| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences vol issue 2023 36865237 |
hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. |
2023-03-03 |
2023-03-06 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences vol issue 2023 36865237 |
high pathologic tau stage (braak stage) or a high burden of hippocampal tau pathology have been associated with cognitive impairment in part. |
2023-03-03 |
2023-03-06 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences vol issue 2023 36865237 |
in this study, we identified loss of synaptophysin puncta and intensity in the ca2 region of the hippocampus in cases of part with either a high stage (braak iv) or a high burden of neuritic tau pathology. |
2023-03-03 |
2023-03-06 |
Not clear |
| Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy. medRxiv : the preprint server for health sciences vol issue 2023 36865237 |
these novel findings suggest the presence of synaptic loss in part associated with either a high hippocampal tau burden or a braak stage iv. |
2023-03-03 |
2023-03-06 |
Not clear |
| Abdel-Azim Assi, Magda M Y Farrag, Dalia M Badary, Essmat A H Allam, Mariam A Nicol. Protective effects of curcumin and Ginkgo biloba extract combination on a\\xc2\\xa0new model of Alzheimer's disease. Inflammopharmacology vol issue 2023 36856916 |
this was associated with a more pronounced inhibitory effect on acetylcholinesterase (ache), caspase-3, hippocampal amyloid beta (a\xce\xb21-42), and phosphorylated tau protein (p-tau) count, and pro-inflammatory cytokines tumor necrosis factor-alpha (tnf-\xce\xb1) and interleukine-1beta (il-1\xce\xb2), as compared to the curcumin alone-treated group. |
2023-03-01 |
2023-03-06 |
rat |
| Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy, Nicholas M Kanaa. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular neurobiology vol issue 2023 36859689 |
phosphomimetics at ser199/ser202/thr205 in tau impairs axonal transport in rat hippocampal neurons. |
2023-03-01 |
2023-03-06 |
rat |
| Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3\\xce\\xb2 signaling pathway and intestinal microbiota. Frontiers in pharmacology vol 14 issue 2023 36843923 |
the pharmacological effects of rrp were evaluated by behavioral tests, brain tissue h&e staining and hippocampal tau protein phosphorylation levels. |
2023-02-27 |
2023-03-06 |
mouse |
| Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3\\xce\\xb2 signaling pathway and intestinal microbiota. Frontiers in pharmacology vol 14 issue 2023 36843923 |
the results showed that rrp ameliorated cognitive dysfunction and neuronal pathological changes of brain tissue in icv-stz mice, reduced tau protein hyperphosphorylation, insr, irs-1, pser473-akt/akt, and pser9-gsk-3\xce\xb2/gsk-3\xce\xb2 levels in hippocampal and cortical tissues. |
2023-02-27 |
2023-03-06 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology vol 12 issue 2 2023 36829593 |
the results showed that haspin was expressed in the hippocampus and phosphorylated tau protein, while the ingestion of soybean sprouts containing coumestrol suppressed the development of spatial cognitive dysfunction in 5xfad. |
2023-02-25 |
2023-03-06 |
mouse |
| Samo Ribari\\xc4\\x8. Detecting Early Cognitive Decline in Alzheimer's Disease with Brain Synaptic Structural and Functional Evaluation. Biomedicines vol 11 issue 2 2023 36830892 |
ad dysregulation of a\xce\xb2 and tau metabolism progressively disrupt normal synaptic function, leading to loss of synapses, decreased hippocampal synaptic density and early hippocampal atrophy. |
2023-02-25 |
2023-03-06 |
Not clear |
| Taku Homma, Yoko Mochizuki, Shinsuke Tobisawa, Takashi Komori, Kazushi Takahash. Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features. Journal of neuropathology and experimental neurology vol issue 2023 36840692 |
we investigated hippocampal nci pathology in 18 msa patient autopsies, focusing on phosphorylated \xce\xb1-synuclein (pas)- and phosphorylated tau (pt)-positive dntncis. |
2023-02-25 |
2023-03-06 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior vol issue 2023 36809844 |
importantly, we found that the hyperphosphorylation of tau in the hippocampus of stz/i.c.v rats was decreased after oral administration of ertugliflozin, which was accompanied by decreased phospho.irs-1 |
2023-02-22 |
2023-03-06 |
rat |
| Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience vol issue 2023 36775930 |
we stained for ferritin, ferroportin, hyper-phosphorylated tau, and \xce\xb2-amyloid proteins in the hippocampal region of apolipoprotein e2 (apoe2), apoe3, or apoe4 mice fed a control diet or a hypothesized inflammation-inducing methionine diet and euthanized at 3, 6, 9, or 12 months. |
2023-02-13 |
2023-03-06 |
mouse |
| Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience vol issue 2023 36775930 |
additionally, there were non-significant trends in each hippocampal subfield of increasing ferroportin and hyper-phosphorylated tau after 6 months of age, and decreasing \xce\xb2-amyloid and ferritin with age. |
2023-02-13 |
2023-03-06 |
mouse |
| Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Bani\\xc4\\x87evi\\xc4\\x87, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C M\\xc3\\xbclle. APPs\\xce\\xb1 rescues CDK5 and GSK3\\xce\\xb2 dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience vol 17 issue 2023 36779015 |
immunohistochemistry revealed a dramatic increase in pathologically phosphorylated (at8 and at180) or misfolded tau species (mc1) in the hippocampus of thy-tau22 mice between 3 and 12 months of age. |
2023-02-13 |
2023-03-06 |
mouse |
| Danny Baltissen, Charlotte S Bold, Lena Rehra, Marija Bani\\xc4\\x87evi\\xc4\\x87, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J Buchholz, Martin Korte, Ulrike C M\\xc3\\xbclle. APPs\\xce\\xb1 rescues CDK5 and GSK3\\xce\\xb2 dysregulation and restores normal spine density in Tau transgenic mice. Frontiers in cellular neuroscience vol 17 issue 2023 36779015 |
using a highly sensitive radioactive kinase assay with recombinant human tau as a substrate and immunoblotting, we demonstrate an increase in gsk3\xce\xb2 and cdk5 activity in the hippocampus of thy-tau22 mice. |
2023-02-13 |
2023-03-06 |
mouse |
| Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RAR\\xce\\xb1 Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research vol issue 2023 36781685 |
western blot results showed that bt75 decreased levels of neuronal nitric oxide synthase (nnos), gfap, and phosphorylated tau, and increased levels of synaptophysin in the hippocampus of icv-stz mice. |
2023-02-13 |
2023-03-06 |
mouse |
| Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na W. Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid \\xce\\xb2 metabolism. Neurobiology of aging vol 124 issue 2023 36758468 |
the results showed that oxa aggravated memory impairments and circadian rhythm disturbance, exacerbated hippocampal ltp depression, and increased a\xce\xb2 and tau pathologies in 3xtg-ad mice by affecting bace1 and nep expression. |
2023-02-09 |
2023-03-06 |
mouse |
| Xiao-Hui Li, Hong-Can Zhu, Xue-Min Cui, Wang Wang, Lin Yang, Li-Bo Wang, Neng-Wei Hu, Dong-Xiao Dua. Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. Neural regeneration research vol 18 issue 8 2023 36751808 |
exercise and treatment with the antidepressant drug citalopram decreased dapk1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive dysfunction. |
2023-02-08 |
2023-03-06 |
mouse |
| Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Chuang Gu. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Experimental neurology vol issue 2023 36750170 |
here, we found that long-term h-iapp treatment attenuated tau hyperphosphorylation levels and induced neuroinflammation and oxidative damage, prevented synaptic loss and neuronal degeneration in the hippocampus, and alleviated behavioral deficits in p301s transgenic mice (a mouse model of tauopathy). |
2023-02-07 |
2023-03-06 |
mouse |