| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
however, the role of tau pathology in microglia activation or their causal relationship remains largely elusive. |
2024-03-15 |
2024-03-17 |
Not clear |
| Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussari. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024-03-11. PMID:38462574. |
this is accompanied by gradual accumulation of tau in the somatodendritic compartment of mouse ecii neurons in vivo, reactivity of surrounding microglia, and microglia-mediated neuron loss. |
2024-03-11 |
2024-03-14 |
mouse |
| Qing-Yi Cao, Yi Tian, Jin-Nong Wan. [Research Progress in the Relationship Between Neurofilament Light Chain Protein and Cognitive Impairment in Type 2 Diabetes Mellitus]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 1. 2024-03-04. PMID:38433638. |
metabolic abnormality in type 2 diabetes mellitus(t2dm)can cause damage to the central nervous system,leading to cognitive decline.neurofilament light chain protein(nfl),as a blood marker of neuroaxonal injuries,is significantly associated with the onset of cognitive impairment and affected by the renal function.it can participate in the development of cognitive impairment in t2dm through inflammation,blood-brain barrier breakdown,interaction between microglia and neurons,and tau protein phosphorylation.we reviewed the mechanism of the occurrence and development of nfl-involved cognitive impairment and the correlation between nfl and renal function in t2dm,hoping to provide a basis for early diagnosis and treatment of cognitive impairment in t2dm patients. |
2024-03-04 |
2024-03-06 |
Not clear |
| Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M Rocha, Konstantinos Chioti. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 2785. 2024-03-01. PMID:38427196. |
alzheimer's disease (ad) - the most common neurodegenerative disorder - is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nfts) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells, i.e., astrocytes and microglia, and neuroinflammatory response, leading to neurodegeneration and cognitive dysfunction. |
2024-03-01 |
2024-03-03 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. |
in alzheimer's disease, microglia get activated to phagocytose damaged neurons, extracellular amyoid-β, and tau deposits. |
2024-03-01 |
2024-03-03 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. |
several tau internalization mechanisms of microglia have been studied which include phagocytosis, pinocytosis, and receptor-mediated endocytosis. |
2024-03-01 |
2024-03-03 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Tazeen Qureshi, Subashchandrabose Chinnathamb. Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427240. |
the 3-dimensional, orthogonal and gallery wise representation of these phagocytic structures provides an overview of the phagocytic mechanism of extracellular tau by microglia. |
2024-03-01 |
2024-03-03 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathamb. Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427241. |
internalization and endosomal trafficking of extracellular tau in microglia improved by α-linolenic acid. |
2024-03-01 |
2024-03-03 |
Not clear |
| Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathamb. Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427241. |
in this study, we focused on analyzing the ability of α-linolenic acid (ala) as a regulator of actin dynamics to balance the signaling pathways in microglia, including endocytosis of extracellular tau burden in ad. |
2024-03-01 |
2024-03-03 |
Not clear |
| G Nicola. Lessons from genetic studies in Alzheimer disease. Revue neurologique. 2024-03-01. PMID:38429159. |
the role of neuroinflammation, microglia, and tau pathology modulation are important sources of research for disease modification. |
2024-03-01 |
2024-03-04 |
Not clear |
| Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Jen Gentsch, Suzanne Schindler, John Morris, David Holtzman, Maria Fernández, Agustín Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sun. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square. 2024-02-27. PMID:38410465. |
the associated proteins cluster in four different protein pseudo-trajectories groups spanning the ad continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages). |
2024-02-27 |
2024-03-02 |
Not clear |
| Roxane Gruel, Baukje Bijnens, Johanna Van Den Daele, Sofie Thys, Roland Willems, Dirk Wuyts, Debby Van Dam, Peter Verstraelen, Rosanne Verboven, Jana Roels, Niels Vandamme, Renzo Mancuso, Juan Diego Pita-Almenar, Winnok H De Vo. S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice. Aging cell. 2024-02-26. PMID:38403918. |
we found that widespread tau pathology in k18-seeded p301l mice caused a significant change in the number and morphology of microglia, but only a mild overrepresentation of disease-associated microglia. |
2024-02-26 |
2024-02-28 |
mouse |
| Zenghui Ten. Novel Development and Prospects in Pathogenesis, Diagnosis, and Therapy of Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 8. issue 1. 2024-02-26. PMID:38405339. |
and neuroinflammation brought on by activated microglia was found to be one risk factor contributing to changes in aβ and tau pathology. |
2024-02-26 |
2024-02-28 |
Not clear |
| Jiangxia Chen, Lijun Zhou, Qingchun Zhao, Zhentong Q. A New Cell Model Overexpressing sTGFBR3 for Studying Alzheimer's Disease in vitro. Current pharmaceutical design. 2024-02-16. PMID:38362698. |
stgfbr3 (a shed extracellular domain of the transforming growth factor type iii receptor) is a newly identified target of microglia polarization dysregulation, whose overexpression can cause abnormal accumulation of transforming growth factor β1 (tgf-β1), promoting aβ, tau, and neuroinflammatory pathology. |
2024-02-16 |
2024-02-18 |
Not clear |
| Aaron Y Lai, Dustin Loren V Almanza, Jessica A Ribeiro, Mary E Hill, Matthew Mandrozos, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328066. |
after 6 months on the high-carbohydrate-high-fat diet, detrimental effects on density of neurons, amyloid-beta plaques, and tau inclusions persisted while the beneficial effects on myelin, microglia, and cognitive functions remained albeit with a lower effect size. |
2024-02-08 |
2024-02-10 |
human |
| Yun Guo, Cheng-Kun Sun, Lian Tang, Meng-Shan Ta. Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease. Current Alzheimer research. 2024-02-07. PMID:38321895. |
consequently, it is reasonable to presume that pyk2 in microglia contributes to amyloid-induced tau pathology in ad via a neuroinflammatory pathway. |
2024-02-07 |
2024-02-09 |
Not clear |
| Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Shen. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-04. PMID:38310653. |
the underlying mechanisms mainly include inhibiting tau hyperphosphorylation, inhibiting aβ formation, affecting activated microglia, regulating nf-κb/mapk signalling pathway, inhibiting neuronal apoptosis, modulating immune system, and inhibiting acetylcholinesterase, etc. |
2024-02-04 |
2024-02-07 |
Not clear |
| Paul Ediso. Astroglial activation: Current concepts and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-02. PMID:38305570. |
activated astrocytes exhibit diverse phenotypes in a region-specific manner in brain and interact with β-amyloid, tau, and α-synuclein species as well as with microglia and neuronal circuits. |
2024-02-02 |
2024-02-04 |
Not clear |
| Samantha M Rossano, Aubrey S Johnson, Anna Smith, Galen Ziaggi, Andrew Roetman, Diana Guzman, Amarachukwu Okafor, Julia Klein, Zeljko Tomljanovic, Yaakov Stern, Adam M Brickman, Seonjoo Lee, William C Kreisl, Patrick La. Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-01. PMID:38298155. |
we characterized microglia with translocator protein (tspo) positron emission tomography (pet) within an ad progression model where global amyloid beta (aβ) precedes local tau and neurodegeneration, resulting in cognitive impairment. |
2024-02-01 |
2024-02-03 |
Not clear |
| André F Batista, Khyrul A Khan, Maria-Tzousi Papavergi, Cynthia A Lemer. The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255891. |
in this review, we provide an overview of previously known and newly established roles for the complement cascade in the cns and we explore how complement interactions with microglia, astrocytes, and other risk factors such as trem2 and apoe4 modulate the processes of neurodegeneration in both amyloid and tau models of ad. |
2024-01-23 |
2024-01-25 |
Not clear |