| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ramón Perea, Marta Bolós, Jesús Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33066368. |
microglia in alzheimer's disease in the context of tau pathology. |
2021-09-07 |
2023-08-13 |
Not clear |
| Juan Ramón Perea, Marta Bolós, Jesús Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33066368. |
in this review, we summarize the most recent studies on the physiological and pathological functions of tau protein and microglia. |
2021-09-07 |
2023-08-13 |
Not clear |
| Clara Y B Low, Jasinda H Lee, Frances T W Lim, Chingli Lee, Clive Ballard, Paul T Francis, Mitchell K P Lai, Michelle G K Ta. Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias. Brain pathology (Zurich, Switzerland). vol 31. issue 2. 2021-09-04. PMID:33128789. |
furthermore, increased fynt expression correlated with hallmark neuropathological lesions, soluble β-amyloid, and phosphorylated tau, as well as markers of microglia and astrocyte activation. |
2021-09-04 |
2023-08-13 |
mouse |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
what is more, we observed that microglia-derived neuroinflammation resulting from sirt1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. |
2021-09-02 |
2023-08-13 |
rat |
| Yasmine V Doust, Anna E King, Jenna M Ziebel. Implications for microglial sex differences in tau-related neurodegenerative diseases. Neurobiology of aging. vol 105. 2021-08-27. PMID:34174592. |
dystrophic and dysfunctional microglia are associated with tau pathology in the healthy and diseased brain which is proposed to contribute to disease development and progression. |
2021-08-27 |
2023-08-13 |
Not clear |
| Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikez. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:32811520. |
microglia can spread tau pathology by secreting tau-containing exosomes, although the specific molecular target is yet to be identified for the therapeutic intervention. |
2021-08-26 |
2023-08-13 |
mouse |
| Mara Mathe. Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease? Seminars in cell & developmental biology. vol 116. 2021-08-23. PMID:34099360. |
via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-β and tau in various brain regions. |
2021-08-23 |
2023-08-13 |
Not clear |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old htau mice. |
2021-08-18 |
2023-08-13 |
mouse |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
while the role of microglia and peripheral macrophages in regulating amyloid beta pathology has been well characterized, the impact of these distinct cell subsets on tau pathology remains poorly understood. |
2021-08-18 |
2023-08-13 |
mouse |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
we undertook the current study to investigate the regulation of tau pathology by microglia and peripheral macrophages using htau transgenic mice, which do not exhibit microglial activation/pathology or macrophage engraftment. |
2021-08-18 |
2023-08-13 |
mouse |
| Keying Zhu, Melanie Pieber, Jinming Han, Klas Blomgren, Xing-Mei Zhang, Robert A Harris, Harald Lun. Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice. Glia. vol 68. issue 7. 2021-08-18. PMID:32039516. |
to assess the direct impact of microglia on tau pathology we developed a protocol for long-term microglial depletion in cx3cr1 |
2021-08-18 |
2023-08-13 |
mouse |
| Patrick Jarmo Paasila, Danielle Suzanne Davies, Greg Trevor Sutherland, Claire Goldsbur. Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of Aβ plaques in Alzheimer's disease. Free neuropathology. vol 1. 2021-08-17. PMID:34396367. |
this shows that tau positive neuritic plaques begin early in ad which is likely of pathogenic importance, however major tau deposition follows the accumulation of aβ and clustering of activated microglia. |
2021-08-17 |
2023-08-13 |
human |
| Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. |
the anesthetic sevoflurane induces tau trafficking from neurons to microglia. |
2021-08-12 |
2023-08-13 |
mouse |
| Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. |
we hypothesized that tau traffics from neurons to microglia via extracellular vesicles (evs), leading to il-6 generation and cognitive impairment. |
2021-08-12 |
2023-08-13 |
mouse |
| Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. |
microglia from tau knockout mice took up tau and p-tau when treated with sevoflurane-conditioned neuron culture medium, leading to il-6 generation. |
2021-08-12 |
2023-08-13 |
mouse |
| Yuanlin Dong, Feng Liang, Lining Huang, Fang Fang, Guang Yang, Rudolph E Tanzi, Yiying Zhang, Qimin Quan, Zhongcong Xi. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Communications biology. vol 4. issue 1. 2021-08-12. PMID:33980987. |
thus, tau trafficking could occur from neurons to microglia to generate il-6, leading to cognitive impairment. |
2021-08-12 |
2023-08-13 |
mouse |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized app mouse model. |
2021-07-31 |
2023-08-13 |
mouse |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
recent studies suggest that microglia contribute to tau pathology progression in alzheimer's disease. |
2021-07-31 |
2023-08-13 |
mouse |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-07-31. PMID:33752701. |
amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (mgnd), which exhibit enhanced phagocytosis of plaques, apoptotic neurons and dystrophic neurites containing aggregated and phosphorylated tau (p-tau). |
2021-07-31 |
2023-08-13 |
mouse |
| Chunmei Liang, Ting Zou, Miaoping Zhang, Weihao Fan, Tianzhen Zhang, Yuling Jiang, Yujie Cai, Feng Chen, Xiongjin Chen, Yuanhong Sun, Bin Zhao, Yan Wang, Lili Cu. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease. Theranostics. vol 11. issue 9. 2021-07-29. PMID:33754051. |
microglia can be neuroprotective by degrading and removing aβ and tau. |
2021-07-29 |
2023-08-13 |
mouse |