| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amber M Tetlow, Brianna M Jackman, Mohammed M Alhadidy, Patricia Muskus, David G Morgan, Marcia N Gordo. Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice. Neurobiology of aging. vol 124. 2023-02-05. PMID:36739619. |
neural atrophy produced by aav tau injections into hippocampus and anterior cortex of middle-aged mice. |
2023-02-05 |
2023-08-14 |
mouse |
| Raffaella Franciotti, Davide Nardini, Mirella Russo, Marco Onofrj, Stefano L Sens. Comparison of Machine Learning-based approaches to predict the conversion to Alzheimer's disease from Mild Cognitive Impairment. Neuroscience. 2023-02-03. PMID:36736612. |
finally, the feature selection procedure indicated that the most critical variables in the respective classes were the adas-cog-13 scale, the medial temporal lobe and hippocampus atrophy, and the ratio between phosphorylated tau and aβ42 proteins. |
2023-02-03 |
2023-08-14 |
human |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
subsequently, an elisa was applied to detect amyloid-β (aβ) 1-40 and aβ1-42 levels in rat hippocampal tissues, quantitative reverse transcription pcr assays were used to detect the mrna expression levels of brain-derived neurotrophic factor (bdnf) and trk b, and western blots were used to detect the protein expression levels of bace1, tau, p-tau, and protein kinase b (akt)/glycogen synthase kinase 3β (gsk3β) pathway-related proteins. |
2023-01-31 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp treatment greatly ameliorated the cognitive disability, reduced aβ1-40 and aβ1-42 levels and tau phosphorylation, and upregulated bace1, trk b, and bdnf expression in the hippocampus of 2vo rats. |
2023-01-31 |
2023-08-14 |
rat |
| Ling-Ling Ye, Yuan-Lu Huang, Xiao-E Cheng, Yin-Qi Shi, Zi-Ye Liu, Ying-Fen Xion. Effect of neurotropin on Alzheimer's disease-like changes and cognitive function in rats with chronic cerebral hypoperfusion. Neuroreport. 2023-01-31. PMID:36719834. |
ntp can ameliorate cognitive disability in cch rats possibly by reducing aβ accumulation and tau phosphorylation in the hippocampus. |
2023-01-31 |
2023-08-14 |
rat |
| Miriam Zamorano, Jenolyn F Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J Heijne. Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice. Immunity & ageing : I & A. vol 20. issue 1. 2023-01-26. PMID:36698170. |
we showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive deficits that are associated with formation of tau deposits in the hippocampus. |
2023-01-26 |
2023-08-14 |
mouse |
| Bastien Herli. Hippocampal sclerosis linked to epilepsy: clinical consequences, histopathology and evolution with aging Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 20. issue 4. 2023-01-26. PMID:36700444. |
hippocampal sclerosis is associated with amyloid and tau deposits inside the hippocampus, which increases with the subjects’ age. |
2023-01-26 |
2023-08-14 |
human |
| Bastien Herli. Hippocampal sclerosis linked to epilepsy: clinical consequences, histopathology and evolution with aging Geriatrie et psychologie neuropsychiatrie du vieillissement. vol 20. issue 4. 2023-01-26. PMID:36700444. |
those deposits pattern is close to the one observed in patients with tau / amyloïd neurodegenerative diseases, which demonstrates a bilateral relationship between epilepsy, hippocampal sclerosis, and neurodegenerative diseases. |
2023-01-26 |
2023-08-14 |
human |
| Guoliang Fang, Jiexiu Zhao, Pengfei Li, Liang Li, Tao Yu, Xingya Yang, Zihong He, Ye Tia. Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. Science bulletin. vol 62. issue 11. 2023-01-20. PMID:36659268. |
long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. |
2023-01-20 |
2023-08-14 |
rat |
| Gouri Patil, Shabda Kulsange, Rubina Kazi, Tejas Chirmade, Vaikhari Kale, Chandrashekhar Mote, Manoj Aswar, Santosh Koratkar, Sachin Agawane, Mahesh Kulkarn. Behavioral and Proteomic Studies Reveal Methylglyoxal Activate Pathways Associated with Alzheimer's Disease. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654748. |
the hippocampal tau phosphorylation level was increased in mgo treated rats, which was reduced in the presence of aminoguanidine and telmisartan. |
2023-01-19 |
2023-08-14 |
rat |
| Nikhil Dave, Jessica M Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K Winstone, Erik A Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazque. Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. Aging cell. 2023-01-16. PMID:36642814. |
tissue analyses showed cardiac and liver pathology, elevated soluble and insoluble amyloid-β and thioflavin s structures, and tau hyperphosphorylation at various pathological epitopes in the hippocampus and cortex of 3xtg-ad ch- mice. |
2023-01-16 |
2023-08-14 |
mouse |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min-Sun Ki. Risperidone ameliorated 1,2-Diacetylbenzene-induced cognitive impairments in mice via activating prolactin signaling pathways. International immunopharmacology. vol 115. 2023-01-15. PMID:36641890. |
risperidone alleviated dab-induced cognitive impairment in hippocampal mice, possibly by inhibiting gsk-3β, β-amyloid, cdk5, bace, and tau hyperphosphorylation. |
2023-01-15 |
2023-08-14 |
mouse |
| Junghyung Park, Jinyoung Won, Chang-Yeop Jeon, Kyung Seob Lim, Won Seok Choi, Sung-Hyun Park, Jincheol Seo, Jiyeon Cho, Jung Bae Seong, Hyeon-Gu Yeo, Keonwoo Kim, Yu Gyeong Kim, Minji Kim, Kyung Sik Yi, Youngjeon Le. XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer's Disease Model Using the Cynomolgus Monkey ( Experimental neurobiology. vol 31. issue 6. 2023-01-11. PMID:36631849. |
the monkeys subjected to xperct-based stz injection via the icm route showed features of ad pathology, including markedly enhanced neuronal loss, synaptic impairment, and tau phosphorylation in the hippocampus. |
2023-01-11 |
2023-08-14 |
human |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| Young-Kook Kim, Yoon Seok Jung, Juhyun Son. Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36614117. |
alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by tau hyperphosphorylation, excessive amyloid beta (aβ) accumulation, the formation of fibrillary tangles, hippocampus atrophy, and neuroinflammation. |
2023-01-08 |
2023-08-14 |
mouse |
| Zheng Liang, Xiaokang Gong, Runjia Ye, Yang Zhao, Jin Yu, Yanna Zhao, Jian Ba. Long-Term High-Fat Diet Consumption Induces Cognitive Decline Accompanied by Tau Hyper-Phosphorylation and Microglial Activation in Aging. Nutrients. vol 15. issue 1. 2023-01-08. PMID:36615907. |
compared with the nd group, the hfd-fed mice showed tau hyperphosphorylation at ps214 in the hippocampus and at ps422 and ps396 in the cortex, which was accompanied by gsk-3β activation. |
2023-01-08 |
2023-08-14 |
mouse |
| Thamires Naela Cardoso Magalhães, Raphael Fernandes Casseb, Christian Luiz Baptista Gerbelli, Luciana Ramalho Pimentel-Siva, Mateus Henrique Nogueira, Camila Vieira Ligo Teixeira, Ana Flávia Mac Knight Carletti, Thiago Junqueira Ribeiro de Rezende, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Orestes Vicente Forlenza, Fernando Cendes, Marcio Luiz Figueredo Balthaza. Whole-brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease. Brain and behavior. 2023-01-05. PMID:36601694. |
whole-brain dti parameters associated with tau protein and hippocampal volume in alzheimer's disease. |
2023-01-05 |
2023-08-14 |
Not clear |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
we conclude that the dg is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. |
2023-01-03 |
2023-08-14 |
human |
| Regina T Vontell, Juan Pablo de Rivero Vaccari, Xiaoyan Sun, Sakir Humayun Gultekin, Helen M Bramlett, W Dalton Dietrich, Robert W Kean. Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). 2022-12-29. PMID:36579934. |
we performed analysis of hippocampal thickness, β-amyloid plaques, and hyperphosphorylated tau to ascertain the cellular pathological changes that occur between low and intermediate ad pathology. |
2022-12-29 |
2023-08-14 |
Not clear |