| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
moreover, berberine downregulated the abnormal phosphorylation of a[formula: see text] and tau protein and improved hippocampal insulin signaling. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
the reduction of neuronal injury, a[formula: see text] deposition, abnormal phosphorylation of tau protein, and neuronal apoptosis in the hippocampus were observed as the related mechanisms of action. |
2021-11-04 |
2023-08-13 |
rat |
| Austin T Marckx, Katja E Fritschle, Laurent Calvier, Joachim Her. Reelin changes hippocampal learning in aging and Alzheimer's disease. Behavioural brain research. vol 414. 2021-11-04. PMID:34333070. |
additionally, we hypothesized that reelin deficiency in the presence of mutated human microtubule associated protein tau (mapt) would further impair hippocampal function. |
2021-11-04 |
2023-08-13 |
mouse |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
the entorhinal cortex, drn, and lc are among the regions that display pathological changes of tau earliest, whereas neurons with gvbs occur first in the hippocampus and have been found in oral raphe nuclei only at the most advanced gvd stage. |
2021-11-01 |
2023-08-13 |
human |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
we studied the relation between tau pathology and gvd in field ca1 of the hippocampus, entorhinal cortex, dorsal (drn) and median (mrn) raphe nucleus, and locus coeruleus from elderly subjects with braak & braak stages of tau pathology ranging from 0 to vi. |
2021-11-01 |
2023-08-13 |
human |
| Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C Hays, Patrick R Hof, W Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I Luebke, Tsuneya Ikez. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Science translational medicine. vol 13. issue 611. 2021-11-01. PMID:34524859. |
wolframin-1-expressing neurons in the entorhinal cortex propagate tau to ca1 neurons and impair hippocampal memory in mice. |
2021-11-01 |
2023-08-13 |
mouse |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
the effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in alzheimer's diseases. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
the present study aims to investigate layer-specific magnetic susceptibility in the hippocampus of ad patients using high-resolution ex-vivo mri, and elucidate its relationship with beta amyloid (aβ) and tau protein histology. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
we manually segmented each sample into seven layers, including four layers in the cornu ammonis1 (ca1) and three layers in the dentate gyrus (dg), and then evaluated ad-related alterations of susceptibility and t2* values and their correlations with aβ and tau in each hippocampal layer. |
2021-11-01 |
2023-08-13 |
Not clear |
| D G Coughlin, R Ittyerah, C Peterson, J S Phillips, S Miller, K Rascovsky, D Weintraub, A D Siderowf, J E Duda, H I Hurtig, D A Wolk, C T McMillan, P A Yushkevich, M Grossman, E B Lee, J Q Trojanowski, D J Irwi. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32892355. |
here we use digital histological methods to test the association between hippocampal syn pathology and the distribution of tau and amyloid-beta (aβ) pathology in lbd and contrast with ad subjects. |
2021-10-28 |
2023-08-13 |
human |
| Bin Wu, Haiqing Cai, Shen Tang, Yilu Xu, Qianqian Shi, Lancheng Wei, Ling Meng, Ning Zhang, Xinhang Wang, Deqiang Xiao, Yunfeng Zou, Xiaobo Yang, Xiyi Li, Cailing L. Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32959271. |
we show that mn-induced neurotoxicity is characterized by pp2ac demethylation accompanied by abnormally decreased lcmt-1 and increased pme-1, which are associated with tau hyperphosphorylation and spatial learning and memory deficits, and that the poor availability of sam in the hippocampus is likely to determine the loss of pp2ac methylation. |
2021-10-28 |
2023-08-13 |
rat |
| Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chan. WWOX and Its Binding Proteins in Neurodegeneration. Cells. vol 10. issue 7. 2021-10-28. PMID:34359949. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2021-10-28 |
2023-08-13 |
mouse |
| Meijuan Zhu, Yanhua Zhao, Yongjun Zheng, Diansan Su, Xiangrui Wan. Relative Higher Hematocrit Attenuates the Cerebral Excitatory Amino Acid Elevation Induced by Deep Hypothermic Circulatory Arrest in Rats. Therapeutic hypothermia and temperature management. vol 3. issue 3. 2021-10-21. PMID:24066268. |
high-performance liquid chromatography was used to determine the concentration of glutamate (glu), aspartate (asp), glycine (gly), gamma-aminobutyric acid (gaba), and taurine (tau) in the cerebral cortex, hippocampus, and thalamus. |
2021-10-21 |
2023-08-12 |
rat |
| Vivek Kumar Sharma, Thakur Gurjeet Singh, Shareen Singh, Nikhil Garg, Sonia Dhima. Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34386919. |
the well-characterized pathological features of ad, including extracellular plaques of amyloid-beta, intracellular hyperphosphorylated tangles of tau protein (nfts), inflammation, mitochondrial dysfunction, oxidative stress, and excitotoxic cell death, also instigate an abnormal apoptotic cascade in susceptible brain regions (cerebral cortex, hippocampus). |
2021-10-21 |
2023-08-13 |
Not clear |
| Troy T Rohn, Polina Kokoulin. Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease. International journal of physiology, pathophysiology and pharmacology. vol 1. issue 1. 2021-10-20. PMID:20411029. |
co-localization of tdpccp with phf-1, a general marker for pick bodies, as well as with an antibody to caspase-cleaved tau (tauc3) was evident within the hippocampus. |
2021-10-20 |
2023-08-12 |
Not clear |
| Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica. vol 142. issue 1. 2021-10-19. PMID:33895869. |
our data reveal that apoe4 boosts tau neurotoxicity via vmat2 inhibition, reduces hippocampal volume, and induces cognitive dysfunction in an aep- and tau n368-dependent manner, while conversely apoe3 binds tau and protects it from cleavage. |
2021-10-19 |
2023-08-13 |
human |
| Xingyu Zhang, Li Zou, Lanxia Meng, Min Xiong, Lina Pan, Guiqin Chen, Yongfa Zheng, Jing Xiong, Zhihao Wang, Duc M Duong, Zhaohui Zhang, Xuebing Cao, Tao Wang, Li Tang, Keqiang Ye, Zhentao Zhan. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. eLife. vol 10. 2021-10-18. PMID:34018922. |
overexpression of amphiphysin i (1-278) in the hippocampus of tau p301s mice induces synaptic dysfunction, tau hyperphosphorylation, and cognitive deficits. |
2021-10-18 |
2023-08-13 |
mouse |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
in addition, tau hyperphosphorylation and aβ expression increase in the cortex and hippocampus of the brain. |
2021-10-18 |
2023-08-13 |
rat |
| Kurt A Jellinge. Neuropathological assessment of the Alzheimer spectrum. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 9. 2021-10-15. PMID:32740684. |
ad is a mixed proteinopathy (amyloid and tau), frequently associated with other age-related co-pathologies, such as cerebrovascular lesions, lewy and tdp-43 pathologies, hippocampal sclerosis, or argyrophilic grain disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. |
concomitantly, it inhibited the hippocampal activity of akt and increased the activity of glycogen synthase kinase 3β and tau protein phosphorylation. |
2021-10-12 |
2023-08-13 |
rat |