| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
we demonstrate that j20/vlw mice (accumulating amyloid-β and hyperphosphorylated tau) exhibit preserved hippocampal rhythmic activity and cognition, as opposed to j20 and vlw animals, which show significant alterations. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
furthermore, we show that the overexpression of mutant human tau in coexistence with amyloid-β accumulation renders a particular hyperphosphorylated tau signature in hippocampal interneurons. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
moreover, they suggest that a differential tau phosphorylation pattern in hippocampal interneurons prevents the loss of gabaergic septohippocampal innervation and alterations in local field potentials, thereby avoiding cognitive deficits. |
2021-08-23 |
2023-08-13 |
mouse |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (amci) and depression history are associated with amyloid beta and tau pathology, thereby increasing the risk for alzheimer's disease (ad). |
2021-08-20 |
2023-08-13 |
Not clear |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 12. 2021-08-19. PMID:32705526. |
effects of single-dose and long-term ketamine administration on tau phosphorylation-related enzymes gsk-3β, cdk5, pp2a, and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-08-13 |
mouse |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 12. 2021-08-19. PMID:32705526. |
in the present study, we administered a single ketamine injection and long-term (6 months) ketamine injections in c57bl/6 mice, to investigate the effects of different doses of ketamine on the expression levels of tau protein and its phosphorylation, the expression levels and activities of the related protein phosphokinases gsk-3β and cdk5, and the expression levels and activities of the related protein phosphatases pp2a and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-08-13 |
mouse |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Piñeiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31812991. |
high baseline strem2 was associated with accelerated cortical thinning in the temporal cortex of the left hemisphere, as well as bilateral hippocampal atrophy, independently of age, aβ42, and tau. |
2021-08-18 |
2023-08-13 |
human |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Piñeiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31812991. |
in conclusion, increased csf strem2 was associated with accelerated cortical and hippocampal atrophy in cognitively unimpaired older participants, particularly in individuals with tau pathology. |
2021-08-18 |
2023-08-13 |
human |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 5. 2021-08-18. PMID:32698244. |
the concept of the hierarchal spread of neurofibrillary tangles (nfts) from the hippocampus to the cortex in alzheimer's disease (ad)/aging brains, initially proposed by braak and braak, revolutionized our understanding by putatively explaining that tau lesions are being unidirectionally extended along neural connections. |
2021-08-18 |
2023-08-13 |
human |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 5. 2021-08-18. PMID:32698244. |
surprisingly, this profile shift from 4r to 3r tau is shared with the hierarchal spread of nft around the hippocampus, which is hardly explained by a simple mechanism such as propagation of a single tau molecule. |
2021-08-18 |
2023-08-13 |
human |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
in vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis, and neuronal loss in the hippocampus of immunized mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Yosra Nadhimi, Daniel A Llan. Does hearing loss lead to dementia? A review of the literature. Hearing research. vol 402. 2021-08-13. PMID:32814645. |
the data suggest that noise-exposure produces a toxic milieu in the hippocampus consisting of a spike in glucocorticoid levels, elevations of mediators of oxidative stress and excitotoxicity, which as a consequence induce cessation of neurogenesis, synaptic loss and tau hyperphosphorylation. |
2021-08-13 |
2023-08-13 |
human |
| Christina N Rogers Flattery, Rebecca F Rosen, Aaron S Farberg, Jeromy M Dooyema, Patrick R Hof, Chet C Sherwood, Lary C Walker, Todd M Preus. Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32909100. |
we also sought evidence of aβ deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. |
2021-08-11 |
2023-08-13 |
human |
| Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine. vol 52. issue 8. 2021-08-10. PMID:32859953. |
the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. |
2021-08-10 |
2023-08-13 |
Not clear |
| Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeli. Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia. Biomedicines. vol 9. issue 7. 2021-08-09. PMID:34356892. |
here, we showed that a single hippocampal administration of mcrp in mice induced memory loss, lasting at least 6 months, along with neurodegenerative changes detected by increased levels of hyperphosphorylated tau protein and a decrease of the neuroplasticity marker |
2021-08-09 |
2023-08-13 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
unilateral hippocampal injection of tau fibrils or α-synuclein fibrils, and to a lesser extent tau + α-synuclein copolymer fibrils prepared from co-incubating individual recombinant monomers, induced robust phosphorylated tau pathology in ps19 mice relative to control mice. |
2021-08-07 |
2023-08-13 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
in m20 mice, unilateral hippocampal injection of α-synuclein fibrils or tau fibrils induced robust bilateral phosphorylated α-synuclein pathology, while tau + α-synuclein copolymer injection resulted in restricted phosphorylated α-synuclein pathology predominantly in the ipsilateral cortex. |
2021-08-07 |
2023-08-13 |
mouse |
| Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Felippo Bifi, Cristiane Matté, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry. vol 87. 2021-08-04. PMID:33065257. |
genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of tau. |
2021-08-04 |
2023-08-13 |
rat |
| José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PloS one. vol 16. issue 2. 2021-08-04. PMID:33592009. |
we used cbg-/- mice, which display low total-corticosterone and high free-corticosterone blood levels at the nadir of corticosterone secretion (morning) and at rest to evaluate the hippocampus for total- and free-corticosterone levels; 11β-hydroxysteroid dehydrogenase expression and activity; the expression of key proteins involved in glucocorticoid activity and insulin signaling; microtubule-associated protein tau phosphorylation, and neuronal and synaptic function markers. |
2021-08-04 |
2023-08-13 |
mouse |
| José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PloS one. vol 16. issue 2. 2021-08-04. PMID:33592009. |
our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished fk506 binding protein 5 expression, increased corticosterone downstream effectors and altered mapk and pi3k pathway with increased py216-gsk3β and phosphorylated tau. |
2021-08-04 |
2023-08-13 |
mouse |