| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefe. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia. Neurobiology of disease. vol 130. 2020-03-24. PMID:31229689. |
asparagine endopeptidase cleaves tau at n167 after uptake into microglia. |
2020-03-24 |
2023-08-13 |
Not clear |
| Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefe. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia. Neurobiology of disease. vol 130. 2020-03-24. PMID:31229689. |
accordingly, we observe tau cleavage at n167 and n368 after endocytotic uptake into microglia, but not neurons. |
2020-03-24 |
2023-08-13 |
Not clear |
| Kathleen M McAvoy, Hameetha Rajamohamed Sait, Galina Marsh, Michael Peterson, Taylor L Reynolds, Jake Gagnon, Sarah Geisler, Prescott Leach, Chris Roberts, Ellen Cahir-McFarland, Richard M Ransohoff, Andrea Crott. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PloS one. vol 14. issue 8. 2020-03-03. PMID:31408457. |
taken together, our data suggest that the contribution of genetic variation in bin1 locus to ad risk could result from a cell-autonomous reduction of neuronal excitability due to bin1 decrease, exacerbated by the presence of aggregated tau, coupled with a non-cell autonomous microglia activation. |
2020-03-03 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
living neurons with tau filaments aberrantly expose phosphatidylserine and are phagocytosed by microglia. |
2020-01-27 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
consequently, co-cultured phagocytes (bv2 cells or primary microglia) identify and phagocytose the living neurons, thereby engulfing insoluble tau inclusions. |
2020-01-27 |
2023-08-13 |
mouse |
| Jack Brelstaff, Aviva M Tolkovsky, Bernardino Ghetti, Michel Goedert, Maria Grazia Spillantin. Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134156. |
to facilitate engulfment, neurons induce contacting microglia to secrete the opsonin milk-fat-globule egf-factor-8 (mfge8) and nitric oxide (no), whereas neurons with tau inclusions are rescued when mfge8 or no production is prevented. |
2020-01-27 |
2023-08-13 |
mouse |
| Cira Dansokho, Michael Thomas Henek. Neuroinflammatory responses in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 5. 2019-11-04. PMID:29273951. |
this review discusses recent knowledge on microglia responses toward amyloid and tau pathology in ad, focusing on the role of toll-like receptors and nod-like receptor protein 3 (nlrp3) inflammasome activation in microglial cells. |
2019-11-04 |
2023-08-13 |
mouse |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, Emily L Munger, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of comparative neurology. vol 526. issue 18. 2019-10-28. PMID:30069930. |
activated microglia density and morphology were not associated with age, sex, pretangle density, nft density, or tau neuritic cluster density. |
2019-10-28 |
2023-08-13 |
human |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, Emily L Munger, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of comparative neurology. vol 526. issue 18. 2019-10-28. PMID:30069930. |
in contrast to human ad brains, activated microglia density was not significantly correlated with tau lesions. |
2019-10-28 |
2023-08-13 |
human |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial priming of antigen presentation and adaptive stimulation in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 76. issue 19. 2019-10-17. PMID:31093687. |
primed microglia process and present self-antigen such as amyloid-β and modified tau to the infiltrated t lymphocytes through mhc i/ii molecules. |
2019-10-17 |
2023-08-13 |
Not clear |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915328. |
similar to what was observed in tau brains, overexpressing mir142 in wildtype cortical neurons augments mrna levels of glial fibrillary acidic protein (gfap) and colony stimulating factor 1 (csf1), accompanied by a significant increase in microglia and reactive astrocyte numbers. |
2019-10-09 |
2023-08-13 |
mouse |
| Shorena Janelidze, Niklas Mattsson, Erik Stomrud, Olof Lindberg, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30054439. |
to measure csf levels of biomarkers reflecting microglia and astrocytes activation, neuroinflammation, and cerebrovascular changes and study their associations with the core biomarkers of alzheimer disease (ad) pathology (β-amyloid [aβ] and tau), structural imaging correlates, and clinical disease progression over time. |
2019-08-19 |
2023-08-13 |
Not clear |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
therefore, we investigated the effects of intracerebroventricular administration of adomet on redox homeostasis, microglia activation, synaptophysin levels, and tau phosphorylation in cerebral cortex and striatum of young rats. |
2019-08-06 |
2023-08-13 |
rat |
| Bianca Seminotti, Ângela Zanatta, Rafael Teixeira Ribeiro, Mateus Struecker da Rosa, Angela T S Wyse, Guilhian Leipnitz, Moacir Wajne. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30058022. |
finally, we verified that adomet produced microglia activation by increasing iba1 staining and tau phosphorylation, as well as reduced synaptophysin levels in cerebral cortex. |
2019-08-06 |
2023-08-13 |
rat |
| Sho Takatori, Wenbo Wang, Akihiro Iguchi, Taisuke Tomit. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747419. |
we further describe the involvement of microglia in tau pathology and the activation of other glial cells. |
2019-08-02 |
2023-08-13 |
Not clear |
| b' Alana N Vagnozzi, Phillip F Giannopoulos, Domenico Pratic\\xc3\\xb. Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice. Aging cell. vol 17. issue 1. 2019-07-30. PMID:29106033.' |
over-expression of 5lo resulted in microglia and astrocyte activation and significant synaptic pathology, which was associated with a significant elevation of tau phosphorylation at specific epitopes, tau insoluble fraction, and activation of the cdk5 kinase. |
2019-07-30 |
2023-08-13 |
mouse |
| Melanie Dani, Melanie Wood, Ruth Mizoguchi, Zhen Fan, Zuzana Walker, Richard Morgan, Rainer Hinz, Maya Biju, Tarun Kuruvilla, David J Brooks, Paul Ediso. Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30052812. |
we investigated the relationship between amyloid plaques, tau tangles and activated microglia using pet imaging. |
2019-07-17 |
2023-08-13 |
human |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
cell-based assay to study antibody-mediated tau clearance by microglia. |
2019-05-20 |
2023-08-13 |
mouse |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
one of the proposed mechanisms by which therapeutic antibodies reduce pathology is antibody-mediated uptake and clearance of pathological aggregated forms of tau by microglia. |
2019-05-20 |
2023-08-13 |
mouse |
| Donata De Marco, Renske Taggenbrock, Rosa Crespo, Wouter Koudstaal, Elizabeth Ramsburg, Adrian Apetr. Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia. Journal of visualized experiments : JoVE. issue 141. 2019-05-20. PMID:30474638. |
here, we describe a quantitative cell-based assay to assess tau uptake by microglia. |
2019-05-20 |
2023-08-13 |
mouse |