| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadha. Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy. Frontiers in aging neuroscience vol 11 issue 2020 31920624 |
we observed that insoluble tau from human ad induced at8-positive neurofibrillary structures in the hippocampus of both lines. |
2020-09-28 |
2023-01-26 |
human |
| Nobuko Hongo, Yusaku Takamura, Hiroshi Nishimaru, Jumpei Matsumoto, Kazuyuki Tobe, Takashi Saito, Takaomi C Saido, Hisao Nishij. Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of Frontiers in pharmacology vol 11 issue 2020 32218736 |
astaxanthin ameliorated parvalbumin-positive neuron deficits and alzheimer's disease-related pathological progression in the hippocampus of growing evidence suggests that oxidative stress due to amyloid \xce\xb2 (a\xce\xb2) accumulation is involved in alzheimer's disease (ad) through the formation of amyloid plaque, which leads to hyperphosphorylation of tau, microglial activation, and cognitive deficits. |
2020-09-28 |
2023-01-26 |
Not clear |
| Mercedes A Hern\\xc3\\xa1ndez-Sapi\\xc3\\xa9ns, Edwin E Reza-Zald\\xc3\\xadvar, Ricardo R Cevallos, Ana L M\\xc3\\xa1rquez-Aguirre, Karlen Gazarian, Alejandro A Canales-Aguirr. A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Frontiers in cellular neuroscience vol 14 issue 2020 32655369 |
alzheimer's disease (ad) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-\xce\xb2 (a\xce\xb2) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory and learning as prefrontal cortex and hippocampus. |
2020-09-28 |
2023-01-26 |
Not clear |
| Isidro Ferrer, Pol Andr\\xc3\\xa9s-Benito, Julia Sala-Jarque, Vanessa Gil, Jos\\xc3\\xa9 Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience vol 13 issue 2020 32670019 |
agd has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. |
2020-09-28 |
2023-01-26 |
mouse |
| Isidro Ferrer, Pol Andr\\xc3\\xa9s-Benito, Julia Sala-Jarque, Vanessa Gil, Jos\\xc3\\xa9 Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience vol 13 issue 2020 32670019 |
abnormal hyper-phosphorylated tau deposits were found in ipsilateral hippocampal neurons, grains (dots) in the hippocampus, and threads, dots and coiled bodies in the fimbria, as well as the ipsilateral and contralateral corpus callosum. |
2020-09-28 |
2023-01-26 |
mouse |
| Isidro Ferrer, Pol Andr\\xc3\\xa9s-Benito, Julia Sala-Jarque, Vanessa Gil, Jos\\xc3\\xa9 Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience vol 13 issue 2020 32670019 |
abnormal hyper-phosphorylated tau deposits were found in neurons in the ipsilateral hippocampus, coiled bodies and threads in the fimbria, and the ipsilateral and contralateral corpus callosum, which extended with time along the anterior-posterior axis and distant regions such as hypothalamic nuclei and nuclei of the septum when comparing mice surviving 7 months with mice surviving 3 months. |
2020-09-28 |
2023-01-26 |
mouse |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications vol 7 issue 1 2020 31722749 |
in brain soluble extracts, despite reduced uncleaved tau in ad, levels of n368-cleaved tau are comparable in ad and control hippocampus, suggesting that lgmn-mediated cleavage of tau is not altered in ad. |
2020-09-25 |
2023-01-26 |
mouse |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications vol 7 issue 1 2020 31722749 |
to assess the potential accumulation of n368-cleaved tau in insoluble tau aggregates, we analyzed sarkosyl-insoluble extracts from ad and control hippocampus. |
2020-09-25 |
2023-01-26 |
mouse |
| Christy M Kelley, Sylvia E Perez, Elliott J Mufso. Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study. Acta neuropathologica communications vol 7 issue 1 2020 31831066 |
the medial temporal lobe (mtl; i.e., hippocampus, subiculum, and entorhinal and perirhinal cortices) memory circuit displays tau lesions during the pathological progression of cte. |
2020-09-25 |
2023-01-26 |
Not clear |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters vol 712 issue 2020 31505240 |
in transgenic mice overexpressing human tau with n279\xe2\x80\xafk mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-01-26 |
mouse |
| M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii vol 33 issue 2 2020 32593241 |
various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid \xce\xb2 peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3\xce\xb2 and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. |
2020-09-22 |
2023-01-26 |
rat |
| Guo-Quan Wang, Peng Zhou, Dao-Jun Xie, Shu Ye, Hua-Wu Gao, Yan Wang, Zheng-Qing Fang, Biao Ca. [Effects of Huangpu Tongqiao Capsules on EGFR-PLC\\xce\\xb3 signal pathway of hippocampus in rats with Alzheimer's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol 45 issue 9 2020 32495567 |
rt-pcr results showed that the mrna levels of egfr, plc\xce\xb3, ip3 r and tau in hippocampus of ad rats were significantly increased(p<0.01), and hptqc could reduce the mrna levels of egfr, plc\xce\xb3, ip3 r and tau in ad rats(p<0.05). |
2020-09-17 |
2023-01-26 |
rat |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces A\\xce\\xb2 and tau pathology in the hippocampus. PLoS biology vol 18 issue 8 2020 32822389 |
chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces a\xce\xb2 and tau pathology in the hippocampus. |
2020-09-17 |
2023-01-26 |
mouse |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces A\\xce\\xb2 and tau pathology in the hippocampus. PLoS biology vol 18 issue 8 2020 32822389 |
using a novel transgenic mouse line to model the impact of human app (happ)/a\xce\xb2 accumulation on tauopathy in the entorhinal cortex-hippocampal (ec-hipp) network, we demonstrate that happ overexpression aggravates ec-tau aggregation and accelerates pathological tau spread into the hippocampus. |
2020-09-17 |
2023-01-26 |
mouse |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces A\\xce\\xb2 and tau pathology in the hippocampus. PLoS biology vol 18 issue 8 2020 32822389 |
chronic chemogenetic attenuation of ec neuronal hyperactivity led to reduced happ/a\xce\xb2 accumulation and reduced pathological tau spread into downstream hippocampus. |
2020-09-17 |
2023-01-26 |
mouse |
| Emily L Munger, Melissa K Edler, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Chet C Sherwood, Mary Ann Raghant. Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees. The Journal of comparative neurology vol 527 issue 7 2020 30578640 |
both prefrontal cortex layer i and hippocampal astrocytes exhibit a high degree of astrogliosis that is positively correlated with accumulation of amyloid beta and tau proteins. |
2020-09-16 |
2023-01-26 |
chimpanzee |
| Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research vol 45 issue 7 2020 32705825 |
[effect of electroacupuncture on cyclin-dependent kinase 5 and tau protein in hippocampus of samp8 mice]. |
2020-09-16 |
2023-01-26 |
mouse |
| Ran Ma, Li-Hong Kong, Feng-Jun Qi, Rui-Yang He, Qing Zheng, Wei Lu, Xiao-Ping F. [Effect of electroacupuncture on cyclin-dependent kinase 5 and Tau protein in hippocampus of SAMP8 mice]. Zhen ci yan jiu = Acupuncture research vol 45 issue 7 2020 32705825 |
to observe the effect of electroacupuncture (ea) and manual acupuncture (ma) on learning-memory ability, changes of ultrastructure of neurons and expression of cdk5 and tau proteins in hippocampus of samp8 mice\xef\xbc\x8cso as to explore its mechanisms underlying improvement of alzheimer's disease (ad)\xef\xbc\x8e. |
2020-09-16 |
2023-01-26 |
mouse |
| Dylan J Finneran, Dave Morgan, Marcia N Gordon, Kevin R Nas. CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology vol 14 issue 2 2020 30499006 |
these benefits were achieved without detectable reductions in tau hyperphosphorylation, hippocampal atrophy, or microglial cd45 expression. |
2020-09-11 |
2023-01-26 |
mouse |
| Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3\\xce\\xb2 and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging vol 11 issue 18 2020 31548435 |
we here show that employing single prolonged stress (sps), as a consensus ptsd model, induced a typical anxiety and abnormal hyperphosphorylation of tau at ser202/thr205 (at8) and ser404 but not at ser199 and ser396 in the hippocampus compared to the control rats. |
2020-09-08 |
2023-01-26 |
rat |