All Relations between microtubule-associated protein tau and microglial cell

Publication Sentence Publish Date Extraction Date Species
Rashmi Das, Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia. Journal of neuroinflammation. vol 17. issue 1. 2020-11-09. PMID:31915009. phagocytosis of full-length tau oligomers by actin-remodeling of activated microglia. 2020-11-09 2023-08-13 Not clear
Lei Zhu, Zhen Zhang, Xiao-Jie Hou, Yong-Feng Wang, Jing-Yu Yang, Chun-Fu W. Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model. Brain research. vol 1722. 2020-10-21. PMID:31344367. in summary, these data suggested that yonk significantly reversed stz-induced memory deficits by inhibiting the over-activation of microglia and astrocytes, as well as ameliorated the levels of pro-inflammatory makers and tau hyperphosphorylation through regulating gsk3β signalling pathway. 2020-10-21 2023-08-13 mouse
Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. genetic deletion of bin1 from microglia resulted in reduction of tau secretion via extracellular vesicles in vitro, and in decrease of tau spreading in vivo in male, but not female, mice, in the context of ps19 background. 2020-10-13 2023-08-13 mouse
Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. interestingly, ablation of bin1 in microglia of male mice resulted in significant reduction in the expression of heat-shock proteins, previously implicated in tau proteostasis. 2020-10-13 2023-08-13 mouse
Andrea Crotti, Hameetha Rajamohamend Sait, Kathleen M McAvoy, Karol Estrada, Ayla Ergun, Suzanne Szak, Galina Marsh, Luke Jandreski, Michael Peterson, Taylor L Reynolds, Isin Dalkilic-Liddle, Andrew Cameron, Ellen Cahir-McFarland, Richard M Ransohof. BIN1 favors the spreading of Tau via extracellular vesicles. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263146. these observations suggest that bin1 could contribute to the progression of ad-related tau pathology by altering tau clearance and promoting release of tau-enriched extracellular vesicles by microglia. 2020-10-13 2023-08-13 mouse
Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. however, whether decrease level of trem2 assists pathology of tau through changed clearance and pathological escalation of tau or through direct contact between microglia and neuron and any alternative possible mechanisms need to examine. 2020-10-06 2023-08-13 Not clear
Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset. Frontiers in aging neuroscience. vol 8. 2020-10-01. PMID:28066237. evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. 2020-10-01 2023-08-13 marmoset
Liping Chen, Chunhui Huang, Jieyi Shentu, Minjun Wang, Sicheng Yan, Fei Zhou, Zaijun Zhang, Chuang Wang, Yifan Han, Qinwen Wang, Wei Cu. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:29234273. those results suggested that 7bio could potently inhibit aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, and activation of astrocytes and microglia, which may contribute to the neuroprotective effects of 7bio. 2020-10-01 2023-08-13 mouse
Kanchan Bisht, Kaushik Sharma, Marie-Ève Trembla. Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. Neurobiology of stress. vol 9. 2020-10-01. PMID:29992181. while microglia have been causally linked to amyloid beta (aβ) accumulation, tau pathology, neurodegeneration, and synaptic loss in ad, they were also attributed beneficial roles, notably in the phagocytic elimination of aβ. 2020-10-01 2023-08-13 Not clear
Juan R Perea, María Llorens-Martín, Jesús Ávila, Marta Boló. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30042659. the role of microglia in the spread of tau: relevance for tauopathies. 2020-10-01 2023-08-13 Not clear
Ricardo B Maccioni, Andrea González, Víctor Andrade, Nicole Cortés, José Pablo Tapia, Leonardo Guzmán-Martíne. Alzheimer´s Disease in the Perspective of Neuroimmunology. The open neurology journal. vol 12. 2020-10-01. PMID:30069256. in the ad, a continuous activation state of microglia appears to generate neuronal injury and neurodegeneration, producing the outflow of pathological tau from the inner of neurons to the extraneuronal space. 2020-10-01 2023-08-13 Not clear
Ricardo B Maccioni, Andrea González, Víctor Andrade, Nicole Cortés, José Pablo Tapia, Leonardo Guzmán-Martíne. Alzheimer´s Disease in the Perspective of Neuroimmunology. The open neurology journal. vol 12. 2020-10-01. PMID:30069256. released tau, together with the contribution of apoe4 protein, would then produce reactivation of microglia, thus inducing a positive feedback that stimulates the vicious cycle in neurodegeneration. 2020-10-01 2023-08-13 Not clear
Atsuko Katsumoto, Hideyuki Takeuchi, Keita Takahashi, Fumiaki Tanak. Microglia in Alzheimer's Disease: Risk Factors and Inflammation. Frontiers in neurology. vol 9. 2020-10-01. PMID:30498474. we also discuss the mechanisms of inflammasomes and neurotransmitters in microglia, which accelerate the development of amyloid-β and tau pathology. 2020-10-01 2023-08-13 mouse
Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. anti-tau antibodies have been shown to reduce tau pathology in in vivo models and antibody-mediated clearance of tau exerted by microglia has been proposed as a contributing factor. 2020-10-01 2023-08-13 mouse
Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. by subjecting primary microglia cultured in vitro to anti-phospho-tau antibodies in complex with pathological tau, we show that microglia internalise and degrade tau in a manner that is dependent on fcγr interaction and functional lysosomes. 2020-10-01 2023-08-13 mouse
Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. we further demonstrate that microglia activation alone is not sufficient to induce significant tau clearance. 2020-10-01 2023-08-13 mouse
Juan Ramón Perea, Esther López, José Carlos Díez-Ballesteros, Jesús Ávila, Félix Hernández, Marta Boló. Extracellular Monomeric Tau Is Internalized by Astrocytes. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31118883. however, in a group of neurodegenerative diseases named tauopathies - characterized by an increase in aggregated and/or hyperphosphorylated tau - the protein accumulates inside other cells, such as astrocytes and microglia. 2020-10-01 2023-08-13 Not clear
Juan Ramón Perea, Esther López, José Carlos Díez-Ballesteros, Jesús Ávila, Félix Hernández, Marta Boló. Extracellular Monomeric Tau Is Internalized by Astrocytes. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31118883. here we studied whether monomeric tau, which has been observed to be internalized by glial cells such as microglia, was also taken up by astrocytes. 2020-10-01 2023-08-13 Not clear
Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. phagocytosis of apoptotic cells is specifically upregulated in apoe4 expressing microglia alzheimer's disease (ad) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (aβ). 2020-10-01 2023-08-13 human
Marianna Alves, Aidan Kenny, Gioacchino de Leo, Edward H Beamer, Tobias Enge. Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31780921. chronic epilepsy in mice also resulted in a strong localization of at8 phospho-tau to microglia, indicating a distinct pattern of tau hyperphosphorylation during chronic epilepsy compared to status epilepticus. 2020-10-01 2023-08-13 mouse