| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. [The Search for Citrus Components with Neuroprotective and Anti-dementia Effects in the Mouse Brain]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078788. |
the c. kawachiensis treatment inhibited microglial activation and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in samp8. |
2021-11-11 |
2023-08-13 |
mouse |
| Mark R Libowitz, Ke Wei, Thao Tran, Karen Chu, Kristina Moncrieffe, Michael G Harrington, Kevin Kin. Regional brain volumes relate to Alzheimer's disease cerebrospinal fluid biomarkers and neuropsychometry: A cross-sectional, observational study. PloS one. vol 16. issue 7. 2021-11-10. PMID:34292973. |
a higher score on the boston naming test was optimally predicted in a selective regression model by greater hippocampus volume (p = 0.002), a higher ratio of ß-amyloid42 to tau protein levels (p < 0.001), greater posterior cingulate volume (p = 0.0193), age (p = 0.0271), and a higher education level (p = 0.002). |
2021-11-10 |
2023-08-13 |
human |
| Yang Gao, Xiao-Qing Wang, Shuai Ma, Yong-Cai Dong, Ya-Zhen Shan. Flavonoids from Stem and Leaf of Scutellaria Baicalensis Georgi Inhibit the Phosphorylation on Multi-sites of Tau Protein Induced by Okadaic Acid and the Regulative Mechanism of Protein Kinases in Rats. Combinatorial chemistry & high throughput screening. vol 24. issue 7. 2021-11-09. PMID:32875975. |
the present study aims to investigate the effect of flavonoids from stem and leaf of scutellaria baicalensis georgi (ssf) on multi-sites phosphorylation of tau protein in the cerebral cortex and hippocampus of rats induced by okadaic acid (oa) and the regulative mechanism of the protein kinases. |
2021-11-09 |
2023-08-13 |
rat |
| Benjamin B Tournier, Cristina Barca, Aïda B Fall, Yesica Gloria, Léa Meyer, Kelly Ceyzériat, Philippe Mille. Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease. Genes, brain, and behavior. vol 20. issue 5. 2021-11-09. PMID:33150709. |
these behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. |
2021-11-09 |
2023-08-13 |
human |
| Vanessa Laversenne, Sameer Nazeeruddin, Emma C Källstig, Philippe Colin, Christel Voize, Bernard L Schneide. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33225991. |
to assess the effect of anti-aβ immunization in this context, we generated a mouse model by overexpressing the human tau protein in the hippocampus of 5xfad mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Philip Regan, Scott J Mitchell, Seung-Chan Kim, Younbok Lee, Jee Hyun Yi, Saviana A Barbati, Christopher Shaw, Kwangwook Ch. Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 34. 2021-11-09. PMID:34290082. |
using combined molecular and electrophysiological analysis with in vitro genetic knock-in of phosphorylation mutant human tau in male rat ca1 hippocampal neurons, we show an interplay between tau and protein kinase c and casein kinase substrate in neurons protein 1 (pacsin1) that regulates synapse function. |
2021-11-09 |
2023-08-13 |
human |
| Mackenzie L Carlson, Tyler N Toueg, M Mehdi Khalighi, Jessa Castillo, Bin Shen, Emily C Azevedo, Phillip DiGiacomo, Nicole Mouchawar, Gustavo Chau, Greg Zaharchuk, Michelle L James, Elizabeth C Mormino, Michael M Zeine. Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-11-09. PMID:34337132. |
hippocampal subfield imaging and fractional anisotropy show parallel changes in alzheimer's disease tau progression using simultaneous tau-pet/mri at 3t. |
2021-11-09 |
2023-08-13 |
Not clear |
| Mackenzie L Carlson, Tyler N Toueg, M Mehdi Khalighi, Jessa Castillo, Bin Shen, Emily C Azevedo, Phillip DiGiacomo, Nicole Mouchawar, Gustavo Chau, Greg Zaharchuk, Michelle L James, Elizabeth C Mormino, Michael M Zeine. Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-11-09. PMID:34337132. |
we assessed tau pathology and white matter connectivity changes in subfields of the hippocampus simultaneously in vivo in ad. |
2021-11-09 |
2023-08-13 |
Not clear |
| V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology. 2021-11-09. PMID:34751792. |
lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. |
2021-11-09 |
2023-08-13 |
Not clear |
| V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology. 2021-11-09. PMID:34751792. |
the aim of the present study is to determine the effect of chronic lithium treatment on the protein expression of tau and its major kinases in cortical and hippocampal neurons, at distinct working concentrations. |
2021-11-09 |
2023-08-13 |
Not clear |
| V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology. 2021-11-09. PMID:34751792. |
statistically significant increments in the protein expression of tau and camkii were observed both in cortical and hippocampal neurons treated with subtherapeutic doses of lithium. |
2021-11-09 |
2023-08-13 |
Not clear |
| V J De-Paula, O V Forlenz. Lithium modulates multiple tau kinases with distinct effects in cortical and hippocampal neurons according to concentration ranges. Naunyn-Schmiedeberg's archives of pharmacology. 2021-11-09. PMID:34751792. |
distinct patterns of changes in the expression of the remaining tau tau-kinases were observed: in cortical neurons, lithium treatment was associated with consistent decrements in akt and pka, whereas hippocampal neurons displayed increased protein expression of akt and decreased pka. |
2021-11-09 |
2023-08-13 |
Not clear |
| James M McCarthy, Jasmeet Virdee, Jessica Brown, Daniel Ursu, Zeshan Ahmed, Annalisa Cavallini, Hugh N Nuthal. Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33986302. |
development of p301s tau seeded organotypic hippocampal slice cultures to study potential therapeutics. |
2021-11-08 |
2023-08-13 |
mouse |
| Philip L Yates, Ankita Patil, Xiaohuan Sun, Alessia Niceforo, Ramnik Gill, Patrick Callahan, Wayne Beck, Emanuela Piermarini, Alvin V Terry, Kimberly A Sullivan, Peter W Baas, Liang Qian. A cellular approach to understanding and treating Gulf War Illness. Cellular and molecular life sciences : CMLS. vol 78. issue 21-22. 2021-11-08. PMID:34580742. |
wistar rats exposed to a similar toxicant regimen showed a mild learning and memory deficit, as well as cell loss and tau pathology selectively in the ca3 region of the hippocampus. |
2021-11-08 |
2023-08-13 |
human |
| David C Hondius, Frank Koopmans, Conny Leistner, Débora Pita-Illobre, Regina M Peferoen-Baert, Fenna Marbus, Iryna Paliukhovich, Ka Wan Li, Annemieke J M Rozemuller, Jeroen J M Hoozemans, August B Smi. The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 3. 2021-11-05. PMID:33492460. |
by combining immunohistochemistry (ihc) and laser microdissection (lmd) we isolated neurons with gvd and those bearing tangles separately from human post-mortem ad hippocampus (n = 12) using their typical markers casein kinase (ck)1δ and phosphorylated tau (at8). |
2021-11-05 |
2023-08-13 |
human |
| Carlos M Soto-Faguás, Paula Sanchez-Molina, Carlos A Saur. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34593029. |
interestingly, genetic inactivation of presenilin 1 (ps1) or both ps genes in mutant human tau transgenic mice exacerbates memory deficits by accelerating phosphorylation and aggregation of tau in excitatory neurons of vulnerable ad brain regions (e.g., hippocampus, cortex and amygdala). |
2021-11-05 |
2023-08-13 |
mouse |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
when focusing on cases with low levels of tdp-43 pathology, we found strong associations between tau pathology and thickness in the erc, srlm and the subiculum/cornu ammonis 1 (ca1) subfields of the hippocampus, consistent with early braak stages. |
2021-11-05 |
2023-08-13 |
human |
| Sanila Amber, Sumera, Fatima J Mirza, Muhammad Asif, Deeba Hassan, Touqeer Ahmed, Saadia Zahi. Amyloid-beta Induced Neurotoxicity Impairs Cognition and Adult Hippocampal Neurogenesis in a Mouse Model for Alzheimer's Disease. Current Alzheimer research. vol 17. issue 11. 2021-11-04. PMID:33357181. |
in the past few years, impaired adult hippocampal neurogenesis emerged as a contributing hallmark of ad pathophysiology along with amyloid beta (aβ) and tau hyper phosphorylation-induced neurotoxicity. |
2021-11-04 |
2023-08-13 |
mouse |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
serum and hippocampal [formula: see text]-amyloid peptide (a[formula: see text], tau and phosphorylated tau protein deposition in the hippocampi were measured. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
berberine also effectively decreased the expression of hippocampal tau protein, phosphorylated tau, and increased insulin receptor antibodies. |
2021-11-04 |
2023-08-13 |
rat |