| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kubra Celik Topkara, Erkan Kilinc, Ayhan Cetinkaya, Asl\\xc4\\xb1han Saylan, Serif Demi. Therapeutic effects of carvacrol on beta-amyloid-induced impairments in in-vitro and in-vivo models of Alzheimer's disease. The European journal of neuroscience vol issue 2021 34904309 |
oxidant-antioxidant parameters (mda, h2o2, sod, and cat) and tau, a\xce\xb21-40 and a\xce\xb21-42 peptide levels in in-vitro supernatant or in-vivo serum and hippocampal samples were measured using elisa. |
2021-12-14 |
2023-01-26 |
cat |
| Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R Nelson, Althea deWeever, Anna Koloteva, Naga S Annamdevula, James M Murphy, Brant M Wagener, Jean-Francois Pittet, Ssang-Taek S Lim, Ron Balczon, Troy Stevens, Mike T Li. Cytotoxic tau released from lung microvascular endothelial cells upon infection with P. aeruginosa promotes neuronal tauopathy. The Journal of biological chemistry vol issue 2021 34896150 |
we previously hypothesized that the lung endothelium contributes to infection-related neurocognitive dysfunction, since bacteria-exposed endothelial cells release a form(s) of cytotoxic tau that is sufficient to impair long-term potentiation in the hippocampus. |
2021-12-13 |
2023-01-26 |
mouse |
| Jianfeng Wu, Qunxi Dong, Jie Zhang, Yi Su, Teresa Wu, Richard J Caselli, Eric M Reiman, Jieping Ye, Natasha Lepore, Kewei Chen, Paul M Thompson, Yalin Wan. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Frontiers in neuroscience vol 15 issue 2021 34899166 |
federated morphometry feature selection for hippocampal morphometry associated beta-amyloid and tau pathology. |
2021-12-13 |
2023-01-26 |
human |
| Xiao-Juan Wang, Lin Qi, Ya-Fang Cheng, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Li-Bo Zo. PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease. Acta pharmacologica Sinica vol issue 2021 34893682 |
we showed that intracerebroventricular (icv) microinjection of forskolin (fsk, 80\xe2\x80\x89\xce\xbcmol) induced tau hyperphosphorylation in the rat brain and resulted in significant spatial working memory impairments in y-maze test, accompanied by synaptic dysfunction (reduced expression of synaptic proteins synaptophysin and postsynaptic density protein 95), and neuronal loss in the hippocampus. |
2021-12-11 |
2023-01-26 |
rat |
| Megan A Iida, Kurt Farrell, Jamie M Walker, Timothy E Richardson, Gabriel A Marx, Clare H Bryce, Dushyant Purohit, Gai Ayalon, Thomas G Beach, Eileen H Bigio, Etty P Cortes, Marla Gearing, Vahram Haroutunian, Corey T McMillan, Edward B Lee, Dennis W Dickson, Ann C McKee, Thor D Stein, John Q Trojanowski, Randall L Woltjer, Gabor G Kovacs, Julia K Kofler, Jeffrey Kaye, Charles L White, John F Crar. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta neuropathologica communications vol 9 issue 1 2021 34353357 |
we compared braak staging, which focuses on hierarchical neuroanatomical progression of ad tau and a\xce\xb2 pathology, with quantitative assessments of neurofibrillary burden using computer-derived positive pixel counts on digitized whole slide images of sections stained immunohistochemically with antibodies targeting abnormal hyperphosphorylated tau (p-tau) in the entorhinal region and hippocampus. |
2021-12-11 |
2023-01-26 |
human |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research vol 175 issue 2021 34838693 |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of a\xce\xb21-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-01-26 |
mouse |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology vol 914 issue 2021 34861210 |
hippocampal sirt1 improves cognitive impairment by deacetylating tau protein in diabetic models. |
2021-12-11 |
2023-01-26 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology vol 914 issue 2021 34861210 |
further study showed that the decreased level of sirt1 may result in the increase of acetylated tau protein in the hippocampus, which may mediate the development of diabetic cognitive impairment. |
2021-12-11 |
2023-01-26 |
rat |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus vol 13 issue 11 2021 34877187 |
thirdly, multiple pathological studies showed that insulin and alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-a\xce\xb2 plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. |
2021-12-11 |
2023-01-26 |
human |
| Zhao-Yan Cheng, Yu-Hui Hu, Qing-Peng Xia, Chen Wang, Ling H. DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. Brain research bulletin vol 175 issue 2021 34284074 |
moreover, our mechanism researches revealed that the drd1 signaling induced by a-68930 significantly rescued stz-induced mitochondrial biogenesis deficit, mitochondrial dysfunction, a\xce\xb2 overexpression, and tau phosphorylation in mice hippocampus and cortex and sh-sy5y cells, which may be mediated through stimulating ampk/pgc-1\xce\xb1 pathway. |
2021-12-10 |
2023-01-26 |
mouse |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 |
first, event-based modelling revealed that the entorhinal cortex and brodmann area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, brodmann area 36 and the parahippocampal cortex. |
2021-12-09 |
2023-01-26 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 |
second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, brodmann area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. |
2021-12-09 |
2023-01-26 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 |
finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. |
2021-12-09 |
2023-01-26 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology vol 144 issue 9 2021 33725124 |
while tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy. |
2021-12-09 |
2023-01-26 |
human |
| Fang Yuan, Xiao-Ping Hong, Yan-Jun Duan, Jiao-Rong Chen, Yong-Ming Ha. [Electroacupuncture at \"Zusanli\"(ST36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. Zhen ci yan jiu = Acupuncture research vol 46 issue 11 2021 34865325 |
[electroacupuncture at "zusanli"(st36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. |
2021-12-08 |
2023-01-26 |
rat |
| Fang Yuan, Xiao-Ping Hong, Yan-Jun Duan, Jiao-Rong Chen, Yong-Ming Ha. [Electroacupuncture at \"Zusanli\"(ST36) ameliorates tau hyperphosphorylation in pancreas and hippocampus of diabetic rats]. Zhen ci yan jiu = Acupuncture research vol 46 issue 11 2021 34865325 |
to observe the effect of electroacupuncture (ea) at "zusanli"(st36) on the phosphorylated tau levels in pancreas and hippocampus of type 2 diabetes mellitus (t2dm) rats\xef\xbc\x8cso as to explore the underlying mechanism of ea in diabetic demention rats. |
2021-12-08 |
2023-01-26 |
rat |
| Katie A Bretland, Li Lin, Kimberly M Bretland, Matthew A Smith, Sheila M Fleming, Christine M Dengler-Cris. Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. Neuropathology and applied neurobiology vol 47 issue 7 2021 33768561 |
irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice. |
2021-12-02 |
2023-01-26 |
mouse |
| Hend M Hussien, Doaa A Ghareeb, Hany E A Ahmed, Hani S Hafez, Samar R Sale. Pharmacological implications of ipriflavone against environmental metal-induced neurodegeneration and dementia in rats. Environmental science and pollution research international vol 28 issue 46 2021 34235690 |
neuropathological biomarkers including oxidative stress (tbars, no, sod, gpx, gst, and gsh), inflammation (tnf- \xce\xb1, il-6, and il-1\xce\xb2), neurotransmission (ache and mao), and insulin resistance (insulin, insulin receptor, and insulin-degrading enzyme) were altered, which consequently elevated the level of amyloid-\xce\xb242 and tau protein in the hippocampus tissues inducing neuronal injury. |
2021-12-02 |
2023-01-26 |
rat |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia vol 68 issue 9 2021 32096580 |
increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged tupaia belangeri. |
2021-11-30 |
2023-01-26 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia vol 68 issue 9 2021 32096580 |
adult (mean age 3.8\xe2\x80\x89years), old (mean age 6\xe2\x80\x89years), and aged (mean age 7.5\xe2\x80\x89years) tree shrews were used for histochemical and immunostaining techniques to determine ferritin and iba1 positive microglia, iron tissue content, tau hyperphosphorylation and oxidized-rna in dentate gyrus, subiculum, and ca1-ca3 hippocampal regions. |
2021-11-30 |
2023-01-26 |
Not clear |