| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
activated microglia, astrocytes and elevated levels of proinflammatory molecules are also pathological hallmarks that are found in brain regions affected by tau pathology. |
2018-04-17 |
2023-08-13 |
Not clear |
| Cheryl E G Leyns, David M Holtzma. Glial contributions to neurodegeneration in tauopathies. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28662669. |
we consider a physical role for microglia in the spread of tau pathology as well as the non-cell autonomous effects of secreted proinflammatory cytokines, specifically interleukin 1 beta, interleukin 6, tumor necrosis factor alpha and complement proteins. |
2018-04-17 |
2023-08-13 |
Not clear |
| Viktoria Johansson, Joel Jakobsson, Rebecca G Fortgang, Henrik Zetterberg, Kaj Blennow, Tyrone D Cannon, Christina M Hultman, Lennart Wetterberg, Mikael Landé. Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders. European archives of psychiatry and clinical neuroscience. vol 267. issue 5. 2018-01-30. PMID:28039552. |
markers of microglia activation [monocyte chemoattractant protein-1 (mcp-1), chitinase 3-like protein 1 (ykl-40), and soluble cluster of differentiation 14 (scd14)], markers of β-amyloid metabolism (aβx-38, aβx-40, aβx-42 and aβ1-42), soluble amyloid precursor proteins (sapp-α and sapp-β), total tau (t-tau), phosphorylated tau (p-tau), and csf/serum albumin ratio were measured in csf using immunoassays. |
2018-01-30 |
2023-08-13 |
Not clear |
| Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
only the full-effector antibody enhanced tau uptake in cultured microglia, which promoted release of proinflammatory cytokines. |
2018-01-16 |
2023-08-13 |
mouse |
| Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, Han Lin, Hilda Solanoy, Robert Brendza, Hai Ngu, Oded Foreman, Ruby Chan, James A Ernst, Danielle DiCara, Isidro Hotzel, Karpagam Srinivasan, David V Hansen, Jasvinder Atwal, Yanmei Lu, Daniela Bumbaca, Andrea Pfeifer, Ryan J Watts, Andreas Muhs, Kimberly Scearce-Levie, Gai Ayalo. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell reports. vol 16. issue 6. 2018-01-16. PMID:27475227. |
in neuron-microglia co-cultures, only effectorless anti-tau protected neurons, suggesting full-effector tau antibodies can induce indirect toxicity via microglia. |
2018-01-16 |
2023-08-13 |
mouse |
| Paul D Wes, Faten A Sayed, Frédérique Bard, Li Ga. Targeting microglia for the treatment of Alzheimer's Disease. Glia. vol 64. issue 10. 2018-01-02. PMID:27100611. |
furthermore, microglia may have a substantial effect on current amyloid β (aβ) and tau immunotherapy approaches, since they are the primary cell type in the brain to mediate fc receptor-facilitated antibody effector function. |
2018-01-02 |
2023-08-13 |
Not clear |
| Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajole. Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method. Cell reports. vol 16. issue 4. 2017-11-20. PMID:27425620. |
we visualized amyloid plaques in 3d together with tau, microglia, and vasculature. |
2017-11-20 |
2023-08-13 |
mouse |
| Douglas G Walker, Lih-Fen Lue, Tiffany M Tang, Charles H Adler, John N Caviness, Marwan N Sabbagh, Geidy E Serrano, Lucia I Sue, Thomas G Beac. Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology. Neurobiology of aging. vol 54. 2017-11-16. PMID:28390825. |
double immunohistochemistry for phosphorylated α-synuclein and markers for microglia showed limited association of microglia with lb pathology, but microglia strongly associated with amyloid plaques or phosphorylated tau. |
2017-11-16 |
2023-08-13 |
Not clear |
| Ana M Catafau, Santiago Bullic. Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation. Current Alzheimer research. vol 14. issue 2. 2017-10-10. PMID:27334945. |
this article will focus on the investigational pet tracers targeting tau and alpha-synuclein as misfolded proteins, and activated microglia and astrocytes as cellular targets for neuroinflammation. |
2017-10-10 |
2023-08-13 |
human |
| Yue Sun, Qian Xiao, Cheng Luo, Yuxing Zhao, Die Pu, Kexiang Zhao, Jinliang Chen, Meili Wang, Zhiyin Lia. High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway. Experimental cell research. vol 359. issue 2. 2017-10-10. PMID:28803064. |
during the tau hyperphosphorylation process, tlr9 in microglia plays bidirectional roles. |
2017-10-10 |
2023-08-13 |
Not clear |
| Darrell Sawmiller, Ahsan Habib, Song Li, Donna Darlington, Huayan Hou, Jun Tian, R Douglas Shytle, Adam Smith, Brian Giunta, Takashi Mori, Jun Ta. Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. Journal of neuroimmunology. vol 299. 2017-08-14. PMID:27725131. |
diosmetin, one major bioactive metabolite of diosmin, increased inhibitory gsk-3β phosphorylation, while selectively reducing γ-secretase activity, aβ generation, tau hyperphosphorylation and pro-inflammatory activation of microglia in vitro, without altering notch processing. |
2017-08-14 |
2023-08-13 |
mouse |
| Zhong-Hao Zhang, Lei Wen, Qiu-Yan Wu, Chen Chen, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Guo-Li Son. Long-Term Dietary Supplementation with Selenium-Enriched Yeast Improves Cognitive Impairment, Reverses Synaptic Deficits, and Mitigates Tau Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease. Journal of agricultural and food chemistry. vol 65. issue 24. 2017-07-03. PMID:28578584. |
as the results revealed that se-yeast significantly improved the spatial learning and memory retention of 3×tg-ad mice, promoted neuronal activity, attenuated the activation of astrocytes and microglia, mitigated synaptic deficits, and reduced the levels of total tau and phosphorylated tau though inhibiting the activity of gsk-3β, dietary supplementation with se-yeast exerted multiple beneficial effects on the prevention or treatment of ad. |
2017-07-03 |
2023-08-13 |
mouse |
| A S M Hung, Y Liang, Tony C H Chow, H C Tang, Sharon L Y Wu, M S M Wai, D T Ye. Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review. Progress in histochemistry and cytochemistry. vol 51. issue 1. 2017-04-21. PMID:26851150. |
this review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in alzheimer disease. |
2017-04-21 |
2023-08-13 |
Not clear |
| Marta Bolós, Juan Ramón Perea, Jesús Avil. Alzheimer's disease as an inflammatory disease. Biomolecular concepts. vol 8. issue 1. 2017-03-20. PMID:28231054. |
alzheimer's disease (ad) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. |
2017-03-20 |
2023-08-13 |
Not clear |
| Yinquan Fang, Lemeng Yao, Chenhui Li, Jing Wang, Jianing Wang, Shujian Chen, Xin-Fu Zhou, Hong Lia. The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. Journal of neuroinflammation. vol 13. issue 1. 2017-02-14. PMID:26939570. |
the blockage of the nogo/ngr signal pathway in microglia alleviates the formation of aβ plaques and tau phosphorylation in app/ps1 transgenic mice. |
2017-02-14 |
2023-08-13 |
mouse |
| José Joaquín Merino, Vilma Muñetón-Gómez, María-Isabel Alvárez, Adolfo Toledano-Día. Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567742. |
in mouse models, inflammatory activation of microglia accelerates tau pathology. |
2016-12-15 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
direct evidence of internalization of tau by microglia in vitro and in vivo. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
here we demonstrate that microglia take up tau in vitro and in vivo. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
in this regard, microglia from primary cultures internalized soluble (human recombinant tau42) and insoluble (homogenates derived from human ad brain) tau in vitro. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
furthermore, using stereotaxic injection of tau in mice in vivo, we show that murine microglia internalize human tau. |
2016-10-07 |
2023-08-13 |
mouse |