| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud LaJoie, Adam M Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy P. Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults. Brain : a journal of neurology. 2022-07-23. PMID:35869598. |
alternative models tested the role of microglia activation as the precipitating event (microglial activation→ amyloid-β → tau). |
2022-07-23 |
2023-08-14 |
human |
| Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud LaJoie, Adam M Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy P. Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults. Brain : a journal of neurology. 2022-07-23. PMID:35869598. |
alternative models suggested that in women, microglial activation was a significant exposure both preceding the amyloid-β to tau relationship (mediational effect: 50%, 95%ci 23-90) and directly related to tau burden (microglia direct effect: 50%, 95%ci 10-77). |
2022-07-23 |
2023-08-14 |
human |
| Torben Johann Hausrat, Philipp C Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneusse. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nature communications. vol 13. issue 1. 2022-07-20. PMID:35858909. |
disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. |
2022-07-20 |
2023-08-14 |
mouse |
| Torben Johann Hausrat, Philipp C Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneusse. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Nature communications. vol 13. issue 1. 2022-07-20. PMID:35858909. |
notably, crossbreeding of the tuba4a knock-in mouse with the htau tauopathy model, expressing a human tau transgene, reversed hyper-phosphorylation and oligomerization of tau and normalized microglia activation in brain. |
2022-07-20 |
2023-08-14 |
mouse |
| Michael J Paidas, Daniela S Cosio, Saad Ali, Norma Sue Kenyon, Arumugam R Jayakuma. Long-Term Sequelae of COVID-19 in Experimental Mice. Molecular neurobiology. 2022-07-13. PMID:35831558. |
these changes were associated with increased reactive astrocytes and microglia, hyperphosphorylated tdp-43 and tau, and a decrease in synaptic protein synaptophysin-1, suggesting the possible long-term impact of sars-cov-2 infection on defective neuronal integrity. |
2022-07-13 |
2023-08-14 |
mouse |
| Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell. vol 29. issue 7. 2022-07-08. PMID:35803230. |
in response to human brain tissue-derived pathological tau, ds microglia undergo cellular senescence and exhibit elevated type-i-interferon signaling. |
2022-07-08 |
2023-08-14 |
mouse |
| Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra C Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie, Kelvin Y Kwan, Zhiping P Pang, Elizabeth Head, Ying Liu, Ronald P Hart, Peng Jian. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell stem cell. vol 29. issue 7. 2022-07-08. PMID:35803230. |
our findings provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes. |
2022-07-08 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min-Sun Ki. Curcumin-Attenuated TREM-1/DAP12/NLRP3/Caspase-1/IL1B, TLR4/NF-κB Pathways, and Tau Hyperphosphorylation Induced by 1,2-Diacetyl Benzene: An in Vitro and in Silico Study. Neurotoxicity research. 2022-07-05. PMID:35781221. |
we aimed to evaluate the effects of 1,2-diacetylbenzene (dab) and curcumin on neuroinflammation induced by dab via triggering receptor expressed on myeloid cells 1 (trem-1), toll-like receptor 4 (tlr4), and nlr family pyrin domain containing 3 (nlp3)/calcium-dependent activator protein for secretion 1 (caps1)/interleukin 1 beta (il1b) pathways; tau hyperphosphorylation; reactive oxygen species (ros); and advanced glycation end-product (age) in microglia cells; and explore the molecular mechanisms involved in the key genes induced by dab and targeted by curcumin in silico analysis. |
2022-07-05 |
2023-08-14 |
Not clear |
| Berke Karaahmet, Linh Le, Monique S Mendes, Ania K Majewska, M Kerry O'Banio. Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology. Journal of neuroinflammation. vol 19. issue 1. 2022-07-05. PMID:35787714. |
repopulated microglia induce expression of cxcl13 with differential changes in tau phosphorylation but do not impact amyloid pathology. |
2022-07-05 |
2023-08-14 |
mouse |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
recent studies implicate microglia, the resident immune cells of the central nervous system, in both negative and positive regulation of tau pathology. |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
experimental manipulation of microglia function can alter tau pathology and microglia-mediated neuroinflammatory cascades can exacerbate tau pathology. |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
microglia also exert protective functions by mitigating tau spread: microglia internalize tau seeds and have the capacity to degrade them. |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
however, when microglia fail to degrade these tau seeds there are deleterious consequences, including secretion of exosomes containing tau that can spread to neurons. |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
this review explores the intersection of microglia and tau from the perspective of neuropathology, neuroimaging, genetics, transcriptomics, and molecular biology. |
2022-06-17 |
2023-08-14 |
Not clear |
| Kristian F Odfalk, Kevin F Bieniek, Sarah C Hop. Microglia: Friend and Foe in Tauopathy. Progress in neurobiology. 2022-06-17. PMID:35714860. |
as tau-targeted therapies such as anti-tau antibodies advance through clinical trials, it is critical to understand the interaction between tau and microglia. |
2022-06-17 |
2023-08-14 |
Not clear |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
in ad, the presence of pathogenic proteins such as extracellular aβ plaques and hyperphosphorylated tau, induce the transformation of ramified microglia into amoeboid microglia. |
2022-06-13 |
2023-08-14 |
Not clear |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
however, the phagocytic ability of microglia gradually declines with age, and thus the clearance of pathogenic proteins becomes highly ineffective, leading to the accumulation of aβ plaques and hyperphosphorylated tau in the aging brain. |
2022-06-13 |
2023-08-14 |
Not clear |
| Jessica S Fortin, Kuang-Wei Wang, Hsiao T Chien, Min-Hao Ku. A Phenotypic-based Drug Discovery Approach to Inhibit the Misfolding of Hyperphosphorylated Tau Isoform 1N4R. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554965. |
microglia when activated have been known to increase tau phosphorylation and drive the trans-synaptic spread of aggregated hyperphosphorylated tau (p-tau). |
2022-05-13 |
2023-08-13 |
human |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
effects of microglia apoe expression on tau pathology. |
2022-05-13 |
2023-08-13 |
mouse |
| Devin Wahl, Julie Moreno, Kelly Santangelo, Alyssa N Cavalier, Karyn L Hamilton, Thomas J LaRocc. Pigmented and Dunkin-Hartley Guinea Pigs as Natural Models for Brain Aging and Alzheimer's Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557423. |
additionally, both pigmented and dunkin-hartley animals exhibit age-associated increases in numerous markers of human brain aging/ad, including neurofilament light chain (nfl, a marker of neuronal damage), s100 calcium-binding protein b (s100ß, a marker of glial activation), ionized calcium-binding adapter molecule 1 (iba1, a marker of reactive microglia), and both aβ and phosphorylated tau. |
2022-05-13 |
2023-08-13 |
human |