Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
protein cytokine arrays, real-time pcr, inhibition of the p38 mapk pathway, phosphatase assays, and quantification of proteins through immunoblotting were used to analyze the effect of extracellular tau on the pro-inflammatory response of microglia. |
2019-03-21 |
2023-08-13 |
Not clear |
Juan Ramón Perea, Jesús Ávila, Marta Boló. Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway. Experimental neurology. vol 310. 2019-03-21. PMID:30138606. |
the main finding of this work is that extracellular non-phosphorylated and dephosphorylated forms of tau, rather than hyperphosphorylated tau, activate the p38 mapk pathway in microglia, thus triggering a pro-inflammatory response in these cells. |
2019-03-21 |
2023-08-13 |
Not clear |
Rachel E Bennett, Annie Bryant, Miwei Hu, Ashley B Robbins, Sarah C Hopp, Bradley T Hyma. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30413160. |
partial reduction of microglia does not affect tau pathology in aged mice. |
2019-01-29 |
2023-08-13 |
mouse |
Rachel E Bennett, Annie Bryant, Miwei Hu, Ashley B Robbins, Sarah C Hopp, Bradley T Hyma. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30413160. |
the goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute to tau protein accumulation and pathology-associated changes in immune and non-immune cell processes such as neuronal degeneration, astrocyte physiology, cytokine expression, and blood vessel morphology. |
2019-01-29 |
2023-08-13 |
mouse |
David V Hansen, Jesse E Hanson, Morgan Shen. Microglia in Alzheimer's disease. The Journal of cell biology. vol 217. issue 2. 2018-12-12. PMID:29196460. |
microglia can mediate synapse loss by engulfment of synapses, likely via a complement-dependent mechanism; they can also exacerbate tau pathology and secrete inflammatory factors that can injure neurons directly or via activation of neurotoxic astrocytes. |
2018-12-12 |
2023-08-13 |
human |
Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
the role of microglia in processing and spreading of bioactive tau seeds in alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
however, recent studies as well as the data contained herein suggest that microglia, the resident immune cells of the central nervous system, play a direct role in the spread of tau pathology. |
2018-12-11 |
2023-08-13 |
Not clear |
Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulia. SPECT and PET imaging in Alzheimer's disease. Annals of nuclear medicine. vol 32. issue 9. 2018-11-02. PMID:30128693. |
beta-amyloid (aβ) deposition and neurofibrillary tangles (nfts) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. |
2018-11-02 |
2023-08-13 |
human |
Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulia. SPECT and PET imaging in Alzheimer's disease. Annals of nuclear medicine. vol 32. issue 9. 2018-11-02. PMID:30128693. |
intense efforts in radiopharmaceuticals research have led to the development of various probes able to detect aβ deposits, tau protein accumulation, microglia activation and neuroinflammation. |
2018-11-02 |
2023-08-13 |
human |
Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
in this study, by employing a microglial-neuronal co-culture model, we showed that microglial inflammatory response induced by lipopolysaccharide led to tau hyperphosphorylation in neurons via activation of a major tau kinase glycogen synthase kinase 3β, confirming the pathogenic effects of activated microglia on the progression of tau pathology. |
2018-10-10 |
2023-08-13 |
mouse |
Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
more importantly, by manipulating trem2 levels in microglia with a lentiviral-mediated strategy, we demonstrated that trem2 ameliorated the pathological effects of activated microglia on neuronal tau hyperphosphorylation via suppression of microglial inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
Elizabeth E Spangenberg, Kim N Gree. Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models. Brain, behavior, and immunity. vol 61. 2018-08-10. PMID:27395435. |
use of these models has identified roles of microglia in several pathological facets of ad, including tau propagation, synaptic stripping, neuronal loss, and cognitive decline. |
2018-08-10 |
2023-08-13 |
Not clear |
Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avil. Absence of CX3CR1 impairs the internalization of Tau by microglia. Molecular neurodegeneration. vol 12. issue 1. 2018-06-12. PMID:28810892. |
absence of cx3cr1 impairs the internalization of tau by microglia. |
2018-06-12 |
2023-08-13 |
Not clear |
Christian Humpe. Platelets: Their Potential Contribution to the Generation of Beta-amyloid Plaques in Alzheimer's Disease. Current neurovascular research. vol 14. issue 3. 2018-05-14. PMID:28677497. |
alzheimer's disease is a severe neurodegenerative brain disorder, showing severe beta-amyloid depositions in the brain (plaques) and in vessels (cerebral amyloid angiopathy, caa), tau pathology, neurodegeneration (and loss of acetylcholine), inflammation with reactive astrocytes and microglia and cerebrovascular damage, all resulting in memory loss. |
2018-05-14 |
2023-08-13 |
Not clear |
Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
activated microglia, astrocytes and elevated levels of proinflammatory molecules are also pathological hallmarks that are found in brain regions affected by tau pathology. |
2018-04-17 |
2023-08-13 |
Not clear |
Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
we consider a physical role for microglia in the spread of tau pathology as well as the non-cell autonomous effects of secreted proinflammatory cytokines, specifically interleukin 1 beta, interleukin 6, tumor necrosis factor alpha and complement proteins. |
2018-04-17 |
2023-08-13 |
Not clear |
Viktoria Johansson, Joel Jakobsson, Rebecca G Fortgang, Henrik Zetterberg, Kaj Blennow, Tyrone D Cannon, Christina M Hultman, Lennart Wetterberg, Mikael Landé. Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders. European archives of psychiatry and clinical neuroscience. vol 267. issue 5. 2018-01-30. PMID:28039552. |
markers of microglia activation [monocyte chemoattractant protein-1 (mcp-1), chitinase 3-like protein 1 (ykl-40), and soluble cluster of differentiation 14 (scd14)], markers of β-amyloid metabolism (aβx-38, aβx-40, aβx-42 and aβ1-42), soluble amyloid precursor proteins (sapp-α and sapp-β), total tau (t-tau), phosphorylated tau (p-tau), and csf/serum albumin ratio were measured in csf using immunoassays. |
2018-01-30 |
2023-08-13 |
Not clear |
Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
only the full-effector antibody enhanced tau uptake in cultured microglia, which promoted release of proinflammatory cytokines. |
2018-01-16 |
2023-08-13 |
mouse |
Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
in neuron-microglia co-cultures, only effectorless anti-tau protected neurons, suggesting full-effector tau antibodies can induce indirect toxicity via microglia. |
2018-01-16 |
2023-08-13 |
mouse |
Paul D Wes, Faten A Sayed, Frédérique Bard, Li Ga. Targeting microglia for the treatment of Alzheimer's Disease. Glia. vol 64. issue 10. 2018-01-02. PMID:27100611. |
furthermore, microglia may have a substantial effect on current amyloid β (aβ) and tau immunotherapy approaches, since they are the primary cell type in the brain to mediate fc receptor-facilitated antibody effector function. |
2018-01-02 |
2023-08-13 |
Not clear |