| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted A\\xce\\xb2 and p-tau accumulation via regulating Akt/GSK-3\\xce\\xb2 signal pathway. The Science of the total environment vol 794 issue 2021 34323745 |
in this study, we observed \xce\xb2-amyloid (a\xce\xb2) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 \xce\xbcg/l) for 180 days. |
2021-09-06 |
2023-01-26 |
mouse |
| Yilin Shen, Haixia Hu, Cui Fan, Quan Wang, Tianyuan Zou, Bin Ye, Mingliang Xian. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons. Neurobiology of disease vol 156 issue 2021 34082124 |
these results suggest that hearing loss alone causes neuronal degeneration, inhibition of neurogenesis, increased tau protein phosphorylation, and increased neuroinflammation in the hippocampus. |
2021-09-03 |
2023-01-26 |
Not clear |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity vol 2020 issue 2021 33381265 |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-01-26 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity vol 2020 issue 2021 33381265 |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-01-26 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity vol 2020 issue 2021 33381265 |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-01-26 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research vol 1740 issue 2021 32304687 |
a\xce\xb2 and total tau in the hippocampus and cerebrospinal fluid (csf) were detected using western blotting (wb) and enzyme-linked immunosorbent assay (elisa). |
2021-09-01 |
2023-01-26 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research vol 1740 issue 2021 32304687 |
after ea intervention, the hippocampal a\xce\xb2 and total tau protein levels, body weight, fpg, fins, and c-p were significantly decreased. |
2021-09-01 |
2023-01-26 |
rat |
| Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Ki. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. Toxics vol 9 issue 8 2021 34437506 |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid \xce\xb2 (a\xce\xb2) aggregates in multiple brain regions, including the hippocampus and cortex. |
2021-08-31 |
2023-01-26 |
human |
| Zhiqun Tang, Dan Liang, Miaoying Cheng, Xinyi Su, Runhe Liu, Yiding Zhang, Hongkun W. Effects of Porphyromonas gingivalis and Its Underlying Mechanisms on Alzheimer-Like Tau Hyperphosphorylation in Sprague-Dawley Rats. Journal of molecular neuroscience : MN vol 71 issue 1 2021 32557144 |
the results showed that the severity of phosphorylated tau at the ad-related sites thr181 and thr231 and the number of activated astrocytes were notably greater in the hippocampus of rats with p. gingivalis injection. |
2021-08-27 |
2023-01-26 |
rat |
| L E M Wisse, S Ravikumar, R Ittyerah, S Lim, J Lane, M L Bedard, L Xie, S R Das, T Schuck, M Grossman, E B Lee, M D Tisdall, K Prabhakaran, J A Detre, G Mizsei, J Q Trojanowski, E Artacho-P\\xc3\\xa9rula, M M de I\\xc3\\xb1iguez de Onzono Martin, M M Arroyo-Jim\\xc3\\xa9nez, M Mu\\xc3\\xb1oz Lopez, F J Molina Romero, M P Marcos Rabal, S Cebada S\\xc3\\xa1nchez, J C Delgado Gonz\\xc3\\xa1lez, C de la Rosa Prieto, M C\\xc3\\xb3rcoles Parada, D A Wolk, D J Irwin, R Insausti, P A Yushkevic. Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions. Acta neuropathologica communications vol 9 issue 1 2021 34289895 |
tau, tar dna-binding protein 43 (tdp-43), amyloid-\xce\xb2 and \xce\xb1-synuclein pathology were rated on a scale of 0 (absent)-3 (severe) in the hippocampus and entorhinal cortex (erc) of 58 individuals with and without neurodegenerative diseases (median age 75.0\xc2\xa0years, 60.3% male). |
2021-08-23 |
2023-01-26 |
Not clear |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 35 issue 9 2021 34384141 |
cytotoxic amyloid and tau species were recovered from the blood and the hippocampus following pneumonia, and they were present in the extracorporeal membrane oxygenation oxygenators of patients with pneumonia, especially in those who died. |
2021-08-23 |
2023-01-26 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 35 issue 9 2021 34384141 |
introduction of immunopurified blood-borne amyloid and tau into either the airways or the blood of uninfected animals acutely and chronically impaired hippocampal information processing. |
2021-08-23 |
2023-01-26 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 35 issue 9 2021 34384141 |
in contrast, the infection did not impair long-term potentiation in tau knockout mice and the amyloid- and tau-dependent disruption in hippocampal signaling was less severe in tau knockout mice. |
2021-08-23 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Arnau Cas\\xc3\\xb2liba-Melich, Georgina Targa-Fabra, Lorena Galera-L\\xc3\\xb3pez, Andr\\xc3\\xa9s Ozaita, Rafael Maldonado, Jes\\xc3\\xbas \\xc3\\x81vila, Jos\\xc3\\xa9 M Delgado-Garc\\xc3\\xada, Agn\\xc3\\xa8s Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology vol issue 2021 34424282 |
we demonstrate that j20/vlw mice (accumulating amyloid-\xce\xb2 and hyperphosphorylated tau) exhibit preserved hippocampal rhythmic activity and cognition, as opposed to j20 and vlw animals, which show significant alterations. |
2021-08-23 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Arnau Cas\\xc3\\xb2liba-Melich, Georgina Targa-Fabra, Lorena Galera-L\\xc3\\xb3pez, Andr\\xc3\\xa9s Ozaita, Rafael Maldonado, Jes\\xc3\\xbas \\xc3\\x81vila, Jos\\xc3\\xa9 M Delgado-Garc\\xc3\\xada, Agn\\xc3\\xa8s Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology vol issue 2021 34424282 |
furthermore, we show that the overexpression of mutant human tau in coexistence with amyloid-\xce\xb2 accumulation renders a particular hyperphosphorylated tau signature in hippocampal interneurons. |
2021-08-23 |
2023-01-26 |
mouse |
| Eva D\\xc3\\xa1vila-Bouziguet, Arnau Cas\\xc3\\xb2liba-Melich, Georgina Targa-Fabra, Lorena Galera-L\\xc3\\xb3pez, Andr\\xc3\\xa9s Ozaita, Rafael Maldonado, Jes\\xc3\\xbas \\xc3\\x81vila, Jos\\xc3\\xa9 M Delgado-Garc\\xc3\\xada, Agn\\xc3\\xa8s Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology vol issue 2021 34424282 |
moreover, they suggest that a differential tau phosphorylation pattern in hippocampal interneurons prevents the loss of gabaergic septohippocampal innervation and alterations in local field potentials, thereby avoiding cognitive deficits. |
2021-08-23 |
2023-01-26 |
mouse |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3\\xce\\xb2, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN vol 70 issue 12 2021 32705526 |
effects of single-dose and long-term ketamine administration on tau phosphorylation-related enzymes gsk-3\xce\xb2, cdk5, pp2a, and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-01-26 |
mouse |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3\\xce\\xb2, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN vol 70 issue 12 2021 32705526 |
in the present study, we administered a single ketamine injection and long-term (6\xc2\xa0months) ketamine injections in c57bl/6 mice, to investigate the effects of different doses of ketamine on the expression levels of tau protein and its phosphorylation, the expression levels and activities of the related protein phosphokinases gsk-3\xce\xb2 and cdk5, and the expression levels and activities of the related protein phosphatases pp2a and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-01-26 |
mouse |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Pi\\xc3\\xb1eiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991) vol 30 issue 4 2021 31812991 |
high baseline strem2 was associated with accelerated cortical thinning in the temporal cortex of the left hemisphere, as well as bilateral hippocampal atrophy, independently of age, a\xce\xb242, and tau. |
2021-08-18 |
2023-01-26 |
human |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Pi\\xc3\\xb1eiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991) vol 30 issue 4 2021 31812991 |
in conclusion, increased csf strem2 was associated with accelerated cortical and hippocampal atrophy in cognitively unimpaired older participants, particularly in individuals with tau pathology. |
2021-08-18 |
2023-01-26 |
human |