| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veronica Astillero-Lopez, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, Alicia Flores-Cuadrado, Isabel Ubeda-Banon, Daniel Saiz-Sanchez, Alino Martinez-Marco. Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. Brain pathology (Zurich, Switzerland). 2024-01-22. PMID:38247340. |
all these proteins showed colocalization with neurons and/or astroglia and microglia and with pathological aβ and tau proteins. |
2024-01-22 |
2024-01-24 |
human |
| Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. |
the fluorescent ligand btvbt2 reveals increased p-tau uptake by retinal microglia in alzheimer's disease patients and app amyloid beta (aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of alzheimer's disease (ad) patients and transgenic ad mice. |
2024-01-03 |
2024-01-06 |
mouse |
| Roshni C Lalwani, Claude-Henry Volmar, Claes Wahlestedt, Keith A Webster, Lina A Shehade. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer's Disease. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137453. |
tau and aβ complexes spread from the entorhinal cortex of the brain to interconnected regions, where they bind pattern recognition receptors on microglia and astroglia to trigger inflammation and neurotoxicity that ultimately lead to neurodegeneration and clinical ad. |
2023-12-23 |
2023-12-25 |
Not clear |
| Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Par. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS chemical neuroscience. 2023-11-28. PMID:38014902. |
tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. |
2023-11-28 |
2023-11-29 |
Not clear |
| Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. |
synaptic loss is closely associated with tau aggregation and microglia activation in later stages of alzheimer's disease (ad). |
2023-11-24 |
2023-11-28 |
Not clear |
| Marcel S Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L Benedet, Nicholas J Ashton, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z Lussier, Thomas K Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Net. 14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2. Journal of neuroinflammation. vol 20. issue 1. 2023-11-24. PMID:38001539. |
it remains unclear whether microglia activation independently causes synaptic cleavage before tau aggregation appears. |
2023-11-24 |
2023-11-28 |
Not clear |
| Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, Tzu-Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zhen. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nature neuroscience. 2023-11-21. PMID:37985800. |
single-nucleus rna sequencing of wild-type and ps19 (tau) transgenic mice expressing the p301s mutant tau identified three unique microglia subclusters in tau mice that were associated with heightened lysosome and immune pathway genes. |
2023-11-21 |
2023-11-29 |
mouse |
| Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, Tzu-Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zhen. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nature neuroscience. 2023-11-21. PMID:37985800. |
crossing the clear mutant with tau mice led to higher tau pathology but diminished microglia response. |
2023-11-21 |
2023-11-29 |
mouse |
| Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Cher. Galectin-3 aggravates microglial activation and tau transmission in tauopathy. The Journal of clinical investigation. 2023-11-21. PMID:37988169. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (ptau), and microglia activation. |
2023-11-21 |
2023-11-29 |
mouse |
| Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Fangmin Yu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-Min Song, Bin Zhang, Qin Ma, Hongjun Fu, Li Gan, Wenjie Lu. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961594. |
specifically, removal of dap12 abolished tau-induced disease-associated clusters in microglia (mg) and intermediate oligodendrocytes (ioli), which are spatially correlated with tau pathology in ad brains. |
2023-11-14 |
2023-11-20 |
mouse |
| Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Fangmin Yu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-Min Song, Bin Zhang, Qin Ma, Hongjun Fu, Li Gan, Wenjie Lu. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961594. |
our study highlights the critical role of interactions between microglia and oligodendrocytes in tau toxicity and dap12 signaling as a promising target for enhancing resilience in ad. |
2023-11-14 |
2023-11-20 |
mouse |
| Wenjie Luo, Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Fangmin Yu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Sue-Ann Mok, Won-Min Song, Bin Zhang, Qin Ma, Hongjun Fu, Li Ga. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. Research square. 2023-11-14. PMID:37961627. |
specifically, removal of dap12 abolished tau-induced disease-associated clusters in microglia (mg) and intermediate oligodendrocytes (ioli), which are spatially correlated with tau pathology in ad brains. |
2023-11-14 |
2023-11-20 |
mouse |
| Wenjie Luo, Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Fangmin Yu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Sue-Ann Mok, Won-Min Song, Bin Zhang, Qin Ma, Hongjun Fu, Li Ga. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. Research square. 2023-11-14. PMID:37961627. |
our study highlights the critical role of interactions between microglia and oligodendrocytes in tau toxicity and dap12 signaling as a promising target for enhancing resilience in ad. |
2023-11-14 |
2023-11-20 |
mouse |
| M Kiraly, J F Foss, T Giordan. Neuroinflammation, its Role in Alzheimer's Disease and Therapeutic Strategie. The journal of prevention of Alzheimer's disease. vol 10. issue 4. 2023-10-24. PMID:37874089. |
in ad, the brain's microglia and astrocytes, which are normally responsible for maintaining the homeostasis of synaptic transmission and its remodeling by pruning, are the initiators of neuroinflammation and toxic tau and amyloid-β (aβ) accumulation. |
2023-10-24 |
2023-11-08 |
Not clear |
| Mahsa Aghajani Mi. Brain Fog: a Narrative Review of the Most Common Mysterious Cognitive Disorder in COVID-19. Molecular neurobiology. 2023-10-24. PMID:37874482. |
although the etiology of brain fog in covid-19 is currently unknown, regarding the mechanisms of pathogenesis, the following hypotheses exist: activation of astrocytes and microglia to release pro-inflammatory cytokines, aggregation of tau protein, and covid-19 entry in the brain can trigger an autoimmune reaction. |
2023-10-24 |
2023-11-08 |
Not clear |
| Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. |
the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. |
2023-10-09 |
2023-10-15 |
rat |
| Raquel N Taddei, Romain Perbet, Anastasie Mate de Gerando, Anne E Wiedmer, Maria Sanchez-Mico, Theresa Connors Stewart, Angelica Gaona, Alexandra Melloni, Ana C Amaral, Karen Duff, Matthew P Frosch, Teresa Gómez-Isl. Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease. JAMA neurology. 2023-10-09. PMID:37812432. |
tau oligomer-containing synapse elimination by microglia and astrocytes in alzheimer disease. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yi-Huan Guan, Ling-Jing Zhang, Shi-Ya Wang, Ya-Dan Deng, Hong-Su Zhou, Dong-Qing Chen, Lan-Chun Zhan. The role of microglia in Alzheimer's disease and progress of treatment. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786418. |
we found that overactivated microglia increase aβ and tau, and aβ and tau in turn act as activators of microglia. |
2023-10-03 |
2023-10-07 |
Not clear |
| Juliana R Lopes, Xiaoming Zhang, Julia Mayrink, Bruna K Tatematsu, Lydia Guo, Danielle S LeServe, Hadi Abou-El-Hassan, Felipe Rong, Maria J Dalton, Marilia G Oliveira, Toby B Lanser, Lei Liu, Oleg Butovsky, Rafael M Rezende, Howard L Weine. Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 37. 2023-09-05. PMID:37669383. |
danger signals including dead neurons, dystrophic axons, phosphorylated tau, and amyloid plaques alter the functional phenotype of microglia from a homeostatic (m0) to a neurodegenerative or disease-associated phenotype, which in turn drives neuroinflammation and promotes disease. |
2023-09-05 |
2023-10-07 |
mouse |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
moreover, microglia also appear to be closely involved in the spread of tau pathology. |
2023-08-12 |
2023-08-16 |
Not clear |