| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry vol 148 issue 1 2019 30238463 |
in another experiment, acutely following reboxetine injections, tau phosphorylation was quantified in the frontal cortex, striatum, and hippocampus of the mice. |
2019-10-28 |
2023-01-26 |
mouse |
| H-B Zheng, Y-T Fu, G Wang, L-H Sun, Y-Y Fan, T-W Yan. Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. European review for medical and pharmacological sciences vol 22 issue 11 2019 29917212 |
hyperphosphorylation of protein tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. |
2019-10-22 |
2023-01-26 |
rat |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 39 issue 3 2019 30482786 |
tau accumulation in clinically normal older adults is associated with hippocampal hyperactivity. |
2019-10-16 |
2023-01-26 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 39 issue 3 2019 30482786 |
the relationship between hippocampal hyperactivity and early ad molecular pathology (amyloid-\xce\xb2 and tau accumulation) before clinical symptoms remains to be elucidated. |
2019-10-16 |
2023-01-26 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 39 issue 3 2019 30482786 |
in this subset, we found that inferior temporal tau accumulation was associated with increased fmri activity in the hippocampus, but showed no clear association with amyloid. |
2019-10-16 |
2023-01-26 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 39 issue 3 2019 30482786 |
together, the findings support a hypothetical model of the evolution of preclinical ad that place hippocampal hyperactivity concurrent with spread of tau pathology to neocortical regions before clinical impairment. |
2019-10-16 |
2023-01-26 |
human |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell vol 17 issue 4 2019 29749079 |
acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. |
2019-10-14 |
2023-01-26 |
mouse |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell vol 17 issue 4 2019 29749079 |
we found that acute knockdown of tau in the adult hippocampus significantly impaired motor coordination and spatial memory. |
2019-10-14 |
2023-01-26 |
mouse |
| Liang Cai, Kai Lu, Xin Chen, Jing-Yuan Huang, Bao-Ping Zhang, Han Zhan. Auricular vagus nerve stimulation protects against postoperative cognitive dysfunction by attenuating neuroinflammation and neurodegeneration in aged rats. Neuroscience letters vol 703 issue 2019 30904576 |
concomitant with these beneficial effects, we found that treatment with avns attenuated postoperative neuroinflammation (i.e., the protein level of interleukin-1\xce\xb2 and tumor necrosis factor-\xce\xb1, along with the nuclear protein expression of nf-\xce\xbab) and alzheimer's-related pathology (tau phosphorylation at at-8 and ser396, as well as the levels of a\xce\xb240 and a\xce\xb242) in the hippocampus of the aged rats. |
2019-10-11 |
2023-01-26 |
rat |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports vol 8 issue 1 2019 29915328 |
to explore whether mir alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal mirs are altered at the presymptomatic and symptomatic stages of tauopathy using rtg4510 mice (tau mice), a well-characterized tauopathy model. |
2019-10-09 |
2023-01-26 |
mouse |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience vol 38 issue 50 2019 30355631 |
cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). |
2019-10-09 |
2023-01-26 |
rat |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience vol 38 issue 50 2019 30355631 |
here we investigated the effect of different tau species on synaptic plasticity in the male rat hippocampus |
2019-10-09 |
2023-01-26 |
rat |
| Lindsay A Welikovitch, Sonia Do Carmo, Zs\\xc3\\xb3fia Magl\\xc3\\xb3czky, P\\xc3\\xa9ter Szocsics, J\\xc3\\xa1nos L\\xc5\\x91ke, Tam\\xc3\\xa1s Freund, A Claudio Cuell. Evidence of intraneuronal A\\xce\\xb2 accumulation preceding tau pathology in the entorhinal cortex. Acta neuropathologica vol 136 issue 6 2019 30362029 |
using well-characterized monoclonal antibodies, we demonstrate that the age-dependent intraneuronal accumulation of soluble a\xce\xb2 is pervasive throughout the entorhinal cortex and hippocampus, and that this phase of the amyloid pathology becomes established within ad-vulnerable regions before the deposition of a\xce\xb2 plaques and the formation of tau neurofibrillary tangles. |
2019-10-09 |
2023-01-26 |
human |
| Kurt A Jellinge. Different patterns of hippocampal tau pathology in Alzheimer's disease and PART. Acta neuropathologica vol 136 issue 5 2019 30088091 |
different patterns of hippocampal tau pathology in alzheimer's disease and part. |
2019-10-08 |
2023-01-26 |
Not clear |
| Alexander J Moszczynski, Jason Gopaul, Patrick McCunn, Kathryn Volkening, Madeline Harvey, Robert Bartha, Susanne Schmid, Michael J Stron. Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology. Journal of neuropathology and experimental neurology vol 77 issue 8 2019 29878234 |
somatic gene transfer using a recombinant adenoviral vector (raav9) encoding pseudophosphorylated human thr175 tau in adult rat hippocampus induces tau pathology. |
2019-10-03 |
2023-01-26 |
rat |
| Alexander J Moszczynski, Jason Gopaul, Patrick McCunn, Kathryn Volkening, Madeline Harvey, Robert Bartha, Susanne Schmid, Michael J Stron. Somatic Gene Transfer Using a Recombinant Adenoviral Vector (rAAV9) Encoding Pseudophosphorylated Human Thr175 Tau in Adult Rat Hippocampus Induces Tau Pathology. Journal of neuropathology and experimental neurology vol 77 issue 8 2019 29878234 |
to determine whether pthr175 tau can induce tau pathology in vivo with an accompanying clinical phenotype, we used a recombinant adenoviral expression vector (raav9) to express a gfp-tagged thr175asp tau protein construct in adult female sprague-dawley rat hippocampus. |
2019-10-03 |
2023-01-26 |
rat |
| Jo\\xc3\\xa3o Vaz-Silva, Patr\\xc3\\xadcia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares-Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO journal vol 37 issue 20 2019 30166454 |
endolysosomal degradation of tau and its role in glucocorticoid-driven hippocampal malfunction. |
2019-10-01 |
2023-01-26 |
Not clear |
| Jo\\xc3\\xa3o Vaz-Silva, Patr\\xc3\\xadcia Gomes, Qi Jin, Mei Zhu, Viktoriya Zhuravleva, Sebastian Quintremil, Torcato Meira, Joana Silva, Chrysoula Dioli, Carina Soares-Cunha, Nikolaos P Daskalakis, Nuno Sousa, Ioannis Sotiropoulos, Clarissa L Waite. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. The EMBO journal vol 37 issue 20 2019 30166454 |
furthermore, we find that gc impair tau degradation by decreasing rab35 levels, and that aav-mediated expression of rab35 in the hippocampus rescues gc-induced tau accumulation and related neurostructural deficits. |
2019-10-01 |
2023-01-26 |
Not clear |
| Xuejin Cao, Hanrong Xu, Weixi Feng, Dongyuan Su, Ming Xia. Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage. Brain research bulletin vol 143 issue 2019 30347264 |
ldclns increased total and phosphorylated tau protein levels in the hippocampus of both genotype mice, but increased hippocampal amyloid beta 1-40 and 1-42 levels only in aqp4 null mice, with up-regulation of beta-site amyloid precursor protein-cleaving enzyme 1 and down-regulation of insulin degrading enzyme. |
2019-09-30 |
2023-01-26 |
mouse |
| Albert Llad\\xc3\\xb3, Adri\\xc3\\xa0 Tort-Merino, Raquel S\\xc3\\xa1nchez-Valle, Neus Falg\\xc3\\xa0s, Mircea Balasa, Beatriz Bosch, Magda Castellv\\xc3\\xad, Jaume Olives, Anna Antonell, Michael Hornberge. The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology. Neurobiology of aging vol 70 issue 2019 29935415 |
the hippocampal longitudinal axis-relevance for underlying tau and tdp-43 pathology. |
2019-09-27 |
2023-01-26 |
human |