| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Connor M Wander, Jui-Heng Tseng, Sheng Song, Heba A Al Housseiny, Dalton S Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B Meeker, David J Irwin, Todd J Cohe. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. vol 23. issue 7. 2021-05-11. PMID:32585593. |
high-resolution imaging and 3d reconstruction suggest a link between tau clusters, reactive astrocytes, and microglia, indicating that early tau accumulation may promote neuroinflammation during aging. |
2021-05-11 |
2023-08-13 |
mouse |
| Mar Carmona-Abellan, Ivan Martinez-Valbuena, Irene Marcilla, Carla DiCaudo, Isabel Gil, Jorge Nuñez, Maria-Rosario Luqui. Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 4. 2021-05-10. PMID:32816165. |
the presence of microglia is related to phosphorylated tau deposits in neurodegenerative diseases. |
2021-05-10 |
2023-08-13 |
human |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis. Traffic (Copenhagen, Denmark). vol 22. issue 5. 2021-05-10. PMID:33527700. |
microglia sense the extracellular tau through several cell-surface receptors and mediate chemotaxis and phagocytosis. |
2021-05-10 |
2023-08-13 |
Not clear |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis. Traffic (Copenhagen, Denmark). vol 22. issue 5. 2021-05-10. PMID:33527700. |
the extracellular tau species directly interacted with p2y12r and also induced this purinoceptor expression in microglia. |
2021-05-10 |
2023-08-13 |
Not clear |
| Chiara Braschi, Simona Capsoni, Roberta Narducci, Andrea Poli, Gabriele Sansevero, Rossella Brandi, Lamberto Maffei, Antonino Cattaneo, Nicoletta Berard. Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis. Aging clinical and experimental research. vol 33. issue 5. 2021-04-30. PMID:32676979. |
the strong improvement in memory performance in bdnf-treated mice was not accompanied by an amelioration of ad-like pathology, aβ burden, tau hyperphosphorylation and cholinergic deficit, but there was a dramatic decrease of cd11b immunoreactive brain microglia. |
2021-04-30 |
2023-08-13 |
mouse |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
it is clear that the classic pathologies of amyloid β (aβ) and tau are usually accompanied by the activation of microglia, and the activation of microglia also serves as an early event in the pathogenesis of ad. |
2021-04-28 |
2023-08-13 |
Not clear |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
apoe-expressing microglia accumulates around aβ plaques, and the presence of apoe4 may disrupt the phagocytosis of aβ aggregates and aggravate neurodegeneration in tau disease models. |
2021-04-28 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Tapan Behl, Rasha A Mansouri, Akram Ahmed Aloqbi, Asma Perveen, Abdul Hafeez, Ghulam Md Ashra. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current pharmaceutical design. vol 27. issue 3. 2021-04-26. PMID:32473620. |
the sustained activation of the microglia, the brain's resident macrophages, and other immune cells has been shown to aggravate both tau and amyloid pathology and may consider as a connection in the ad pathogenesis. |
2021-04-26 |
2023-08-13 |
Not clear |
| Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C Saido, Seiko Ikezu, Tsuneya Ikez. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular neurodegeneration. vol 16. issue 1. 2021-04-18. PMID:33853665. |
correction to: plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized app mouse model. |
2021-04-18 |
2023-08-13 |
mouse |
| Huifangjie Li, William C Knight, Pengfei Yang, Yingqiu Guo, Joel S Perlmutter, John C Morris, Randall J Bateman, Tammie L S Benzinger, Jinbin X. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype. International journal of molecular sciences. vol 21. issue 17. 2021-04-09. PMID:32842621. |
to test the correlations of microglia dystrophy and tauopathy, we quantified translocator protein (tspo) and tau fibrils using autoradiography. |
2021-04-09 |
2023-08-13 |
Not clear |
| Rebecca M Fleeman, Elizabeth A Procto. Astrocytic Propagation of Tau in the Context of Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-04-06. PMID:33815065. |
while the contribution of microglia to tau processing and propagation is beginning to be recognized and understood, astrocytes, glial cells in the brain important for maintaining neuronal metabolic, synaptic, trophic, and immune function which can produce, internalize, degrade, and propagate tau are understudied in their ability to affect ad progression through tau pathology. |
2021-04-06 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. |
α- linolenic acid modulates phagocytosis and endosomal pathways of extracellular tau in microglia. |
2021-04-02 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. |
the extracellular burden of amyloid-β plaques and tau seed fabricate the activation of microglia. |
2021-04-02 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. |
the increased phagocytosis of extracellular tau monomer and aggregates have been observed upon ala exposure to microglia cells. |
2021-04-02 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Subashchandrabose Chinnathamb. α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. Cell adhesion & migration. vol 15. issue 1. 2021-04-02. PMID:33724164. |
our results suggest that microglia could be influenced to reduce extracellular tau seed with dietary fatty acids. |
2021-04-02 |
2023-08-13 |
Not clear |
| Junling Yang, Leslie Wise, Ken-Ichiro Fukuch. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in immunology. vol 11. 2021-03-31. PMID:32391019. |
aβ fibrils and tau aggregates in the brain are closely associated with neuroinflammation and synapse loss, characterized by activated microglia and dystrophic neurites. |
2021-03-31 |
2023-08-13 |
Not clear |
| Dipro Bose, Punnag Saha, Ayan Mondal, Brian Fanelli, Ratanesh K Seth, Patricia Janulewicz, Kimberly Sullivan, Stephen Lasley, Ronnie Horner, Rita R Colwell, Ashok K Shetty, Nancy Klimas, Saurabh Chatterje. Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. vol 12. issue 9. 2021-03-26. PMID:32927823. |
microbial dysbiosis was also associated with frontal cortex levels of increased il6 and il1β, activated microglia, decreased levels of brain derived neurotrophic factor (bdnf), and higher accumulation of phosphorylated tau, an indicator of neuroinflammation-led increased risk of cognitive deficiencies. |
2021-03-26 |
2023-08-13 |
mouse |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. |
therefore, omvs increase the permeability of the bbb and promote the activation of astrocytes and microglia, inducing an inflammatory response and tau hyperphosphorylation by activating the gsk-3β pathway and finally leading to cognitive impairment. |
2021-03-08 |
2023-08-13 |
Not clear |
| Lisi Flores-Aguilar, M Florencia Iulita, Olivia Kovecses, Maria D Torres, Sarah M Levi, Yian Zhang, Manor Askenazi, Thomas Wisniewski, Jorge Busciglio, A Claudio Cuell. Evolution of neuroinflammation across the lifespan of individuals with Down syndrome. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33206953. |
moreover, an increase in dystrophic microglia and rod-like microglia aligning to neurons harbouring tau pathology were also observed. |
2021-03-01 |
2023-08-13 |
human |