| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Xiao Wan, Guang Shi, Ling-Yan Jian, Xin-Yu Fa. Blockade of endocannabinoid system by oxytocin attenuates memory deficits in oxycodone-treated rats. Addiction biology. vol 28. issue 1. 2022-12-28. PMID:36577736. |
this finding was accompanied by elevation of pser396, pser404 in the tau, and reduction of the number of neurons, dendritic spines and synaptic density in the hippocampus. |
2022-12-28 |
2023-08-14 |
rat |
| Mariana G Fronza, Manoela Sacramento, Diego Alves, Domenico Praticò, Lucielli Savegnag. QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice. Molecular neurobiology. 2022-12-25. PMID:36567360. |
among them, the reduction of amyloid beta (aβ) production mediated by changes in amyloid precursor protein metabolism and hippocampal tau phosphorylation through the inhibition of kinases. |
2022-12-25 |
2023-08-14 |
mouse |
| Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wan. GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations. Molecular neurobiology. 2022-12-16. PMID:36525154. |
here, we reported that mice with reduced grk5 in the hippocampus exhibit cognitive impairment and some alzheimer's disease (ad)-related molecular pathologies, such as significant neuronal damage and loss, enhanced tau protein phosphorylation, and increased levels of aβ peptides in the hippocampus. |
2022-12-16 |
2023-08-14 |
mouse |
| Laurel A Becket. Alzheimer's-related brain damage shows sex-specific links with risk factors. PLoS biology. vol 20. issue 12. 2022-12-14. PMID:36516115. |
alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. |
2022-12-14 |
2023-08-14 |
Not clear |
| Vani Jangra, Jeshnu Topl. Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus? Cureus. vol 14. issue 11. 2022-12-12. PMID:36505102. |
thirdly, several pathological research has also shown that beta-amyloid plaques, hyperphosphorylated tau protein, and brain shrinkage, particularly in the hippocampus, are shared brain lesions between insulin and alzheimer's disease. in light of this, type 2 diabetes mellitus may be viewed as a liability for dementia and alzheimer's disease. |
2022-12-12 |
2023-08-14 |
human |
| Chaitali Anand, Pedro D Maia, Justin Torok, Christopher Mezias, Ashish Ra. The effects of microglia on tauopathy progression can be quantified using Nexopathy in silico (Nexis) models. Scientific reports. vol 12. issue 1. 2022-12-08. PMID:36477076. |
trem2 appears to reduce tau accumulation rate while increasing its interregional spread from the hippocampal seed area, causing higher tau burden in the striatum, pallidum, and contralateral hippocampus. |
2022-12-08 |
2023-08-14 |
Not clear |
| Zhi-Yuan Lu, Chen-Yi Zhao, Guang Yang, Yu-Ting Tong, Zong-Tao Ba, Ahelijiang Reaila, Jian-Mei Yang, Ying X. [Modified Kaixin San improves memory and synaptic damage of mice with Alzheimer's disease by modulating αCaMKⅡ-PSD95 protein binding through inhibition of neuroinflammation:a study of mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 22. 2022-12-06. PMID:36471948. |
novel object reco-gnition task was employed to detect the recognition memory of mice, and western blot to detect the protein levels of synapse-associated proteins in the hippocampus(hpc) of mice, such as nr1, nr2 a, nr2 b, p-αcamkⅡ, tau, and p-tau. |
2022-12-06 |
2023-08-14 |
mouse |
| Jianfeng Wu, Yi Su, Wenhui Zhu, Negar Jalili Mallak, Natasha Lepore, Eric M Reiman, Richard J Caselli, Paul M Thompson, Kewei Chen, Yalin Wan. Improved Prediction of Amyloid-β and Tau Burden Using Hippocampal Surface Multivariate Morphometry Statistics and Sparse Coding. Journal of Alzheimer's disease : JAD. 2022-12-04. PMID:36463452. |
improved prediction of amyloid-β and tau burden using hippocampal surface multivariate morphometry statistics and sparse coding. |
2022-12-04 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
cognitive decline in alzheimer's disease correlates with the extent of tau pathology, in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the hippocampus. |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
studies from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including aging. |
2022-12-01 |
2023-08-14 |
Not clear |
| Zhengtao Hu, Tomas Ondrejcak, Pengpeng Yu, Yangyang Zhang, Yin Yang, Igor Klyubin, Sean P Kennelly, Michael J Rowan, Neng-Wei H. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453396. |
conversely, certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau, in particular, phosphorylation at residue ser396. |
2022-12-01 |
2023-08-14 |
Not clear |
| Wei-En Wang, Rob Chen, Robin Perry Mayrand, Malek Adjouadi, Ruogu Fang, Steven T DeKosky, Ranjan Duara, Stephen A Coombes, David E Vaillancour. Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition. Neurobiology of aging. vol 121. 2022-12-01. PMID:36455492. |
when the 3 groups were combined, increasing amyloid burden was associated with reduced extracellular free-water in the entorhinal cortex and hippocampus in those with amyloid-negative status whereas increasing tau burden was associated with increased extracellular free-water regardless of amyloid status. |
2022-12-01 |
2023-08-14 |
human |
| Alessandra Dos Santos, Fernanda Cardoso Teixeira, Daniel Schuch da Silva, Tayná Amaral Veleda, Julia Eisenhart de Mello, Karina Pereira Luduvico, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Wilson Cunico Filho, Roselia Maria Spanevell. Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: comparison with donepezil drug. Brain research bulletin. 2022-11-28. PMID:36442692. |
memory, acetylcholinesterase (ache) activity, phosphorylated tau protein levels and oxidative stress were analyzed in the cerebral cortex, hippocampus, and cerebellum. |
2022-11-28 |
2023-08-14 |
rat |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
brain extracts containing tau aggregates were unilaterally injected into the hippocampus and the overlying cerebral cortex of ps19 mice. |
2022-11-24 |
2023-08-14 |
mouse |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
the hippocampal sparing subtype of alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
we also implemented several methods for ad subtyping on tau pet to identify hippocampal sparing ad cases. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
in contrast, tau pet did identify ad participants with tracer retention in the association cortex while completely sparing the hippocampus. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
we conclude that tau pet can identify hippocampal sparing ad cases with nft completely sparing the hippocampus. |
2022-11-15 |
2023-08-14 |
human |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
alteration in the synaptic and extrasynaptic organization of ampa receptors in the hippocampus of p301s tau transgenic mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Rocio Alfaro-Ruiz, Carolina Aguado, Alejandro Martín-Belmonte, Ana Esther Moreno-Martínez, Jesús Merchán-Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Lujá. Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36362317. |
here, we determined the impact of tau pathology on ampar expression, density, and subcellular distribution in the hippocampus of p301s mice using immunoblot, histoblot, and quantitative sds-digested freeze-fracture replica labeling (sds-frl). |
2022-11-11 |
2023-08-14 |
mouse |