| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
here, we found that tau preformed fibrils (pff) caused induction of inflammation in microglia by specifically activating the tlr2-myd88, but not tlr4-myd88, pathway. |
2023-08-08 |
2023-08-16 |
mouse |
| Nur Jury-Garfe, Yanwen You, Pablo Martínez, Javier Redding-Ochoa, Hande Karahan, Travis S Johnson, Jie Zhang, Jungsu Kim, Juan C Troncoso, Cristian A Lasagna-Reeve. Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546928. |
our findings support that the amyloid-plaque microenvironment in asymad cases is characterized by microglia with highly efficient actin-based cell motility mechanisms and decreased tau seeding compared to ad. |
2023-08-07 |
2023-08-14 |
human |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
the discovery of the genetic association between triggering receptor expressed on myeloid cells 2 (trem2) with increased ad risk points to a causal link between microglia and ad pathogenesis, and revealed a crucial role of trem2-dependent clustering of microglia around amyloid plaques that prevents aβ toxicity to facilitate tau deposition near the plaques. |
2023-07-31 |
2023-08-14 |
mouse |
| Shuai Jin, Lijuan Zhang, Lin Wan. Kaempferol, a potential neuroprotective agent in neurodegenerative diseases: From chemistry to medicine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-26. PMID:37494786. |
kaempferol and its derivatives exert a neuroprotective role mainly by preventing the deposition of amyloid fibrils (such as aβ, tau, and α-synuclein), inhibiting microglia activation, reducing the release of inflammatory factors, restoring the mitochondrial membrane to prevent oxidative stress, protecting the blood-brain barrier, and inhibiting specific enzyme activities (such as cholinesterase). |
2023-07-26 |
2023-08-14 |
Not clear |
| Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiméne. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer's disease? Neural regeneration research. vol 18. issue 12. 2023-07-14. PMID:37449594. |
although brain endothelial cell function is crucial for brain homeostasis, their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia, astroglia, neurons, or even molecules such as amyloid beta, tau, or alpha-synuclein. |
2023-07-14 |
2023-08-14 |
Not clear |
| Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
extracellular tau induces primary phagocytosis of stressed neurons and neuronal loss by activating microglia. |
2023-07-07 |
2023-08-14 |
human |
| Lu Wang, Yingjuan Wei, Zhenzhou Sun, Lin-Hua Jiang, Yaling Yin, Panpan Zheng, Yun Fu, Hongwei Wang, Changzheng Li, Jian-Zhi Wan. DpdtpA, A Multi-Metal Ion Chelator, Attenuates Tau Phosphorylation and Microglial Inflammatory Response via Regulating the PI3K/AKT/GSK-3β Signal Pathways. Neuroscience. 2023-07-07. PMID:37419407. |
collectively, these results show that dpdtpa can attenuate tau phosphorylation and inflammatory responses of microglia by regulating the pi3k/akt/gsk-3β signal pathways, providing a new option to alleviate neuroinflammation for the treatment of ad. |
2023-07-07 |
2023-08-14 |
human |
| Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Ki. Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation. Scientific reports. vol 13. issue 1. 2023-07-05. PMID:37407605. |
aβ monomers transform into aβ oligomers, which are toxic species, inducing tau hyperphosphorylation and the downstream effects on microglia and astrocytes, triggering synaptic and cognitive dysfunctions. |
2023-07-05 |
2023-08-14 |
mouse |
| Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
extracellular tau stimulates phagocytosis of living neurons by activated microglia via toll-like 4 receptor-nlrp3 inflammasome-caspase-1 signalling axis. |
2023-07-04 |
2023-08-14 |
Not clear |
| Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
we have previously shown that extracellular tau protein (2n4r isoform) can stimulate microglia to phagocytose live neurons, i.e. |
2023-07-04 |
2023-08-14 |
Not clear |
| Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C Brown, Vilmante Borutait. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor-NLRP3 inflammasome-caspase-1 signalling axis. Scientific reports. vol 13. issue 1. 2023-07-04. PMID:37402829. |
overall, our data indicate that extracellular tau protein stimulates microglia to phagocytose live neurons via toll-like 4 receptor-nlrp3 inflammasome-caspase-1 axis and nadph oxidase, each of which may serve as a potential molecular target for pharmacological treatment of tauopathies. |
2023-07-04 |
2023-08-14 |
Not clear |
| Jasvinder Singh Bhatti, Satinder Kaur, Jayapriya Mishra, Harikrishnareddy Dibbanti, Arti Singh, Arubala P Reddy, Gurjit Kaur Bhatti, P Hemachandra Redd. Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-07-01. PMID:37392948. |
alzheimer's disease (ad) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microrna deregulation, hormonal imbalance, increased astrocytes & microglia, accumulation of amyloid β (aβ) and phosphorylated tau in the brains of ad patients. |
2023-07-01 |
2023-08-14 |
Not clear |
| Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L Oblak, Cristian A Lasagna-Reeve. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. vol 12. issue 12. 2023-06-28. PMID:37371067. |
trem2-deficient microglia attenuate tau spreading in vivo. |
2023-06-28 |
2023-08-14 |
mouse |
| Khoren K Epremyan, Dmitry V Mamaev, Renata A Zvyagilskay. Alzheimer's Disease: Significant Benefit from the Yeast-Based Models. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37372938. |
alzheimer's disease (ad) is an age-related, multifaceted neurological disorder associated with accumulation of aggregated proteins (amyloid aβ and hyperphosphorylated tau), loss of synapses and neurons, and alterations in microglia. |
2023-06-28 |
2023-08-14 |
Not clear |
| Meshal Alshamran. Recent Trends in Active and Passive Immunotherapies of Alzheimer's Disease. Antibodies (Basel, Switzerland). vol 12. issue 2. 2023-06-27. PMID:37366656. |
potential efforts in the field of pathogenesis have prompted researchers to explore novel therapies such as active and passive vaccines against aβ proteins (aβ immunotherapy), intravenous immunoglobulin, and tau immunotherapy, as well as targets that include microglia and several cytokines for the treatment of ad. |
2023-06-27 |
2023-08-14 |
Not clear |
| Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica. 2023-06-21. PMID:37341831. |
however, the hmw preparation appears to be far more potent in inducing a glial response including clec7a-positive rod microglia in the absence of neurodegeneration or synapse loss and promotes more rapid propagation of misfolded tau to distal, anatomically connected regions, such as entorhinal and perirhinal cortices. |
2023-06-21 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
ab-t1 enhanced the uptake of misfolded tau to microglia and induced a non-cell autonomous attenuation of spontaneous tau seeding and phosphorylation in primary neurons from human tau transgenic mice. |
2023-06-11 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
collectively, these observations show that trem2 engagement with an agonistic antibody result in reduced tau burden concomitant with attenuated neurodegeneration ascribed to the education of resident microglia. |
2023-06-11 |
2023-08-14 |
mouse |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |