| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjin Yang, Gaoyi Li, Ke Cao, Peng Ma, Yijun Guo, Wusong Tong, Jian Wa. Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation. Neuropeptides vol 83 issue 2021 32863068 |
additionally, igf-1 attenuated tau phosphorylation in ischemic hippocampus. |
2021-07-16 |
2023-01-26 |
rat |
| Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Ga. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer's Disease. Molecular neurobiology vol 58 issue 8 2021 33914267 |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular hyperphosphorylated tau in the hippocampus and cerebral cortex. |
2021-07-15 |
2023-01-26 |
Not clear |
| Shi-Dong Chen, Yu-Yuan Huang, Xue-Ning Shen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease. Translational psychiatry vol 11 issue 1 2021 34120152 |
a longitudinal increase of plasma p-tau181 was associated with abnormal cerebrospinal fluid biomarker levels (low a\xce\xb242, high phosphorylated tau, and high total tau, all p\xe2\x80\x89<\xe2\x80\x890.001), amyloid accumulation (p\xe2\x80\x89<\xe2\x80\x890.001) and hypometabolism (p\xe2\x80\x89=\xe2\x80\x890.002) on positron emission tomography, atrophy in structure imaging (small hippocampal (p\xe2\x80\x89=\xe2\x80\x890.030), middle temporal (p\xe2\x80\x89=\xe2\x80\x890.008), and whole brain (p\xe2\x80\x89=\xe2\x80\x890.027) volume, and large ventricular volume (p\xe2\x80\x89=\xe2\x80\x890.008)), and deteriorated cognitive performance (global cognition and memory, language, executive function, and visuospatial function, all p\xe2\x80\x89<\xe2\x80\x890.050) at baseline. |
2021-07-14 |
2023-01-26 |
human |
| Chong Lu, Yikui Zhao, Yan Cao, Li Liu, Shanshan Wu, Dongbin Li, Shuang Liu, Shuyuan Xiao, Yafen Wei, Xinyu L. MALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose. Clinical interventions in aging vol 16 issue 2021 34188461 |
malat1 regulated mtor-mediated tau hyperphosphorylation by acting as a cerna of mir144 in hippocampus cells exposed to high glucose. |
2021-07-14 |
2023-01-26 |
Not clear |
| Takashi Ando, Yuichi Riku, Akio Akagi, Hiroaki Miyahara, Mitsuaki Hirano, Toshimasa Ikeda, Hiroyuki Yabata, Ryuichi Koizumi, Chisato Oba, Saori Morozumi, Keizo Yasui, Atsuko Goto, Taiji Katayama, Satoko Sakakibara, Ikuko Aiba, Motoko Sakai, Masaaki Konagaya, Keiko Mori, Yasuhiro Ito, Hiroyuki Yuasa, Masayo Nomura, Kristine Joyce L Porto, Jun Mitsui, Shoji Tsuji, Maya Mimuro, Yoshio Hashizume, Masahisa Katsuno, Yasushi Iwasaki, Mari Yoshid. Multiple system atrophy variant with severe hippocampal pathology. Brain pathology (Zurich, Switzerland) vol issue 2021 34255887 |
immunohistochemistry for hyperphosphorylated tau and phosphorylated tdp-43 revealed minimal aggregations in the hippocampus of the hippocampal msa patients. |
2021-07-13 |
2023-01-26 |
Not clear |
| Chrysoula Dioli, Patr\\xc3\\xadcia Patr\\xc3\\xadcio, Lucilia-Goreti Pinto, Clemence Marie, M\\xc3\\xb3nica Morais, Sheela Vyas, Jo\\xc3\\xa3o M Bessa, Luisa Pinto, Ioannis Sotiropoulo. Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress. Cell proliferation vol 54 issue 7 2021 33988263 |
despite tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. |
2021-07-12 |
2023-01-26 |
Not clear |
| Qing Zhang, Jing Wang, Liang Zhu, Shi-Jie Jiang, Juan Liu, Lin-Xiao Wang, Xi-Hu Qi. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats. Current medical science vol 41 issue 3 2021 34169425 |
memory deficits can be caused by hhcy via pathologies of ad-like tau and amyloid-\xce\xb2 (a\xce\xb2) in the hippocampus. |
2021-07-12 |
2023-01-26 |
rat |
| Qing Zhang, Jing Wang, Liang Zhu, Shi-Jie Jiang, Juan Liu, Lin-Xiao Wang, Xi-Hu Qi. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats. Current medical science vol 41 issue 3 2021 34169425 |
we found that the pathologies of tau and a\xce\xb2 were induced by hcy in the hippocampus, while the hcy-induced tau hyperphosphorylation and a\xce\xb2 accumulation could be markedly attenuated by simultaneous ligustrazine treatment. |
2021-07-12 |
2023-01-26 |
rat |
| Weizhuo Lu, Jiyue We. Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic brain disease vol 35 issue 5 2021 32219683 |
we next sought to demonstrate the role of tfc on cognitive rehabilitation and the tau phosphorylation in hippocampal tissues at 30d after sah. |
2021-07-09 |
2023-01-26 |
rat |
| Weizhuo Lu, Jiyue We. Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic brain disease vol 35 issue 5 2021 32219683 |
not surprisingly, cognitive dysfunction and the upregulation of tau phosphorylation at ser262 (p-tau-ser262) in hippocampal tissues were markedly reduced by tfc treatment. |
2021-07-09 |
2023-01-26 |
rat |
| Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica] vol 73 issue 3 2021 34230948 |
the results showed that: (1) chronic sleep deprivation did not affect anxiety- (p = 0.539) and depression-like behaviors (p = 0.874) in 3xtg-ad mice; (2) chronic sleep deprivation exacerbated the impairments of object recognition memory (p < 0.001), working memory (p = 0.002) and the conditioned fear memory (p = 0.039) in 3xtg-ad mice; (3) chronic sleep deprivation increased amyloid \xce\xb2 (a\xce\xb2) deposition (p < 0.001) and microglial activation (p < 0.001) in the hippocampus of 3xtg-ad mice, without inducing abnormal tau phosphorylation and neurofibrillary tangles. |
2021-07-08 |
2023-01-26 |
mouse |
| Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S Larson, Abhijeet Sharma, Robert K S Wong, Kirill Y Gorbachev, Ana C Pereir. Neuronal Network Excitability in Alzheimer's Disease: The Puzzle of Similar versus Divergent Roles of Amyloid \\xce\\xb2 and Tau. eNeuro vol 8 issue 2 2021 33741601 |
similarly, pathologic accumulation of hyperphosphorylated tau has been associated with hyperexcitability in the hippocampus. |
2021-07-02 |
2023-01-26 |
Not clear |
| Ellen Dicks, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Betty M Tijm. Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease. Neurobiology of aging vol 94 issue 2021 32585492 |
here, we show that within individuals with preclinical ad, gray matter network measures predict hippocampal atrophy rates, whereas other ad biomarkers (total gray matter volume, cerebrospinal fluid total tau, and\xc2\xa0mini-mental state examination) do not. |
2021-06-29 |
2023-01-26 |
Not clear |
| Ellen Dicks, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Betty M Tijm. Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease. Neurobiology of aging vol 94 issue 2021 32585492 |
when repeating analyses in age-matched, cognitively unimpaired individuals without amyloid or tau pathology, we did not find any associations between network measures and hippocampal atrophy, suggesting that the associations are specific for preclinical ad. |
2021-06-29 |
2023-01-26 |
Not clear |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience vol 53 issue 2 2021 33169893 |
we hypothesized that these mice would also display memory and hippocampal synaptic plasticity deficits as has been reported for many plaque bearing mouse models which express endogenous mouse tau. |
2021-06-28 |
2023-01-26 |
mouse |
| Zohreh Abbasi, Mohammad Mahdi Ghahramani Seno, Masoud Fereidon. A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease. Journal of molecular neuroscience : MN vol 71 issue 7 2021 33492616 |
these impairments were associated with altered gene expression of insulin receptor, tau and choline acetyltransferase, along with increased astrocyte and dark neuron densities in the hippocampus. |
2021-06-28 |
2023-01-26 |
rat |
| Niels D Prins, John E Harrison, Hui-May Chu, Kelly Blackburn, John J Alam, Philip Schelten. A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease. Alzheimer's research & therapy vol 13 issue 1 2021 34044875 |
in animal models, it mediates impaired synaptic dysfunction in the hippocampus, causing memory deficits, and is involved in amyloid-beta (a\xce\xb2) production and tau pathology. |
2021-06-24 |
2023-01-26 |
Not clear |
| Shengyi Yang, Huanhuan Zhou, Guiping Wang, Xiao-Hong Zhong, Qi-Liang Shen, Xue-Jing Zhang, Ru-Yi Li, Li-Hua Chen, Ya-Han Zhang, Zhongxiao Wa. Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Journal of food biochemistry vol 44 issue 4 2021 32065675 |
key markers involved in a\xce\xb2, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. |
2021-06-21 |
2023-01-26 |
mouse |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry vol 10 issue 1 2021 32546772 |
modelling this cyfip2 reduction in mice, we find age-dependent a\xce\xb2 accumulation in the thalamus, development of tau pathology in entorhinal cortex and hippocampus, as well as gliosis and synapse loss in the hippocampus, together with deficits in memory formation. |
2021-06-18 |
2023-01-26 |
mouse |
| Cem S\\xc3\\xbcer, Nurbanu Y\\xc4\\xb1ld\\xc4\\xb1z, \\xc3\\x96zlem Barut\\xc3\\xa7u, Burak Tan, Nurcan Dursu. Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. Pharmacological reports : PR vol 73 issue 3 2021 33797746 |
long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. |
2021-06-07 |
2023-01-26 |
rat |