| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujin Kim, Yunkwon Nam, Min-Joo Ham, Chisoo Park, Minho Moon, Doo-Han Yo. Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review. Frontiers in aging neuroscience. vol 13. 2021-08-03. PMID:34335229. |
this review postulates potential neurological mechanisms of emotional or social interaction through aai in countering ad-related pathologies, such as aβ deposition, tau hyperphosphorylation, neuroinflammation, and impaired adult hippocampal neurogenesis (ahn), and proposes insights for future research by organizing accumulated previous evidence. |
2021-08-03 |
2023-08-13 |
Not clear |
| Mara A Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra, Rosalinda Guevara-Guzmá. Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β BMC neuroscience. vol 22. issue 1. 2021-07-31. PMID:33653273. |
studies have demonstrated that apn administration decreases aβ neurotoxicity and tau hyperphosphorylation in the hipp, reducing cognitive impairment. |
2021-07-31 |
2023-08-13 |
rat |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32372343. |
quantitative assessment of hippocampal tau pathology in ad and part. |
2021-07-29 |
2023-08-13 |
Not clear |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32372343. |
to quantitatively assess the distribution pattern of hippocampal tau pathology in alzheimer's disease (ad) and primary age-related tauopathy (part), we investigated the distribution of phosphorylated tau protein (at8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in part and ad. |
2021-07-29 |
2023-08-13 |
Not clear |
| Karlo Toljan, Jan Homola. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225969. |
the understanding of alzheimer's disease (ad) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, insulin resistance, and circadian rhythm alterations. |
2021-07-28 |
2023-08-13 |
Not clear |
| Rodrigo A Quntanilla, Carola Tapia-Monsalve. The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection. Current neuropharmacology. vol 18. issue 11. 2021-07-26. PMID:32448104. |
more importantly, tau protein contributes to the physiological regulation of mitochondria through the opening/interaction with mptp in hippocampal neurons. |
2021-07-26 |
2023-08-13 |
mouse |
| Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo León-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296096. |
morphological alterations have been described in hippocampal dendritic spines during hibernation-a state of inactivity and metabolic depression that occurs via a transient neuronal tau hyperphosphorylation. |
2021-07-24 |
2023-08-13 |
Not clear |
| Wei Chen, Lingfei Jiang, Yueqiang Hu, Nong Tang, Ni Liang, Xing-Feng Li, Ye-Wen Chen, Hongling Qin, Lin W. Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis. Brain research. vol 1752. 2021-07-22. PMID:33333054. |
the morris water maze (mwm) test and tau hyperphosphorylation test were performed on hippocampal neurons to establish a mcao model. |
2021-07-22 |
2023-08-13 |
rat |
| Ida Cariati, Laura Masuelli, Roberto Bei, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangel. Neurodegeneration in Niemann-Pick Type C Disease: An Updated Review on Pharmacological and Non-Pharmacological Approaches to Counteract Brain and Cognitive Impairment. International journal of molecular sciences. vol 22. issue 12. 2021-07-20. PMID:34202978. |
in addition, different pathological similarities, including degeneration of hippocampal and cortical neurons, hyperphosphorylated tau, and neurofibrillary tangle formation, have been identified between npc disease and other neurodegenerative pathologies. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yanyan Kong, Lin Huang, Weihao Li, Xuanting Liu, Yinping Zhou, Cuiping Liu, Shibo Zhang, Fang Xie, Zhengwei Zhang, Donglang Jiang, Weiyan Zhou, Ruiqing Ni, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Gua. The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment. Frontiers in cell and developmental biology. vol 9. 2021-07-20. PMID:34277597. |
we found that the expression of sv2a was down-regulated in the hippocampus of ad patients, yet the relation of sv2a to other hallmarks of ad pathology such as amyloid precursor protein (app), β-amyloid (aβ), and tau protein is not thoroughly clear. |
2021-07-20 |
2023-08-13 |
Not clear |
| Wenjin Yang, Gaoyi Li, Ke Cao, Peng Ma, Yijun Guo, Wusong Tong, Jian Wa. Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation. Neuropeptides. vol 83. 2021-07-16. PMID:32863068. |
additionally, igf-1 attenuated tau phosphorylation in ischemic hippocampus. |
2021-07-16 |
2023-08-13 |
rat |
| Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Ga. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33914267. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular hyperphosphorylated tau in the hippocampus and cerebral cortex. |
2021-07-15 |
2023-08-13 |
Not clear |
| Shi-Dong Chen, Yu-Yuan Huang, Xue-Ning Shen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34120152. |
a longitudinal increase of plasma p-tau181 was associated with abnormal cerebrospinal fluid biomarker levels (low aβ42, high phosphorylated tau, and high total tau, all p < 0.001), amyloid accumulation (p < 0.001) and hypometabolism (p = 0.002) on positron emission tomography, atrophy in structure imaging (small hippocampal (p = 0.030), middle temporal (p = 0.008), and whole brain (p = 0.027) volume, and large ventricular volume (p = 0.008)), and deteriorated cognitive performance (global cognition and memory, language, executive function, and visuospatial function, all p < 0.050) at baseline. |
2021-07-14 |
2023-08-13 |
human |
| Chong Lu, Yikui Zhao, Yan Cao, Li Liu, Shanshan Wu, Dongbin Li, Shuang Liu, Shuyuan Xiao, Yafen Wei, Xinyu L. MALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose. Clinical interventions in aging. vol 16. 2021-07-14. PMID:34188461. |
malat1 regulated mtor-mediated tau hyperphosphorylation by acting as a cerna of mir144 in hippocampus cells exposed to high glucose. |
2021-07-14 |
2023-08-13 |
Not clear |
| Takashi Ando, Yuichi Riku, Akio Akagi, Hiroaki Miyahara, Mitsuaki Hirano, Toshimasa Ikeda, Hiroyuki Yabata, Ryuichi Koizumi, Chisato Oba, Saori Morozumi, Keizo Yasui, Atsuko Goto, Taiji Katayama, Satoko Sakakibara, Ikuko Aiba, Motoko Sakai, Masaaki Konagaya, Keiko Mori, Yasuhiro Ito, Hiroyuki Yuasa, Masayo Nomura, Kristine Joyce L Porto, Jun Mitsui, Shoji Tsuji, Maya Mimuro, Yoshio Hashizume, Masahisa Katsuno, Yasushi Iwasaki, Mari Yoshid. Multiple system atrophy variant with severe hippocampal pathology. Brain pathology (Zurich, Switzerland). 2021-07-13. PMID:34255887. |
immunohistochemistry for hyperphosphorylated tau and phosphorylated tdp-43 revealed minimal aggregations in the hippocampus of the hippocampal msa patients. |
2021-07-13 |
2023-08-13 |
Not clear |
| Chrysoula Dioli, Patrícia Patrício, Lucilia-Goreti Pinto, Clemence Marie, Mónica Morais, Sheela Vyas, João M Bessa, Luisa Pinto, Ioannis Sotiropoulo. Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress. Cell proliferation. vol 54. issue 7. 2021-07-12. PMID:33988263. |
despite tau and its malfunction is increasingly related to deficits of adult hippocampal neurogenesis and brain plasticity under pathological conditions [e.g. |
2021-07-12 |
2023-08-13 |
Not clear |
| Qing Zhang, Jing Wang, Liang Zhu, Shi-Jie Jiang, Juan Liu, Lin-Xiao Wang, Xi-Hu Qi. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats. Current medical science. vol 41. issue 3. 2021-07-12. PMID:34169425. |
memory deficits can be caused by hhcy via pathologies of ad-like tau and amyloid-β (aβ) in the hippocampus. |
2021-07-12 |
2023-08-13 |
rat |
| Qing Zhang, Jing Wang, Liang Zhu, Shi-Jie Jiang, Juan Liu, Lin-Xiao Wang, Xi-Hu Qi. Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats. Current medical science. vol 41. issue 3. 2021-07-12. PMID:34169425. |
we found that the pathologies of tau and aβ were induced by hcy in the hippocampus, while the hcy-induced tau hyperphosphorylation and aβ accumulation could be markedly attenuated by simultaneous ligustrazine treatment. |
2021-07-12 |
2023-08-13 |
rat |
| Weizhuo Lu, Jiyue We. Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32219683. |
we next sought to demonstrate the role of tfc on cognitive rehabilitation and the tau phosphorylation in hippocampal tissues at 30d after sah. |
2021-07-09 |
2023-08-13 |
rat |
| Weizhuo Lu, Jiyue We. Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32219683. |
not surprisingly, cognitive dysfunction and the upregulation of tau phosphorylation at ser262 (p-tau-ser262) in hippocampal tissues were markedly reduced by tfc treatment. |
2021-07-09 |
2023-08-13 |
rat |