2021-11-16 |
2023-08-13 |
mouse |
| Emma Gerrits, Nieske Brouwer, Susanne M Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, Jan Mulder, Markus Kummer, Thomas Möller, Knut Biber, Wilfred F A den Dunnen, Peter P De Deyn, Bart J L Eggen, Erik W G M Boddek. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33609158. |
the ad2-microglia abundance strongly correlated with tissue phospho-tau load and these microglia were more abundant in samples with overt tau pathology. |
2021-11-16 |
2023-08-13 |
mouse |
| Miren Ettcheto, Amanda Cano, Elena Sanchez-López, Ester Verdaguer, Jaume Folch, Carme Auladell, Antoni Camin. Masitinib for the treatment of Alzheimer's disease. Neurodegenerative disease management. vol 11. issue 4. 2021-11-15. PMID:34412534. |
masitinib is a potent and selective phenylaminothiazole-type tyrosine kinase inhibitor which is currently in phase iii studies for the treatment of alzheimer's disease (ad) with the aim of modifying its evolution and with multiple pharmacological targets such as inhibition of mast cells activity, inhibition of microglia activation, modulation of aβ and tau protein signaling pathway and prevention of synaptic damage. |
2021-11-15 |
2023-08-13 |
Not clear |
| Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Li. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases. Translational neurodegeneration. vol 10. issue 1. 2021-11-13. PMID:34753506. |
pathological tau, which is detached from axonal microtubules and mislocalized into pre- and postsynaptic neuronal compartments, is suggested to induce synaptic dysfunction in several ways, including reducing mobility and release of presynaptic vesicles, decreasing glutamatergic receptors, impairing the maturation of dendritic spines at postsynaptic terminals, disrupting mitochondrial transport and function in synapses, and promoting the phagocytosis of synapses by microglia. |
2021-11-13 |
2023-08-13 |
Not clear |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. |
tau was strongly expressed in mature oligodendrocytes and displayed little to no expression in oligodendrocyte precursor cells, astrocytes or microglia. |
2021-11-12 |
2023-08-13 |
rat |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
indeed, while p2x7-deficiency had a moderate effect on tau pathology itself, we observed a significant reduction of microglia activation and of tau-related inflammatory mediators, particularly ccl4. |
2021-11-11 |
2023-08-13 |
mouse |
| You Jung Kang, Hsih-Yin Tan, Charles Y Lee, Hansang Ch. An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 8. issue 21. 2021-11-11. PMID:34561961. |
finally, it is observed that additional proinflammatory mediators and nitric oxide released from the m1 microglia exacerbate neuronal damages, such as synaptic impairment, phosphoric tau accumulation, and neuronal death. |
2021-11-11 |
2023-08-13 |
human |
| Vanessa Laversenne, Sameer Nazeeruddin, Emma C Källstig, Philippe Colin, Christel Voize, Bernard L Schneide. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33225991. |
anti-aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. |
2021-11-09 |
2023-08-13 |
mouse |