| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong-Yao Hou, Yang Zhou, Ling-Shuang Zhu, Xiong Wang, Pei Pang, Ding-Qi Wang, Zhen-Yu Liuyang, Hengye Man, Youming Lu, Ling-Qiang Zhu, Dan Li. Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease. Journal of neurochemistry vol 154 issue 4 2020 31951013 |
we found that artificially replicating the abnormalities in mir-124/ptpn1 signaling induced ad-like tau pathology in the hippocampus of wild-type mice, including hyperphosphorylation at multiple sites, insolubility and somadendritic aggregation, as well as learning/memory deficits. |
2020-12-07 |
2023-01-26 |
mouse |
| Zuntao Wu, Lin Bai, Runqi Tu, Lijie Zhang, Yue Ba, Huizhen Zhang, Xing Li, Xuemin Cheng, Wenjie Li, Hui Huan. Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. Environmental toxicology and pharmacology vol 76 issue 2020 32058320 |
furthermore, the expression of bace1 protein and tau phosphorylation level in pfc and hippocampus increased, app mrnas in pfc and prolonged induction of bace1 in hippocampus. |
2020-12-04 |
2023-01-26 |
mouse |
| Natalia Dos Santos Tramontin, Sabrina da Silva, Rychard Arruda, Kellen Simon Ugioni, Paula Bortuluzzi Canteiro, Gustavo de Bem Silveira, Carolini Mendes, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model. Molecular neurobiology vol 57 issue 2 2020 31612296 |
oa increases tau phosphorylation in the cortex and hippocampus, while aunp treatment maintained it as normal. |
2020-11-25 |
2023-01-26 |
rat |
| Ryszard Pluta, Marzena U\\xc5\\x82amek-Kozio\\xc5\\x82, Janusz Kocki, Jacek Bogucki, S\\xc5\\x82awomir Januszewski, Anna Bogucka-Kocka, Stanis\\xc5\\x82aw J Czuczwa. Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Molecular neurobiology vol 57 issue 2 2020 31713815 |
expression of the tau protein and amyloid protein precursor processing genes in the ca3 area of the hippocampus in the ischemic model of alzheimer's disease in the rat. |
2020-11-25 |
2023-01-26 |
rat |
| Ryszard Pluta, Marzena U\\xc5\\x82amek-Kozio\\xc5\\x82, Janusz Kocki, Jacek Bogucki, S\\xc5\\x82awomir Januszewski, Anna Bogucka-Kocka, Stanis\\xc5\\x82aw J Czuczwa. Expression of the Tau Protein and Amyloid Protein Precursor Processing Genes in the CA3 Area of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat. Molecular neurobiology vol 57 issue 2 2020 31713815 |
data show that brain ischemia activates neuronal changes and death in the ca3 region of the hippocampus in a manner dependent on amyloid and tau protein, thus determining a new and important way to regulate the survival and/or death of ischemic neurons. |
2020-11-25 |
2023-01-26 |
rat |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research vol 45 issue 2 2020 31865521 |
brain derived neurotrophic factor (bdnf), synaptophysin, and tau hyperphosphorylation (t396) in the hippocampus were also examined. |
2020-11-17 |
2023-01-26 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research vol 45 issue 2 2020 31865521 |
following partial hepatectomy, the levels of phosphorylated mtor, phosphorylated 70s6k, and phosphorylated tau were all increased in the hippocampus. |
2020-11-17 |
2023-01-26 |
mouse |
| Yanhua Jiang, Yongjian Zhou, Hong Ma, Xuezhao Cao, Zhe Li, Fengshou Chen, Hongnan Wan. Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice. Neurochemical research vol 45 issue 2 2020 31865521 |
rapamycin treatment restored autophagy function, attenuated phosphorylation of tau protein, and increased bdnf and synaptophysin expression in the hippocampus of surgical mice. |
2020-11-17 |
2023-01-26 |
mouse |
| Mona Khalifa, Marwa M Safar, Rania M Abdelsalam, Hala F Zak. Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats. Neurotoxicity research vol 37 issue 2 2020 31332715 |
it reversed the increase in hippocampal amyloid beta protein, phosphorylated tau protein contents together with augmentation of neprilysin level, it also diminished levels of nuclear factor kappa-b, fas ligand, tumor necrosis factor-alpha, malondialdehyde, and acetylcholinesterase content.these findings show the protective action of telmisartan against ad-like pathological alterations. |
2020-11-12 |
2023-01-26 |
rat |
| Yanchong Zhang, Feng Wu, Khalid Iqbal, Cheng-Xin Gong, Wen Hu, Fei Li. Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Scientific reports vol 9 issue 1 2020 30846870 |
we detected hyperphosphorylation of tau at multiple sites in ipsilateral hippocampus 6 weeks but not 7 months after cci. |
2020-11-10 |
2023-01-26 |
mouse |
| Marzena U\\xc5\\x82amek-Kozio\\xc5\\x82, Stanis\\xc5\\x82aw Jerzy Czuczwar, S\\xc5\\x82awomir Januszewski, Ryszard Plut. Proteomic and Genomic Changes in Tau Protein, Which Are Associated with Alzheimer's Disease after Ischemia-Reperfusion Brain Injury. International journal of molecular sciences vol 21 issue 3 2020 32019137 |
data show that brain ischemia activates neuronal changes and death in the hippocampus in a manner dependent on tau protein, thus determining a new and important way to regulate the survival and/or death of post-ischemic neurons. |
2020-11-09 |
2023-01-26 |
Not clear |
| Arnaud Charil, Sergey Shcherbinin, Sudeepti Southekal, Michael D Devous, Mark Mintun, Melissa E Murray, Bradley B Miller, Adam J Schwar. Tau Subtypes of Alzheimer's Disease Determined in vivo Using Flortaucipir PET Imaging. Journal of Alzheimer's disease : JAD vol 71 issue 3 2020 31476153 |
worse performance on delayed recall was associated with increased hippocampal tau signal, and worse performance on the trail making test b-a was associated with lower values of the hippocampus to cortex ratio. |
2020-11-05 |
2023-01-26 |
human |
| Satoshi Okuyama, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. [Neuroprotective effects of the peel of Citrus kawachiensis (Kawachi Bankan) and auraptene in the hippocampus of hyperglycemia mice and global cerebral ischemia/reperfusion injury mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica vol 155 issue 4 2020 32612031 |
the c. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the type 2 diabetic db/db mice. |
2020-11-02 |
2023-01-26 |
mouse |
| Oc\\xc3\\xa9ane Guillemaud, Kelly Ceyz\\xc3\\xa9riat, Thomas Saint-Georges, Karine Cambon, Fanny Petit, Lucile Ben Haim, Maria-Angeles Carrillo-de Sauvage, Martine Guillermier, Sueva Bernier, Anne-Sophie H\\xc3\\xa9rard, Charl\\xc3\\xa8ne Jos\\xc3\\xa9phine, Alexis Pierre B\\xc3\\xa9melmans, Emmanuel Brouillet, Philippe Hantraye, Gilles Bonvento, Carole Escarti. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiology of aging vol 90 issue 2020 32171592 |
we aimed to evaluate whether reactive astrocytes contribute to tau as well as amyloid pathologies in the hippocampus of 3xtg-ad mice, an ad model that develops tau hyper-phosphorylation and amyloid deposition. |
2020-10-29 |
2023-01-26 |
mouse |
| Oc\\xc3\\xa9ane Guillemaud, Kelly Ceyz\\xc3\\xa9riat, Thomas Saint-Georges, Karine Cambon, Fanny Petit, Lucile Ben Haim, Maria-Angeles Carrillo-de Sauvage, Martine Guillermier, Sueva Bernier, Anne-Sophie H\\xc3\\xa9rard, Charl\\xc3\\xa8ne Jos\\xc3\\xa9phine, Alexis Pierre B\\xc3\\xa9melmans, Emmanuel Brouillet, Philippe Hantraye, Gilles Bonvento, Carole Escarti. Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease. Neurobiology of aging vol 90 issue 2020 32171592 |
jak2-stat3 pathway-mediated modulation of reactive astrocytes in 25% of the hippocampus of 3xtg-ad mice did not significantly influence tau phosphorylation or amyloid processing and deposition at early, advanced, and terminal disease stage. |
2020-10-29 |
2023-01-26 |
mouse |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-\\xce\\xb2 and tau in a mouse model of Alzheimer's disease. Human molecular genetics vol 29 issue 2 2020 31814000 |
we analyzed the animals' memory function, hippocampal ca2+ levels and amyloid-\xce\xb2 (a\xce\xb2) and tau pathologies when they were 12\xc2\xa0months old. |
2020-10-19 |
2023-01-26 |
mouse |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-\\xce\\xb2 and tau in a mouse model of Alzheimer's disease. Human molecular genetics vol 29 issue 2 2020 31814000 |
we found that compared with 3xtg-ad-/-/trpv1+/+ mice, 3xtg-ad+/+/trpv1+/+ mice had memory impairment and increased levels of hippocampal ca2+, a\xce\xb2 and total and phosphorylated tau. |
2020-10-19 |
2023-01-26 |
mouse |
| Juyong Kim, Siyoung Lee, Jaekyoon Kim, Sangwoo Ham, Jung Han Yoon Park, Seungbong Han, Yong-Keun Jung, Insop Shim, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-\\xce\\xb2 and tau in a mouse model of Alzheimer's disease. Human molecular genetics vol 29 issue 2 2020 31814000 |
however, 3xtg-ad+/+/trpv1-/- mice had better memory function and lower levels of hippocampal ca2+, a\xce\xb2, tau and p-tau, compared with 3xtg-ad+/+/trpv1+/+ mice. |
2020-10-19 |
2023-01-26 |
mouse |
| Onder Albayram, Bryce MacIver, John Mathai, Anne Verstegen, Sean Baxley, Chenxi Qiu, Carter Bell, Barbara J Caldarone, Xiao Zhen Zhou, Kun Ping Lu, Mark Zeide. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific reports vol 9 issue 1 2020 31201348 |
hyperphosphorylated tau deposition and neural tangle-like pathology occurred in cortical and hippocampal regions only of igg control mice accompanied with post-traumatic neuroinflammation and was not seen in midbrain and hindbrain regions associated with bladder filling and voiding reflex arcs. |
2020-10-15 |
2023-01-26 |
mouse |
| Beibei Wu, Yujing Wang, Chenggang Shi, Yao Chen, Lexiang Yu, Juan Li, Weiwei Li, Yan Wei, Rongqiao H. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. Journal of Alzheimer's disease : JAD vol 71 issue 1 2020 31381511 |
injections of rrsa were found to trigger tau hyperphosphorylation in the rat hippocampus via gsk-3\xce\xb2 activation. |
2020-10-13 |
2023-01-26 |
rat |