| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
here, we exposed primary microglia to 5 and 15 nanomolar (nm) of monomeric tau for 18 h, followed by a recovery period of 48 h. |
2023-06-06 |
2023-08-14 |
mouse |
| Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia degrade tau oligomers deposit via purinergic p2y12-associated podosome and filopodia formation and induce chemotaxis. |
2023-05-23 |
2023-08-14 |
Not clear |
| Subashchandrabose Chinnathambi, Rashmi Da. Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis. Cell & bioscience. vol 13. issue 1. 2023-05-23. PMID:37221563. |
microglia are the immune cells in the central nervous system, sense the extracellular tau via various cell surface receptors. |
2023-05-23 |
2023-08-14 |
Not clear |
| Risako Fujikawa, Makoto Tsud. The Functions and Phenotypes of Microglia in Alzheimer's Disease. Cells. vol 12. issue 8. 2023-05-16. PMID:37190116. |
in this review, we systematically summarize the microglial response to amyloid-β and tau tangles, and the risk factor genes expressed in microglia. |
2023-05-16 |
2023-08-14 |
Not clear |
| Giulia Bivona, Matilda Iemmolo, Giulio Ghers. CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175935. |
cx3cl1 has an effect on aβ clearance and tau phosphorylation, as well as in microglia activation and priming. |
2023-05-14 |
2023-08-14 |
Not clear |
| Davin Devara, Yashmit Choudhary, Subodh Kuma. Role of MicroRNA-502-3p in Human Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 4. 2023-04-28. PMID:37111289. |
the most common causes of synapse dysfunction in ad are amyloid beta, hyperphosphorylated tau, and microglia activation. |
2023-04-28 |
2023-08-14 |
human |
| Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Brian Grone, Misha Zilberter, Oscar Yip, Antara Rao, Maxine R Nelson, Yanxia Hao, Reuben Thomas, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits. Nature aging. vol 3. issue 3. 2023-04-28. PMID:37118426. |
single-nucleus rna-sequencing revealed that the removal of neuronal apoe4 greatly diminished neurodegenerative disease-associated subpopulations of neurons, oligodendrocytes, astrocytes and microglia whose accumulation correlated to the severity of tau pathology, neurodegeneration and myelin deficits. |
2023-04-28 |
2023-08-14 |
mouse |
| Joana B Pereira, Shorena Janelidze, Olof Strandberg, Christopher D Whelan, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson-Carlgren, Oskar Hansso. Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology. Nature aging. vol 2. issue 12. 2023-04-28. PMID:37118533. |
the role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying alzheimer's disease (ad) |
2023-04-28 |
2023-08-14 |
Not clear |
| Joe C Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S Torres, Gillian K Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T Gill, Ravikiran M Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E Tracy, Rajiv R Ratan, Li-Huei Tsai, Subhash C Sinha, Li Ga. Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023-04-24. PMID:37095396. |
pathogenic tau activates cgas and ifn-i responses in microglia, in part mediated by cytosolic leakage of mitochondrial dna. |
2023-04-24 |
2023-08-14 |
mouse |
| Subashchandrabose Chinnathambi, Rashmi Das, Smita Eknath Desal. Tau aggregates improve the purinergic receptor P2Y12-associated podosome rearrangements in microglial cells. Biochimica et biophysica acta. Molecular cell research. 2023-04-15. PMID:37061007. |
the extracellular release of aggregated tau is sensed by surveilling microglia through the involvement of various cell surface receptors. |
2023-04-15 |
2023-08-14 |
Not clear |
| Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelman. Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology. Neurobiology of disease. 2023-04-13. PMID:37054900. |
development of an aav-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in tau pathology. |
2023-04-13 |
2023-08-14 |
mouse |
| Jasvinder Singh Bhatti, Naina Khullar, Jayapriya Mishra, Satinder Kaur, Abhishek Sehrawat, Eva Sharma, Gurjit Kaur Bhatti, Ashley Selman, P Hemachandra Redd. Stem cells in the treatment of Alzheimer's disease - Promises and pitfalls. Biochimica et biophysica acta. Molecular basis of disease. 2023-04-08. PMID:37030521. |
the underlying mechanisms of ad include the build-up of amyloid-β and phosphorylated tau, synaptic damage, elevated levels of microglia and astrocytes, abnormal micrornas, mitochondrial dysfunction, hormonal imbalance, and age-related neuronal loss. |
2023-04-08 |
2023-08-14 |
Not clear |
| Lucia A A Giannini, Marjolein Bulk, Boyd Kenkhuis, Ana Rajicic, Shamiram Melhem, Ingrid Hegeman-Kleinn, Lucia Bossoni, Ernst Suidgeest, Elise G P Dopper, John C van Swieten, Louise van der Weerd, Harro Seelaa. Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration. Brain pathology (Zurich, Switzerland). 2023-03-28. PMID:36974379. |
we studied patterns of cortical iron accumulation and its colocalization with the corresponding underlying pathologies (tau and tdp-43), brain cells (microglia and astrocytes), and myelination. |
2023-03-28 |
2023-08-14 |
Not clear |
| Lucia A A Giannini, Marjolein Bulk, Boyd Kenkhuis, Ana Rajicic, Shamiram Melhem, Ingrid Hegeman-Kleinn, Lucia Bossoni, Ernst Suidgeest, Elise G P Dopper, John C van Swieten, Louise van der Weerd, Harro Seelaa. Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration. Brain pathology (Zurich, Switzerland). 2023-03-28. PMID:36974379. |
cortical iron accumulation was associated with the severity of proteinopathy (tau or tdp-43) and neuronal degeneration, in part with clinical severity, and with the presence of activated microglia, reactive astrocytes and myelin loss. |
2023-03-28 |
2023-08-14 |
Not clear |
| Soraya Meftah, Jian Ga. Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression. Frontiers in synaptic neuroscience. vol 15. 2023-03-27. PMID:36970154. |
other important future avenues of note in this field include the role of non-neuronal cell types such as astrocytes and microglia, and mechanisms of dysfunction independent of amyloid and tau in alzheimer's disease. |
2023-03-27 |
2023-08-14 |
mouse |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Moxin Wu, Zhiying Chen, Min Jiang, Bing Bao, Dongling Li, Xiaoping Yin, Xueren Wang, Dan Liu, Ling-Qiang Zh. Friend or foe: role of pathological tau in neuronal death. Molecular psychiatry. 2023-03-15. PMID:36918705. |
in contrast, pathological tau always detaches from microtubules and is implicated in a series of neurological disorders that are characterized by irreversible neuronal death, such as necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy-dependent neuronal death and phagocytosis by microglia. |
2023-03-15 |
2023-08-14 |
Not clear |
| Mahima Kapoor, Subashchandrabose Chinnathamb. TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective. Journal of neuroinflammation. vol 20. issue 1. 2023-03-14. PMID:36915196. |
channelizing microglia to target extracellular tau could be a good strategy to combat the prion-like transmission and seeding problem in alzheimer's disease. |
2023-03-14 |
2023-08-14 |
Not clear |
| Cuicui Wang, Shuai Zong, Xiaolin Cui, Xueying Wang, Shuang Wu, Le Wang, Yingchao Liu, Zhiming L. The effects of microglia-associated neuroinflammation on Alzheimer's disease. Frontiers in immunology. vol 14. 2023-03-13. PMID:36911732. |
here, we summarize the effects of microglia-mediated neuroinflammation on ad, focusing on the temporal and spatial changes in microglial phenotype, the interactions among microglia, aβ, tau, and neurons, and the prospects and recent advances in neuroinflammation as a diagnostic and therapeutic target of ad. |
2023-03-13 |
2023-08-14 |
human |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |