| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports vol 11 issue 1 2021 33627790 |
most importantly, we showed that tau phf-1 is located in hippocampal mitochondria and accumulates in the mitochondria of old mice. |
2021-11-15 |
2023-01-26 |
mouse |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports vol 11 issue 1 2021 33627790 |
these results demonstrated the presence of phosphorylated tau at phf-1 commonly related to tauopathy, inside the mitochondria from the hippocampus of healthy aged mice for the first time. |
2021-11-15 |
2023-01-26 |
mouse |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience vol 14 issue 2021 33986642 |
thus, we set out to help clarify the normal localization of tau in the adult cns of middle-aged rats and rhesus macaque using the hippocampus as a representative brain structure. |
2021-11-12 |
2023-01-26 |
rat |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience vol 14 issue 2021 33986642 |
the physiological concentration of tau in the rat hippocampus was 6.6 \xce\xbcm and in white matter was 3.6 \xce\xbcm as determined by quantitative sandwich elisas. |
2021-11-12 |
2023-01-26 |
rat |
| Min Xiong, Li Zou, Lanxia Meng, Xingyu Zhang, Ye Tian, Guoxin Zhang, Jiaolong Yang, Guiqin Chen, Jing Xiong, Keqiang Ye, Zhentao Zhan. A \\xce\\xb3-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Progress in neurobiology vol 203 issue 2021 33992672 |
expression of the \xce\xb3-adducin (1-357) fragment in the hippocampus of tau p301s transgenic mice resulted in significant ad-like pathology and cognitive deficits. |
2021-11-11 |
2023-01-26 |
Not clear |
| Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-\\xce\\xb2-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology vol 203 issue 2021 34004220 |
in an ad mouse model that manifests both a\xce\xb2 and tau pathologies, genetic downregulation of plexin-a4 in the hippocampus reduced tau pathology and ameliorated spatial memory impairment. |
2021-11-11 |
2023-01-26 |
Not clear |
| Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. [The Search for Citrus Components with Neuroprotective and Anti-dementia Effects in the Mouse Brain]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan vol 141 issue 6 2021 34078788 |
the c. kawachiensis treatment inhibited microglial activation and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in samp8. |
2021-11-11 |
2023-01-26 |
mouse |
| Mark R Libowitz, Ke Wei, Thao Tran, Karen Chu, Kristina Moncrieffe, Michael G Harrington, Kevin Kin. Regional brain volumes relate to Alzheimer's disease cerebrospinal fluid biomarkers and neuropsychometry: A cross-sectional, observational study. PloS one vol 16 issue 7 2021 34292973 |
a higher score on the boston naming test was optimally predicted in a selective regression model by greater hippocampus volume (p = 0.002), a higher ratio of \xc3\x9f-amyloid42 to tau protein levels (p < 0.001), greater posterior cingulate volume (p = 0.0193), age (p = 0.0271), and a higher education level (p = 0.002). |
2021-11-10 |
2023-01-26 |
human |
| Yang Gao, Xiao-Qing Wang, Shuai Ma, Yong-Cai Dong, Ya-Zhen Shan. Flavonoids from Stem and Leaf of Scutellaria Baicalensis Georgi Inhibit the Phosphorylation on Multi-sites of Tau Protein Induced by Okadaic Acid and the Regulative Mechanism of Protein Kinases in Rats. Combinatorial chemistry & high throughput screening vol 24 issue 7 2021 32875975 |
the present study aims to investigate the effect of flavonoids from stem and leaf of scutellaria baicalensis georgi (ssf) on multi-sites phosphorylation of tau protein in the cerebral cortex and hippocampus of rats induced by okadaic acid (oa) and the regulative mechanism of the protein kinases. |
2021-11-09 |
2023-01-26 |
rat |
| Benjamin B Tournier, Cristina Barca, A\\xc3\\xafda B Fall, Yesica Gloria, L\\xc3\\xa9a Meyer, Kelly Ceyz\\xc3\\xa9riat, Philippe Mille. Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease. Genes, brain, and behavior vol 20 issue 5 2021 33150709 |
these behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. |
2021-11-09 |
2023-01-26 |
rat |
| Vanessa Laversenne, Sameer Nazeeruddin, Emma C K\\xc3\\xa4llstig, Philippe Colin, Christel Voize, Bernard L Schneide. Anti-A\\xce\\xb2 antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta neuropathologica communications vol 8 issue 1 2021 33225991 |
to assess the effect of anti-a\xce\xb2 immunization in this context, we generated a mouse model by overexpressing the human tau protein in the hippocampus of 5xfad mice. |
2021-11-09 |
2023-01-26 |
mouse |
| Mackenzie L Carlson, Tyler N Toueg, M Mehdi Khalighi, Jessa Castillo, Bin Shen, Emily C Azevedo, Phillip DiGiacomo, Nicole Mouchawar, Gustavo Chau, Greg Zaharchuk, Michelle L James, Elizabeth C Mormino, Michael M Zeine. Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T. Alzheimer's & dementia (Amsterdam, Netherlands) vol 13 issue 1 2021 34337132 |
we assessed tau pathology and white matter connectivity changes in subfields of the hippocampus simultaneously in vivo in ad. |
2021-11-09 |
2023-01-26 |
Not clear |
| Philip L Yates, Ankita Patil, Xiaohuan Sun, Alessia Niceforo, Ramnik Gill, Patrick Callahan, Wayne Beck, Emanuela Piermarini, Alvin V Terry, Kimberly A Sullivan, Peter W Baas, Liang Qian. A cellular approach to understanding and treating Gulf War Illness. Cellular and molecular life sciences : CMLS vol 78 issue 21-22 2021 34580742 |
wistar rats exposed to a similar toxicant regimen showed a mild learning and memory deficit, as well as cell loss and tau pathology selectively in the ca3 region of the hippocampus. |
2021-11-08 |
2023-01-26 |
rat |
| David C Hondius, Frank Koopmans, Conny Leistner, D\\xc3\\xa9bora Pita-Illobre, Regina M Peferoen-Baert, Fenna Marbus, Iryna Paliukhovich, Ka Wan Li, Annemieke J M Rozemuller, Jeroen J M Hoozemans, August B Smi. The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease. Acta neuropathologica vol 141 issue 3 2021 33492460 |
by combining immunohistochemistry (ihc) and laser microdissection (lmd) we isolated neurons with gvd and those bearing tangles separately from human post-mortem ad hippocampus (n\xe2\x80\x89=\xe2\x80\x8912) using their typical markers casein kinase (ck)1\xce\xb4 and phosphorylated tau (at8). |
2021-11-05 |
2023-01-26 |
human |
| Carlos M Soto-Fagu\\xc3\\xa1s, Paula Sanchez-Molina, Carlos A Saur. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta neuropathologica communications vol 9 issue 1 2021 34593029 |
interestingly, genetic inactivation of presenilin 1 (ps1) or both ps genes in mutant human tau transgenic mice exacerbates memory deficits by accelerating phosphorylation and aggregation of tau in excitatory neurons of vulnerable ad brain regions (e.g., hippocampus, cortex and amygdala). |
2021-11-05 |
2023-01-26 |
mouse |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-P\\xc3\\xa9rula, Maria Mercedes I\\xc3\\xb1iguez de Onzo\\xc3\\xb1o Martin, Mar\\xc3\\xada Del Mar Arroyo Jim\\xc3\\xa9nez, Monica Mu\\xc3\\xb1oz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada S\\xc3\\xa1nchez, Jos\\xc3\\xa9 Carlos Delgado Gonz\\xc3\\xa1lez, Carlos de la Rosa Prieto, Marta C\\xc3\\xb3rcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications vol 9 issue 1 2021 34689831 |
when focusing on cases with low levels of tdp-43 pathology, we found strong associations between tau pathology and thickness in the erc, srlm and the subiculum/cornu ammonis 1 (ca1) subfields of the hippocampus, consistent with early braak stages. |
2021-11-05 |
2023-01-26 |
human |
| Sanila Amber, Sumera, Fatima J Mirza, Muhammad Asif, Deeba Hassan, Touqeer Ahmed, Saadia Zahi. Amyloid-beta Induced Neurotoxicity Impairs Cognition and Adult Hippocampal Neurogenesis in a Mouse Model for Alzheimer's Disease. Current Alzheimer research vol 17 issue 11 2021 33357181 |
in the past few years, impaired adult hippocampal neurogenesis emerged as a contributing hallmark of ad pathophysiology along with amyloid beta (a\xce\xb2) and tau hyper phosphorylation-induced neurotoxicity. |
2021-11-04 |
2023-01-26 |
Not clear |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine vol 49 issue 6 2021 34137676 |
serum and hippocampal [formula: see text]-amyloid peptide (a[formula: see text], tau and phosphorylated tau protein deposition in the hippocampi were measured. |
2021-11-04 |
2023-01-26 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine vol 49 issue 6 2021 34137676 |
berberine also effectively decreased the expression of hippocampal tau protein, phosphorylated tau, and increased insulin receptor antibodies. |
2021-11-04 |
2023-01-26 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine vol 49 issue 6 2021 34137676 |
moreover, berberine downregulated the abnormal phosphorylation of a[formula: see text] and tau protein and improved hippocampal insulin signaling. |
2021-11-04 |
2023-01-26 |
rat |