| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Wang, Xu Cao, Jing Yin, Wen-Rui Gao, Wei-Ran Li, Jin-Shun Qi, Mei-Na W. [Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230948. |
the results showed that: (1) chronic sleep deprivation did not affect anxiety- (p = 0.539) and depression-like behaviors (p = 0.874) in 3xtg-ad mice; (2) chronic sleep deprivation exacerbated the impairments of object recognition memory (p < 0.001), working memory (p = 0.002) and the conditioned fear memory (p = 0.039) in 3xtg-ad mice; (3) chronic sleep deprivation increased amyloid β (aβ) deposition (p < 0.001) and microglial activation (p < 0.001) in the hippocampus of 3xtg-ad mice, without inducing abnormal tau phosphorylation and neurofibrillary tangles. |
2021-07-08 |
2023-08-13 |
mouse |
| Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S Larson, Abhijeet Sharma, Robert K S Wong, Kirill Y Gorbachev, Ana C Pereir. Neuronal Network Excitability in Alzheimer's Disease: The Puzzle of Similar versus Divergent Roles of Amyloid β and Tau. eNeuro. vol 8. issue 2. 2021-07-02. PMID:33741601. |
similarly, pathologic accumulation of hyperphosphorylated tau has been associated with hyperexcitability in the hippocampus. |
2021-07-02 |
2023-08-13 |
Not clear |
| Ellen Dicks, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Betty M Tijm. Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease. Neurobiology of aging. vol 94. 2021-06-29. PMID:32585492. |
here, we show that within individuals with preclinical ad, gray matter network measures predict hippocampal atrophy rates, whereas other ad biomarkers (total gray matter volume, cerebrospinal fluid total tau, and mini-mental state examination) do not. |
2021-06-29 |
2023-08-13 |
Not clear |
| Ellen Dicks, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Betty M Tijm. Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease. Neurobiology of aging. vol 94. 2021-06-29. PMID:32585492. |
when repeating analyses in age-matched, cognitively unimpaired individuals without amyloid or tau pathology, we did not find any associations between network measures and hippocampal atrophy, suggesting that the associations are specific for preclinical ad. |
2021-06-29 |
2023-08-13 |
Not clear |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. |
we hypothesized that these mice would also display memory and hippocampal synaptic plasticity deficits as has been reported for many plaque bearing mouse models which express endogenous mouse tau. |
2021-06-28 |
2023-08-13 |
mouse |
| Zohreh Abbasi, Mohammad Mahdi Ghahramani Seno, Masoud Fereidon. A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33492616. |
these impairments were associated with altered gene expression of insulin receptor, tau and choline acetyltransferase, along with increased astrocyte and dark neuron densities in the hippocampus. |
2021-06-28 |
2023-08-13 |
rat |
| Niels D Prins, John E Harrison, Hui-May Chu, Kelly Blackburn, John J Alam, Philip Schelten. A phase 2 double-blind placebo-controlled 24-week treatment clinical study of the p38 alpha kinase inhibitor neflamapimod in mild Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:34044875. |
in animal models, it mediates impaired synaptic dysfunction in the hippocampus, causing memory deficits, and is involved in amyloid-beta (aβ) production and tau pathology. |
2021-06-24 |
2023-08-13 |
Not clear |
| Shengyi Yang, Huanhuan Zhou, Guiping Wang, Xiao-Hong Zhong, Qi-Liang Shen, Xue-Jing Zhang, Ru-Yi Li, Li-Hua Chen, Ya-Han Zhang, Zhongxiao Wa. Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Journal of food biochemistry. vol 44. issue 4. 2021-06-21. PMID:32065675. |
key markers involved in aβ, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. |
2021-06-21 |
2023-08-13 |
mouse |
| Smriti Tripathi, Uma Kumari, Papiya Mitra Mazumde. Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers. Journal of food biochemistry. vol 44. issue 12. 2021-06-21. PMID:33084094. |
experiments have affirmed that pretreatment of acv, chrysin, and rivastigmine has displayed protective outcomes in mtt reduction, tau phosphorylation, amyloid aggregation, attenuated memory impairment as well as oxidative stress, and protected cholinergic hippocampal neurons from degeneration. |
2021-06-21 |
2023-08-13 |
mouse |
| Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Par. Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. Redox biology. vol 32. 2021-06-18. PMID:32046944. |
low concentrations of aβ (1 μm) induced rhoa-mediated ser422 phosphorylation of tau protein (p-ser422 tau), but reduced the expression of atp citrate lyase (acl) in the ht22 hippocampal neuronal cell line. |
2021-06-18 |
2023-08-13 |
mouse |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32546772. |
modelling this cyfip2 reduction in mice, we find age-dependent aβ accumulation in the thalamus, development of tau pathology in entorhinal cortex and hippocampus, as well as gliosis and synapse loss in the hippocampus, together with deficits in memory formation. |
2021-06-18 |
2023-08-13 |
mouse |
| Tiago Mendes, Adrien Herledan, Florence Leroux, Benoit Deprez, Jean-Charles Lambert, Devrim Kilin. High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons. Current protocols in cell biology. vol 86. issue 1. 2021-06-17. PMID:31876395. |
we recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds using a pla between tau and bridging integrator 1, a genetic risk factor for alzheimer's disease. |
2021-06-17 |
2023-08-13 |
rat |
| Marta Pérez-González, Maite Mendioroz, Sara Badesso, Diego Sucunza, Miren Roldan, Maria Espelosín, Susana Ursua, Rafael Luján, Mar Cuadrado-Tejedor, Ana Garcia-Ost. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment. Progress in neurobiology. vol 191. 2021-06-09. PMID:32380223. |
we demonstrated that adeno-associated viral vector-mediated overexpression of pla2g4e in hippocampal neurons completely restored cognitive deficits in elderly app/ps1 mice, without affecting the amyloid or tau pathology. |
2021-06-09 |
2023-08-13 |
mouse |
| Cem Süer, Nurbanu Yıldız, Özlem Barutçu, Burak Tan, Nurcan Dursu. Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. Pharmacological reports : PR. vol 73. issue 3. 2021-06-07. PMID:33797746. |
long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. |
2021-06-07 |
2023-08-13 |
rat |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and alzheimer's disease. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
while the neuropathologic hallmark of cte is found in the cortex, hippocampal tau has proven to be an important neuropathologic feature to examine the extent of disease severity. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
cte demonstrated high levels of tau in hippocampal subfields ca2 and ca3 compared to ca1. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
overall, this work demonstrates that the relative deposition of tau isoforms among hippocampal subfields can aid in differential diagnosis of ad and cte, and might help improve specificity of biomarkers for in vivo diagnosis. |
2021-06-07 |
2023-08-13 |
Not clear |
| Yu Guo, Chenghong Zhang, Chunyang Wang, Yufei Huang, Jingyun Liu, Haiying Chu, Xiang Ren, Li Kong, Haiying M. Thioredoxin-1 Is a Target to Attenuate Alzheimer-Like Pathology in Diabetic Encephalopathy by Alleviating Endoplasmic Reticulum Stress and Oxidative Stress. Frontiers in physiology. vol 12. 2021-06-05. PMID:34079471. |
the immunocontent of the ad-related protein tau and the levels of cell apoptosis, β-amyloid (aβ) plaque formation and neuronal degeneration in the hippocampus of the diabetic group were increased. |
2021-06-05 |
2023-08-13 |
mouse |
| Viridiana Navarrete-Yañez, Alejandra Garate-Carrillo, Alonso Rodriguez, Patricia Mendoza-Lorenzo, Guillermo Ceballos, Claudia Calzada-Mendoza, Michael C Hogan, Francisco Villarreal, Israel Ramirez-Sanche. Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. Food & function. vol 11. issue 12. 2021-06-01. PMID:33201160. |
effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. |
2021-06-01 |
2023-08-13 |
mouse |