All Relations between microtubule-associated protein tau and hippocampus

Reference Sentence Publish Date Extraction Date Species
Dhwani S Korde, Christian Humpe. Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures. Biomolecules vol 12 issue 9 2022 36139003 slices with un- and hyperphosphorylated p301s aggregated tau demonstrate significant spreading to the ventral parts of the hippocampal slices compared to empty collagen hydrogels after 8 weeks. 2022-09-23 2022-09-29 Not clear
Jianfeng Wu, Yi Su, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging vol 2022 issue 2022 36147309 investigating the effect of tau deposition and apoe on hippocampal morphometry in alzheimer's disease: a federated chow test model. 2022-09-23 2022-09-29 Not clear
Georgiana F Stan, Timothy W Church, Ellie Randall, Jenna R M Harvey, Jon T Brown, Kevin A Wilkinson, Jonathan G Hanley, Neil V Marrio. Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. Scientific reports vol 12 issue 1 2022 36075936 tau isoform-specific enhancement of l-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons. 2022-09-08 2022-09-14 Not clear
Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology vol issue 2022 36059072 intriguingly, the loss of bin1 also mitigated tau neuropathology in select regions, including the hippocampus, entorhinal/piriform cortex, and amygdala, thus attenuating hippocampal synapse loss, neuronal death, neuroinflammation, and brain atrophy. 2022-09-04 2022-09-06 Not clear
Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology vol issue 2022 36059072 we conclude that forebrain neuronal bin1 expression promotes hippocampal tau pathogenesis and neuroinflammation. 2022-09-04 2022-09-06 Not clear
Sara R Guerreiro, Marco R Guimar\\xc3\\xa3es, Joana M Silva, Chrysoula Dioli, Anastasia Vamvaka-Iakovou, Raquel Sousa, Patr\\xc3\\xadcia Gomes, Anastasia Megalokonomou, Carlos Campos-Marques, Ana Margarida Cunha, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida, Ioannis Sotiropoulo. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Molecular psychiatry vol issue 2022 36056171 interestingly, genetic ablation of tau blocks the establishment of sni-induced hippocampal morphofunctional deficits supporting the mediating role of tau in sni-evoked hippocampal pathology and memory impairment. 2022-09-02 2022-09-06 Not clear
Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991) vol issue 2022 36047921 tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. 2022-09-01 2022-09-06 Not clear
Hao Liu, Zhi Yang, Chunyan Yu, Hao Dong, Shiyan Wang, Gang Wang, Denian Wan. Tau aggravates stress-induced anxiety by inhibiting adult ventral hippocampal neurogenesis in mice. Cerebral cortex (New York, N.Y. : 1991) vol issue 2022 36047921 taken together, our findings reveal a novel mechanism by which tau exacerbates stress responses and anxiety-related behavior by inhibiting the proliferation and maturation of hippocampal vdg neurons, providing a potential molecular target for the treatment of anxiety-like behavior induced by stress. 2022-09-01 2022-09-06 Not clear
Yujun Tu, Qi Chen, Wenjia Guo, Pu Xiang, Haifeng Huang, Huizhi Fei, Lin Chen, Yang Yang, Zhe Peng, Chao Gu, Xiaodan Tan, Xia Liu, Yi Lu, Rongchun Chen, Hong Wang, Ying Luo, Junqing Yan. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Experimental neurology vol issue 2022 36029808 in vivo, diabetic mice with cognitive dysfunction and hippocampal neuronal damage had a concomitant increase in amyloid precursor protein (app), amyloid beta(a\xce\xb2), tau, bax protein expressions; by contrast, bcl-2 protein expression was significantly decreased. 2022-08-27 2022-08-29 Not clear
Luis A Campero-Garcia, Jose A Cantoral-Ceballos, Alejandra Martinez-Maldonado, Jose Luna-Mu\\xc3\\xb1oz, Miguel A Ontiveros-Torres, Andres E Gutierrez-Rodrigue. A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net. Biology vol 11 issue 8 2022 36009757 however, the standard approach to exploring the phenomenon of neurodegeneration in tauopathies has not been directed at understanding the molecular mechanism that causes the aberrant polymeric and fibrillar behavior of the tau protein, which forms neurofibrillary tangles that replace neuronal populations in the hippocampal and cortical regions. 2022-08-26 2022-08-29 Not clear
Keerti Gupta, Jitendra Vishwakarma, Asmita Garg, Rukmani Pandey, Veena Jain, Raksha Gupta, Uttara Das, Somendu Roy, Sanghamitra Bandyopadhya. Arsenic Induces GSK3\\xce\\xb2-dependent p-tau, neuronal apoptosis and cognitive impairment via an interdependent hippocampal ER\\xce\\xb1 and IL-1/IL-1R1 mechanism in female rats. Toxicological sciences : an official journal of the Society of Toxicology vol issue 2022 35993674 we observed that environmentally relevant arsenic exposure increased tau phosphorylation and the principal tau kinase, glycogen synthase kinase-3 beta (gsk3\xce\xb2), in the female rat hippocampal neurons. 2022-08-22 2022-08-29 Not clear
Juan Jiang, Chen Yang, Jia-Qi Ai, Qi-Lei Zhang, Xiao-Lu Cai, Tian Tu, Lily Wan, Xiao-Sheng Wang, Hui Wang, Aihua Pan, Jim Manavis, Wei-Ping Gai, Chong Che, Ewen Tu, Xiao-Ping Wang, Zhen-Yan Li, Xiao-Xin Ya. Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation. Frontiers in aging neuroscience vol 14 issue 2022 35978952 intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation. 2022-08-18 2022-08-22 Not clear
Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 35944999 here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and \xce\xb2-amyloid (5\xc3\x97fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. 2022-08-09 2022-08-15 Not clear
Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan V\\xc3\\xb6glein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology vol issue 2022 35925685 the temporal evolutions and relative orderings of alzheimer disease biomarkers, including csf amyloid-\xce\xb242 (a\xce\xb242), a\xce\xb240, total tau (tau) and phosphorylated tau181 (ptau181), standardized uptake value ratio (suvr) from the molecular imaging of cerebral fibrillar amyloid-\xce\xb2 with pet using the 11c-pittsburgh compound-b (pib), mri-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. 2022-08-04 2022-08-08 Not clear
Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan V\\xc3\\xb6glein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology vol issue 2022 35925685 the earliest acceleration of longitudinal change occurred for csf a\xce\xb242 and a\xce\xb242/a\xce\xb240 ratio (with an increase) and for tau, and ptau181 (with a decrease) at the next baseline age interval of 45-50 years, followed by an accelerated increase for pib suvr at the baseline age of 50-55 years and an accelerated decrease for hippocampal volume at the baseline age of 55-60 years and finally by an accelerated decline for cortical thickness and cognition at the baseline age of 65-70 years. 2022-08-04 2022-08-08 Not clear
Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan V\\xc3\\xb6glein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology vol issue 2022 35925685 another acceleration in the rate of change occurred at the baseline age of 65-70 years for a\xce\xb242/a\xce\xb240 ratio, tau, ptau181, pib suvr and hippocampal volume. 2022-08-04 2022-08-08 Not clear
Selena P Maxwell, Meghan K Cash, Sultan Darves. Neuropathology and cholinesterase expression in the brains of octogenarians and older. Chemico-biological interactions vol issue 2022 35872043 tissues from age- and sex-matched cnoo and alzheimer's disease (ad) rpfc and hippocampal formation were stained for \xce\xb2-amyloid (a\xce\xb2), tau, \xce\xb1-synuclein, phosphorylated tar dna-binding protein 43 (ptdp-43), acetylcholinesterase (ache), and butyrylcholinesterase (bche). 2022-07-25 2022-08-08 Not clear
Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica vol issue 2022 35871112 here, we investigated the distribution and burden of phosphorylated and c-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of alzheimer's disease (ad). 2022-07-23 2022-07-25 Not clear
Parul Katiyar, Aaina Singh Rathore, Somesh Banerjee, Sandip Nathani, Walia Zahra, Surya Pratap Singh, Debabrata Sircar, Partha Ro. Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice. Food & function vol issue 2022 35861716 wheatgrass treatment of mice also regulated the phosphorylation of tau protein and simultaneously prevented its aggregation in the hippocampal region of the brain. 2022-07-21 2022-07-25 Not clear
Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying M. A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. Molecules (Basel, Switzerland) vol 27 issue 13 2022 35807406 in vivo, bg45 alleviated the apoptosis-mediated loss of hippocampal neurons, upregulated synapse-related proteins, reduced a\xce\xb2 deposition and phosphorylation of tau, and increased the levels of the synapse-related genes grik2, scn3b, syp, grm2, and grid2ip. 2022-07-09 2022-07-11 Not clear
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