| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1\\xce\\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport vol 32 issue 10 2021 34029285 |
immunohistochemical and western blot assays were used to assess the expression levels of il-1\xce\xb2 and il-6, as well as tau protein and its phosphorylation status in the hippocampus. |
2021-09-20 |
2023-01-26 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1\\xce\\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport vol 32 issue 10 2021 34029285 |
our results showed that chronic alcohol exposure impaired the spatial recognition ability of mice upregulated the expression of il-1\xce\xb2 and il-6 in the serum and hippocampus and increased the phosphorylation of tau protein in the hippocampus. |
2021-09-20 |
2023-01-26 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1\\xce\\xb2 upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport vol 32 issue 10 2021 34029285 |
the present results indicate that hippocampal il-1\xce\xb2, il-6, and phosphorylated tau proteins may be involved in the neurotoxic mechanism of chronic alcohol exposure by mediating synaptic dysfunction. |
2021-09-20 |
2023-01-26 |
mouse |
| Akinori Futamura, Sotaro Hieda, Yukiko Mori, Azusa Sugimoto, Hideyo Kasai, Takeshi Kuroda, Satoshi Yano, Kensaku Kasuga, Hidetomo Murakami, Takeshi Ikeuchi, Kenjiro On. Cingulate Island Sign in Single Photon Emission Computed Tomography: Clinical Biomarker Correlations in Lewy Body Disease and Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol 79 issue 3 2021 33361600 |
our results showed cis was not related to csf biomarkers in lbd and high csf tau levels were related to clinical disease severity and hippocampal atrophy. |
2021-09-17 |
2023-01-26 |
Not clear |
| Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD vol 79 issue 4 2021 33459641 |
new biomolecular findings reveal the interplay of cbh in increasing tau phosphorylation (p-tau) in the hippocampus and cortex of ad mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mtor), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of ad. |
2021-09-15 |
2023-01-26 |
mouse |
| Lei Huang, Yang Zhang, Yongwei Wang, Yajia La. Relationship Between Chronic Noise Exposure, Cognitive Impairment, and Degenerative Dementia: Update on the Experimental and Epidemiological Evidence and Prospects for Further Research. Journal of Alzheimer's disease : JAD vol 79 issue 4 2021 33459723 |
experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-\xce\xb2 deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. |
2021-09-15 |
2023-01-26 |
Not clear |
| Anastasia No\\xc3\\xabl, B\\xc3\\xa9n\\xc3\\xa9dicte Foveau, Andr\\xc3\\xa9a C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease vol 12 issue 3 2021 33649324 |
intraneuronal hippocampal tau hyperphosphorylation at s202/t205, s422, and t231, and tau conformational change were absent in both ctc and cto brains. |
2021-09-14 |
2023-01-26 |
mouse |
| Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease vol 36 issue 7 2021 34269982 |
during in vitro experiment, high-fat diet mice showed cognitive dysfunction, significant hyperphosphorylation of tau protein and neuronal pyroptosis in hippocampus compared with the sham mice. |
2021-09-14 |
2023-01-26 |
mouse |
| Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease vol 36 issue 7 2021 34269982 |
inhibition of the signaling pathway using axl1717 or znpp ix re-deteriorated cognitive function, tau pathology and neuronal pyroptosis in hippocampus. |
2021-09-14 |
2023-01-26 |
mouse |
| Mohamed A Salem, Barbara Budzy\\xc5\\x84ska, Joanna Kowalczyk, Nesrine S El Sayed, Suzan M Mansou. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/\\xce\\xb2-catenin, AMPK/mTOR signaling pathways. Toxicology and applied pharmacology vol 429 issue 2021 34428446 |
administration of tad or bg at doses of 20 and 25\xc2\xa0mg/kg, respectively, for 21 consecutive days attenuated stz-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the morris water maze and object recognition tests paralleled by reduction in a\xce\xb2 expression by 79 and 89% and tau hyperphosphorylation by 60 and 61%, respectively. |
2021-09-14 |
2023-01-26 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience vol 13 issue 2021 34512303 |
amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. |
2021-09-14 |
2023-01-26 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience vol 13 issue 2021 34512303 |
we investigated if alleviation of hippocampal ir by the antidiabetic agent metformin could reduce tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. |
2021-09-14 |
2023-01-26 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience vol 13 issue 2021 34512303 |
the effects of prolonged (6 h) isoflurane anesthesia on hippocampal ir, hippocampal tau hyperphosphorylation, and hippocampus-dependent cognitive function were evaluated in wild type (wt) adult mice and the high-fat diet plus streptozotocin (hfd/stz) mouse model of t2dm. |
2021-09-14 |
2023-01-26 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience vol 13 issue 2021 34512303 |
isoflurane also induced hippocampal tau hyperphosphorylation and metformin reversed this effect. |
2021-09-14 |
2023-01-26 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience vol 13 issue 2021 34512303 |
our findings show hippocampal ir and tau hyperphosphorylation contribute to acute isoflurane-induced cognitive dysfunction. |
2021-09-14 |
2023-01-26 |
mouse |
| Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal vol 478 issue 7 2021 33660768 |
the known inhibitory effect of rivastigmine on cognition and acetylcholinesterase activity was observed in both cortex and hippocampus and further its effect on tau level, amyloid aggregation, biochemical alterations, endoplasmic reticulum (er) stress, calcium homeostasis, proteasome activity and apoptosis was estimated. |
2021-09-13 |
2023-01-26 |
rat |
| David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology vol 80 issue 8 2021 34388235 |
others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and creutzfeldt-jakob disease. |
2021-09-13 |
2023-01-26 |
Not clear |
| Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardso. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of neuropathology and experimental neurology vol 80 issue 5 2021 33860327 |
asymmetry of hippocampal tau pathology in primary age-related tauopathy and alzheimer disease. |
2021-09-09 |
2023-01-26 |
Not clear |
| Xin Wang, En-Jie Liu, Qian Liu, Shi-Hong Li, Ting Li, Qiu-Zhi Zhou, Yan-Chao Liu, Huaqiu Zhang, Jian-Zhi Wan. Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice. Journal of Alzheimer's disease : JAD vol 77 issue 1 2021 32804150 |
tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice. |
2021-09-08 |
2023-01-26 |
mouse |
| Israa M Abd El-Fatah, Heba M A Abdelrazek, Sherehan M Ibrahim, Dalaal M Abdallah, Hanan S El-Abha. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3\\xce\\xb2, adiponectin/Adipo1R, and NF-\\xce\\xbaB/IL-1\\xce\\xb2/ROS trajectories. Neurochemistry international vol 148 issue 2021 34052296 |
mechanistically, dmf suppressed the hippocampal contents of ad-surrogate markers; viz., apolipoprotein (apo)-e1, bace1, a\xce\xb242, and hyperphosphorylated tau. |
2021-09-08 |
2023-01-26 |
rat |