| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia vol 66 issue 2 2020 32420892 |
the content of asp, glu, gaba, gly, and tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (hplc) in intact km rats, km rats exposed to a series of epileptiform seizures, and wistar rats (control group). |
2020-09-08 |
2023-01-26 |
rat |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia vol 66 issue 2 2020 32420892 |
the changes observed in male rats after the set of seizures included the increase in gaba concentration and a decrease in the gly level in all investigated brain parts, as well as the decrease of the tau content in the cortex and hippocampus. |
2020-09-08 |
2023-01-26 |
rat |
| Tauqeerunnisa Syeda, Rachel M Foguth, Emily Llewellyn, Jason R Canno. PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease. Toxicology vol 437 issue 2020 32169473 |
phip exposure for 16 weeks resulted in increased hippocampal oxidative damage, app, bace1, a\xce\xb2 aggregation, and tau phosphorylation. |
2020-08-31 |
2023-01-26 |
mouse |
| Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying X. Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-\\xce\\xbaB pathway in presenilin1/2 conditional double knockout mice. Brain, behavior, and immunity vol 82 issue 2020 31376499 |
we observed that tca treatment reversed abnormal expression of synaptic proteins and tau hyperphosphorylation in the hippocampus and prefrontal cortex of ps cdko mice. |
2020-08-25 |
2023-01-26 |
mouse |
| Heidi I L Jacobs, Jean C Augustinack, Aaron P Schultz, Bernard J Hanseeuw, Joseph Locascio, Rebecca E Amariglio, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnso. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology vol 94 issue 18 2020 32273431 |
to identify the hippocampal subregions linking initial amyloid and tau pathology to memory performance in clinically normal older individuals, reflecting preclinical alzheimer disease (ad). |
2020-08-21 |
2023-01-26 |
Not clear |
| Anna Mietelska-Porowska, Anna Gasiorowska, Ewelina Palasz, Dave J Koss, Gernot Riedel, Grazyna Niewiadomsk. Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride. Journal of neuroscience methods vol 319 issue 2020 30448465 |
wistar rats 3, 9 and 15 month-old were surgically prepared for hippocampal loading with pore-former polymeric 1,3-alkylpyridinium salts (poly-aps) and recombinant human tau including pharmacological inhibition of phosphatase activity by okadaic acid co-administration. |
2020-08-19 |
2023-01-26 |
rat |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-\\xce\\xb2 attenuation. Brain : a journal of neurology vol 143 issue 1 2020 31782760 |
amyloid-\xce\xb2 peptide attenuation reduced hippocampal tau pathology and rescued adult hippocampal neurogenesis and neuronal function, via improvements in cross-frequency coupling between theta and gamma bands. |
2020-08-18 |
2023-01-26 |
rat |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-\\xce\\xb2 attenuation. Brain : a journal of neurology vol 143 issue 1 2020 31782760 |
reduction of amyloid-\xce\xb2 peptide in the entorhinal cortex had no effect on entorhinal tau pathology or entorhinal-hippocampal neuronal network dysfunction, as measured by an impairment in hippocampal response to entorhinal stimulation. |
2020-08-18 |
2023-01-26 |
rat |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology vol 143 issue 1 2020 31834353 |
we examined these pathways, as well as amyloid-\xce\xb2 and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). |
2020-08-18 |
2023-01-26 |
Not clear |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology vol 143 issue 1 2020 31834353 |
pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-\xce\xb21-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. |
2020-08-18 |
2023-01-26 |
Not clear |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology vol 143 issue 1 2020 31834353 |
in temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. |
2020-08-18 |
2023-01-26 |
Not clear |
| Lexiang Yu, Yao Chen, Yong Xu, Tao He, Yan Wei, Rongqiao H. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging vol 11 issue 14 2020 31307014 |
furthermore, advanced glycation end products (age), tau hyperphosphorylation and neuronal death in the hippocampal ca4/dg region were detected in t1dm rats. |
2020-08-06 |
2023-01-26 |
rat |
| Jessica Z K Caldwell, Jeffrey L Cummings, Sarah J Banks, Sebastian Palmqvist, Oskar Hansso. Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume. Alzheimer's research & therapy vol 11 issue 1 2020 31878968 |
we examined interactive effects of sex, diagnosis, and cerebrospinal fluid (csf) amyloid beta/phosphorylated tau ratio (a\xce\xb2/p-tau) on verbal memory and hippocampal volumes. |
2020-08-06 |
2023-01-26 |
Not clear |
| Maud Gratuze, Nicolas Josset, Franck R Petry, Mathieu Pflieger, Laura Eyoum Jong, Geoffrey Truchetti, Isabelle Poitras, Jacinthe Julien, Fran\\xc3\\xa7ois Bezeau, Fran\\xc3\\xa7oise Morin, Pershia Samadi, Francesca Cicchetti, Fr\\xc3\\xa9d\\xc3\\xa9ric Bretzner, Emmanuel Plane. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research vol 1711 issue 2020 30641037 |
mptp also induced a slight but significant increase in tau phosphorylation (thr205) in the hippocampus of htau mice, as well as a significant decrease in the soluble and insoluble tau fractions that correlated with the loss of dopaminergic neurons in the brainstem. |
2020-08-04 |
2023-01-26 |
mouse |
| Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herledan, Nicolas Malmanche, Petra M\\xc3\\xa4kinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Ana\\xc3\\xafs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, Benoit D\\xc3\\xa9prez, Fran\\xc3\\xa7ois-Xavier Cantrelle, Damien Mar\\xc3\\xa9chal, Laurent Pradier, Mikko Hiltunen, Isabelle Landrieu, Devrim Kilinc, Yann Herault, Jocelyn Laporte, Jean-Charles Lamber. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr Acta neuropathologica vol 138 issue 4 2020 31065832 |
after killing the cohort at 18\xc2\xa0months, immunohistochemistry revealed that bin1 overexpression prevents both tau mislocalization and somatic inclusion in the hippocampus, where an increase in bin1-tau interaction was also observed. |
2020-08-04 |
2023-01-26 |
mouse |
| David Berron, Danielle van Westen, Rik Ossenkoppele, Olof Strandberg, Oskar Hansso. Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease. Brain : a journal of neurology vol 143 issue 4 2020 32252068 |
furthermore, correlation analysis in this group revealed decreasing functional connectivity between bilateral perirhinal/entorhinal cortices, anterior hippocampus and posterior-medial regions with increasing levels of phosphorylated tau. |
2020-07-31 |
2023-01-26 |
human |
| Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akane Nomori, Satoko Wada-Kakuda, Akihiko Takashima, Mitsuhiro Kawata, Shigeo Murayama, Yasuo Ihara, Tomohiro Miyasak. Distribution of endogenous normal tau in the mouse brain. The Journal of comparative neurology vol 527 issue 5 2020 30408165 |
interestingly, tau antibodies strongly labeled nonmyelinated axons such as hippocampal mossy fibers, while white matters generally exhibited low levels of immunoreactivity. |
2020-07-28 |
2023-01-26 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity vol 2019 issue 2020 31285742 |
here, a tau-seeding model in which preformed synthetic tau fibrils (k18) were unilaterally injected into the lc of p301l mice, equipped with multichannel electrodes for recording eeg in frontal cortical and ca1-ca3 hippocampal areas, was used to longitudinally quantify over 20 weeks of functional network dynamics in (1) power spectra; (2) fc using intra- and intersite phase-amplitude theta-gamma coupling (pac); (3) coherence, partial coherence, and global coherent network efficiency (eglob) estimates; and (4) the directionality of functional connectivity using extended partial direct coherence (pdc). |
2020-07-27 |
2023-01-26 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity vol 2019 issue 2020 31285742 |
the present results demonstrate early dysfunctional hippocampal networks, despite no spreading tau pathology to the hippocampus and frontal cortex. |
2020-07-27 |
2023-01-26 |
mouse |
| A Ahnaou, C Walsh, N V Manyakov, S A Youssef, W H Drinkenbur. Early Electrophysiological Disintegration of Hippocampal Neural Networks in a Novel Locus Coeruleus Tau-Seeding Mouse Model of Alzheimer's Disease. Neural plasticity vol 2019 issue 2020 31285742 |
the ability of the k18 seed in the brainstem lc to elicit such robust functional alterations in distant hippocampal structures in the absence of pathology challenges the classic view that tau pathology spread to an area is necessary to elicit functional impairments in that area. |
2020-07-27 |
2023-01-26 |
mouse |